K Hussain

Summary

Affiliation: University College London
Country: UK

Publications

  1. Hussain K. Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus. Rev Endocr Metab Disord. 2010;11:179-83 pubmed publisher
    ....
  2. request reprint
    Hussain K, Aynsley Green A. Hyperinsulinism in infancy: understanding the pathophysiology. Int J Biochem Cell Biol. 2003;35:1312-7 pubmed
    ..So far mutations in five different genes have been described which lead to dysregulated insulin secretion from beta-cells. Despite these advances the genetic defect is still unknown in about 60% of cases...
  3. request reprint
    Hussain K, Cosgrove K, Shepherd R, Luharia A, Smith V, Kassem S, et al. Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels. J Clin Endocrinol Metab. 2005;90:4376-82 pubmed
    ..However, in a small group of patients the hypoglycemia can be persistent and may require pancreatectomy. The mechanism of persistent hyperinsulinemic hypoglycemia in this group of patients is unclear...
  4. request reprint
    Hussain K, Bryan J, Christesen H, Brusgaard K, Aguilar Bryan L. Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism. Diabetes. 2005;54:2946-51 pubmed
    ..Other possible mechanisms such as the suppressive effect of prolonged hyperinsulinemia on alpha-cell secretion should be considered...

Detail Information

Publications4

  1. Hussain K. Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus. Rev Endocr Metab Disord. 2010;11:179-83 pubmed publisher
    ....
  2. request reprint
    Hussain K, Aynsley Green A. Hyperinsulinism in infancy: understanding the pathophysiology. Int J Biochem Cell Biol. 2003;35:1312-7 pubmed
    ..So far mutations in five different genes have been described which lead to dysregulated insulin secretion from beta-cells. Despite these advances the genetic defect is still unknown in about 60% of cases...
  3. request reprint
    Hussain K, Cosgrove K, Shepherd R, Luharia A, Smith V, Kassem S, et al. Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels. J Clin Endocrinol Metab. 2005;90:4376-82 pubmed
    ..However, in a small group of patients the hypoglycemia can be persistent and may require pancreatectomy. The mechanism of persistent hyperinsulinemic hypoglycemia in this group of patients is unclear...
  4. request reprint
    Hussain K, Bryan J, Christesen H, Brusgaard K, Aguilar Bryan L. Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism. Diabetes. 2005;54:2946-51 pubmed
    ..Other possible mechanisms such as the suppressive effect of prolonged hyperinsulinemia on alpha-cell secretion should be considered...