Marko Hyvonen

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint CHRD, a novel domain in the BMP inhibitor chordin, is also found in microbial proteins
    Marko Hyvonen
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK
    Trends Biochem Sci 28:470-3. 2003
  2. pmc Structural basis for the inhibition of activin signalling by follistatin
    Adrian E Harrington
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    EMBO J 25:1035-45. 2006
  3. pmc An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily
    Bert van Loo
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    Proc Natl Acad Sci U S A 107:2740-5. 2010
  4. pmc Using a fragment-based approach to target protein-protein interactions
    Duncan E Scott
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    Chembiochem 14:332-42. 2013
  5. doi request reprint A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum
    Stefanie Jonas
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB21GA, UK
    J Mol Biol 384:120-36. 2008
  6. ncbi request reprint Targeting protein-protein interactions and fragment-based drug discovery
    Eugene Valkov
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK
    Top Curr Chem 317:145-79. 2012
  7. ncbi request reprint Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding
    C Axel Innis
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 278:39969-77. 2003
  8. ncbi request reprint Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1
    Peter D Ellis
    Section of Cardiovascular Biology, University of Cambridge, Cambridge, UK
    J Vasc Res 40:234-43. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint CHRD, a novel domain in the BMP inhibitor chordin, is also found in microbial proteins
    Marko Hyvonen
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK
    Trends Biochem Sci 28:470-3. 2003
    ..It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made...
  2. pmc Structural basis for the inhibition of activin signalling by follistatin
    Adrian E Harrington
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    EMBO J 25:1035-45. 2006
    ..The structure provides a detailed description of the inhibitory mechanism and gives insights into interactions of follistatin with other TGF-beta family proteins...
  3. pmc An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily
    Bert van Loo
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    Proc Natl Acad Sci U S A 107:2740-5. 2010
    ..PMH is thus one of the most promiscuous hydrolases described to date. The functional links between superfamily activities can be presumed to have played a role in functional evolution by gene duplication...
  4. pmc Using a fragment-based approach to target protein-protein interactions
    Duncan E Scott
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    Chembiochem 14:332-42. 2013
    ..This represents the first report of fragments or any small molecule binding at this protein-protein interaction site...
  5. doi request reprint A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum
    Stefanie Jonas
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB21GA, UK
    J Mol Biol 384:120-36. 2008
    ..coli alkaline phosphatase and Pseudomonas aeruginosa arylsulfatase. R/PMH represents a further example of conservation of the overall structure and mechanism within the alkaline phosphatase superfamily...
  6. ncbi request reprint Targeting protein-protein interactions and fragment-based drug discovery
    Eugene Valkov
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK
    Top Curr Chem 317:145-79. 2012
    ..We will review recent developments in the field of PPI inhibition, with emphasis on fragment-based methods, and discuss various factors one should take into account when developing small molecule inhibitors targeted at PPI interfaces...
  7. ncbi request reprint Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding
    C Axel Innis
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 278:39969-77. 2003
    ....
  8. ncbi request reprint Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1
    Peter D Ellis
    Section of Cardiovascular Biology, University of Cambridge, Cambridge, UK
    J Vasc Res 40:234-43. 2003
    ....