R Elwyn Isaac

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. request reprint
    Isaac R, Johnson E, Audsley N, Shirras A. Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila. J Exp Biol. 2007;210:4465-70 pubmed
    ....
  2. Isaac R, Bland N, Shirras A. Neuropeptidases and the metabolic inactivation of insect neuropeptides. Gen Comp Endocrinol. 2009;162:8-17 pubmed publisher
    ..We also discuss how the sequencing of insect genomes has led to the molecular identification of candidate neuropeptidase genes. ..
  3. Isaac R, Li C, Leedale A, Shirras A. Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female. Proc Biol Sci. 2010;277:65-70 pubmed publisher
    ..The stress resulting from SP-dependent sleep deprivation might be an important contribution to the toxic side-effects of male accessory gland products that are known to reduce lifespan in post-mated females. ..
  4. Isaac R, Kim Y, Audsley N. The degradome and the evolution of Drosophila sex peptide as a ligand for the MIP receptor. Peptides. 2014;53:258-64 pubmed publisher
    ..melanogaster. SP has evolved relatively recently as a MIP receptor ligand that is particularly well adapted to surviving in the hostile degradome of the male accessory gland and seminal fluid. ..
  5. request reprint
    Isaac R, Parkin E, Keen J, Nassel D, Siviter R, Shirras A. Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders. Peptides. 2002;23:725-33 pubmed
    ....
  6. Bland N, Pinney J, Thomas J, Turner A, Isaac R. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. BMC Evol Biol. 2008;8:16 pubmed publisher
    ..It is predicted that differences in the S2' subsite are fundamental to determining the substrate specificities that facilitate this functional diversity. ..

Locale

Detail Information

Publications6

  1. request reprint
    Isaac R, Johnson E, Audsley N, Shirras A. Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila. J Exp Biol. 2007;210:4465-70 pubmed
    ....
  2. Isaac R, Bland N, Shirras A. Neuropeptidases and the metabolic inactivation of insect neuropeptides. Gen Comp Endocrinol. 2009;162:8-17 pubmed publisher
    ..We also discuss how the sequencing of insect genomes has led to the molecular identification of candidate neuropeptidase genes. ..
  3. Isaac R, Li C, Leedale A, Shirras A. Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female. Proc Biol Sci. 2010;277:65-70 pubmed publisher
    ..The stress resulting from SP-dependent sleep deprivation might be an important contribution to the toxic side-effects of male accessory gland products that are known to reduce lifespan in post-mated females. ..
  4. Isaac R, Kim Y, Audsley N. The degradome and the evolution of Drosophila sex peptide as a ligand for the MIP receptor. Peptides. 2014;53:258-64 pubmed publisher
    ..melanogaster. SP has evolved relatively recently as a MIP receptor ligand that is particularly well adapted to surviving in the hostile degradome of the male accessory gland and seminal fluid. ..
  5. request reprint
    Isaac R, Parkin E, Keen J, Nassel D, Siviter R, Shirras A. Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders. Peptides. 2002;23:725-33 pubmed
    ....
  6. Bland N, Pinney J, Thomas J, Turner A, Isaac R. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. BMC Evol Biol. 2008;8:16 pubmed publisher
    ..It is predicted that differences in the S2' subsite are fundamental to determining the substrate specificities that facilitate this functional diversity. ..