D A Hume

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function
    Clare Pridans
    1 The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK 2
    Sci Rep 3:3013. 2013
  2. pmc The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus
    Kristin A Sauter
    Developmental Biology, The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, United Kingdom
    PLoS ONE 8:e54935. 2013
  3. pmc The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide
    Ronan Kapetanovic
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, United Kingdom
    BMC Genomics 14:581. 2013
  4. pmc Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)
    Deborah J Gow
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG Scotland, UK
    Cytokine 61:630-8. 2013
  5. pmc Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34
    Deborah J Gow
    The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK
    Cytokine 60:793-805. 2012
  6. pmc Structural and functional annotation of the porcine immunome
    Harry D Dawson
    USDA ARS, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, MD 20705, USA
    BMC Genomics 14:332. 2013
  7. pmc Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Leukoc Biol 92:433-44. 2012
  8. doi Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    David A Hume
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
    Blood 119:1810-20. 2012
  9. pmc The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
    Hideya Kawaji
    RIKEN Omics Science Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho Tsurumi ku Yokohama, Kanagawa, 230 0045 Japan
    Genome Biol 10:R40. 2009
  10. pmc Data-driven normalization strategies for high-throughput quantitative RT-PCR
    Jessica C Mar
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Bioinformatics 10:110. 2009

Collaborators

  • Constanze Bonifer
  • Danielle Gunn-Moore
  • Tom C Freeman
  • Sobia Raza
  • Kim M Summers
  • Kerry E Simpson
  • Ronan Kapetanovic
  • Clare Pridans
  • Deborah J Gow
  • David P Sester
  • Kristin A Sauter
  • Lynsey Fairbairn
  • Dario Beraldi
  • Harry D Dawson
  • Christopher K Tuggle
  • Alan L Archibald
  • Valerie Garceau
  • Jessica C Mar
  • Katharine M Irvine
  • Hideya Kawaji
  • Yoshihide Hayashizaki
  • Harukazu Suzuki
  • Julie O'Neal
  • Ryan Pei Yen Cheng
  • Bouabid Badaoui
  • Richard M Ingram
  • Hirohide Uenishi
  • Michael P Murtaugh
  • Denise Carvalho-Silva
  • Tahar Ait-Ali
  • Takeya Morozumi
  • Frank Blecha
  • Claire Rogel-Gaillard
  • Celine Chen
  • John C Schwartz
  • Matthew Astley
  • Catherine Snow
  • Katherine M Mann
  • Jie Zhang
  • James G R Gilbert
  • Clara Amid
  • Kristin Baer
  • Matthew Hardy
  • Elisabetta Giuffra
  • Geraldine Pascal
  • Jane E Loveland
  • Hiromi Tagoh
  • Mike Kay
  • Charles Steward
  • Joan K Lunney
  • Sara Botti
  • Shu Hong Zhao
  • Daniel Berman
  • Daisuke Toki
  • Yongming Sang
  • Megan Bystrom
  • Alison Downing
  • Zhiliang Hu
  • Ting Hua Huang
  • M Amine Bouhlel
  • Jennifer L Harrow
  • Eric Fritz
  • David Lloyd
  • Laurens Wilming
  • James M Reecy
  • Anna Anselmo
  • Toby Hunt
  • Holger Kissel
  • Ranjit Kataria
  • Hiroki Shinkai
  • Bertrand Bed'hom
  • Adam G Gow
  • Mark Thomas
  • Greg J Fici
  • Thomas L Wilson
  • John A Shelly
  • Carsten O Daub
  • Andrew Waterhouse
  • Kate Schroder
  • Jessica Severin
  • Yasumasa Kimura
  • Alistair R R Forrest
  • John Quackenbush
  • Marina Lizio
  • Shintaro Katayama
  • Piero Carninci

