E Hypponen

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    E Hypponen
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 358:1500-3. 2001
  2. doi request reprint High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, WC1N 1EH, London, UK
    J Nutr 141:843-8. 2011
  3. ncbi request reprint Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guildford St, London, WC1N 1EH, UK
    Diabetes Care 29:2244-6. 2006
  4. ncbi request reprint Does vitamin D supplementation in infancy reduce the risk of pre-eclampsia?
    E Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    Eur J Clin Nutr 61:1136-9. 2007
  5. doi request reprint Vitamin D and increasing incidence of type 1 diabetes-evidence for an association?
    E Hypponen
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Diabetes Obes Metab 12:737-43. 2010
  6. doi request reprint Avoidance of vitamin D deficiency in pregnancy in the United Kingdom: the case for a unified approach in National policy
    Elina Hypponen
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health and Centre for Paediatric Epidemiology and Biostatistics, 30 Guilford Street, London, UK
    Br J Nutr 104:309-14. 2010
  7. ncbi request reprint Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    Am J Clin Nutr 85:860-8. 2007
  8. ncbi request reprint Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard
    Elina Hypponen
    Centre for Pediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 92:4615-22. 2007
  9. ncbi request reprint 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
  10. pmc 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort
    Elina Hypponen
    Medical Research Council Centre for Epidemiology of Child Health and Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UK
    PLoS ONE 5:e10801. 2010

