P J Hutchinson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Physiol Meas 26:423-8. 2005
  2. ncbi request reprint Surgery for brain edema
    Peter Hutchinson
    University of Cambridge Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurg Focus 22:E14. 2007
  3. ncbi request reprint Headache. Diagnosing subarachnoid hemorrhage: are CT scans enough?
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Rev Neurol 8:126-7. 2011
  4. pmc Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure
    Thomas Geeraerts
    University Division of Anaesthesia and Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Crit Care 12:R114. 2008
  5. doi request reprint A combined microdialysis and FDG-PET study of glucose metabolism in head injury
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Acta Neurochir (Wien) 151:51-61; discussion 61. 2009
  6. ncbi request reprint Decompressive craniectomy in head injury
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Curr Opin Crit Care 10:101-4. 2004
  7. ncbi request reprint Microdialysis in the management of hepatic encephalopathy
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 5:202-5. 2006
  8. ncbi request reprint Microdialysis in traumatic brain injury--methodology and pathophysiology
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, UK
    Acta Neurochir Suppl 95:441-5. 2005
  9. ncbi request reprint Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:17-20. 2006
  10. ncbi request reprint Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra
    Peter J Hutchinson
    Academic Unit of Neurosurgery, Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, and Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 24:1545-57. 2007

Detail Information

Publications61

  1. ncbi request reprint Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Physiol Meas 26:423-8. 2005
    ..CMA71 microdialysis catheters can, therefore, be used for routine clinical monitoring of extracellular substances, as well as for their intended research role of larger molecular weight protein sampling...
  2. ncbi request reprint Surgery for brain edema
    Peter Hutchinson
    University of Cambridge Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurg Focus 22:E14. 2007
    ..They also address the current evidence for the technique (predominantly observational series) and the ongoing randomized studies of decompressive craniectomy in TBI and ischemic stroke...
  3. ncbi request reprint Headache. Diagnosing subarachnoid hemorrhage: are CT scans enough?
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Rev Neurol 8:126-7. 2011
    ..According to results from a recent study, CT scans enable clinicians to identify patients with subarachnoid hemorrhage, with a high sensitivity. Does CT imaging rule out the need for lumbar puncture in patients who present with headache?..
  4. pmc Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure
    Thomas Geeraerts
    University Division of Anaesthesia and Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Crit Care 12:R114. 2008
    ..The objective of this study was to assess the relationship between optic nerve sheath diameter (ONSD), as measured using MRI, and ICP...
  5. doi request reprint A combined microdialysis and FDG-PET study of glucose metabolism in head injury
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Acta Neurochir (Wien) 151:51-61; discussion 61. 2009
    ..In particular, we aimed to determine the fate of glucose in terms of differential metabolism to pyruvate and lactate...
  6. ncbi request reprint Decompressive craniectomy in head injury
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Curr Opin Crit Care 10:101-4. 2004
    ..To examine the evidence for the role of decompressive craniectomy in the management of traumatic brain injury...
  7. ncbi request reprint Microdialysis in the management of hepatic encephalopathy
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 5:202-5. 2006
    ..Fulminant hepatic encephalopathy has a high mortality...
  8. ncbi request reprint Microdialysis in traumatic brain injury--methodology and pathophysiology
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, UK
    Acta Neurochir Suppl 95:441-5. 2005
    ..This manuscript describes the place of microdialysis in traumatic brain injury in terms of the fundamental principles, methodology, pathophysiology and clinical application...
  9. ncbi request reprint Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:17-20. 2006
    ..We describe the concept of decompressive craniectomy in traumatic brain injury and the rationale and protocol of the RESCUEicp study...
  10. ncbi request reprint Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra
    Peter J Hutchinson
    Academic Unit of Neurosurgery, Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, and Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 24:1545-57. 2007
    ..It remains to be seen whether exogenous IL-1ra or other agents can be used to manipulate cytokine levels in the brain, for potential therapeutic effect...
  11. ncbi request reprint Clinical cerebral microdialysis: a methodological study
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 93:37-43. 2000
    ....
  12. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  13. ncbi request reprint Ventriculostomy for control of raised ICP in acute traumatic brain injury
    I Timofeev
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Hills Road, Cambridge CB2 0QQ, UK
    Acta Neurochir Suppl 102:99-104. 2008
    ....
  14. ncbi request reprint Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy
    I Timofeev
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:11-6. 2006
    ..Formal prospective randomized studies of decompressive craniectomy are now indicated...
  15. ncbi request reprint Monitoring and interpretation of intracranial pressure after head injury
    M Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:114-8. 2006
    ..To investigate the relationships between long-term computer-assisted monitoring of intracranial pressure (ICP) and indices derived from its waveform versus outcome, age, and sex...
