Mohammad Ilyas

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays
    Nilanjana Tewari
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre National Institute for Health Research Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMC Cancer 13:436. 2013
  2. pmc Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas
    Saleh Al-Ghamdi
    Division of Pathology, Nottingham University, Nottingham, United Kingdom
    PLoS ONE 6:e20919. 2011
  3. pmc Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?
    Mark M Aloysius
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMC Cancer 10:80. 2010
  4. pmc Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia
    Mark M Aloysius
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMC Cancer 9:327. 2009
  5. ncbi request reprint C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer
    Saleh Al-Ghamdi
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham University, Nottingham, UK
    Pancreas 42:135-40. 2013
  6. pmc The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer
    Tarek M A Elsaba
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 5:e10714. 2010
  7. ncbi request reprint C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer
    Abdulkader Albasri
    Division of Pathology, Nottingham University, Nottingham NG7 2UH, UK
    J Pathol 218:57-65. 2009
  8. pmc Comparative analysis of pyrosequencing and QMC-PCR in conjunction with high resolution melting for KRAS/BRAF mutation detection
    Salih Ibrahem
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Int J Exp Pathol 91:500-5. 2010
  9. ncbi request reprint MLH1 function is context dependent in colorectal cancers
    Thomas Jackson
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre Campus, University of Nottingham, Nottingham, UK
    J Clin Pathol 64:141-5. 2011
  10. ncbi request reprint A CD44⁻/CD24⁺ phenotype is a poor prognostic marker in early invasive breast cancer
    Mohamed A H Ahmed
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 133:979-95. 2012

Collaborators

Detail Information

Publications15

  1. pmc The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays
    Nilanjana Tewari
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre National Institute for Health Research Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMC Cancer 13:436. 2013
    ..Tumour-associated lymphocytes (TALs) have been linked with good prognosis in several solid tumours. This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma...
  2. pmc Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas
    Saleh Al-Ghamdi
    Division of Pathology, Nottingham University, Nottingham, United Kingdom
    PLoS ONE 6:e20919. 2011
    ..001). We conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility...
  3. pmc Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?
    Mark M Aloysius
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMC Cancer 10:80. 2010
    ..Therefore, we studied the expression profile of MMCs I, III, IV and V in periampullary cancers, reactive pancreatitis, normal pancreas and chronic pancreatitis...
  4. pmc Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia
    Mark M Aloysius
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMC Cancer 9:327. 2009
    ..We aimed to characterise the immunohistochemical expression of M2-PK in archived specimens of pancreaticobiliary and duodenal cancers, premalignant lesions, chronic pancreatitis, and normal pancreas...
  5. ncbi request reprint C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer
    Saleh Al-Ghamdi
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham University, Nottingham, UK
    Pancreas 42:135-40. 2013
    ..Its role in pancreatic cancer is unknown and was thus investigated in this study...
  6. pmc The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer
    Tarek M A Elsaba
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 5:e10714. 2010
    ..We conclude that CD133 expression in CRCs is associated with some features attributable to stemness and that there is plasticity of CD133 expression. Further studies are necessary to delineate the mechanistic basis of these features...
  7. ncbi request reprint C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer
    Abdulkader Albasri
    Division of Pathology, Nottingham University, Nottingham NG7 2UH, UK
    J Pathol 218:57-65. 2009
    ..Furthermore, Cten induction is associated with post-transcriptional repression of E-cadherin...
  8. pmc Comparative analysis of pyrosequencing and QMC-PCR in conjunction with high resolution melting for KRAS/BRAF mutation detection
    Salih Ibrahem
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Int J Exp Pathol 91:500-5. 2010
    ..Both HRM and pyrosequencing can detect small numbers of mutant alleles although HRM has a lower limit of detection. Both are suitable for use in mutation detection and are both more sensitive than Sanger sequencing...
  9. ncbi request reprint MLH1 function is context dependent in colorectal cancers
    Thomas Jackson
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre Campus, University of Nottingham, Nottingham, UK
    J Clin Pathol 64:141-5. 2011
    ..However, it is uncertain whether loss of MMR alters any other cellular function. The aim of this study was to investigate the role of MMR in regulating cell numbers and apoptosis...
  10. ncbi request reprint A CD44⁻/CD24⁺ phenotype is a poor prognostic marker in early invasive breast cancer
    Mohamed A H Ahmed
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 133:979-95. 2012
    ..This shows that the relationship between basic cell biology and clinical behaviour is not always straightforward and warrants further investigations of the true clinical impact of breast cancer stem cells...
  11. ncbi request reprint CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis
    Abdulkader Albasri
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 126:47-54. 2011
    ..In conclusion, our results demonstrated the oncogenetic role of increased CTEN expression and its association with poor prognostic parameters. These data could help in prognostic assessment in BC patients...
  12. ncbi request reprint The utility of diagnostic biopsy specimens for predictive molecular testing in colorectal cancer
    Wakkas Fadhil
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Histopathology 61:1117-24. 2012
    ..The aim of this study was to evaluate whether a diagnostic biopsy was adequately representative of the main tumour in colorectal cancer...
  13. pmc DNA content analysis of colorectal cancer defines a distinct 'microsatellite and chromosome stable' group but does not predict response to radiotherapy
    Wakkas Fadhil
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Int J Exp Pathol 95:16-23. 2014
    ..We conclude that MACS-CRCs form a significant proportion of microsatellite-stable CRCs with a mutation profile overlapping that of CRCs with CIN. A diploid genotype does not, however, predict the responsiveness to radiotherapy. ..
  14. ncbi request reprint Guidelines and considerations for conducting experiments using tissue microarrays
    Mohammad Ilyas
    School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham University, Nottingham, UK
    Histopathology 62:827-39. 2013
    ..A checklist is presented which can be used both for planning a TMA experiment and interpreting the results of such an experiment. For studies of cancer biomarkers, this checklist could be used as a supplement to the REMARK guidelines...
  15. ncbi request reprint Quick-multiplex-consensus (QMC)-PCR followed by high-resolution melting: a simple and robust method for mutation detection in formalin-fixed paraffin-embedded tissue
    Wakkas Fadhil
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    J Clin Pathol 63:134-40. 2010
    ..Mutation detection in tumours will become increasingly important in pathological diagnosis as 'predictive' mutations are identified. A cheap and reliable test that works on formalin-fixed paraffin-embedded (FFPE) tissue is required...