Research Topics
| P G IsaacsonSummaryAffiliation: University College London Country: UK Publications
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Publications
Gastrointestinal lymphomas of T- and B-cell typesP G Isaacson
Department of Histopathology, University College London Medical School, England
Mod Pathol 12:151-8. 1999..Enteropathy (celiac disease)-associated T-cell lymphoma (EATL) is the most common primary gastrointestinal T-cell lymphoma This is a clinically aggressive tumor that arises from the intraepithelial T-cell population...- Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10Ayoma Attygalle
Department of Histopathology, Royal Free and University College Medical School, London, United Kingdom
Blood 99:627-33. 2002..The presence of these cells distinguishes AITL from other PTLs. This finding provides an objective criterion for accurate and early diagnosis of AITL... - Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case reportRobin H Johns
Department of Intensive Care, Royal Free Hospital, London, UK
J Med Case Reports 4:32. 2010..A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition... - MALT lymphoma: from morphology to moleculesPeter G Isaacson
Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
Nat Rev Cancer 4:644-53. 2004 - Gastrointestinal lymphoma: where morphology meets molecular biologyPeter G Isaacson
Department of Histopathology, University College London, London WC1E 6JJ, UK
J Pathol 205:255-74. 2005..Here, the histopathology and recent advances in phenotypic and molecular characterization of gastric MALT lymphoma and ETL and their applications in diagnosis and clinical management are reviewed... - Update on MALT lymphomasPeter G Isaacson
Department of Histopathology, University College London, London WC1E 6JJ, UK
Best Pract Res Clin Haematol 18:57-68. 2005..These three chromosomal translocations that involve different genes appear to share common oncogenic properties by targeting the same nuclear factor kappa B (NF kappa B) oncogenic pathway... - Haematopathology practice: the commonest problems encountered in a consultation practiceP G Isaacson
Department of Pathology, University College London, London, UK
Histopathology 50:821-34. 2007..This review is an attempt to clarify a logical approach to the differential diagnosis of these lesions... - Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disordersM Q Du
Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
Blood 97:2130-6. 2001..Activation of the IL-6 receptor signaling pathway may play a role in differentiation of KSHV-infected naive B cells into plasmablasts and development of lymphoproliferative lesions. (Blood. 2001;97:2130-2136).. - BCL10 gene mutation in lymphomaM Q Du
Department of Histopathology, Royal Free and University College London Medical School, London, United Kingdom
Blood 95:3885-90. 2000..Blood. 2000;95:3885-3890).. - Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanismR A Hamoudi
Department of Pathology, University of Cambridge, Cambridge, UK
Leukemia 24:1487-97. 2010..Our findings provide novel insights into the molecular mechanism of MALT lymphomas with and without translocation, potentially explaining their different clinical behaviors... - Continual monitoring of intraepithelial lymphocyte immunophenotype and clonality is more important than snapshot analysis in the surveillance of refractory coeliac diseaseH Liu
Department of Histopathology, Addenbrooke s Hospital, Cambridge, UK
Gut 59:452-60. 2010..However, the utility of continual monitoring of IEL immunophenotype and clonality in the surveillance of RCD remains to be studied... - Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissueA Dogan
Department of Histopathology, University College London Medical School, United Kingdom
Am J Pathol 151:1361-9. 1997.... - A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glandsE Chanudet
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
J Pathol 217:420-30. 2009..007), a higher proportion of relapse (67% versus 37%) and a shorter relapse-free survival (p=0.033). A20 deletion and gain at TNFA/B/C locus may thus play an important role in the development of translocation-negative MALT lymphoma... - T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10H Liu
Department of Histopathology, Royal Free and University College Medical School, London, United Kingdom
Blood 98:1182-7. 2001..These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other. (Blood. 2001;98:1182-1187).. - Gastric MALT lymphoma: from concept to cureP G Isaacson
Department of Histopathology, Royal Free and University College Medical School, London, UK
Ann Oncol 10:637-45. 1999..Cloning of the breakpoint in t(1;14) has allowed the identification of a new tumour suppresser gene, bc110. High grade transformation of MALT lymphoma has been associated with p53 inactivation, deletions of p16 and t(8;14)... - Immunoglobulin gene rearrangement in immunoproliferative small intestinal disease (IPSID)W J Smith
Department of Histopathology, School of Medicine, University College London
J Clin Pathol 40:1291-7. 1987.... - Gastric lymphomas: genetics and resistance to H. pylori eradicationP G Isaacson
