J P Iredale

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Cirrhosis: new research provides a basis for rational and targeted treatments
    John P Iredale
    Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD
    BMJ 327:143-7. 2003
  2. ncbi request reprint Reversal of liver fibrosis and cirrhosis--an emerging reality
    J A Fallowfield
    Liver Research Group, Division of Infection, Inflammation and Repair, University of Southhampton
    Scott Med J 49:3-6. 2004
  3. ncbi request reprint Hepatic stellate cell behavior during resolution of liver injury
    J P Iredale
    Liver Research Group, Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Tremona Road, Southampton, Hampshire SO16 6YD, United Kingdom
    Semin Liver Dis 21:427-36. 2001
  4. pmc Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    E J Williams
    Liver Research Group, Division of Cell and Molecular Medicine, D Level, South Academic Block, Southampton General Hospital, Southampton, UK
    Gut 49:577-83. 2001
  5. ncbi request reprint Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis
    M J Arthur
    University Medicine, University of Southampton, United Kingdom
    J Gastroenterol Hepatol 13:S33-8. 1998
  6. pmc Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    R Issa
    Liver Research Group, Division of Cell and Molecular Medicine, Level D, South Lab and Path Block, Southampton General Hospital, Southampton, UK
    Gut 48:548-57. 2001
  7. ncbi request reprint Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    R C Benyon
    University Medicine, Southampton General Hospital, Southampton, United Kingdom
    Hepatology 30:977-86. 1999
  8. pmc Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis
    W M Howell
    The Pancreatic and Liver Fibrosis Research Groups, Divisions of Human Genetics, Allergy and Repair, University of Southampton, Southampton SO16 6YD, UK
    J Clin Pathol 58:595-9. 2005
  9. ncbi request reprint Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease
    M J Arthur
    University Medicine, University of Southampton, Hampshire, United Kingdom
    Alcohol Clin Exp Res 23:940-3. 1999
  10. pmc Sporadic acute hepatitis E in the united kingdom: an underdiagnosed phenomenon?
    R McCrudden
    Division of Cell and Molecular Medicine, D Level South Block Mail Point 811, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Gut 46:732-3. 2000

Collaborators

  • M J Arthur
  • R C Benyon
  • D A Mann
  • P A Johnson
  • W F Ferris
  • R McCrudden
  • E J Williams
  • G Murphy
  • E N Unemori
  • W M Howell
  • S M Turner
  • Stuart J Forbes
  • Hideaki Nagase
  • S J Campbell
  • Fabian Docagne
  • Shahriar Islam
  • M Alison
  • Junlong Zhang
  • V H Perry
  • Andreas Knorr
  • JEREMY DUFFIELD
  • Xiaoying Zhou
  • Jonathan A Fallowfield
  • Fiona Oakley
  • Neil C Henderson
  • Razao Issa
  • Francesco P Russo
  • Christothea Constandinou
  • Christothea M Constandinou
  • Harry Millward-Sadler
  • Nathan Trim
  • Marianna D A Gaca
  • Frank R Murphy
  • David C Hay
  • Timothy J Kendall
  • Andrew J Fowell
  • J A Fallowfield
  • A C Bateman
  • R Issa
  • James R Black
  • Judy Fletcher
  • Davina Wojtacha
  • John D Terrace
  • Philip N Newsome
  • Zara Hannoun
  • Kay Samuel
  • Catherine Payne
  • Jan Snoeys
  • Anne Pryde
  • Celine Filippi
  • Ian S Currie
  • Ronald C J Gallagher
  • James A Ross
  • Masashi Mizuno
  • James Chan
  • Rosemary Jeffery
  • Brian W Bigger
  • Aqeel Jamil
  • Alison C Mackinnon
  • Christopher Haslett
  • George Bou-Gharios
  • Tariq Sethi
  • Eunice Amofah
  • Aikaterini Florou
  • Francoise Poirier
  • Andrew Nash
  • Farhana Amin
  • Sarah L Farnworth
  • Kenneth J Simpson
  • Shakir Ali
  • David E Smart
  • Jelena Mann
  • Michael J May
  • Sarah Nailard
  • Matthew C Wright
  • Carylyn J Marek
  • Karen Green
  • Neil Henderson
  • Muriel Meso
  • Narendra Mungalsingh
  • Susan J Wilson
  • Emma Sands
  • Ibnauf Suliman
  • Susannah Pawley
  • Nitu Gehdu
  • Christopher J Hovell
  • Jonathan Fallowfield
  • Matthew I Hutchings
  • Alane M Gray
  • Tim Kendall

