Ruth F Itzhaki

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Neurosci Lett 429:95-100. 2007
  2. ncbi Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Moffat Building, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Prog Lipid Res 45:73-90. 2006
  3. ncbi Herpes simplex virus type 1 and Alzheimer's disease: the autophagy connection
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Neurovirol 14:1-4. 2008
  4. ncbi Herpes simplex virus type 1 in Alzheimer's disease: the enemy within
    Ruth F Itzhaki
    Faculty of Life Science, The University of Manchester, Manchester, UK
    J Alzheimers Dis 13:393-405. 2008
  5. ncbi Alzheimer's disease-like changes in herpes simplex virus type 1 infected cells: the case for antiviral therapy
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Rejuvenation Res 11:319-20. 2008
  6. ncbi Herpesviruses in brain and Alzheimer's disease
    Woan-Ru Lin
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Pathol 197:395-402. 2002
  7. ncbi Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e25152. 2011
  8. ncbi Absence of Chlamydia pneumoniae in brain of vascular dementia patients
    Matthew A Wozniak
    Department of Optometry and Neuroscience, Molecular Neurobiology Laboratory, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Neurobiol Aging 24:761-5. 2003
  9. ncbi Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients
    Matthew A Wozniak
    Molecular Neurobiology Laboratory, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    J Med Virol 75:300-6. 2005
  10. ncbi Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Alzheimers Dis 16:341-50. 2009

Collaborators

Detail Information

Publications24

  1. ncbi Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Neurosci Lett 429:95-100. 2007
    ..These novel data show that HSV1 can directly contribute to the development of senile plaques...
  2. ncbi Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Moffat Building, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Prog Lipid Res 45:73-90. 2006
    ..We also link the damage due to two major consequences of HSV1 infection--inflammatory and oxidative processes--to lipid peroxidation in brain, and consider the influence of the different apoE isoforms in this process...
  3. ncbi Herpes simplex virus type 1 and Alzheimer's disease: the autophagy connection
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Neurovirol 14:1-4. 2008
    ....
  4. ncbi Herpes simplex virus type 1 in Alzheimer's disease: the enemy within
    Ruth F Itzhaki
    Faculty of Life Science, The University of Manchester, Manchester, UK
    J Alzheimers Dis 13:393-405. 2008
    ..It is concluded that there is strong evidence that the virus is indeed a major factor in AD and therefore there is a strong case for appropriate treatment, and possibly for prevention in the future...
  5. ncbi Alzheimer's disease-like changes in herpes simplex virus type 1 infected cells: the case for antiviral therapy
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Rejuvenation Res 11:319-20. 2008
  6. ncbi Herpesviruses in brain and Alzheimer's disease
    Woan-Ru Lin
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Pathol 197:395-402. 2002
    ....
  7. ncbi Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e25152. 2011
    ..Since antiviral agents reduce greatly Aβ and P-tau accumulation in HSV1-infected cells, they would be suitable for treating AD with great advantage unlike current AD therapies, only the virus, not the host cell, would be targeted...
  8. ncbi Absence of Chlamydia pneumoniae in brain of vascular dementia patients
    Matthew A Wozniak
    Department of Optometry and Neuroscience, Molecular Neurobiology Laboratory, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Neurobiol Aging 24:761-5. 2003
    ..025 IFU. Our results do not support a role for Cpn in the aetiology of VaD, either in the 83% of patients in whose brains we detected CMV, or in the remaining 17% without CMV in brain...
  9. ncbi Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients
    Matthew A Wozniak
    Molecular Neurobiology Laboratory, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    J Med Virol 75:300-6. 2005
    ..The HSV1 results confirm the original PCR findings that show the presence of HSV1 DNA sequences in many elderly brains, and indicate also that the whole functional HSV1 genome is present, and that the virus has replicated...
  10. ncbi Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Alzheimers Dis 16:341-50. 2009
    ..Together with our previous data, our results point to the use of antiviral agents to slow the progression of the disease...
  11. ncbi Does apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus?
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Eur J Hum Genet 15:672-8. 2007
    ....
  12. ncbi Herpes simplex virus interferes with amyloid precursor protein processing
    Suzanne J Shipley
    Faculty of Life Sciences, University of Manchester, Manchester, M60 1QD, UK
    BMC Microbiol 5:48. 2005
    ..In order to find if HSV1 directly affects APP and its degradation, we have examined this protein from human neuroblastoma cells (normal and transfected with APP 695) infected with the virus, using Western blotting...
  13. ncbi Do infectious agents play a role in dementia?
    Curtis B Dobson
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    Trends Microbiol 11:312-7. 2003
  14. ncbi Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus
    Matthew A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester, UK
    Hepatology 36:456-63. 2002
    ..This is yet another case in which apoE may determine the severity of a viral disease...
  15. ncbi Alzheimer's disease, the neuroimmune axis, and viral infection
    Ruth F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optomery and Neuroscience, UMIST, PO Box 88, Manchester M60 1QD, United Kingdom
    J Neuroimmunol 156:1-2. 2004
  16. ncbi Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients
    Woan-Ru Lin
    Molecular Neurobiology Laboratory, UMIST, Manchester, M60 1QD, United Kingdom
    Neurobiol Dis 9:82-7. 2002
    ..0002); the proportions of the patients harboring the other viruses in brain do not differ significantly from those of the normals. Further studies are needed to reveal whether or not the association of CMV with VaD is causal...
  17. ncbi Inflammatory consequences: benevolent, or virulent?
    Ruth F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Neurobiol Aging 23:681-2; discussion 683-4. 2002
  18. ncbi Intravenous immunoglobulin reduces beta amyloid and abnormal tau formation caused by herpes simplex virus type 1
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    J Neuroimmunol 257:7-12. 2013
    ..We show that IVIG is effective at reducing the accumulation of these abnormal molecules and that it acts synergistically with the antiviral acyclovir, suggesting that their combined use would be beneficial for treating AD...
  19. ncbi Viral infection and cognitive decline
    Ruth F Itzhaki
    J Am Geriatr Soc 55:131. 2007
  20. ncbi Commentary on 'Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer's disease' by Prasanna Satpute-Krishnan et al. Aging Cell Vol. 2, Issue 6, 305-318 (2003)
    Ruth F Itzhaki
    Aging Cell 3:79-80. 2004
  21. ncbi Herpes simplex virus type 1 and Alzheimer's disease
    Ruth F Itzhaki
    Ann Neurol 55:299-300; author reply 300-1. 2004
  22. ncbi The significance of environmental factors in the etiology of Alzheimer's disease
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    J Alzheimers Dis 4:179-89. 2002
    ..Diet, aluminum, and viral infections may increase the prevalence of AD by eliciting inflammation, which may cause the neurological damage that results in AD...
  23. ncbi Alzheimer's disease and herpes
    Ruth F Itzhaki
    CMAJ 167:13. 2002
  24. ncbi Apolipoprotein E and hepatitis C virus
    Ruth F Itzhaki
    Hepatology 38:1060. 2003