Stefan G Hubscher

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Recurrent autoimmune hepatitis after liver transplantation: diagnostic criteria, risk factors, and outcome
    S G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Liver Transpl 7:285-91. 2001
  2. pmc Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease
    Allister J Grant
    Liver Research Labs Centre for Immune Regulation and the Department of Pathology, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Am J Pathol 160:1445-55. 2002
  3. ncbi request reprint Hepatitis C virus receptor expression in normal and diseased liver tissue
    Gary M Reynolds
    Liver Laboratories, Institute for Biomedical Research, University of Birmingham and University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Hepatology 47:418-27. 2008
  4. doi request reprint Antibody-mediated rejection in the liver allograft
    Stefan G Hubscher
    School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
    Curr Opin Organ Transplant 17:280-6. 2012
  5. ncbi request reprint Transplantation pathology
    Stefan G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Semin Diagn Pathol 23:170-81. 2006
  6. ncbi request reprint Role of liver biopsy in the assessment of non-alcoholic fatty liver disease
    Stefan G Hubscher
    Department of Pathology, University of Birmingham, UK
    Eur J Gastroenterol Hepatol 16:1107-15. 2004
  7. ncbi request reprint Histological assessment of non-alcoholic fatty liver disease
    S G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Histopathology 49:450-65. 2006
  8. doi request reprint Transplantation pathology
    Stefan G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Semin Liver Dis 29:74-90. 2009
  9. doi request reprint What does the long-term liver allograft look like for the pediatric recipient?
    Stefan Hubscher
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Liver Transpl 15:S19-24. 2009
  10. doi request reprint What is the long-term outcome of the liver allograft?
    Stefan G Hubscher
    School of Cancer Sciences, University of Birmingham and Department of Cellular Pathology, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Hepatol 55:702-17. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Recurrent autoimmune hepatitis after liver transplantation: diagnostic criteria, risk factors, and outcome
    S G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Liver Transpl 7:285-91. 2001
    ....
  2. pmc Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease
    Allister J Grant
    Liver Research Labs Centre for Immune Regulation and the Department of Pathology, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Am J Pathol 160:1445-55. 2002
    ..This study provides further evidence for the existence of portal-associated lymphoid tissue and is the first evidence that ectopic CCL21 is associated with lymphoid neogenesis in human inflammatory disease...
  3. ncbi request reprint Hepatitis C virus receptor expression in normal and diseased liver tissue
    Gary M Reynolds
    Liver Laboratories, Institute for Biomedical Research, University of Birmingham and University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Hepatology 47:418-27. 2008
    ..In contrast, CLDN4 hepatocellular staining was comparable in normal and diseased liver tissue...
  4. doi request reprint Antibody-mediated rejection in the liver allograft
    Stefan G Hubscher
    School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
    Curr Opin Organ Transplant 17:280-6. 2012
    ..This article will review the pathology of antibody-mediated rejection (AMR) focusing on recent studies which have improved our understanding of the clinicopathological features and diagnostic approaches...
  5. ncbi request reprint Transplantation pathology
    Stefan G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Semin Diagn Pathol 23:170-81. 2006
    ..Consideration should also be given to the therapeutic implications of the biopsy report, in particular whether changes in immunosuppression are indicated...
  6. ncbi request reprint Role of liver biopsy in the assessment of non-alcoholic fatty liver disease
    Stefan G Hubscher
    Department of Pathology, University of Birmingham, UK
    Eur J Gastroenterol Hepatol 16:1107-15. 2004
    ....
  7. ncbi request reprint Histological assessment of non-alcoholic fatty liver disease
    S G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Histopathology 49:450-65. 2006
    ..These require further evaluation, but have a potentially important role to play in determining prognosis and monitoring therapeutic responses...
  8. doi request reprint Transplantation pathology
    Stefan G Hubscher
    Department of Pathology, University of Birmingham, Birmingham, UK
    Semin Liver Dis 29:74-90. 2009
    ..g., coexistent metabolic fatty liver disease). In cases where there is a dual pathology, liver biopsy may also help to identify the predominant cause of graft damage...
  9. doi request reprint What does the long-term liver allograft look like for the pediatric recipient?
    Stefan Hubscher
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Liver Transpl 15:S19-24. 2009
    ..6. Further studies are required to investigate the role of protocol liver biopsies in determining therapeutic strategies in children who appear to have good graft function according to noninvasive investigations...
  10. doi request reprint What is the long-term outcome of the liver allograft?
