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Genomes and Genes | Koichi IchimuraSummaryAffiliation: University of Cambridge Country: UK Publications
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1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomasK Ichimura
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK
Oncogene 27:2097-108. 2008..Akt3 amplifications were found in four glioblastomas. Our results indicate that 1p deletions are common anaplastic astrocytomas and glioblastomas but are distinct from the 1p abnormalities in oligodendrogliomas...- IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomasKoichi Ichimura
Molecular Histopathology, Level 3, Lab Block, Addenbrooke s Hospital, Box 231, Cambridge CB20QQ, UK
Neuro Oncol 11:341-7. 2009.... - Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGHK Ichimura
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Oncogene 25:1261-71. 2006..We confirmed the high frequency of chromosome 6 deletions in AA and GB, and identified two novel commonly deleted regions that may harbour TSGs... 
Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterpartsDavid T W Jones
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
Acta Neuropathol 121:753-61. 2011..Genes involved in DNA replication and the cell cycle were also enriched in the adult tumours, suggesting that their more aggressive behaviour may be due to derivation from a more rapidly dividing, less differentiated cell type...- MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutationsShani Mulholland
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Int J Cancer 131:1104-13. 2012..We suggest that MGMT methylation may be one of the earliest events in the development of astrocytic and oligodendroglial tumors... - Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomasDavid T W Jones
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, United Kingdom
Cancer Res 68:8673-7. 2008..This is the first report of BRAF activation through rearrangement as a frequent feature in a sporadic tumor. The frequency and specificity of this change underline its potential both as a therapeutic target and as a diagnostic tool... - Genomic analysis of pilocytic astrocytomas at 0.97 Mb resolution shows an increasing tendency toward chromosomal copy number change with ageDavid T W Jones
Department of Pathology, Division of Molecular Histopathology, Cambridge University, Cambridge, UK
J Neuropathol Exp Neurol 65:1049-58. 2006..One case (2%) showed a region of gain on chromosome 3 and one (2%) a deletion on 6q as their sole abnormalities. This is the first genomewide study to show this nonrandom pattern of genetic alteration in pilocytic astrocytomas... - Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomasLu Liu
Division of Molecular Histopathology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, P.O.Box 231, Cambridge, CB2 2QQ, UK
J Mol Med 83:917-26. 2005..However, in AAs, although uncommon, EGFR aberrations appear to be associated with shorter survival... - PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant miceGeorge Poulogiannis
Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
Proc Natl Acad Sci U S A 107:15145-50. 2010..We conclude that PARK2 is a tumor suppressor gene whose haploinsufficiency cooperates with mutant APC in colorectal carcinogenesis... - Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognosesArtemis P Vogazianou
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Level 3, Lab Block, Addenbrooke s Hospital, Box 231, Cambridge CB2 0QQ, UK
Neuro Oncol 12:664-78. 2010..An accurate identification of total 1p/19q loss and discriminating this from other 1p/19q changes is, however, critical when the 1p/19q copy number status is used to stratify patients in clinical trials... - Genome-wide analysis of subependymomas shows underlying chromosomal copy number changes involving chromosomes 6, 7, 8 and 14 in a proportion of casesKathreena M Kurian
Department of Pathology, Division of Molecular Histopathology, Cambridge University, Cambridge, UK
Brain Pathol 18:469-73. 2008..This is the first array-based, genome-wide study of SE. The observation that five of 12 cases examined (42%) at 0.97-Mb resolution showed chromosomal copy number abnormalities is a novel finding in this tumor type... - A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenograftsDeborah S Malley
Division of Molecular Histopathology, Department of Pathology, Level 3, Lab Block, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK
Acta Neuropathol 121:651-61. 2011.... 
Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysisTzer Jing Seng
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Genes Chromosomes Cancer 43:181-93. 2005..Supplementary material for this article can be found on the Genes, Chromosomes and Cancer website at http://www.interscience.wiley.com/jpages/1045-2257/suppmat/index.html...- NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signatureM Talal F Al-Mayhani
Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK
Neuro Oncol 13:830-45. 2011..The expression of NG2 by such an aggressive and actively cycling GBM population combined with its location on the cell surface identifies this cell population as a potential therapeutic target in a subset of patients with GBM... - Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpointMartin G McCabe
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, UK
Genes Chromosomes Cancer 48:121-31. 2009.... - Application of array CGH on archival formalin-fixed paraffin-embedded tissues including small numbers of microdissected cellsNicola A Johnson
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, Cambridgeshire, UK
Lab Invest 86:968-78. 2006..With the help of microdissection and WGA, it is also possible to apply aCGH to histologically defined lesions, such as carcinoma in situ... - High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumorsMartin Gerard McCabe
Department of Pathology, University of Cambridge, Division of Molecular Histopathology, UK
J Neuropathol Exp Neurol 65:549-61. 2006.... - High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53Abhi Veerakumarasivam
Cancer Research UK Cambridge Research Institute, Cambridge, UK
Clin Cancer Res 14:2527-34. 2008..The aim of this study was to characterize novel DNA copy number changes to identify putative therapeutic targets... - Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTENL Magnus Bäcklund
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Box 231, Cambridge CB2 2QQ, United Kingdom
Clin Cancer Res 9:4151-8. 2003..Survival is typically <1 year but varies between a few months and a couple of years. The aim of the study was to find novel genetic prognostic factors in a well-defined GB series... - An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumoursTalal M Fael Al-Mayhani
Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom
J Neurosci Methods 176:192-9. 2009..Improving the efficiency of derivation will facilitate the improvement of in vitro and in vivo model systems to study disease mechanisms, screen drugs and develop novel therapeutic approaches in the future... - Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytomaN Zeng
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK
Neuropathol Appl Neurobiol 35:353-66. 2009..We report a comparative study on the mRNA expression of ErbB receptor tyrosine kinases, and in particular ERBB4 transcript variants, in two common paediatric brain tumours: medulloblastoma (MB) and pilocytic astrocytoma (PA)... - Molecular pathogenesis of astrocytic tumoursKoichi Ichimura
Department of Pathology, University of Cambridge, Cambridge, UK
J Neurooncol 70:137-60. 2004.... - Prognostic relevance of DNA copy number changes in colorectal cancerGeorge Poulogiannis
Department of Pathology, University of Cambridge, Cambridge, UK
J Pathol 220:338-47. 2010..The data show that the different patterns of DNA copy number alterations in primary tumours reveal prognostic information and can aid identification of novel prognosis-associated genes... - Analysis of sex chromosome abnormalities using X and Y chromosome DNA tiling path arraysA C Karcanias
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
J Med Genet 44:429-36. 2007..Array comparative genomic hybridisation is a powerful tool for the detection of copy number changes in the genome... - Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumoursA Miyakawa
Department of Pathology, University of Cambridge, Addenbrooke s Hospital, UK
Br J Cancer 82:543-9. 2000..Five commonly deleted regions were identified on 6q. These observations suggest that a number of tumour suppressor genes are located on 6q and that these genes may be involved in the progression of astrocytic tumours... - Allelic gain and amplification on the long arm of chromosome 17 in anaplastic meningiomasRainer Büschges
Department of Pathology, University of Cambridge, Addenbrooke s Hospital, United Kingdom
Brain Pathol 12:145-53. 2002..Our findings are fundamental for the identification of the gene(s) in 17q22-q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types... - Structural genomic abnormalities of chromosomes 9 and 18 in myxopapillary ependymomasMaria Betania Mahler-Araujo
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
J Neuropathol Exp Neurol 62:927-35. 2003..Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE... - Replication timing of human chromosome 6Kathryn Woodfine
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Cell Cycle 4:172-6. 2005..Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity... - p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumoursM Dimitriadi
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Box 231, Cambridge CB2 0QQ, UK
Br J Cancer 99:1144-52. 2008..Our findings also indicate that elevated MDM2 mRNA levels in tumours with MDM2 amplification are preferentially driven by the P1 promoter and that the P2 promoter is not only regulated by p53 but also by other transcription factor(s)... - Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytomaD T W Jones
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, Cambridgeshire, UK
Oncogene 28:2119-23. 2009.... - A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glandsE Chanudet
Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
J Pathol 217:420-30. 2009..007), a higher proportion of relapse (67% versus 37%) and a shorter relapse-free survival (p=0.033). A20 deletion and gain at TNFA/B/C locus may thus play an important role in the development of translocation-negative MALT lymphoma... - Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genesK D Howarth
Department of Pathology, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
Oncogene 27:3345-59. 2008..Two gene fusions were demonstrated, TAX1BP1-AHCY and RIF1-PKD1L1. Our results support the idea that chromosome rearrangements may play an important role in common epithelial cancers such as breast cancer... - Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomasL M Bäcklund
Department of Oncology Pathology, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
Br J Cancer 93:124-30. 2005..013). The findings suggest that analysis of the genes coding for Rb1 pathway components provides additional prognostic information in AA patients receiving conventional therapy... - Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genesM Wolter
Department of Neuropathology, Heinrich-Heine-University, , Germany
J Neuropathol Exp Neurol 60:1170-80. 2001..Taken together, our results indicate that hypermethylation of CDKN2A, p14ARF, and CDKN2B is an important epigenetic mechanism by which oligodendroglial tumors may escape from p53- and pRb-dependent growth control... - Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomasJ Bostrom
Departments of Neurosurgery and Neuropathology, University of Bonn Medical Center, Bonn, Germany
Am J Pathol 159:661-9. 2001..Thus, inactivation of the G(1)/S-phase cell-cycle checkpoint is an important aberration in anaplastic meningiomas... - Structure of the human retinoblastoma-related p107 gene and its intragenic deletion in a B-cell lymphoma cell lineK Ichimura
2nd Department of Pathology, Okayama University Medical School, Shikata cho, Japan
Gene 251:37-43. 2000..We also show a detailed structure of an intragenic deletion of the p107 gene found in a human B-cell lymphoma cell line, KAL-1, which was shown to occur by homologous recombination between the two directly repeated Alu family sequences... - Constitutional translocation t(4;22) (q12;q12.2) associated with neurofibromatosis type 2E Arai
Department of Cytogenetics, Tokyo Medical and Dental University, Japan
Am J Med Genet 44:163-7. 1992..Several explanations are offered for the different expression of the translocation between the patient and her father...