Research Topics
Genomes and Genes | J P IredaleSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Cirrhosis: new research provides a basis for rational and targeted treatmentsJohn P Iredale
Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD
BMJ 327:143-7. 2003
Reversal of liver fibrosis and cirrhosis--an emerging realityJ A Fallowfield
Liver Research Group, Division of Infection, Inflammation and Repair, University of Southhampton
Scott Med J 49:3-6. 2004- Hepatic stellate cell behavior during resolution of liver injuryJ P Iredale
Liver Research Group, Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Tremona Road, Southampton, Hampshire SO16 6YD, United Kingdom
Semin Liver Dis 21:427-36. 2001..Our increasing understanding of the process of stellate cell behavior in recovery from injury is likely to be important to the design of antifibrotic therapies... - Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivoE J Williams
Liver Research Group, Division of Cell and Molecular Medicine, D Level, South Academic Block, Southampton General Hospital, Southampton, UK
Gut 49:577-83. 2001..CONCLUSION: These data demonstrate that relaxin modulates effective collagen deposition by HSC, at least in part, due to changes in the pattern of matrix degradation... - Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosisM J Arthur
University Medicine, University of Southampton, United Kingdom
J Gastroenterol Hepatol 13:S33-8. 1998..This may represent an important therapeutic target in the design of anti-fibrotic strategies for chronic liver disease... - Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factorsR Issa
Liver Research Group, Division of Cell and Molecular Medicine, Level D, South Lab and Path Block, Southampton General Hospital, Southampton, UK
Gut 48:548-57. 2001..CONCLUSION: HSC apoptosis plays a critical role in the spontaneous recovery from biliary fibrosis. Both survival and apoptosis of HSC are regulated by growth factors expressed during fibrotic liver injury... - Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferationR C Benyon
University Medicine, Southampton General Hospital, Southampton, United Kingdom
Hepatology 30:977-86. 1999..Gelatinase A activity is required for maximal proliferation of HSCs in vitro suggesting this metalloproteinase is an autocrine proliferation factor for HSCs... - Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitisW M Howell
The Pancreatic and Liver Fibrosis Research Groups, Divisions of Human Genetics, Allergy and Repair, University of Southampton, Southampton SO16 6YD, UK
J Clin Pathol 58:595-9. 2005.... - Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver diseaseM J Arthur
University Medicine, University of Southampton, Hampshire, United Kingdom
Alcohol Clin Exp Res 23:940-3. 1999..In alcoholic liver disease, the role of TIMPs has not been studied exhaustively, but the evidence currently available supports a role for inhibition of matrix degradation by TIMPs in this progressive fibrotic liver disease... - Sporadic acute hepatitis E in the united kingdom: an underdiagnosed phenomenon?R McCrudden
Division of Cell and Molecular Medicine, D Level South Block Mail Point 811, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Gut 46:732-3. 2000..Case reports of HEV in individuals in the United Kingdom relate to travel to endemic areas or contact with individuals who have visited these areas... - Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet functionA C Bateman
The Pancreatic and Liver Fibrosis Research Groups, Division of Infection, University of Southampton, Southampton General Hospital, UK
Gut 50:542-8. 2002..This is mirrored pathologically by extensive acinar cell destruction and islet preservation. The mechanisms underlying this differential rate of cellular destruction are unknown... - Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosisJ P Iredale
University of Medicine, Southampton General Hospital, Southampton, England
Hepatology 24:176-84. 1996..We suggest that increased expression of TIMP-1 relative to interstitial collagenase by HSCs may promote progression of liver fibrosis in these rat models by preventing degradation of secreted collagens... - Targeted treatments for cirrhosisJonathan A Fallowfield
Liver Research Group, Division of Infection, Inflammation and Repair, Southampton General Hospital, Mailpoint 811, D Level, Southampton, SO16 6YD, UK
Expert Opin Ther Targets 8:423-35. 2004..This review draws on recent scientific advances, and highlights emerging therapeutic interventions in liver fibrosis... - Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repairJeremy S Duffield
Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
J Clin Invest 115:56-65. 2005..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring... - Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosisXiaoying Zhou
Liver Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton, Hants, SO16 6YD, United Kingdom
J Biol Chem 281:39757-65. 2006.... - Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linkingRazao Issa
Division of Infection Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Gastroenterology 126:1795-808. 2004..We suggest resolution is limited by tTg-mediated matrix cross-linking and a failure of HSC apoptosis... - Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosisFrank R Murphy
Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Hampshire SO16 6YD, United Kingdom
J Biol Chem 277:11069-76. 2002..We conclude that TIMP-1 inhibits apoptosis of activated HSC via MMP inhibition... - CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injurySandra J Campbell
Molecular Neuropathology Laboratory, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Southampton S016 7PX, UK
FASEB J 17:1168-70. 2003..Hepatic CINC-1 synthesis following injury presents a novel focus for treatment of inflammation... - A cut above the rest? MMP-8 and liver fibrosis gene therapyJohn P Iredale
Gastroenterology 126:1199-201. 2004 - Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosisJonathan A Fallowfield
Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
J Immunol 178:5288-95. 2007..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver... - Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organJohn P Iredale
Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
J Clin Invest 117:539-48. 2007..This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ... - Liver fibrosis: cellular mechanisms of progression and resolutionNeil C Henderson
MRC University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4TJ, U K
Clin Sci (Lond) 112:265-80. 2007.... - Reversal of fibrosis: no longer a pipe dream?Jonathan A Fallowfield
Liver Research Group, Division of Infection, Inflammation and Repair, Mailpoint 811, D Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
Clin Liver Dis 10:481-97, viii. 2006..A return to normal hepatic architecture from advanced fibrosis is achievable in some cases, and cirrhosis itself may be partly remediable... - Emerging therapies for liver fibrosisAndrew J Fowell
Liver Research Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, UK
Dig Dis 24:174-83. 2006..In this review, these mechanisms are highlighted and the growing number of emerging antifibrotic agents discussed... - The bone marrow functionally contributes to liver fibrosisFrancesco P Russo
Department of Medicine, Imperial College, London, United Kingdom
Gastroenterology 130:1807-21. 2006..Clinical trials of BM cell therapy for liver regeneration should be vigilant for the possibility of enhanced organ fibrosis... - Galectin-3 regulates myofibroblast activation and hepatic fibrosisNeil C Henderson
Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, 51 Little France Crescent, EH16 4SA Edinburgh, Scotland, United Kingdom
Proc Natl Acad Sci U S A 103:5060-5. 2006..Finally, in vivo siRNA knockdown of Galectin-3 inhibited myofibroblast activation after hepatic injury and may therefore provide an alternative therapeutic approach to the prevention and treatment of liver fibrosis... - Modeling liver fibrosis in rodentsChristothea Constandinou
University of Southampton, Southampton General Hospital, Southampton, UK
Methods Mol Med 117:237-50. 2005..Mechanistic studies using gene knockout and transgenic animals can also be established using CCl(4). Together these models have provided unparalleled insights into the mechanisms underlying hepatic fibrosis... - Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injuryFiona Oakley
Liver Group, Southampton General Hospital, Southampton SO16 6YD UK
Am J Pathol 166:695-708. 2005..Taken together these data indicate that the p50 NF-kappaB subunit plays a critical protective role in the injured liver by limiting the expression of TNF-alpha and its recruitment of inflammatory cells... - Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosisFiona Oakley
Liver Group, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Southampton SO16 6YD, England, UK
Gastroenterology 128:108-20. 2005.... - Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cellsMarianna D A Gaca
Liver Research Group, University of Southampton Division of Infection, Inflammation and Repair, Southampton General Hospital, SO16 6YD, Southampton, UK
Matrix Biol 22:229-39. 2003.... - Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysisXiaoying Zhou
Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK
Liver Int 24:492-501. 2004..During liver fibrosis resolution, as TIMP expression decays, the persistence of MMP-2 and MMP-14 may permit collagen degradation... - Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosisFiona Oakley
Liver Research Group, IIR Division, School of Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
Am J Pathol 163:1849-58. 2003..These data provide evidence that NGF is expressed during fibrotic liver injury and may regulate number of activated HSCs via induction of apoptosis... - Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cellsXiaoying Zhou
Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, United Kingdom
J Biol Chem 279:23996-4006. 2004.... - Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signalingDavid C Hay
Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
Proc Natl Acad Sci U S A 105:12301-6. 2008..These studies represent an important step toward the use of hESC-derived hepatocytes in high-throughput metabolic analysis of human liver function...