Detail Information

Publications34

  1. pmc Cirrhosis: new research provides a basis for rational and targeted treatments
    John P Iredale
    Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD
    BMJ 327:143-7. 2003
  2. ncbi request reprint Reversal of liver fibrosis and cirrhosis--an emerging reality
    J A Fallowfield
    Liver Research Group, Division of Infection, Inflammation and Repair, University of Southhampton
    Scott Med J 49:3-6. 2004
  3. ncbi request reprint Hepatic stellate cell behavior during resolution of liver injury
    J P Iredale
    Liver Research Group, Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Tremona Road, Southampton, Hampshire SO16 6YD, United Kingdom
    Semin Liver Dis 21:427-36. 2001
    ..Our increasing understanding of the process of stellate cell behavior in recovery from injury is likely to be important to the design of antifibrotic therapies...
  4. pmc Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    E J Williams
    Liver Research Group, Division of Cell and Molecular Medicine, D Level, South Academic Block, Southampton General Hospital, Southampton, UK
    Gut 49:577-83. 2001
    ..CONCLUSION: These data demonstrate that relaxin modulates effective collagen deposition by HSC, at least in part, due to changes in the pattern of matrix degradation...
  5. ncbi request reprint Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis
    M J Arthur
    University Medicine, University of Southampton, United Kingdom
    J Gastroenterol Hepatol 13:S33-8. 1998
    ..This may represent an important therapeutic target in the design of anti-fibrotic strategies for chronic liver disease...
  6. pmc Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    R Issa
    Liver Research Group, Division of Cell and Molecular Medicine, Level D, South Lab and Path Block, Southampton General Hospital, Southampton, UK
    Gut 48:548-57. 2001
    ..CONCLUSION: HSC apoptosis plays a critical role in the spontaneous recovery from biliary fibrosis. Both survival and apoptosis of HSC are regulated by growth factors expressed during fibrotic liver injury...
  7. ncbi request reprint Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    R C Benyon
    University Medicine, Southampton General Hospital, Southampton, United Kingdom
    Hepatology 30:977-86. 1999
    ..Gelatinase A activity is required for maximal proliferation of HSCs in vitro suggesting this metalloproteinase is an autocrine proliferation factor for HSCs...
  8. pmc Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis
    W M Howell
    The Pancreatic and Liver Fibrosis Research Groups, Divisions of Human Genetics, Allergy and Repair, University of Southampton, Southampton SO16 6YD, UK
    J Clin Pathol 58:595-9. 2005
    ....
  9. ncbi request reprint Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease
    M J Arthur
    University Medicine, University of Southampton, Hampshire, United Kingdom
    Alcohol Clin Exp Res 23:940-3. 1999
    ..In alcoholic liver disease, the role of TIMPs has not been studied exhaustively, but the evidence currently available supports a role for inhibition of matrix degradation by TIMPs in this progressive fibrotic liver disease...
  10. pmc Sporadic acute hepatitis E in the united kingdom: an underdiagnosed phenomenon?
    R McCrudden
    Division of Cell and Molecular Medicine, D Level South Block Mail Point 811, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Gut 46:732-3. 2000
    ..Case reports of HEV in individuals in the United Kingdom relate to travel to endemic areas or contact with individuals who have visited these areas...
  11. pmc Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet function
    A C Bateman
    The Pancreatic and Liver Fibrosis Research Groups, Division of Infection, University of Southampton, Southampton General Hospital, UK
    Gut 50:542-8. 2002
    ..This is mirrored pathologically by extensive acinar cell destruction and islet preservation. The mechanisms underlying this differential rate of cellular destruction are unknown...
  12. ncbi request reprint Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
    J P Iredale
    University of Medicine, Southampton General Hospital, Southampton, England
    Hepatology 24:176-84. 1996
    ..We suggest that increased expression of TIMP-1 relative to interstitial collagenase by HSCs may promote progression of liver fibrosis in these rat models by preventing degradation of secreted collagens...
  13. ncbi request reprint Targeted treatments for cirrhosis
    Jonathan A Fallowfield
    Liver Research Group, Division of Infection, Inflammation and Repair, Southampton General Hospital, Mailpoint 811, D Level, Southampton, SO16 6YD, UK
    Expert Opin Ther Targets 8:423-35. 2004
    ..This review draws on recent scientific advances, and highlights emerging therapeutic interventions in liver fibrosis...
  14. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  15. ncbi request reprint Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis
    Xiaoying Zhou
    Liver Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton, Hants, SO16 6YD, United Kingdom
    J Biol Chem 281:39757-65. 2006
    ....
  16. ncbi request reprint Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking
    Razao Issa
    Division of Infection Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Gastroenterology 126:1795-808. 2004
    ..Previously considered irreversible, we have studied a model of cirrhosis to determine the mechanisms mediating and limiting spontaneous recovery...
  17. ncbi request reprint Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis
    Frank R Murphy
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Hampshire SO16 6YD, United Kingdom
