Helen Imrie

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Insulin resistance, lipotoxicity and endothelial dysfunction
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, The LIGHT Laboratories, Clarendon Way, Leeds, LS29JT, UK
    Biochim Biophys Acta 1801:320-6. 2010
  2. ncbi Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 61:2359-68. 2012
  3. ncbi Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis
    Adil Rajwani
    Division of Cardiovascular and Diabetes Research, MultidisciplinaryCardiovascular Research Centre, University of Leeds, Leeds, U K
    Diabetes 61:915-24. 2012
  4. ncbi The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
    Afroze Abbas
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 60:2169-78. 2011
  5. ncbi Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration
    Matthew B Kahn
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Diabetes 60:1295-303. 2011
  6. ncbi Vascular insulin-like growth factor-I resistance and diet-induced obesity
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom
    Endocrinology 150:4575-82. 2009

Collaborators

Detail Information

Publications6

  1. ncbi Insulin resistance, lipotoxicity and endothelial dysfunction
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, The LIGHT Laboratories, Clarendon Way, Leeds, LS29JT, UK
    Biochim Biophys Acta 1801:320-6. 2010
    ..In this review we discuss the mechanisms linking insulin resistance to endothelial dysfunction, with a particular emphasis on a potential role for a toxic effect of free fatty acids on endothelial cell homeostasis...
  2. ncbi Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 61:2359-68. 2012
    ..The IGF-1R, although reducing NO bioavailability, enhances in situ endothelium regeneration. Manipulating IGF-1R in the endothelium may be a useful strategy to treat disorders of vascular growth and repair...
  3. ncbi Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis
    Adil Rajwani
    Division of Cardiovascular and Diabetes Research, MultidisciplinaryCardiovascular Research Centre, University of Leeds, Leeds, U K
    Diabetes 61:915-24. 2012
    ....
  4. ncbi The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
    Afroze Abbas
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Diabetes 60:2169-78. 2011
    ....
  5. ncbi Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration
    Matthew B Kahn
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Diabetes 60:1295-303. 2011
    ..Type 2 diabetes is associated with fewer circulating APCs, APC dysfunction, and impaired endothelial repair. We set out to determine whether insulin resistance adversely affects APCs and endothelial regeneration...
  6. ncbi Vascular insulin-like growth factor-I resistance and diet-induced obesity
    Helen Imrie
    Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom
    Endocrinology 150:4575-82. 2009
    ..Vascular IGF-I resistance may represent a novel therapeutic target to prevent or slow the accelerated vasculopathy seen in humans with obesity or type 2 diabetes mellitus...