  16. ncbi request reprint Multiparameter brain tissue monitoring--correlation between parameters and identification of CPP thresholds
    P G Al-Rawi
    University Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Zentralbl Neurochir 61:74-9. 2000
    ..The results must be interpreted whilst considering catheter position, autoregulation and systemic arterial changes for each individual...
  17. ncbi request reprint Cerebrovascular reactivity during hypothermia and rewarming
    A Lavinio
    Department of Clinical Neurosciences, Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Anaesth 99:237-44. 2007
    ..The effects of hypothermia and subsequent rewarming on cerebral vasoreactivity in human TBI are unknown...
  18. ncbi request reprint Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study
    M T O'Connell
    Department of Anaesthesia, University of Cambridge, Cambridge CB2 2QQ, UK
    Acta Neurochir Suppl 95:165-8. 2005
    ..Further observations are required with regions of interest (microdialysis catheters positioned) adjacent to mass lesions notably contusions...
  19. ncbi request reprint Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients
    K Guendling
    Academic Department of Clinical Neuroscience, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:108-13. 2006
    ..To summarize our experience from the first 2 years of use of the ICM+ software in our Neurocritical Care Unit (NCCU)...
  20. pmc Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent
    P J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Clin Pharmacol 53:275-83. 2002
    ....
  21. doi request reprint Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study
    S J Price
    Academic Neurosurgery Unit, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Clin Radiol 64:52-63. 2009
    ..To compare regional variations in uptake of 3'-deoxy-3'- [(18)F]-fluorothymidine (FLT) images using positron-emission tomography (PET) with measures of cellular proliferation from biopsy specimens obtained by image-guided brain biopsies...
  22. ncbi request reprint Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury
    A K Gupta
    Department of Anesthesia, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 88:549-53. 1999
    ..Thus, monitoring of PbO2 is a useful addition to multimodal monitoring of patients with traumatic head injury...
  23. ncbi request reprint Analysis of acute traumatic axonal injury using diffusion tensor imaging
    V F J Newcombe
    University Division of Anaesthesia, Cambridge University, Cambridge, UK
    Br J Neurosurg 21:340-8. 2007
    ..This technique holds promise for examining disease progression, and may help define therapeutic windows for the treatment of diffuse brain injury...
  24. ncbi request reprint Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism
    R Kett-White
    Academic Department of Neurosurgery, Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 81:327-9. 2002
    ....
  25. pmc Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:99-105. 2002
    ....
  26. doi request reprint Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study
    S J Price
    Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, UK
    AJNR Am J Neuroradiol 32:501-6. 2011
    ..The aim of this study was to see how rCBV, a known marker of tumor vascularity, relates to cellular packing attenuation and cellular proliferation...
  27. ncbi request reprint How can we measure substrate, metabolite and neurotransmitter concentrations in the human brain?
    P J Hutchinson
    Department of Neurosurgery and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, University of Cambridge, UK
    Physiol Meas 23:R75-109. 2002
    ..voltammetry and spectrophotometry) and functional imaging (e.g. positron emission tomography and magnetic resonance spectroscopy). This review describes these techniques in terms of their principles and clinical applications...
  28. ncbi request reprint A new cranial access device for cerebral monitoring
    P J Hutchinson
    Academic Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Neurosurg 14:46-8. 2000
    ..The bolt has been successfully applied to 100 patients with severe head injury and subarachnoid haemorrhage...
  29. pmc Standards for head injury management in acute hospitals: evidence from the six million population of the Eastern region
    H M Seeley
    Neurosciences Department, Addenbrooke s Hospital, Cambridge, UK
    Emerg Med J 23:128-32. 2006
    ..To develop standards of care for head injury and thereby identify and prioritize areas of the service needing development; to report the findings from a survey of compliance with such standards in the Eastern region of UK...
  30. pmc Late epilepsy following open surgery for aneurysmal subarachnoid haemorrhage
    S J Buczacki
    University of Cambridge, Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 75:1620-2. 2004
    ..To determine the risk for late epilepsy (>2 weeks postoperatively) following aneurysmal subarachnoid haemorrhage (SAH) treated by early aneurysm clipping...
  31. ncbi request reprint Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage
    J D Pickard
    Academic Neurosurgery Unit and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Blood Coagul Fibrinolysis 11:S117-20. 2000
    ..The last patient developed middle cerebral artery branch thrombosis contralateral to the aneurysm. The study is currently suspended pending further investigation...
