Koichi Ichimura

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc 1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas
    K Ichimura
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK
    Oncogene 27:2097-108. 2008
  2. pmc IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
    Koichi Ichimura
    Molecular Histopathology, Level 3, Lab Block, Addenbrooke s Hospital, Box 231, Cambridge CB20QQ, UK
    Neuro Oncol 11:341-7. 2009
  3. pmc Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH
    K Ichimura
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Oncogene 25:1261-71. 2006
  4. doi request reprint Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts
    David T W Jones
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
    Acta Neuropathol 121:753-61. 2011
  5. doi request reprint MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations
    Shani Mulholland
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Int J Cancer 131:1104-13. 2012
  6. pmc Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    David T W Jones
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, United Kingdom
    Cancer Res 68:8673-7. 2008
  7. pmc Genomic analysis of pilocytic astrocytomas at 0.97 Mb resolution shows an increasing tendency toward chromosomal copy number change with age
    David T W Jones
    Department of Pathology, Division of Molecular Histopathology, Cambridge University, Cambridge, UK
    J Neuropathol Exp Neurol 65:1049-58. 2006
  8. pmc Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas
    Lu Liu
    Division of Molecular Histopathology, Department of Pathology, Addenbrooke s Hospital, University of Cambridge, P O Box 231, Cambridge, CB2 2QQ, UK
    J Mol Med (Berl) 83:917-26. 2005
  9. pmc PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice
    George Poulogiannis
    Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    Proc Natl Acad Sci U S A 107:15145-50. 2010
  10. pmc Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses
    Artemis P Vogazianou
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Level 3, Lab Block, Addenbrooke s Hospital, Box 231, Cambridge CB2 0QQ, UK
    Neuro Oncol 12:664-78. 2010

