Colin A Hutchison

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis
    Colin A Hutchison
    Department of Nephrology, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Clin J Am Soc Nephrol 4:745-54. 2009
  2. pmc Diagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital and University of Birmingham, Birmingham, UK
    BMC Clin Pathol 12:12. 2012
  3. doi request reprint Immunoglobulin free light chain levels and recovery from myeloma kidney on treatment with chemotherapy and high cut-off haemodialysis
    Colin A Hutchison
    University of Birmingham, Birmingham, UK
    Nephrol Dial Transplant 27:3823-8. 2012
  4. pmc The pathogenesis and diagnosis of acute kidney injury in multiple myeloma
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital Birmingham and University of Birmingham, Birmingham, UK
    Nat Rev Nephrol 8:43-51. 2012
  5. pmc Early reduction of serum-free light chains associates with renal recovery in myeloma kidney
    Colin A Hutchison
    Renal Institute of Birmingham, Renal Unit, University Hospital Birmingham, Edgbaston, Birmingham, UK
    J Am Soc Nephrol 22:1129-36. 2011
  6. doi request reprint Serum free light chain assessment in monoclonal gammopathy and kidney disease
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital Birmingham, and Department of Infection and Immunity, University of Birmingham, Birmingham, UK
    Nat Rev Nephrol 5:621-8. 2009
  7. pmc Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease
    Colin A Hutchison
    Renal Unit, University Hospital Birmingham, Birmingham, UK
    Clin J Am Soc Nephrol 3:1684-90. 2008
  8. doi request reprint Serum free-light chain removal by high cutoff hemodialysis: optimizing removal and supportive care
    Colin A Hutchison
    Department of Nephrology, Queen Elizabeth Hospital, UK
    Artif Organs 32:910-7. 2008
  9. doi request reprint Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis
    Stephen Harding
    The Binding Site, Birmingham, UK
    Nephrol Dial Transplant 26:1438. 2011
  10. doi request reprint Differential progression of renal scarring and determinants of late renal recovery in sustained dialysis dependent acute kidney injury secondary to myeloma kidney
    Kolitha Basnayake
    Department of Nephrology, Queen Elizabeth Medical Centre, Renal Institute of Birmingham, University of Birmingham, Birmingham, UK
    J Clin Pathol 63:884-7. 2010

