Osamu Inoue

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2
    Osamu Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Cell Biol 160:769-80. 2003
  2. ncbi request reprint Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 102:1367-73. 2003
  3. ncbi request reprint Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C
    Andrew C Pearce
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 100:3561-9. 2002
  4. ncbi request reprint Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 277:21561-6. 2002
  5. doi request reprint Regulation of adaptor protein GIT1 in platelets, leading to the interaction between GIT1 and integrin alpha(IIb)beta3
    Hitomi Sato
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 368:157-61. 2008
  6. ncbi request reprint Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    Yukinari Kato
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Cancer Sci 99:54-61. 2008
  7. ncbi request reprint Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    J Biol Chem 282:25993-6001. 2007
  8. pmc Involvement of Src kinases and PLCgamma2 in clot retraction
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Yamanashi University, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Thromb Res 120:251-8. 2007
  9. pmc Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, 1110 Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:1405-12. 2006
  10. ncbi request reprint Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation
    Qun Yi
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Nakakoma, Japan
    Biochem Biophys Res Commun 337:446-51. 2005

Detail Information

Publications18

  1. pmc Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2
    Osamu Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Cell Biol 160:769-80. 2003
    ....
  2. ncbi request reprint Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 102:1367-73. 2003
    ..These results provide strong evidence that engagement of GPVI stimulates limited integrin activation in PLCgamma2-/- platelets via PLCgamma1 and PI3-kinase...
  3. ncbi request reprint Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C
    Andrew C Pearce
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 100:3561-9. 2002
    ..The present study has provided evidence for a possible role of Vav1 but not Vav2 in the later stages of platelet aggregation...
  4. ncbi request reprint Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 277:21561-6. 2002
    ..These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI...
  5. doi request reprint Regulation of adaptor protein GIT1 in platelets, leading to the interaction between GIT1 and integrin alpha(IIb)beta3
    Hitomi Sato
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Biochem Biophys Res Commun 368:157-61. 2008
    ..These results suggest that tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac GEF betaPIX to the vicinity of the integrin...
  6. ncbi request reprint Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    Yukinari Kato
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Cancer Sci 99:54-61. 2008
    ..Podoplanin and CLEC-2 might represent promising therapeutic targets in cancer metastasis...
  7. ncbi request reprint Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    J Biol Chem 282:25993-6001. 2007
    ..These findings suggest that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplanin...
  8. pmc Involvement of Src kinases and PLCgamma2 in clot retraction
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Yamanashi University, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Thromb Res 120:251-8. 2007
    ..These results demonstrate a partial role for Src kinase-dependent activation of PLCgamma2 and MLC phosphorylation in mediating clot retraction downstream of integrin alpha(IIb)beta(3)...
  9. pmc Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, 1110 Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:1405-12. 2006
    ..We speculate that laminin contributes to platelet spreading in vivo through a direct interaction with GPVI...
  10. ncbi request reprint Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation
    Qun Yi
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Nakakoma, Japan
    Biochem Biophys Res Commun 337:446-51. 2005
    ..These findings provide evidence for a functional role of Gab2 in supporting platelet activation by GPVI...
  11. ncbi request reprint A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, University of Yamanashi, Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:542-9. 2006
    ..CLEC-2 is the first C-type lectin receptor to be found on platelets which signals through this novel pathway...
  12. doi request reprint Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898 Japan
    J Biol Chem 283:16279-82. 2008
    ..This mechanism is similar to that of collagen. We propose that integrins, GPVI, GPIb-IX-V, and VWF represent a general paradigm for the interaction between platelets and subendothelial matrices...
  13. ncbi request reprint Binding kinetics of 11C-N-methyl piperidyl benzilate (11C-NMPB) in a rhesus monkey brain using the cerebellum as a reference region
    Takashi Itoh
    Center for Information and Sciences, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Ann Nucl Med 19:499-505. 2005
    ..When 11C-NMPB binding was compared between ketamine-treated and awake animals, a significant increase in 11C-NMPB binding was observed in the striatum but not in other brain regions of ketamine-treated animals...
  14. ncbi request reprint Acute treatment with pentobarbital alters the kinetics of in vivo receptor binding in the mouse brain
    Yojiro Sakiyama
    Division of Clinical Research, National Institute of Radiological Sciences, Inage Ku, Chibashi 263 8555, Japan
    Nucl Med Biol 33:535-41. 2006
    ..These results suggest that apparent increases in binding at 20 min after tracer injection were due to the decrease in the association and dissociation rates of binding in vivo...
  15. ncbi request reprint Lack of cyclic AMP-specific phosphodiesterase 4 activation during naloxone-precipitated morphine withdrawal in rats
    Megumi Kimura
    Department of Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co Ltd, Toyonaka, Osaka, Japan
    Neurosci Lett 404:107-11. 2006
    ..These results suggest that the lack of PDE4 activation leading to remarkable elevation of cyclic AMP is involved in naloxone-precipitated morphine withdrawal symptoms...
  16. ncbi request reprint Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain
    Rie Hosoi
    Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Suita, Japan
    Ann Nucl Med 17:123-30. 2003
    ..Although the mechanism is still unclear, sabcomeline altered dopamine D2 receptor affinity or availability by modulations via neural networks...
  17. ncbi request reprint Sensitivities of benzodiazepine receptor binding and muscarinic acetylcholine receptor binding for the detection of neural cell death caused by sodium nitroprusside microinjection in rat brain
    Osamu Inoue
    Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Osaka 565 0871, Japan
    Synapse 49:134-41. 2003
    ..These results indicate that mAChR binding may be superior to BZR binding for detecting cell death in brain tissue, in contrast to what was previously thought...
  18. ncbi request reprint Increment of in vivo binding of [3H]SCH 23390, a dopamine D1 receptor ligand, induced by cyclic AMP-dependent protein kinase in rat brain
    Kohji Abe
    Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, 1 7 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res 952:211-7. 2002
    ..These results strongly indicate that the PKA-mediated phosphorylation may play a pivotal role in the regulating the in vivo [(3)H]SCH 23390 dopamine D(1) receptor binding in intact rat brain...