    Stefan G Hubscher
    School of Cancer Sciences, University of Birmingham and Department of Cellular Pathology, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Hepatol 55:702-17. 2011
    ..This article will provide an overview of the main histological changes occurring in long-term survivors post-LT, focusing on areas where the assessment of late post-transplant biopsies is most relevant clinically...
  11. pmc Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    Bertus Eksteen
    Liver Research Laboratories, Institute for Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, England, UK
    J Exp Med 200:1511-7. 2004
    ..This is the first demonstration in humans that T cells activated in the gut can be recruited to an extra-intestinal site of disease and provides a paradigm to explain the pathogenesis of extra-intestinal complications of IBD...
  12. ncbi request reprint Cirrhosis after orthotopic liver transplantation in the absence of primary disease recurrence
    Moataz Seyam
    Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Liver Transpl 13:966-74. 2007
    ..Chronic hepatitis is the most frequent underlying pathological process in cases where the cause of cirrhosis remains uncertain...
  13. ncbi request reprint Natural history of unexplained chronic hepatitis after liver transplantation
    Wing Kin Syn
    Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, United Kingdom
    Liver Transpl 13:984-9. 2007
    ..Standard liver tests do not reflect the extent of these changes, so protocol liver biopsies may be required to detect these changes. We recommend careful history and follow-up in these patients...
  14. pmc CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry
    Helen J Harris
    University of Birmingham, Division of Infection and Immunity, Institute for Biomedical Research, Vincent Dr, Birmingham B15 2TT, United Kingdom
    J Virol 82:5007-20. 2008
    ....
  15. doi request reprint Post-transplant liver biopsy and the immune response: lessons for the clinician
    Shishir Shetty
    Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK
    Expert Rev Clin Immunol 8:645-61. 2012
    ..Future developments in genetic and immune profiling may lead to liver biopsy becoming a predictive tool to identify patients in which immunosuppression can be safely withdrawn...
  16. doi request reprint Recruitment mechanisms of primary and malignant B cells to the human liver
    Shishir Shetty
    Center for Liver Research, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    Hepatology 56:1521-31. 2012
    ..Certain features of lymphocyte homing are maintained in lymphoma recruitment to the liver, suggesting that therapeutic targets for lymphocyte recruitment may also prevent hepatic lymphoma dissemination...
  17. doi request reprint Current views on rejection pathology in liver transplantation
    Desley A H Neil
    Department of Pathology, University of Birmingham, Birmingham, UK
    Transpl Int 23:971-83. 2010
    ..This review will focus on these difficult and controversial areas in the pathology of rejection, documenting what is currently known and identifying areas where further clarification is required...
  18. ncbi request reprint The role of Notch receptor expression in bile duct development and disease
    Diana M Flynn
    Liver Research Laboratories, Queen Elizabeth Hospital, Edgbaston, UK
    J Pathol 204:55-64. 2004
    ..Further studies are required to investigate the presence of Notch2 and Notch3 at other periods in liver development and to clarify the role of Notch signalling in paediatric cholestases...
  19. doi request reprint Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium
    Shishir Shetty
    Centre for Liver Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom B152TT
    J Immunol 186:4147-55. 2011
    ..Thus, CLEVER-1/stabilin-1 and VAP-1 may provide an organ-specific signal for Treg recruitment to the inflamed liver and to hepatocellular carcinoma...
  20. doi request reprint CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
    Ye Htun Oo
    Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham, Birmingham, United Kingdom
    J Hepatol 57:1044-51. 2012
    ..IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their recruitment and positioning within the liver is unknown...
  21. pmc A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration
    Garrick K Wilson
    Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    J Hepatol 56:803-9. 2012
    ..However, the role of infection in HCC pathogenesis is poorly understood. We investigated the effect(s) of HCV infection and viral glycoprotein expression on hepatoma biology to gain insights into the development of HCV associated HCC...
  22. ncbi request reprint Histologic and biochemical changes during the evolution of chronic rejection of liver allografts
    Desley A H Neil
    Department of Pathology, Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom B15 2TT
    Hepatology 35:639-51. 2002
    ..In conclusion, findings from this study may help identify patients at risk of progressing to graft loss from CR at a stage when the disease process is potentially reversible and amenable to treatment...
  23. doi request reprint Non-cirrhotic intrahepatic portal hypertension: associated gut diseases and prognostic factors
    C E Eapen
    Liver Unit, Queen Elizabeth Hospital, and Department of Pathology, University of Birmingham, Edgbaston, Birmingham, B15 2TH, UK
    Dig Dis Sci 56:227-35. 2011
    ..We have studied a cohort followed-up at a tertiary referral center and postulate that gut-derived prothrombotic factors may contribute to the pathogenesis and prognosis of NCIPH...