Detail Information

Publications32

  1. ncbi request reprint Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    E Hypponen
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 358:1500-3. 2001
    ..Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes...
  2. doi request reprint High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, WC1N 1EH, London, UK
    J Nutr 141:843-8. 2011
    ....
  3. ncbi request reprint Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guildford St, London, WC1N 1EH, UK
    Diabetes Care 29:2244-6. 2006
    ..Obesity is a well-known risk factor for vitamin D deficiency. We evaluated the interrelationship between vitamin D status, body size, and glucose homeostasis, measured by HbA1c (A1C)...
  4. ncbi request reprint Does vitamin D supplementation in infancy reduce the risk of pre-eclampsia?
    E Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    Eur J Clin Nutr 61:1136-9. 2007
    ..Together with earlier observations on a reduced risk of type 1 diabetes after vitamin D supplementation, these data suggest that vitamin D intake in infancy may affect long-term programming of the immune response pattern...
  5. doi request reprint Vitamin D and increasing incidence of type 1 diabetes-evidence for an association?
    E Hypponen
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Diabetes Obes Metab 12:737-43. 2010
    ....
  6. doi request reprint Avoidance of vitamin D deficiency in pregnancy in the United Kingdom: the case for a unified approach in National policy
    Elina Hypponen
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health and Centre for Paediatric Epidemiology and Biostatistics, 30 Guilford Street, London, UK
    Br J Nutr 104:309-14. 2010
    ..Lack of unified advice on vitamin D supplementation of pregnant mothers in the UK hinders the implementation of primary prevention strategies and is likely to leave some deficient mothers without supplementation...
  7. ncbi request reprint Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    Am J Clin Nutr 85:860-8. 2007
    ..Increased awareness of the importance of vitamin D to health has led to concerns about the prevalence of hypovitaminosis D in many parts of the world...
  8. ncbi request reprint Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard
    Elina Hypponen
    Centre for Pediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 92:4615-22. 2007
    ..Variation between 25(OH)D assays hampers between-study comparisons and the definition of relevant cutoffs for hypovitaminosis D...
  9. ncbi request reprint 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
    ..Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence...
  10. pmc 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort
    Elina Hypponen
    Medical Research Council Centre for Epidemiology of Child Health and Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UK
    PLoS ONE 5:e10801. 2010
    ..Our aim was to investigate the association between 25-hydroxyvitamin D [25(OH)D, a measure for vitamin D status] concentrations with pre-clinical variations in markers of inflammation and hemostasis...
  11. ncbi request reprint Vitamin D for the prevention of preeclampsia? A hypothesis
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nutr Rev 63:225-32. 2005
    ....
  12. doi request reprint Working patterns and vitamin D status in mid-life: a cross-sectional study of the 1958 British birth cohort
    Maria Ward
    MRC Centre for the Epidemiology of Child Health, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Occup Environ Med 68:902-7. 2011
    ..To assess the association between working patterns and vitamin D status in men and women and to determine the potential influence of related lifestyle and socioeconomic factors...
  13. pmc Parental diabetes and birth weight of offspring: intergenerational cohort study
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH
    BMJ 326:19-20. 2003
  14. ncbi request reprint Prenatal growth, BMI, and risk of type 2 diabetes by early midlife
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    Diabetes Care 26:2512-7. 2003
    ..small size at birth has been associated with increased risk of type 2 diabetes. Our aim was to evaluate how risk of diabetes associated with low birth weight is affected by accumulation of body mass from childhood to adulthood...
  15. pmc Effects of grandmothers' smoking in pregnancy on birth weight: intergenerational cohort study
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH
    BMJ 327:898. 2003
    ..To investigate the influences on birth weight of maternal smoking during pregnancy across generations...
  16. ncbi request reprint Parental growth at different life stages and offspring birthweight: an intergenerational cohort study
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    Paediatr Perinat Epidemiol 18:168-77. 2004
    ..Maternal height in childhood was positively related to offspring birthweight, while the effect of her BMI was restricted to adulthood...
  17. ncbi request reprint Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Ann N Y Acad Sci 1037:84-95. 2004
    ..Further study is required to determine whether these observations reflect long-term effects on immune regulation or differences in unmeasured determinants of vitamin D supplementation...
  18. ncbi request reprint An intergenerational and lifecourse study of health and mortality risk in parents of the 1958 birth cohort: (I) methods and tracing
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Public Health 119:599-607. 2005
    ....
  19. ncbi request reprint An intergenerational and lifecourse study of health and mortality risk in parents of the 1958 birth cohort: (II) mortality rates and study representativeness
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Public Health 119:608-15. 2005
    ..This paper evaluates the representativeness of the study population and assesses our success in identifying the biological parents...
  20. doi request reprint Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey
    K Atherton
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Ann Rheum Dis 68:817-22. 2009
    ..Vitamin D deficiency has been suggested as a new modifiable risk factor for CWP...
  21. pmc Genetic association analysis of vitamin D pathway with obesity traits
    K S Vimaleswaran
    Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Int J Obes (Lond) 37:1399-406. 2013
    ..Therefore, we investigated the involvement of vitamin D metabolic pathway genes in obesity-related traits in a large population-based study...
  22. doi request reprint Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency
    K S Vimaleswaran
    Centre for Paediatric Epidemiology and Biostatistics and MRC Centre for the Epidemiology of Child Health, UCL Institute of Child Health, London, UK
    Allergy 67:1033-40. 2012
    ..Certain genotypes have been seen to alter the association between vitamin D deficiency (VDD) and the risk of food sensitization in children...
  23. ncbi request reprint Diabetes risk in British adults in mid life: a national prevalence study of glycated haemoglobin
    C Thomas
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Diabet Med 24:317-21. 2007
    ..Information on the population at risk of developing Type 2 diabetes in the UK is scarce. We used data from the 1958 British birth cohort to estimate geographical and socio-economic variations in HbA(1c) in mid life...
  24. doi request reprint Associations between parental and offspring adiposity up to midlife: the contribution of adult lifestyle factors in the 1958 British Birth Cohort Study
    Rachel Cooper
    Medical Research Council Unit for Lifelong Health and Ageing and Division of Population Health, University College London, London, United Kingdom
    Am J Clin Nutr 92:946-53. 2010
    ..Parent-offspring associations in adiposity are well known, but the extent to which they are explained by modifiable environmental and lifestyle factors remains to be elucidated...
  25. ncbi request reprint An intergenerational study of birthweight: investigating the birth order effect
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    BJOG 111:377-9. 2004
    ..Our findings suggest that underlying causes of a given birthweight should be taken into account in studies that investigate long term health outcomes...
  26. ncbi request reprint Type 2 diabetes mellitus in midlife estimated from the Cambridge Risk Score and body mass index
    Claudia Thomas
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, England
    Arch Intern Med 166:682-8. 2006
    ..We assessed the ability of the CRS to predict glycosylated hemoglobin (HbA(1c)) levels and determined whether the CRS was better than body mass index (BMI) at predicting HbA(1c) levels in midlife...
  27. doi request reprint Obesity and type 2 diabetes risk in midadult life: the role of childhood adversity
    Claudia Thomas
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, United Kingdom
    Pediatrics 121:e1240-9. 2008
    ....
  28. ncbi request reprint Prenatal exposures and glucose metabolism in adulthood: are effects mediated through birth weight and adiposity?
    Claudia Thomas
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK
    Diabetes Care 30:918-24. 2007
    ....
  29. pmc Socioeconomic position in childhood and early adult life and risk of mortality: a prospective study of the mothers of the 1958 British birth cohort
    Chris Power
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London WC1N 1EH, England
    Am J Public Health 95:1396-402. 2005
    ..We sought to establish whether women's childhood socioeconomic position influenced their risk of mortality separately from the effects of adult socioeconomic position...
  30. doi request reprint Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship
    E Hypponen
    MRC Centre for the Epidemiology of Child Health, UCL Institute of Child Health, London, UK
    Allergy 64:613-620. 2009
    ....
  31. pmc Parental obesity and risk factors for cardiovascular disease among their offspring in mid-life: findings from the 1958 British Birth Cohort Study
    R Cooper
    MRC Unit for Lifelong Health and Ageing, University College London, London, UK
    Int J Obes (Lond) 37:1590-6. 2013
    ....
  32. ncbi request reprint Micronutrients and the risk of type 1 diabetes: vitamin D, vitamin E, and nicotinamide
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, United Kingdom
    Nutr Rev 62:340-7. 2004
    ..Despite plausible theoretical background evidence from animal experiments and supportive data from pilot studies, randomized, controlled trials using nicotinamide have not provided any evidence for a beneficial effect...