Department of Histopathology, University College London, UK
Verh Dtsch Ges Pathol 87:116-22. 2003..These three chromosomal translocations that involve different genes appear to share common oncogenic properties by targeting the to target the same NFkappaB oncogenic pathway... - Gastrointestinal lymphomaP G Isaacson
Department of Histopathology, University College London Medical School, UK
Hum Pathol 25:1020-9. 1994..This is a clinically aggressive tumor that arises from the intraepithelial T-cell population, which is increased in celiac disease... - Improvements to B cell clonality analysis using PCR amplification of immunoglobulin light chain genesT C Diss
Histopathology Department, Royal Free and University College Medical School, University Street, London WC1E 6JJ, UK
Mol Pathol 55:98-101. 2002..However, the method has a relatively high false negative rate. In an attempt to improve detection rates simple PCR strategies for clonality analysis of B cell populations using amplification of Ig light chain genes have been developed... - Why I became a haematopathologistP G Isaacson
J Clin Pathol 59:477-8. 2006 - Splenic marginal zone lymphomaAhmet Dogan
Department of Histopathology, University, College London, London, United Kingdom
Semin Diagn Pathol 20:121-7. 2003..Histological differential diagnosis include a number of entities such as lymphoid hyperplasias, other marginal zone lymphomas, mantle cell lymphoma, follicular lymphoma, and B-CLL... - Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosisAhmet Dogan
Department of Histopathology, University College London, London, UK
Am J Surg Pathol 27:903-11. 2003..The main differential diagnoses include granulomatous inflammation, Hodgkin's lymphoma, follicular lymphoma, and peripheral T-cell lymphomas... - KSHV- and EBV-associated germinotropic lymphoproliferative disorderMing Qing Du
Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
Blood 100:3415-8. 2002..We propose calling this distinctive entity "KSHV-associated germinotropic lymphoproliferative disorder.".. - Immunoproliferative small-intestinal disease. An immunohistochemical studyP G Isaacson
Department of Histopathology, University College and Middlesex School of Medicine, London, England
Am J Surg Pathol 13:1023-33. 1989.... - Loss of heterozygosity at chromosome 9p21 is a frequent finding in enteropathy-type T-cell lymphomaE C Obermann
Department of Histopathology, University College London, UK
J Pathol 202:252-62. 2004..The results of this study show that LOH at chromosome 9p21 is frequent in ETL, especially in tumours with large cell morphology; this finding suggests that gene loss at this locus may play a role in the development of ETL... - t(1;14) and t(11;18) in the differential diagnosis of Waldenström's macroglobulinemiaHongtao Ye
Department of Pathology, University of Cambridge, UK
Mod Pathol 17:1150-4. 2004..Thus, detection of t(1;14)(p22;q32) and t(11;18)(q21;q21) is useful in the differential diagnosis between lymphoplasmacytic lymphoma and mucosa-associated lymphoid tissue lymphoma... - t(11;18)(q21;q21) of mucosa-associated lymphoid tissue lymphoma results from illegitimate non-homologous end joining following double strand breaksHongxiang Liu
Department of Pathology, University of Cambridge, Cambridge, UK
Br J Haematol 125:318-29. 2004..Our results suggest that t(11;18) may result from illegitimate non-homologous end joining following double strand breaks... - T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradicationHongxiang Liu
Department of Histopathology, University College London, London, England
Gastroenterology 122:1286-94. 2002..pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma... - Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified, using morphology, immunophenotype and molecular geneticsA D Attygalle
Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
Histopathology 50:498-508. 2007..To identify distinguishing histological, immunophenotypic and molecular genetic features between angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma (PTL)... - Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disordersM Q Du
Department of Pathology, University of Cambridge, Cambridge, UK
J Clin Pathol 60:1350-7. 2007..The recent advances in our understanding of the histology, immunophenotype and pathogenesis of these KSHV-associated lymphoproliferative disorders are reviewed... - BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphomaH Ye
Department of Histopathology, Royal Free and University College Medical School, London, United Kingdom
Am J Pathol 157:1147-54. 2000..The subcellular localization of BCL10 was frequently altered in MALT lymphoma in comparison with its normal cell counterparts, suggesting that ectopic BCL10 expression may be important in the development of this type of tumor... - Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosisA James Watkins
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
J Pathol 220:461-74. 2010..In conclusion, 7q32 deletion is a characteristic feature of SMZL, albeit seen in isolated cases of splenic B-cell lymphoma/leukaemia unclassifiable, and its detection may help the differential diagnosis of splenic B-cell lymphomas... - Atypical marginal zone hyperplasia of mucosa-associated lymphoid tissue: a reactive condition of childhood showing immunoglobulin lambda light-chain restrictionAyoma D Attygalle