  24. pmc Acute liver failure due to primary angiosarcoma: a case report and review of literature
    Chandra S Bhati
    Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    World J Surg Oncol 6:104. 2008
    ..Hepatic angiosarcoma is a primary sarcoma of the liver, accounting for only 2% of all primary hepatic malignancies. Acute liver failure is an extremely rare presentation of a primary liver tumour...
  25. doi request reprint Autoimmune liver diseases and recurrence after orthotopic liver transplantation: what have we learned so far?
    Tim C M A Schreuder
    Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Transpl Int 22:144-52. 2009
    ..Risk factors for rPBC include use of tacrolimus compared with cyclosporine; for rPSC include absence of colon peri-transplantation and for rAIH possible associations with some HLA haplotypes have been suggested...
  26. ncbi request reprint Does the Banff rejection activity index predict outcome in patients with early acute cellular rejection following liver transplantation?
    Barbara S Höroldt
    Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    Liver Transpl 12:1144-51. 2006
    ..In conclusion, although the Banff RAI score is a useful marker of the severity of rejection, neither the total RAI score nor any of the individual components correlated with response to steroids or graft survival...
  27. ncbi request reprint The role of cytokines and chemokines in the development of steatohepatitis
    Patricia F Lalor
    Liver Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    Semin Liver Dis 27:173-93. 2007
    ..A better understanding of this process might allow therapeutic intervention to switch off the inflammatory response before irreversible damage occurs in both ALD and NAFLD...
  28. ncbi request reprint CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver
    Mathis Heydtmann
    Birmingham University, Edgbaston, United Kingdom
    J Immunol 174:1055-62. 2005
    ..Thus, CXCL16 can promote lymphocyte adhesion to epithelial cells and may function to attract and retain effector cells that promote biliary and hepatocyte destruction in inflammatory liver disease...
  29. doi request reprint Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice
    Joanna K Dowman
    PhD, FRCP, Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom
    Endocrinology 154:4536-47. 2013
    ..05). 5αR1 deletion accelerates the development of hepatic steatosis but may protect against the development of NAFLD-related hepatocellular neoplasia and therefore has potential as a therapeutic target. ..
  30. pmc Systemic viral infections and collateral damage in the liver
    David H Adams
    Liver Research Laboratories, Institute for Biomedical Research, University of Birmingham Medical School, Wolfson Dr, Birmingham, B15 2TT, UK
    Am J Pathol 168:1057-9. 2006
  31. pmc Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects
    Sarbjit S Nijjar
    Department of Pathology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Am J Pathol 160:1695-703. 2002
    ..This, together with aberrant Jagged-1 expression suggests that the Notch signaling pathway may play a role in the neovascularization and biliary defects observed in the liver during the development of cirrhosis...
  32. ncbi request reprint Human liver-derived stem cells
    Alastair J Strain
    University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Semin Liver Dis 23:373-84. 2003
    ..However, whether any of the current liver stem cell approaches will be converted into effective clinical cell transplantation or gene therapy treatments has yet to be proven...
  33. doi request reprint Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver
    Ye H Oo
    Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Immunol 184:2886-98. 2010
    ..Thus, different chemokine receptors play distinct roles in the recruitment and positioning of T(regs) at sites of hepatitis in chronic liver disease...
  34. ncbi request reprint Invasive gastrointestinal zygomycosis in a liver transplant recipient: case report
    Alonso Vera
    Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, England, B15 2TH
    Transplantation 73:145-7. 2002
    ..Gastric zygomycosis is a rare but potentially lethal complication in transplant patients. Forty-two cases of gastric mucormycosis have been described in the literature, with a mortality of 98%...
  35. ncbi request reprint Absence of Epstein-Barr virus DNA in the tumor cells of European hepatocellular carcinoma
    Jia Junying
    Department of Pathology, University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK
    Virology 306:236-43. 2003
    ..Furthermore, none of the German or U.K. HCC tumors tested positive for EBER or EBNAI expression in tumor cells. Our results provide strong evidence that HCCs from the U.K. or Germany are not associated with EBV...
  36. ncbi request reprint Adult T-cell leukemia presenting with acute liver failure
    Nicholas Powell
    Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK
    Leuk Res 30:1315-7. 2006
    ..Liver histology revealed massive infiltration with atypical lymphocytes typical of ATL and liver necrosis...