Affiliation: University of Cambridge
- A prospective longitudinal study of early cognitive development in tuberous sclerosis - a clinic based studyAyla Humphrey
Developmental Psychiatry Section, University of Cambridge Douglas House 18b, Trumpington Road, Cambridge CB2 2AH, England
Eur Child Adolesc Psychiatry 13:159-65. 2004..In three children, the developmental quotient changed by more than 20 points during the course of the study. The findings are considered in relation to the neurobiological risk factors for cognitive development in Tuberous Sclerosis...
- Monozygotic twins with tuberous sclerosis discordant for the severity of developmental deficitsAyla Humphrey
Developmental Psychiatry Section, University of Cambridge, Addenbrooke s Hospital, Cambridge, Institute of Psychiatry, London, UK
Neurology 62:795-8. 2004..The findings also raise questions about the mechanisms giving rise to autism in TS...
- The Early Childhood Epilepsy Severity Scale (E-Chess)Ayla Humphrey
Department of Psychiatry, Developmental Psychiatry Section, University of Cambridge, Douglas House, Cambridge, UK
Epilepsy Res 79:139-45. 2008....
- Autistic regression associated with seizure onset in an infant with tuberous sclerosisAyla Humphrey
Developmental Psychiatry Section, University of Cambridge, UK
Dev Med Child Neurol 48:609-11. 2006..The case suggests the need to consider if possible visual field defects with vigabatrin outweigh the potentially deleterious effects of uncontrolled seizures...
- Intellectual development before and after the onset of infantile spasms: a controlled prospective longitudinal study in tuberous sclerosisAyla Humphrey
Section of Developmental Psychiatry, University of Cambridge, Cambridge, United Kingdom
Epilepsia 55:108-16. 2014..We tested the hypothesis in a longitudinal study of children with tuberous sclerosis (TS), who have a high risk of developing IS...
- The Tuberous Sclerosis 2000 Study: presentation, initial assessments and implications for diagnosis and managementJohn R W Yates
Department of Medical Genetics, University of Cambridge, Cambridge, UK
Arch Dis Child 96:1020-5. 2011..The Tuberous Sclerosis 2000 Study is the first comprehensive longitudinal study of tuberous sclerosis (TS) and aims to identify factors that determine prognosis. Mode of presentation and findings at initial assessments are reported here...
- Biological markers of intellectual disability in tuberous sclerosisArmin Raznahan
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, UK
Psychol Med 37:1293-304. 2007..We have used univariate and multivariate analyses, including both CT and epilepsy measures as predictors, in an attempt to clarify the pattern of cross-sectional associations between these variables and ID in TS...
- Consensus clinical guidelines for the assessment of cognitive and behavioural problems in Tuberous SclerosisPetrus de Vries
Developmental Psychiatry Section, University of Cambridge, Cambridge, UK
Eur Child Adolesc Psychiatry 14:183-90. 2005..The paper outlines the problems associated with TSC, the purpose of recommended assessments, developmentally appropriate stages for assessment, and identifies specific areas that should be targeted for assessment...
- LEGO therapy and the social use of language programme: an evaluation of two social skills interventions for children with high functioning autism and Asperger SyndromeGina Owens
Autism Research Centre, University of Cambridge, Douglas House, Cambridge, CB2 2AH, UK
J Autism Dev Disord 38:1944-57. 2008..There was a non-significant trend for SULP and LEGO groups to improve more than the no-intervention group in communication and socialisation skills...
- Characterization of autism in young children with tuberous sclerosis complexShafali S Jeste
Department of Neurology, Children s Hospital, Boston, MA 02115, USA
J Child Neurol 23:520-5. 2008..The authors conclude that clinic-referred children with tuberous sclerosis complex and autism are at considerable risk for cognitive impairment. These characteristics may help to guide more tailored services for these high-risk children...