R F Itzhaki

Summary

Affiliation: University of Manchester Institute of Science and Technology
Country: UK

Publications

  1. ncbi request reprint Herpes simplex virus type 1 in Alzheimer's disease: the enemy within
    Ruth F Itzhaki
    Faculty of Life Science, The University of Manchester, Manchester, UK
    J Alzheimers Dis 13:393-405. 2008
  2. ncbi request reprint Commentary on 'Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer's disease' by Prasanna Satpute-Krishnan et al. Aging Cell Vol. 2, Issue 6, 305-318 (2003)
    Ruth F Itzhaki
    Aging Cell 3:79-80. 2004
  3. ncbi request reprint Infiltration of the brain by pathogens causes Alzheimer's disease
    R F Itzhaki
    Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology UMIST, Manchester M60 1QD, UK
    Neurobiol Aging 25:619-27. 2004
  4. ncbi request reprint The role of viruses and of APOE in dementia
    R F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, P O Box 88, Manchester M60 1QD, UK
    Ann N Y Acad Sci 1019:15-8. 2004
  5. ncbi request reprint Herpes simplex virus type 1, apolipoprotein E and Alzheimer' disease
    Ruth Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester, UK
    Herpes 11:77A-82A. 2004
  6. ncbi request reprint Alzheimer's disease, the neuroimmune axis, and viral infection
    Ruth F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optomery and Neuroscience, UMIST, PO Box 88, Manchester M60 1QD, United Kingdom
    J Neuroimmunol 156:1-2. 2004
  7. ncbi request reprint Inflammatory consequences: benevolent, or virulent?
    Ruth F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Neurobiol Aging 23:681-2; discussion 683-4. 2002
  8. pmc Apolipoprotein E polymorphisms and risk of malaria
    M A Wozniak
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 41:145-6. 2004
  9. ncbi request reprint Vaccination prevents latent HSV1 infection of mouse brain
    W R Lin
    University of Manchester Institute of Science and Technology, Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, M60 1QD, Manchester, UK
    Neurobiol Aging 22:699-703. 2001
  10. pmc Herpes simplex encephalitis: involvement of apolipoprotein E genotype
    W R Lin
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    J Neurol Neurosurg Psychiatry 70:117-9. 2001