  32. ncbi request reprint Outcome after surgical decompression of severe traumatic brain injury
    I Timofeev
    University of Cambridge Academic Neurosurgery Unit, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Injury 37:1125-32. 2006
    ..This article reviews the existing evidence on the role of decompressive craniectomy in management of patients with traumatic brain injury and stresses the need for randomised controlled trials...
  33. doi request reprint Critical thresholds for cerebrovascular reactivity after traumatic brain injury
    E Sorrentino
    Neurosurgery, University of Cambridge, Cambridge, UK
    Neurocrit Care 16:258-66. 2012
    ..We also investigated how these thresholds depend on clinical factors such as age, gender and initial GCS...
  34. doi request reprint Low-dose and high-dose synacthen tests and the hemodynamic response to hydrocortisone in acute traumatic brain injury
    R S Wijesurendra
    University Division of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Box 93, Hills Road, Cambridge CB2 2QQ, UK
    Neurocrit Care 11:158-64. 2009
    ....
  35. ncbi request reprint Concept of "true ICP" in monitoring and prognostication in head trauma
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:341-4. 2005
    ..To propose a new coefficient, which contains information about both the absolute ICP and the position of the 'working point' on the pressure-volume curve...
  36. ncbi request reprint Multi-modal monitoring of acute brain injury
    R Kett-White
    Academic Neurosurgical Unit and the Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Adv Tech Stand Neurosurg 27:87-134. 2002
    ..Thirdly, the respective roles of jugular venous oxygen and brain tissue oxygen monitoring are analysed. Fourthly, the use of cerebral microdialysis is described, together with an overview of its utility...
  37. ncbi request reprint Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner
    J P Coles
    Department of Anaesthesia and Wolfson Brain Imaging Centre, Box 93, Addenbrookes Hospital, University of Cambridge, CB2 2QQ, UK
    Anaesthesia 58:143-8. 2003
    ..Although the system is MR compatible and produces generally acceptable imaging even at 3 Tesla, there is significant degradation of image quality during gradient echo sequences...
  38. ncbi request reprint Outcome from poor grade aneurysmal subarachnoid haemorrhage--which poor grade subarachnoid haemorrhage patients benefit from aneurysm clipping?
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbroke s Hospital, UK
    Br J Neurosurg 14:105-9. 2000
    ..However, following resuscitation and correction of any acute hydrocephalus, a patient subgroup identified on simple clinical criteria can be identified who can expect a better outcome...
  39. ncbi request reprint Inappropriate acute neurosurgical bed occupancy and short falls in rehabilitation: implications for the National Service Framework
    L J Bradley
    Department of Rehabilitation Medicine, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:36-9. 2006
    ..Addressing this unmet need would increase the availability of acute neurosurgery beds, without needing to build and staff more neurosurgery wards...
  40. doi request reprint Community consultation in emergency neurotrauma research: results from a pre-protocol survey
    D J Clark
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital and University of Cambridge, Cambridge, UK
    Acta Neurochir (Wien) 155:1329-34; discussion 1334. 2013
    ..Clinical trials in the emergency setting face the problem that potential participants may be incapacitated and their next of kin initially unavailable. As a result, consent and enrolment of participants can often be difficult...
  41. pmc Acute head injury for the neurologist
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 73:i3-7. 2002
  42. doi request reprint The management of primary chronic subdural haematoma: a questionnaire survey of practice in the United Kingdom and the Republic of Ireland
    T Santarius
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Br J Neurosurg 22:529-34. 2008
    ..The current literature provides Class II and III evidence and there is a need for randomized studies to address the role of external drainage, steroids and postoperative bed rest...
  43. doi request reprint Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: a prospective clinical study
    M Y Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Br J Neurosurg 22:257-68. 2008
    ..Intravenous fluid therapy using synthetic colloids or blood transfusions may be associated with increased unfavourable outcome following aSAH...
  44. ncbi request reprint Effect of hypothermia on brain tissue oxygenation in patients with severe head injury
    A K Gupta
    Department of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Anaesth 88:188-92. 2002
    ..In this study we have investigated the effects of hypothermia on brain tissue oxygenation in patients with severe head injury...
  45. ncbi request reprint Is the recommended target of 4 hours from head injury to emergency craniotomy achievable?
    I G Sergides
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:301-5. 2006
    ..In order to investigate whether it is possible to reduce delays in transportation time, theoretical models were created to determine whether direct transfer to the RNU would be faster by land or air ambulance...