Department of Histopathology, Royal Free and University College Medical School, Rockefeller Bldg, University St, London WC1E 6JJ, United Kingdom
Blood 104:3343-8. 2004..In contrast, MZ (intraepithelial) B cells of 6 control tonsils had a similar immunophenotype, except for expression of CD27 and polytypic light chains, whereas molecular studies showed that they were polyclonal with mutated Ig genes... - High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphomaHongtao Ye
Department of Histopathology, University College London, United Kingdom
Blood 101:2547-50. 2003..Translocation-positive gastric MALT lymphomas tend to be aggressive, and patients with such lymphomas might benefit from prompt treatment and close follow-up... - Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21)Yuanping Zhou
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
Br J Haematol 133:35-42. 2006..Moreover, our findings suggest that genomic gain of genes that modulate NFkappaB activation, such as MALT1, TRAF2 and CARD9, may play a role in the pathogenesis of the translocation-negative MALT lymphoma... - MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expressionHongtao Ye
Department of Pathology, University of Cambridge, Cambridge, UK
J Pathol 205:293-301. 2005..These results show that MALT1 expression pattern is identical to that of BCL10 in normal lymphoid tissues but varies in MALT lymphomas, with high cytoplasmic expression of both MALT1 and BCL10 characterizing those with t(14;18)(q32;q21)... - Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphomaHongtao Ye
Department of Histopathology, University College London, United Kingdom
Blood 102:1012-8. 2003..Oxidative damage might play a role in development of t(11;18)(q21; q21)... - CD10 expression in extranodal dissemination of angioimmunoblastic T-cell lymphomaAyoma D Attygalle
Department of Histopathology, University College, London, U.K
Am J Surg Pathol 28:54-61. 2004..Our data show that aberrant CD10 expression is a useful phenotypic marker for diagnosis of AITL in most involved extranodal sites, except bone marrow, and suggest a possible role of FDC in the pathogenesis of AITL... - First steps in unraveling the genotype of enteropathy-type T-cell lymphomaMing-Qing Du
Department of Histopathology, Royal Free and University College Medical School, University College London, United Kingdom
Am J Pathol 161:1527-9. 2002 - Primary effusion lymphoma: genomic profiling revealed amplification of SELPLG and CORO1C encoding for proteins important for cell migrationShi Lu Luan
Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ, UK
J Pathol 222:166-79. 2010..SELPLG is critical for cell migration and chemotaxis, while CORO1C regulates actin-dependent processes, thus important for cell motility. Their overexpression in PEL is expected to play an important role in its pathogenesis... - Translocation t(11;18)(q21;q21) is not predictive of response to chemotherapy with 2CdA in patients with gastric MALT lymphomaBerthold Streubel
Department of Pathology, University of Vienna, Austria
Oncology 66:476-80. 2004..2CdA appears to be an attractive agent for treatment of gastric MALT lymphoma unresponsive to H. pylori eradication, including those positive for t(11;18)(q21;q21)... - Bacterial infection and MALT lymphomaJulie Parsonnet
Department of Medicine, Stanford University Medical Center, Stanford, Calif, USA
N Engl J Med 350:213-5. 2004 - Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasmHenry Y Dong
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 29:1633-41. 2005..We conclude that most plasmacytic tumors in HIV-positive individuals are extramedullary, clinically aggressive EBV(+) tumors identical to plasmablastic lymphoma that does not have the clinical features of plasma cell myeloma... - Helicobacter pylori-associated peptic ulcer and florid follicular gastritis mimicking a malignancyShih-Sung Chuang
J Clin Pathol 60:1071-2. 2007 - The pattern of genomic gains in salivary gland MALT lymphomasYuanping Zhou
Division of Molecular Histopathology, Department of Pathology University of Cambridge, Cambridge, United Kingdom
Haematologica 92:921-7. 2007..The aim of this sudy was to investigate chromosomal changes in these lymphomas... - Novel markers of normal and neoplastic human plasmacytoid dendritic cellsTeresa Marafioti
Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
Blood 111:3778-92. 2008.... - High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformationShih-Sung Chuang
Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan
Br J Haematol 120:97-100. 2003..One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation... - A relapsing inflammatory syndrome and HHV-8Ahmet Dogan
N Engl J Med 353:1746-7; author reply 1746-7. 2005 - High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman diseaseEric Oksenhendler
Department of Immunology and Hematology, Laboratory of Hematology, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
Blood 99:2331-6. 2002..In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions...