J A Irving
Affiliation: University of Newcastle
- The role of alternative splicing of the adhesion molecule, CD44, in lymphoid malignancyJ A Irving
Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
J Clin Pathol 51:776-80. 1998....
- Mismatch repair defects as a cause of resistance to cytotoxic drugsJ A Irving
Paediatric Oncology Research Unit, Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Expert Rev Anticancer Ther 1:149-58. 2001..Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects...
- Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center settingJulie Irving
Northern Institute for Cancer Research, Newcastle upon Tyne, Tyne and Wear, UK
Haematologica 94:870-4. 2009..01%) was 86% (n=134). Thus, this standardized protocol is highly reproducible between laboratories, sensitive, applicable, and shows good concordance with molecular-based analysis...
- Use of denaturing HPLC for detection of mutations in the BCR-ABL kinase domain in patients resistant to ImatinibJulie A E Irving
Leukaemia Research Fund Molecular Pharmacology Laboratory, School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle, Newcastle, UK
Clin Chem 50:1233-7. 2004
- Loss of heterozygosity and somatic mutations of the glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease courseJulie A E Irving
Northern Institute for Cancer Research and Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
Cancer Res 65:9712-8. 2005..We hypothesize that the mutated allele present in a leukemic subclone at initial diagnosis was selected for during remission induction with glucocorticoids and contributed to the emergence of a glucocorticoid-resistant cell population...
- Molecular diagnostics: a healthcare perspectiveAndrew G Hall
Leukaemia Research Fund Laboratory, Northern Institute for Cancer Research, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Expert Rev Mol Diagn 3:13-6. 2003..However, such an outcome may be neither achievable nor desirable when viewed from the perspective of suppliers of healthcare...
- Mismatch repair and the downstream target genes, PAX5 and Ikaros, in childhood acute lymphoblastic leukemiaAndrew Best
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
Leuk Res 34:1098-102. 2010..Whilst MMR deficiency is not highly prevalent in primary ALL, optimisation of the drug regimen to omit/replace thioguanines should be considered for children with MMR deficiency and/or reduced expression of key pathway components...
- Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United KingdomAkheel A Syed
School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
J Clin Endocrinol Metab 89:232-5. 2004..3 vs. 3%, respectively). Therefore, the N363S polymorphism is unlikely to be an important factor in obesity and/or dysmetabolic traits in people of South Asian origin living in the United Kingdom...
- Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysisJulie A E Irving
Northern Institute for Cancer Research and Institute for Human Genetics, Newcastle University, Newcastle, NE2 4HH, UK
Cancer Res 65:3053-8. 2005..These observations show that SNP array analysis is a powerful new tool for the analysis of allelic imbalance in leukemic blasts...
- Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemiaMarian Case
Northern Institute for Cancer Research, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Cancer Res 68:6803-9. 2008..Inhibitors of the pathway, which are currently undergoing clinical trial, may be a novel therapeutic option for cALL, particularly at relapse...
- A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroupsSarina Sulong
Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
Blood 113:100-7. 2009..The variation in the incidence of CDKN2A deletions by cytogenetic subgroup may explain its inconsistent association with outcome. CNN LOH without apparent CDKN2A inactivation suggests the presence of other relevant genes in this region...
- Association of glucocorticoid receptor polymorphism A3669G in exon 9beta with reduced central adiposity in womenAkheel A Syed
School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
Obesity (Silver Spring) 14:759-64. 2006..These data suggest that the 3669G allele may attenuate the undesirable effects of glucocorticoids on fat distribution and lipid metabolism, although its penetrance may vary in different ethnic groups...
- DNA mismatch repair pathway defects in the pathogenesis and evolution of myelomaMark R Velangi
Northern Institute for Cancer Research, University of Newcastle upon Tyne, UK
Carcinogenesis 25:1795-803. 2004..Thus we show that MMR defects are found in plasma cell dyscrasias and the increased frequency during more active stages of the disease suggests a contributory role in disease progression...
- DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivoElizabeth C Matheson
Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK
Carcinogenesis 28:1341-6. 2007....
- A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in menAkheel A Syed
Newcastle University Teaching Hospitals, Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 68:879-84. 2008..Our objective was to test the association of rs2918419, a T-->C single nucleotide change in intron 2 downstream of the Bcl1 locus, with components of the metabolic syndrome and its interaction with the Bcl1 locus...
- Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptorStefan Schmidt
Tyrolean Cancer Research Institute, Innrain 66, A 6020 Innsbruck, Austria
FASEB J 20:2600-2. 2006..In all instances, GC-resistance occurred at the level of the GR in both models...