Detail Information

Publications28

  1. ncbi request reprint Herpes simplex virus type 1 in Alzheimer's disease: the enemy within
    Ruth F Itzhaki
    Faculty of Life Science, The University of Manchester, Manchester, UK
    J Alzheimers Dis 13:393-405. 2008
    ..It is concluded that there is strong evidence that the virus is indeed a major factor in AD and therefore there is a strong case for appropriate treatment, and possibly for prevention in the future...
  2. ncbi request reprint Commentary on 'Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer's disease' by Prasanna Satpute-Krishnan et al. Aging Cell Vol. 2, Issue 6, 305-318 (2003)
    Ruth F Itzhaki
    Aging Cell 3:79-80. 2004
  3. ncbi request reprint Infiltration of the brain by pathogens causes Alzheimer's disease
    R F Itzhaki
    Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology UMIST, Manchester M60 1QD, UK
    Neurobiol Aging 25:619-27. 2004
    ..pneumoniae, amyloid plaques/deposits consistent with those observed in the AD brain develop, thus implicating this infection in the etiology of AD...
  4. ncbi request reprint The role of viruses and of APOE in dementia
    R F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, P O Box 88, Manchester M60 1QD, UK
    Ann N Y Acad Sci 1019:15-8. 2004
    ..It is hoped that the discovery of the involvement of HSV1 in AD will lead to future antiviral therapy and possibly to immunization against the virus in infancy...
  5. ncbi request reprint Herpes simplex virus type 1, apolipoprotein E and Alzheimer' disease
    Ruth Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester, UK
    Herpes 11:77A-82A. 2004
    ..Further research into the possible link between herpesviruses and Alzheimer's disease is therefore required...
  6. ncbi request reprint Alzheimer's disease, the neuroimmune axis, and viral infection
    Ruth F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optomery and Neuroscience, UMIST, PO Box 88, Manchester M60 1QD, United Kingdom
    J Neuroimmunol 156:1-2. 2004
  7. ncbi request reprint Inflammatory consequences: benevolent, or virulent?
    Ruth F Itzhaki
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Neurobiol Aging 23:681-2; discussion 683-4. 2002
  8. pmc Apolipoprotein E polymorphisms and risk of malaria
    M A Wozniak
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 41:145-6. 2004
  9. ncbi request reprint Vaccination prevents latent HSV1 infection of mouse brain
    W R Lin
    University of Manchester Institute of Science and Technology, Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, M60 1QD, Manchester, UK
    Neurobiol Aging 22:699-703. 2001
    ..001). Thus, ISCOMs protect the CNS also, suggesting their possible future usage in humans...
  10. pmc Herpes simplex encephalitis: involvement of apolipoprotein E genotype
    W R Lin
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    J Neurol Neurosurg Psychiatry 70:117-9. 2001
    ..6, 95% confidence interval (95% CI) 2. 0-10.8). The apoE epsilon3 and epsilon4 allele frequencies did not differ significantly between the two groups. Thus, it seems that apoE epsilon2 is a risk factor for HSE...
  11. pmc Does apolipoprotein E polymorphism influence susceptibility to malaria?
    M A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 40:348-51. 2003
    ..Parasite densities, all of which were low, did not differ significantly. This effect, although based on small numbers, suggests that APOE epsilon 2 may be a risk factor for early infection...
  12. doi request reprint Alzheimer's disease-like changes in herpes simplex virus type 1 infected cells: the case for antiviral therapy
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Rejuvenation Res 11:319-20. 2008
  13. doi request reprint Herpes simplex virus type 1 and Alzheimer's disease: the autophagy connection
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Neurovirol 14:1-4. 2008
    ....
  14. ncbi request reprint Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients
    Matthew A Wozniak
    Molecular Neurobiology Laboratory, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    J Med Virol 75:300-6. 2005
    ..The HSV1 results confirm the original PCR findings that show the presence of HSV1 DNA sequences in many elderly brains, and indicate also that the whole functional HSV1 genome is present, and that the virus has replicated...
  15. ncbi request reprint Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Neurosci Lett 429:95-100. 2007
    ..These novel data show that HSV1 can directly contribute to the development of senile plaques...
  16. ncbi request reprint Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders
    Ruth F Itzhaki
    Faculty of Life Sciences, The University of Manchester, Moffat Building, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Prog Lipid Res 45:73-90. 2006
    ..We also link the damage due to two major consequences of HSV1 infection--inflammatory and oxidative processes--to lipid peroxidation in brain, and consider the influence of the different apoE isoforms in this process...
  17. ncbi request reprint Viral infection and cognitive decline
    Ruth F Itzhaki
    J Am Geriatr Soc 55:131. 2007
  18. ncbi request reprint Herpesviruses in brain and Alzheimer's disease
    Woan Ru Lin
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Pathol 197:395-402. 2002
    ....
  19. pmc Alzheimer's disease and herpes
    Ruth F Itzhaki
    CMAJ 167:13. 2002
  20. ncbi request reprint The significance of environmental factors in the etiology of Alzheimer's disease
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    J Alzheimers Dis 4:179-89. 2002
    ..Diet, aluminum, and viral infections may increase the prevalence of AD by eliciting inflammation, which may cause the neurological damage that results in AD...
  21. ncbi request reprint Do infectious agents play a role in dementia?
    Curtis B Dobson
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    Trends Microbiol 11:312-7. 2003
  22. pmc Herpes simplex virus interferes with amyloid precursor protein processing
    Suzanne J Shipley
    Faculty of Life Sciences, University of Manchester, Manchester, M60 1QD, UK
    BMC Microbiol 5:48. 2005
    ..In order to find if HSV1 directly affects APP and its degradation, we have examined this protein from human neuroblastoma cells (normal and transfected with APP 695) infected with the virus, using Western blotting...
  23. ncbi request reprint Absence of Chlamydia pneumoniae in brain of vascular dementia patients
    Matthew A Wozniak
    Department of Optometry and Neuroscience, Molecular Neurobiology Laboratory, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Neurobiol Aging 24:761-5. 2003
    ..025 IFU. Our results do not support a role for Cpn in the aetiology of VaD, either in the 83% of patients in whose brains we detected CMV, or in the remaining 17% without CMV in brain...
  24. ncbi request reprint Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus
    Matthew A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester, UK
    Hepatology 36:456-63. 2002
    ..This is yet another case in which apoE may determine the severity of a viral disease...
  25. ncbi request reprint Does apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus?
    Matthew A Wozniak
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Eur J Hum Genet 15:672-8. 2007
    ....
  26. ncbi request reprint Apolipoprotein E and hepatitis C virus
    Ruth F Itzhaki
    Hepatology 38:1060. 2003
  27. ncbi request reprint Herpes simplex virus type 1 and Alzheimer's disease
    Ruth F Itzhaki
    Ann Neurol 55:299-300; author reply 300-1. 2004
  28. ncbi request reprint Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients
    Woan Ru Lin
    Molecular Neurobiology Laboratory, UMIST, Manchester, M60 1QD, United Kingdom
    Neurobiol Dis 9:82-7. 2002
    ..0002); the proportions of the patients harboring the other viruses in brain do not differ significantly from those of the normals. Further studies are needed to reveal whether or not the association of CMV with VaD is causal...