Detail Information

Publications15

  1. pmc CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function
    Clare Pridans
    1 The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK 2
    Sci Rep 3:3013. 2013
    ..Since Csf1r signaling requires receptor dimerization initiated by CSF1 binding, the data suggest a mechanism for phenotypic dominance of the mutant allele in HDLS...
  2. pmc The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus
    Kristin A Sauter
    Developmental Biology, The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, United Kingdom
    PLoS ONE 8:e54935. 2013
    ..Mutation of transcription initiation sites within FIRE also reduced transcription. These results demonstrate that FIRE is an orientation-specific transcribed enhancer element...
  3. pmc The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide
    Ronan Kapetanovic
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, United Kingdom
    BMC Genomics 14:581. 2013
    ..Pig breeds have been reported to differ in their resistance to infectious disease. In this study we examine whether there are corresponding differences in gene expression in innate immune cells..
  4. pmc Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)
    Deborah J Gow
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG Scotland, UK
    Cytokine 61:630-8. 2013
    ..These results set the scene for therapeutic use of CSF-1 and IL-34 in cats...
  5. pmc Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34
    Deborah J Gow
    The Roslin Institute, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK
    Cytokine 60:793-805. 2012
    ..The pig CSF-1R was equally responsive to both mouse and human IL-34. Based upon the published crystal structures of CSF-1/CSF-1R and IL34/CSF-1R complexes, we discuss the molecular basis for the species specificity...
  6. pmc Structural and functional annotation of the porcine immunome
    Harry D Dawson
    USDA ARS, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, MD 20705, USA
    BMC Genomics 14:332. 2013
    ..The completion of the pig genome provides the opportunity to annotate the pig immunome, and compare and contrast pig and human immune systems...
  7. pmc Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Leukoc Biol 92:433-44. 2012
    ..The data and publication deluge related to macrophage biology require the development of new analytical tools and ways of presenting information in an accessible form...
  8. doi Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    David A Hume
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
    Blood 119:1810-20. 2012
    ..As a treatment, CSF-1 has therapeutic potential in tissue repair. Conversely, inhibition of CSF-1R is unlikely to be effective in inflammatory disease but may have utility in cancer...
  9. pmc The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
    Hideya Kawaji
    RIKEN Omics Science Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho Tsurumi ku Yokohama, Kanagawa, 230 0045 Japan
    Genome Biol 10:R40. 2009
    ..In addition, data regarding chromatin status derived from ChIP-chip to elucidate the transcriptional regulatory interactions are included. Here we present these data to the research community as an integrated web resource...
  10. pmc Data-driven normalization strategies for high-throughput quantitative RT-PCR
    Jessica C Mar
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Bioinformatics 10:110. 2009
    ..The use of appropriate normalization algorithms for qPCR-based data is therefore a highly important aspect of the data preprocessing pipeline...
  11. doi Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity
    David A Hume
    The Roslin Institute, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK
    J Leukoc Biol 89:525-38. 2011
    ..Nevertheless, they have proved valuable in cell isolation, functional genomics, and live imaging of myeloid cell behavior in many different pathologies...
  12. doi Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations
    David A Hume
    The Roslin Institute, Roslin Biocentre, Roslin, Midlothian, UK
    Genomics 95:328-38. 2010
    ..We discuss the limitations placed upon such data by the presence of alternative promoters with distinct tissue specificity within many protein-coding genes...
  13. ncbi Differentiation and heterogeneity in the mononuclear phagocyte system
    D A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, Roslin Biocentre, University of Edinburgh, Roslin, Scotland, UK
    Mucosal Immunol 1:432-41. 2008
    ..Those features clearly include antigen-presenting dendritic cells within the MPS and argue against any basis for separating them from macrophages...
  14. ncbi Macrophages as APC and the dendritic cell myth
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Immunol 181:5829-35. 2008
    ....
  15. doi The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease
    Lynsey Fairbairn
    The Roslin Institute and Royal Dick School of Veterinary Medicine, University of Edinburgh, Roslin Biocentre, Scotland, United Kingdom
    J Leukoc Biol 89:855-71. 2011
    ....