D A Hume

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Leukoc Biol 92:433-44. 2012
  2. ncbi Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    David A Hume
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
    Blood 119:1810-20. 2012
  3. ncbi The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
    Hideya Kawaji
    RIKEN Omics Science Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho Tsurumi ku Yokohama, Kanagawa, 230 0045 Japan
    Genome Biol 10:R40. 2009
  4. ncbi Data-driven normalization strategies for high-throughput quantitative RT-PCR
    Jessica C Mar
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Bioinformatics 10:110. 2009
  5. ncbi Macrophages as APC and the dendritic cell myth
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Immunol 181:5829-35. 2008
  6. ncbi Differentiation and heterogeneity in the mononuclear phagocyte system
    D A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, Roslin Biocentre, University of Edinburgh, Roslin, Scotland, UK
    Mucosal Immunol 1:432-41. 2008
  7. ncbi Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations
    David A Hume
    The Roslin Institute, Roslin Biocentre, Roslin, Midlothian, UK
    Genomics 95:328-38. 2010
  8. ncbi Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity
    David A Hume
    The Roslin Institute, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK
    J Leukoc Biol 89:525-38. 2011
  9. ncbi The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease
    Lynsey Fairbairn
    The Roslin Institute and Royal Dick School of Veterinary Medicine, University of Edinburgh, Roslin Biocentre, Scotland, United Kingdom
    J Leukoc Biol 89:855-71. 2011

Collaborators

  • Sobia Raza
  • Kim M Summers
  • Lynsey Fairbairn
  • Jessica C Mar
  • Yoshihide Hayashizaki
  • Hideya Kawaji
  • Katharine M Irvine
  • Harukazu Suzuki
  • David P Sester
  • Ronan Kapetanovic
  • Yasumasa Kimura
  • Shintaro Katayama
  • John Quackenbush
  • Kate Schroder
  • Carsten O Daub
  • Alistair R R Forrest
  • Marina Lizio
  • Piero Carninci
  • Andrew Waterhouse
  • Jessica Severin

Detail Information

Publications9

  1. ncbi Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Leukoc Biol 92:433-44. 2012
    ..The data and publication deluge related to macrophage biology require the development of new analytical tools and ways of presenting information in an accessible form...
  2. ncbi Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    David A Hume
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
    Blood 119:1810-20. 2012
    ..As a treatment, CSF-1 has therapeutic potential in tissue repair. Conversely, inhibition of CSF-1R is unlikely to be effective in inflammatory disease but may have utility in cancer...
  3. ncbi The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
    Hideya Kawaji
    RIKEN Omics Science Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho Tsurumi ku Yokohama, Kanagawa, 230 0045 Japan
    Genome Biol 10:R40. 2009
    ..In addition, data regarding chromatin status derived from ChIP-chip to elucidate the transcriptional regulatory interactions are included. Here we present these data to the research community as an integrated web resource...
  4. ncbi Data-driven normalization strategies for high-throughput quantitative RT-PCR
    Jessica C Mar
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Bioinformatics 10:110. 2009
    ..The use of appropriate normalization algorithms for qPCR-based data is therefore a highly important aspect of the data preprocessing pipeline...
  5. ncbi Macrophages as APC and the dendritic cell myth
    David A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom
    J Immunol 181:5829-35. 2008
    ....
  6. ncbi Differentiation and heterogeneity in the mononuclear phagocyte system
    D A Hume
    The Roslin Institute and Royal Dick School of Veterinary Studies, Roslin Biocentre, University of Edinburgh, Roslin, Scotland, UK
    Mucosal Immunol 1:432-41. 2008
    ..Those features clearly include antigen-presenting dendritic cells within the MPS and argue against any basis for separating them from macrophages...
  7. ncbi Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations
    David A Hume
    The Roslin Institute, Roslin Biocentre, Roslin, Midlothian, UK
    Genomics 95:328-38. 2010
    ..We discuss the limitations placed upon such data by the presence of alternative promoters with distinct tissue specificity within many protein-coding genes...
  8. ncbi Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity
    David A Hume
    The Roslin Institute, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK
    J Leukoc Biol 89:525-38. 2011
    ..Nevertheless, they have proved valuable in cell isolation, functional genomics, and live imaging of myeloid cell behavior in many different pathologies...
  9. ncbi The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease
    Lynsey Fairbairn
    The Roslin Institute and Royal Dick School of Veterinary Medicine, University of Edinburgh, Roslin Biocentre, Scotland, United Kingdom
    J Leukoc Biol 89:855-71. 2011
    ....