Research Topics
| Paul HuntSummaryAffiliation: University of Edinburgh Country: UK Publications
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Detail Information
Publications
Numerous, robust genetic markers for Plasmodium chabaudi by the method of amplified fragment length polymorphismKatrina Grech
University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 123:95-104. 2002..6 x 10(-4) per base pair. This is consistent with the sequence diversity found between alleles of candidate drug resistance genes from P. c. chabaudi clones AS and AJ identified and sequenced in this laboratory...- Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance transporter (crt) and multi-drug resistance (mdr1) orthologues involved?Paul Hunt
Institute of Cell, Animal and Population Biology, University of Edinburgh, EH9 3JT, Scotland, UK
Mol Biochem Parasitol 133:27-35. 2004..This showed that neither of these genes, nor genes closely linked to them, were determinants of the chloroquine resistance in the P. chabaudi mutants... 
Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasitesPaul Hunt
Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
BMC Genomics 11:499. 2010..Such genetic markers will further the investigation of resistance and its control in natural infections of the human malaria, P. falciparum...- Malaria genomics meets drug-resistance phenotyping in the fieldPaul Hunt
Institute for Immunology and Infection Research, University of Edinburgh, Ashworth Laboratory, Kings Buildings, Edinburgh EH9 3JT, UK
Genome Biol 10:314. 2009..A report of the 2nd Wellcome Trust Conference on Genomic Epidemiology of Malaria, Hinxton, UK, 14-17 June 2009... - Estimating SNP proportions in populations of malaria parasites by sequencing: validation and applicationsPaul Hunt
Institute for Immunity and Infection Research, School of Biological Science, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
Mol Biochem Parasitol 143:173-82. 2005..This technique can be used in the mapping of genetic loci underlying phenotypic traits and in the evaluation of the effects of different alleles upon the reproductive success (fitness) of parasites... - Gene synteny and chloroquine resistance in Plasmodium chabaudiPaul Hunt
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
Mol Biochem Parasitol 136:157-64. 2004..The genetic order of the markers in P. chabaudi is co-linear with the physical linkage represented in the P. falciparum genome database. The findings provide evidence for extensive conservation of synteny between the two species... - Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasitesPaul Hunt
Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratory, Kings Buildings, Edinburgh EH9 3JT, UK
Mol Microbiol 65:27-40. 2007..No mutations in the UBP-1 gene encoding the P. falciparum orthologue of the deubiquitinating enzyme were observed. The possible significance of these mutations in parasite responses to chloroquine or artemisinin is discussed... - Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malariaKatarzyna Kinga Modrzynska
Institute for Immunology and Infection Research, University of Edinburgh, UK
BMC Genomics 13:106. 2012..chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions... - An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudiAxel Martinelli
Institute for Immunology and Infection Research, School of Biological Science, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Malar J 4:11. 2005..Despite the availability of some genome sequence data, an extensive genetic linkage map is needed for mapping the genes involved in certain traits... - Linkage group selection: rapid gene discovery in malaria parasitesRichard Culleton
Institute of Immunity and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Genome Res 15:92-7. 2005..We show that molecular markers closely linked to dhfr, and only those linked to this gene, were reduced or removed by pyrimethamine treatment in accordance with the expectations of LGS... - Amplified fragment length polymorphism measures proportions of malaria parasites carrying specific alleles in complex genetic mixturesAxel Martinelli
University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 136:117-22. 2004..The precision of the method is sufficient to detect reliably the effects of phenotypic selection at loci closely linked to a genetic locus under selection... - A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasitesAxel Martinelli
Institute of Immunology and Infection Research, Ashworth Laboratories, King's Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
Proc Natl Acad Sci U S A 102:814-9. 2005..Another affected locus, unlinked to this selection valley, contained a member of the serine repeat antigen gene family... - Validation of Pyrosequencing for accurate and high throughput estimation of allele frequencies in malaria parasitesSandra Cheesman
Institute for Immunology and Infection Research, School of Biological Sciences, The University of Edinburgh, Ashworth Laboratories, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 152:213-9. 2007 - Linkage Group Selection--a fast approach to the genetic analysis of malaria parasitesRichard Carter
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, West Mains Road, Edinburgh EH9 3JT, UK
Int J Parasitol 37:285-93. 2007..We have called the method Linkage Group Selection... - Fitness of drug-resistant malaria parasitesDavid Walliker
Institute of Infection and Immunology Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
Acta Trop 94:251-9. 2005.... - Genetics of mefloquine resistance in the rodent malaria parasite Plasmodium chabaudiPedro V L Cravo
Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Antimicrob Agents Chemother 47:709-18. 2003..However, not all mefloquine-resistant progeny contained the duplicated gene, showing that at least one other gene was involved in resistance... - Detection of mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) gene by dot-blot hybridizationAbdel-Muhsin A Abdel-Muhsin
Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, United Kingdom
Am J Trop Med Hyg 67:24-7. 2002..The method has been successfully extended for analysis of other point mutations in dhfr at residues 51 and 59, which are associated with a high level of pyrimethamine resistance... - Accurate and reliable high-throughput detection of copy number variation in the human genomeHeike Fiegler
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
Genome Res 16:1566-74. 2006..Based on these studies, we developed a variance-based automatic copy number detection analysis process (CNVfinder) and have demonstrated its robustness by comparison with the SW-ARRAY method...