Helen Imrie

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. doi request reprint Insulin resistance, lipotoxicity and endothelial dysfunction
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, The LIGHT Laboratories, Clarendon Way, Leeds, LS29JT, UK
    Biochim Biophys Acta 1801:320-6. 2010
  2. doi request reprint Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species
    Matthew C Gage
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, United Kingdom
    Atherosclerosis 230:131-9. 2013
  3. pmc Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 61:2359-68. 2012
  4. pmc Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis
    Adil Rajwani
    Division of Cardiovascular and Diabetes Research, MultidisciplinaryCardiovascular Research Centre, University of Leeds, Leeds, U K
    Diabetes 61:915-24. 2012
  5. pmc The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
    Afroze Abbas
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 60:2169-78. 2011
  6. pmc Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction
    Piruthivi Sukumar
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 62:2130-4. 2013
  7. doi request reprint Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype
    Nadira Y Yuldasheva
    From the Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, United Kingdom
    Arterioscler Thromb Vasc Biol 34:2051-8. 2014
  8. pmc Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration
    Matthew B Kahn
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Diabetes 60:1295-303. 2011
  9. doi request reprint Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential
    Richard M Cubbon
    Leeds Multidisciplinary Cardiovascular Research Centre, LIGHT Laboratories, The University of Leeds, Clarendon Way, Leeds, United Kingdom
    Stem Cells 32:2714-23. 2014
  10. doi request reprint The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium
    V Kate Gatenby
    Department of Diabetes and Cardiovascular Research, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds, LS2 9NL, UK
    Pflugers Arch 465:1065-74. 2013

Collaborators

Detail Information

Publications11

  1. doi request reprint Insulin resistance, lipotoxicity and endothelial dysfunction
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, The LIGHT Laboratories, Clarendon Way, Leeds, LS29JT, UK
    Biochim Biophys Acta 1801:320-6. 2010
    ..In this review we discuss the mechanisms linking insulin resistance to endothelial dysfunction, with a particular emphasis on a potential role for a toxic effect of free fatty acids on endothelial cell homeostasis...
  2. doi request reprint Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species
    Matthew C Gage
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, United Kingdom
    Atherosclerosis 230:131-9. 2013
    ..We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species...
  3. pmc Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 61:2359-68. 2012
    ..The IGF-1R, although reducing NO bioavailability, enhances in situ endothelium regeneration. Manipulating IGF-1R in the endothelium may be a useful strategy to treat disorders of vascular growth and repair...
  4. pmc Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis
    Adil Rajwani
    Division of Cardiovascular and Diabetes Research, MultidisciplinaryCardiovascular Research Centre, University of Leeds, Leeds, U K
    Diabetes 61:915-24. 2012
    ....
  5. pmc The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
    Afroze Abbas
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 60:2169-78. 2011
    ....
  6. pmc Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction
    Piruthivi Sukumar
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 62:2130-4. 2013
    ..It also establishes pharmacological inhibition of Nox2 as a novel therapeutic target in insulin resistance-related vascular disease...
  7. doi request reprint Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype
    Nadira Y Yuldasheva
    From the Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, United Kingdom
    Arterioscler Thromb Vasc Biol 34:2051-8. 2014
    ..In this report, we examined partial deletion of the IGF1R as a potential strategy to enhance endothelial repair...
  8. pmc Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration
    Matthew B Kahn
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Diabetes 60:1295-303. 2011
    ..Type 2 diabetes is associated with fewer circulating APCs, APC dysfunction, and impaired endothelial repair. We set out to determine whether insulin resistance adversely affects APCs and endothelial regeneration...
  9. doi request reprint Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential
    Richard M Cubbon
    Leeds Multidisciplinary Cardiovascular Research Centre, LIGHT Laboratories, The University of Leeds, Clarendon Way, Leeds, United Kingdom
    Stem Cells 32:2714-23. 2014
    ..Reduced signaling via the Akt/eNOS axis is causally linked with impaired OEC-mediated vascular repair in South Asian men. These data prove the principle of rescuing marked reparative dysfunction in OEC derived from these men...
  10. doi request reprint The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium
    V Kate Gatenby
    Department of Diabetes and Cardiovascular Research, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds, LS2 9NL, UK
    Pflugers Arch 465:1065-74. 2013
    ....
  11. doi request reprint Vascular insulin-like growth factor-I resistance and diet-induced obesity
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom
    Endocrinology 150:4575-82. 2009
    ..Vascular IGF-I resistance may represent a novel therapeutic target to prevent or slow the accelerated vasculopathy seen in humans with obesity or type 2 diabetes mellitus...