    J Biol Chem 277:11069-76. 2002
    ..We conclude that TIMP-1 inhibits apoptosis of activated HSC via MMP inhibition...
  18. ncbi request reprint CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury
    Sandra J Campbell
    Molecular Neuropathology Laboratory, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Southampton S016 7PX, UK
    FASEB J 17:1168-70. 2003
    ..Hepatic CINC-1 synthesis following injury presents a novel focus for treatment of inflammation...
  19. ncbi request reprint A cut above the rest? MMP-8 and liver fibrosis gene therapy
    John P Iredale
    Gastroenterology 126:1199-201. 2004
  20. ncbi request reprint Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
    ..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver...
  21. pmc Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
    John P Iredale
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 117:539-48. 2007
    ..This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ...
  22. ncbi request reprint Liver fibrosis: cellular mechanisms of progression and resolution
    Neil C Henderson
    MRC University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4TJ, U K
    Clin Sci (Lond) 112:265-80. 2007
    ....
  23. ncbi request reprint Reversal of fibrosis: no longer a pipe dream?
    Jonathan A Fallowfield
    Liver Research Group, Division of Infection, Inflammation and Repair, Mailpoint 811, D Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Clin Liver Dis 10:481-97, viii. 2006
    ..A return to normal hepatic architecture from advanced fibrosis is achievable in some cases, and cirrhosis itself may be partly remediable...
  24. ncbi request reprint Emerging therapies for liver fibrosis
    Andrew J Fowell
    Liver Research Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, UK
    Dig Dis 24:174-83. 2006
    ..In this review, these mechanisms are highlighted and the growing number of emerging antifibrotic agents discussed...
  25. ncbi request reprint The bone marrow functionally contributes to liver fibrosis
    Francesco P Russo
    Department of Medicine, Imperial College, London, United Kingdom
    Gastroenterology 130:1807-21. 2006
    ..We have studied this axis of regeneration and scarring in murine models of cirrhosis, including an assessment of the temporal and functional contribution of the BM-derived myofibroblasts...
  26. pmc Galectin-3 regulates myofibroblast activation and hepatic fibrosis
    Neil C Henderson
    Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, 51 Little France Crescent, EH16 4SA Edinburgh, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 103:5060-5. 2006
    ..Finally, in vivo siRNA knockdown of Galectin-3 inhibited myofibroblast activation after hepatic injury and may therefore provide an alternative therapeutic approach to the prevention and treatment of liver fibrosis...
  27. ncbi request reprint Modeling liver fibrosis in rodents
    Christothea Constandinou
    University of Southampton, Southampton General Hospital, Southampton, UK
    Methods Mol Med 117:237-50. 2005
    ..Mechanistic studies using gene knockout and transgenic animals can also be established using CCl(4). Together these models have provided unparalleled insights into the mechanisms underlying hepatic fibrosis...
  28. pmc Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury
    Fiona Oakley
    Liver Group, Southampton General Hospital, Southampton SO16 6YD UK
    Am J Pathol 166:695-708. 2005
    ..Taken together these data indicate that the p50 NF-kappaB subunit plays a critical protective role in the injured liver by limiting the expression of TNF-alpha and its recruitment of inflammatory cells...
  29. ncbi request reprint Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    Fiona Oakley
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Southampton SO16 6YD, England, UK
    Gastroenterology 128:108-20. 2005
    ..The aim of this study was to determine whether the inhibitor of kappaB kinase suppressor sulfasalazine stimulates hepatic myofibroblast apoptosis and recovery from fibrosis...
  30. ncbi request reprint Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells
    Marianna D A Gaca
    Liver Research Group, University of Southampton Division of Infection, Inflammation and Repair, Southampton General Hospital, SO16 6YD, Southampton, UK
    Matrix Biol 22:229-39. 2003
    ....
  31. ncbi request reprint Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis
    Xiaoying Zhou
    Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK
    Liver Int 24:492-501. 2004
    ..We examined MMP-2 and MMP-14 expression in established and resolving fibrosis to assess their role in resolution of liver fibrosis...
  32. pmc Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis
    Fiona Oakley
    Liver Research Group, IIR Division, School of Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Am J Pathol 163:1849-58. 2003
    ..These data provide evidence that NGF is expressed during fibrotic liver injury and may regulate number of activated HSCs via induction of apoptosis...
  33. ncbi request reprint Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells
    Xiaoying Zhou
    Liver Research Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, United Kingdom
    J Biol Chem 279:23996-4006. 2004
    ....
  34. pmc Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling
    David C Hay
    Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Proc Natl Acad Sci U S A 105:12301-6. 2008
    ..These studies represent an important step toward the use of hESC-derived hepatocytes in high-throughput metabolic analysis of human liver function...