Detail Information

Publications19

  1. pmc Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis
    Colin A Hutchison
    Department of Nephrology, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Clin J Am Soc Nephrol 4:745-54. 2009
    ..This study assessed the combination of chemotherapy and HCO-HD on serum free light chain concentrations and renal recovery in patients with myeloma kidney (cast nephropathy) and dialysis-dependent acute renal failure...
  2. pmc Diagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital and University of Birmingham, Birmingham, UK
    BMC Clin Pathol 12:12. 2012
    ..abstract:..
  3. doi request reprint Immunoglobulin free light chain levels and recovery from myeloma kidney on treatment with chemotherapy and high cut-off haemodialysis
    Colin A Hutchison
    University of Birmingham, Birmingham, UK
    Nephrol Dial Transplant 27:3823-8. 2012
    ..To determine the efficacy of immunoglobulin free light chain (FLC) removal by high cut-off haemodialysis (HCO-HD) as an adjuvant treatment to chemotherapy for patients with acute kidney injury complicating multiple myeloma (MM)...
  4. pmc The pathogenesis and diagnosis of acute kidney injury in multiple myeloma
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital Birmingham and University of Birmingham, Birmingham, UK
    Nat Rev Nephrol 8:43-51. 2012
    ..In this Review, we discuss the mechanisms of disease and diagnostic approaches to patients with acute kidney injury complicating multiple myeloma...
  5. pmc Early reduction of serum-free light chains associates with renal recovery in myeloma kidney
    Colin A Hutchison
    Renal Institute of Birmingham, Renal Unit, University Hospital Birmingham, Edgbaston, Birmingham, UK
    J Am Soc Nephrol 22:1129-36. 2011
    ..In conclusion, recovery of renal function in myeloma kidney depends on early reduction of serum FLCs, and this recovery associates with a significant survival advantage...
  6. doi request reprint Serum free light chain assessment in monoclonal gammopathy and kidney disease
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital Birmingham, and Department of Infection and Immunity, University of Birmingham, Birmingham, UK
    Nat Rev Nephrol 5:621-8. 2009
    ..Here, we review the biology of FLC production in health and disease, and the utility of FLC immunoassays in the assessment of monoclonal gammopathies in kidney disease...
  7. pmc Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease
    Colin A Hutchison
    Renal Unit, University Hospital Birmingham, Birmingham, UK
    Clin J Am Soc Nephrol 3:1684-90. 2008
    ..Polyclonal FLC, however, have not been assessed in patients with chronic kidney disease (CKD) yet could potentially play an important pathologic role. This study describes for the first time polyclonal FLC in patients with CKD...
  8. doi request reprint Serum free-light chain removal by high cutoff hemodialysis: optimizing removal and supportive care
    Colin A Hutchison
    Department of Nephrology, Queen Elizabeth Hospital, UK
    Artif Organs 32:910-7. 2008
    ..001). Different protocols are required to optimize the removal of kappa and lambda FLCs in patients with myeloma and renal failure...
  9. doi request reprint Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis
    Stephen Harding
    The Binding Site, Birmingham, UK
    Nephrol Dial Transplant 26:1438. 2011
    ..It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality...
  10. doi request reprint Differential progression of renal scarring and determinants of late renal recovery in sustained dialysis dependent acute kidney injury secondary to myeloma kidney
    Kolitha Basnayake
    Department of Nephrology, Queen Elizabeth Medical Centre, Renal Institute of Birmingham, University of Birmingham, Birmingham, UK
    J Clin Pathol 63:884-7. 2010
    ..Established scarring at presentation is rarely severe. There is little data on in situ evolution of renal injury...
  11. ncbi request reprint Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies
    Colin A Hutchison
    Department of Renal Medicine, Queen Elizabeth Hospital, QEMC, Birmingham, B15 2TH UK
    J Am Soc Nephrol 18:886-95. 2007
    ..A total of 1.7 kg of FLC was removed from one patient during 6 wk. Extended hemodialysis with the Gambro HCO 1100 dialyzer allowed continuous, safe removal of FLC in large amounts. Proof of clinical value now will require larger studies...
  12. pmc Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure
    Colin A Hutchison
    Department of Nephrology, University Hospital Birmingham, UK
    BMC Nephrol 9:11. 2008
    ..37-3.1). This study evaluated the diagnostic sensitivity and specificity of the immunoassays in patients with severe renal failure...
  13. doi request reprint Novel approaches for reducing free light chains in patients with myeloma kidney
    Colin A Hutchison
    Renal Institute of Birmingham, University Hospital Birmingham and University of Birmingham, Birmingham, UK c a hutchison bham ac uk
    Nat Rev Nephrol 8:234-43. 2012
    ..In this Review, we address the current state of knowledge in the management of myeloma kidney...
  14. doi request reprint The biology of immunoglobulin free light chains and kidney injury
    Kolitha Basnayake
    Renal Institute of Birmingham, University Hospital Birmingham, Birmingham, UK
    Kidney Int 79:1289-301. 2011
    ..Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury...
  15. doi request reprint Management options for cast nephropathy in multiple myeloma
    Paul Cockwell
    Renal Institute of Birmingham, University Hospitals Birmingham, Birmingham, UK
    Curr Opin Nephrol Hypertens 19:550-5. 2010
    ....
  16. ncbi request reprint National survey of heparin-induced thrombocytopenia in the haemodialysis population of the UK population
    Colin A Hutchison
    Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, Warwickshire, U K
    Nephrol Dial Transplant 22:1680-4. 2007
    ..But to date, there has never been a large study to estimate the prevalence, demography or treatment options for this syndrome in the haemodialysis population...
  17. ncbi request reprint Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease?
    Colin A Hutchison
    Queen Elizabeth Hospital, Department of Renal Medicine, QEMC, Birmingham, B15 2TH, UK
    Expert Opin Ther Targets 12:667-76. 2008
    ..Free light chains (FLCs) are bi-products of normal immunoglobulin synthesis and are predominately removed from the circulation by the kidneys. This study assessed polyclonal FLCs as a novel biomarker of early diabetic kidney disease...
  18. pmc Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database
    Colin A Hutchison
    University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, B15 2TH, UK
    Crit Care 11:R50. 2007
    ....
  19. doi request reprint High cut-off dialysis membranes: current uses and future potential
    Bertrand Gondouin
    Renal Institute of Birmingham, University of Birmingham, University Hospital Birmingham, United Kingdom
    Adv Chronic Kidney Dis 18:180-7. 2011
    ..The purpose of this review was to summarize the current evidence base for the use of high cut-off hemodialysis membranes and discuss their future clinical relevance...