  46. doi request reprint Surgical management of acute subdural haematomas: current practice patterns in the United Kingdom and the Republic of Ireland
    A G Kolias
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital and University of Cambridge, Cambridge, UK
    Br J Neurosurg 27:330-3. 2013
    ..In this study, we used an online questionnaire to assess the current practice patterns in the management of ASDH in the UK and the Republic of Ireland, and to gauge neurosurgical opinion regarding the proposed RESCUE-ASDH trial...
  47. pmc Mapping rehabilitation resources for head injury
    J D Pickard
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J R Soc Med 97:384-9. 2004
    ..The definitions and mapping system that emerged from this study should facilitate the design of care pathways for patients and identify gaps in the services...
  48. ncbi request reprint Head injury rehabilitation: the role of a neurotrauma clinic
    Helen M Seeley
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 23:530-7. 2009
    ..Early indications show that a specialist clinic can assist in providing continuity of patient care, in improving coordination of services, and act as a resource for further research on epidemiology, outcome and impact of rehabilitation...
  49. doi request reprint Neurotrauma - a multidisciplinary disease
    M H Wilson
    The Traumatic Brain Injury Centre, Department of Neurosurgery, St Mary s Hospital, Imperial College, London, UK London s Air Ambulance, The Helipad, The Royal London Hospital, Queen Mary University of London, London, UK The British Neurotrauma Group, The Society of British Neurosurgeons, Royal College of Surgeons, London, UK
    Int J Clin Pract 68:5-7. 2014
    ..Public health policy is key to reducing its incidence. Integrated multidisciplinary clinical care is vital to minimise its morbidity and mortality...
  50. ncbi request reprint Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study
    S J Price
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Department pf Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
    AJNR Am J Neuroradiol 27:1969-74. 2006
    ..In this study, results of histologic examination from samples obtained from image-guided brain biopsies were correlated with diffusion tensor images...
  51. ncbi request reprint Future perspectives in the acute management of head injury
    P J Hutchinson
    Academic Neurosurgery Unit, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Surg 90:769-71. 2003
  52. ncbi request reprint The pharmacology of chlormethiazole: a potential neuroprotective agent?
    M J Wilby
    Academic Department of Neurosurgery, Box 167, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    CNS Drug Rev 10:281-94. 2004
    ..In addition, novel approaches involving human neurochemical analyses in vivo are described which may help bridge the gap between animal models and future phase III trials...
  53. ncbi request reprint Post traumatic brain contusions and lacerations. An international focus meeting, September 19-20, 2003, Rimini, Italy
    P J Hutchinson
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 146:535-6. 2004
  54. ncbi request reprint Neurosurgical history: Comparing the management of penetrating head injury in 1969 with 2005
    N C H Keong
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:227-32. 2006
    ..Two unusual cases demonstrate the progress made in emergency medicine, radiology neurointensive care, and neurosurgical head injury management over 36 years...
  55. ncbi request reprint Prospective study of clinical and radiological outcome after anterior cervical discectomy
    R J Laing
    Academic Department of Neurosurgery, University of Cambridge, Cambridge, UK
    Br J Neurosurg 15:319-23. 2001
    ..Disturbance of cervical and segmental alignment is common in patients following cervical discectomy, but does not appear to compromise clinical outcome at 12 months...
  56. ncbi request reprint Decompressive craniectomy in traumatic brain injury--time for randomised trials?
    P J Hutchinson
    Acta Neurochir (Wien) 147:1-3. 2005
  57. ncbi request reprint Bifrontal decompressive craniectomy in the management of posttraumatic intracranial hypertension
    P C Whitfield
    Department of Academic Neurosurgery, Addenbrookes NHS Trust, Cambridge UK
    Br J Neurosurg 15:500-7. 2001
    ..Our results support the continued use of bifrontal decompressive craniectomy in selected patients after head injury...
  58. ncbi request reprint Microdialysis to monitor scalp flap viability
    P A Bodkin
    J Reconstr Microsurg 23:57. 2007
  59. ncbi request reprint Chronic subdural haematoma: time to rationalize treatment?
    T Santarius
    Br J Neurosurg 18:328-32. 2004
    ..Current management strategies are summarized and the need to rationalise treatment backed up by Class I randomized studies is discussed...
  60. ncbi request reprint Large diameter twist drill craniostomy
    P J Hutchinson
    Br J Neurosurg 18:403. 2004
  61. pmc Timing of surgery for supratentorial aneurysmal subarachnoid haemorrhage: report of a prospective study
    N Ross
    University Department of Neurosurgery, Box 167, Block A, Level 4, Addenbrookes Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:480-4. 2002
    ..By following a strict management protocol for SAH, the hypothesis has been tested that in the modern arena of treatment for aneurysmal SAH the timing of surgery to secure supratentorial aneurysms does not affect surgical outcome...