C E Hughes

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2)
    Craig E Hughes
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 288:5127-35. 2013
  2. pmc G6f-like is an ITAM-containing collagen receptor in thrombocytes
    Craig E Hughes
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    PLoS ONE 7:e52622. 2012
  3. pmc Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
    C E Hughes
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 6:2152-9. 2008
  4. pmc A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1)
    G E Jarvis
    School of Pharmacy, Queen s University Belfast, Belfast, UK
    J Thromb Haemost 10:268-77. 2012
  5. doi The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets
    J C Spalton
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Thromb Haemost 7:1192-9. 2009
  6. doi Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide
    B Grygielska
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 7:339-46. 2009

Collaborators

Detail Information

Publications6

  1. pmc Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2)
    Craig E Hughes
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 288:5127-35. 2013
    ..These results further emphasize the distinct nature of the proximal events in signaling by hemITAM relative to ITAM receptors...
  2. pmc G6f-like is an ITAM-containing collagen receptor in thrombocytes
    Craig E Hughes
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    PLoS ONE 7:e52622. 2012
    ..Thus, G6f-like is a physiologically relevant collagen receptor in fish thrombocytes which signals through the same ITAM-based signalling pathway as mammalian GPVI, providing a novel example of convergent evolution...
  3. pmc Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
    C E Hughes
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 6:2152-9. 2008
    ..SLP-76 is constitutively associated with the adapter Gads in platelets, which also binds to tyrosine phosphorylated LAT, thereby providing a potential pathway of regulation of SLP-76...
  4. pmc A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1)
    G E Jarvis
    School of Pharmacy, Queen s University Belfast, Belfast, UK
    J Thromb Haemost 10:268-77. 2012
    ..Adhesion and degranulation-promoting adapter protein (ADAP) regulates α(IIb) β(3) in platelets and α(L) β(2) in T cells, and is phosphorylated in GPVI-deficient platelets activated by collagen...
  5. doi The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets
    J C Spalton
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Thromb Haemost 7:1192-9. 2009
    ..A recent study identified the novel small molecule R406 as a selective inhibitor of Syk...
  6. doi Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide
    B Grygielska
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 7:339-46. 2009
    ....