Collaborators

Detail Information

Publications39

  1. pmc 1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas
    K Ichimura
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK
    Oncogene 27:2097-108. 2008
    ..Akt3 amplifications were found in four glioblastomas. Our results indicate that 1p deletions are common anaplastic astrocytomas and glioblastomas but are distinct from the 1p abnormalities in oligodendrogliomas...
  2. pmc IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
    Koichi Ichimura
    Molecular Histopathology, Level 3, Lab Block, Addenbrooke s Hospital, Box 231, Cambridge CB20QQ, UK
    Neuro Oncol 11:341-7. 2009
    ....
  3. pmc Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH
    K Ichimura
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Oncogene 25:1261-71. 2006
    ..We confirmed the high frequency of chromosome 6 deletions in AA and GB, and identified two novel commonly deleted regions that may harbour TSGs...
  4. doi request reprint Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts
    David T W Jones
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
    Acta Neuropathol 121:753-61. 2011
    ..Genes involved in DNA replication and the cell cycle were also enriched in the adult tumours, suggesting that their more aggressive behaviour may be due to derivation from a more rapidly dividing, less differentiated cell type...
  5. doi request reprint MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations
    Shani Mulholland
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Int J Cancer 131:1104-13. 2012
    ..We suggest that MGMT methylation may be one of the earliest events in the development of astrocytic and oligodendroglial tumors...
  6. pmc Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    David T W Jones
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, United Kingdom
    Cancer Res 68:8673-7. 2008
    ..This is the first report of BRAF activation through rearrangement as a frequent feature in a sporadic tumor. The frequency and specificity of this change underline its potential both as a therapeutic target and as a diagnostic tool...
  7. pmc Genomic analysis of pilocytic astrocytomas at 0.97 Mb resolution shows an increasing tendency toward chromosomal copy number change with age
    David T W Jones
    Department of Pathology, Division of Molecular Histopathology, Cambridge University, Cambridge, UK
    J Neuropathol Exp Neurol 65:1049-58. 2006
    ..One case (2%) showed a region of gain on chromosome 3 and one (2%) a deletion on 6q as their sole abnormalities. This is the first genomewide study to show this nonrandom pattern of genetic alteration in pilocytic astrocytomas...
  8. pmc Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas
    Lu Liu
    Division of Molecular Histopathology, Department of Pathology, Addenbrooke s Hospital, University of Cambridge, P O Box 231, Cambridge, CB2 2QQ, UK
    J Mol Med (Berl) 83:917-26. 2005
    ..However, in AAs, although uncommon, EGFR aberrations appear to be associated with shorter survival...
  9. pmc PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice
    George Poulogiannis
    Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    Proc Natl Acad Sci U S A 107:15145-50. 2010
    ..We conclude that PARK2 is a tumor suppressor gene whose haploinsufficiency cooperates with mutant APC in colorectal carcinogenesis...
  10. pmc Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses
    Artemis P Vogazianou
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Level 3, Lab Block, Addenbrooke s Hospital, Box 231, Cambridge CB2 0QQ, UK
    Neuro Oncol 12:664-78. 2010
    ..An accurate identification of total 1p/19q loss and discriminating this from other 1p/19q changes is, however, critical when the 1p/19q copy number status is used to stratify patients in clinical trials...
  11. pmc Genome-wide analysis of subependymomas shows underlying chromosomal copy number changes involving chromosomes 6, 7, 8 and 14 in a proportion of cases
    Kathreena M Kurian
    Department of Pathology, Division of Molecular Histopathology, Cambridge University, Cambridge, UK
    Brain Pathol 18:469-73. 2008
    ..This is the first array-based, genome-wide study of SE. The observation that five of 12 cases examined (42%) at 0.97-Mb resolution showed chromosomal copy number abnormalities is a novel finding in this tumor type...
  12. doi request reprint A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts
    Deborah S Malley
    Division of Molecular Histopathology, Department of Pathology, Level 3, Lab Block, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK
    Acta Neuropathol 121:651-61. 2011
    ....
  13. ncbi request reprint Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis
    Tzer Jing Seng
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Genes Chromosomes Cancer 43:181-93. 2005
    ..Supplementary material for this article can be found on the Genes, Chromosomes and Cancer website at http://www.interscience.wiley.com/jpages/1045-2257/suppmat/index.html...
  14. doi request reprint Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma
    Sally R Lambert
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neuropathol 126:291-301. 2013
    ..These findings have implications for future basic research and clinical trials, as therapeutic targets and drug sensitivity may differ according to tumor location. ..
  15. pmc NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature
    M Talal F Al-Mayhani
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK
    Neuro Oncol 13:830-45. 2011
    ..The expression of NG2 by such an aggressive and actively cycling GBM population combined with its location on the cell surface identifies this cell population as a potential therapeutic target in a subset of patients with GBM...
  16. doi request reprint Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint
    Martin G McCabe
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, UK
    Genes Chromosomes Cancer 48:121-31. 2009
    ....
  17. pmc Application of array CGH on archival formalin-fixed paraffin-embedded tissues including small numbers of microdissected cells
    Nicola A Johnson
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, Cambridgeshire, UK
    Lab Invest 86:968-78. 2006
    ..With the help of microdissection and WGA, it is also possible to apply aCGH to histologically defined lesions, such as carcinoma in situ...
  18. pmc High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors
    Martin Gerard McCabe
    Department of Pathology, University of Cambridge, Division of Molecular Histopathology, UK
    J Neuropathol Exp Neurol 65:549-61. 2006
    ....
  19. doi request reprint High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53
    Abhi Veerakumarasivam
    Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Clin Cancer Res 14:2527-34. 2008
    ..The aim of this study was to characterize novel DNA copy number changes to identify putative therapeutic targets...
  20. ncbi request reprint Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN
    L Magnus Bäcklund
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Box 231, Cambridge CB2 2QQ, United Kingdom
    Clin Cancer Res 9:4151-8. 2003
    ..Survival is typically <1 year but varies between a few months and a couple of years. The aim of the study was to find novel genetic prognostic factors in a well-defined GB series...
  21. doi request reprint An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours
    Talal M Fael Al-Mayhani
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom
    J Neurosci Methods 176:192-9. 2009
    ..Improving the efficiency of derivation will facilitate the improvement of in vitro and in vivo model systems to study disease mechanisms, screen drugs and develop novel therapeutic approaches in the future...
  22. pmc Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma
    N Zeng
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK
    Neuropathol Appl Neurobiol 35:353-66. 2009
    ..We report a comparative study on the mRNA expression of ErbB receptor tyrosine kinases, and in particular ERBB4 transcript variants, in two common paediatric brain tumours: medulloblastoma (MB) and pilocytic astrocytoma (PA)...
  23. ncbi request reprint Molecular pathogenesis of astrocytic tumours
    Koichi Ichimura
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Neurooncol 70:137-60. 2004
    ....
  24. doi request reprint Prognostic relevance of DNA copy number changes in colorectal cancer
    George Poulogiannis
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Pathol 220:338-47. 2010
    ..The data show that the different patterns of DNA copy number alterations in primary tumours reveal prognostic information and can aid identification of novel prognosis-associated genes...
  25. pmc Analysis of sex chromosome abnormalities using X and Y chromosome DNA tiling path arrays
    A C Karcanias
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Med Genet 44:429-36. 2007
    ..Array comparative genomic hybridisation is a powerful tool for the detection of copy number changes in the genome...
  26. pmc Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours
    A Miyakawa
    Department of Pathology, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Cancer 82:543-9. 2000
    ..Five commonly deleted regions were identified on 6q. These observations suggest that a number of tumour suppressor genes are located on 6q and that these genes may be involved in the progression of astrocytic tumours...
  27. ncbi request reprint Allelic gain and amplification on the long arm of chromosome 17 in anaplastic meningiomas
    Rainer Büschges
    Department of Pathology, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Brain Pathol 12:145-53. 2002
    ..Our findings are fundamental for the identification of the gene(s) in 17q22-q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types...
  28. ncbi request reprint Replication timing of human chromosome 6
    Kathryn Woodfine
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Cell Cycle 4:172-6. 2005
    ..Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity...
  29. ncbi request reprint Structural genomic abnormalities of chromosomes 9 and 18 in myxopapillary ependymomas
    Maria Betania Mahler-Araujo
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Neuropathol Exp Neurol 62:927-35. 2003
    ..Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE...
  30. ncbi request reprint Prognostic and predictive markers in recurrent high grade glioma; results from the BR12 randomised trial
    Vincent Peter Collins
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK
    Acta Neuropathol Commun 2:68. 2014
    ....
  31. pmc Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
    D T W Jones
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, Cambridgeshire, UK
    Oncogene 28:2119-23. 2009
    ....
  32. pmc p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours
    M Dimitriadi
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Box 231, Cambridge CB2 0QQ, UK
    Br J Cancer 99:1144-52. 2008
    ..Our findings also indicate that elevated MDM2 mRNA levels in tumours with MDM2 amplification are preferentially driven by the P1 promoter and that the P2 promoter is not only regulated by p53 but also by other transcription factor(s)...
  33. doi request reprint A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands
    E Chanudet
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
    J Pathol 217:420-30. 2009
    ..007), a higher proportion of relapse (67% versus 37%) and a shorter relapse-free survival (p=0.033). A20 deletion and gain at TNFA/B/C locus may thus play an important role in the development of translocation-negative MALT lymphoma...
  34. pmc Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes
    K D Howarth
    Department of Pathology, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
    Oncogene 27:3345-59. 2008
    ..Two gene fusions were demonstrated, TAX1BP1-AHCY and RIF1-PKD1L1. Our results support the idea that chromosome rearrangements may play an important role in common epithelial cancers such as breast cancer...
  35. pmc Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas
    L M Bäcklund
    Department of Oncology Pathology, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Br J Cancer 93:124-30. 2005
    ..013). The findings suggest that analysis of the genes coding for Rb1 pathway components provides additional prognostic information in AA patients receiving conventional therapy...
  36. ncbi request reprint Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes
    M Wolter
    Department of Neuropathology, Heinrich-Heine-University, , Germany
    J Neuropathol Exp Neurol 60:1170-80. 2001
    ..Taken together, our results indicate that hypermethylation of CDKN2A, p14ARF, and CDKN2B is an important epigenetic mechanism by which oligodendroglial tumors may escape from p53- and pRb-dependent growth control...
  37. pmc Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas
    J Bostrom
    Departments of Neurosurgery and Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Am J Pathol 159:661-9. 2001
    ..Thus, inactivation of the G(1)/S-phase cell-cycle checkpoint is an important aberration in anaplastic meningiomas...
  38. ncbi request reprint Structure of the human retinoblastoma-related p107 gene and its intragenic deletion in a B-cell lymphoma cell line
    K Ichimura
    2nd Department of Pathology, Okayama University Medical School, Shikata cho, Japan
    Gene 251:37-43. 2000
    ..We also show a detailed structure of an intragenic deletion of the p107 gene found in a human B-cell lymphoma cell line, KAL-1, which was shown to occur by homologous recombination between the two directly repeated Alu family sequences...
  39. ncbi request reprint Constitutional translocation t(4;22) (q12;q12.2) associated with neurofibromatosis type 2
    E Arai
    Department of Cytogenetics, Tokyo Medical and Dental University, Japan
    Am J Med Genet 44:163-7. 1992
    ..Several explanations are offered for the different expression of the translocation between the patient and her father...