Thomas A Hughes

Summary

Affiliation: University College London
Country: UK

Publications

  1. request reprint
    Hughes T, Brady H. Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. Cancer Lett. 2006;233:338-47 pubmed
    ..Additionally, we show that stability of axin2 protein provides a further level of expression regulation. We discuss this complex regulation in terms of axin2's function in carcinogenesis. ..
  2. request reprint
    Hughes T, Brady H. E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem Biophys Res Commun. 2005;329:1267-74 pubmed
    ..Second, E2F1 induces stabilisation of axin2 mRNAs. We discuss this regulation with respect to other known E2F targets. ..
  3. request reprint
    Hughes T, Brady H. Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA. J Biol Chem. 2005;280:8581-8 pubmed
    ..We discuss this complex regulation in the context of the function of Axin2 as a tumor suppressor. ..