J M M Howson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, UK
    Genet Epidemiol 29:51-67. 2005
  2. pmc Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Cambridge, UK
    Diabetes 61:3012-7. 2012
  3. pmc Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 55:1978-84. 2012
  4. pmc Evidence of association with type 1 diabetes in the SLC11A1 gene region
    Jennie H M Yang
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    BMC Med Genet 12:59. 2011
  5. pmc Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2XY, UK
    BMC Med Genet 7:20. 2006
  6. pmc Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods
    Heather J Cordell
    University of Cambridge, Department of Medical Genetics, JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, United Kingdom
    BMC Genet 4:S6. 2003
  7. pmc Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetesand Inflammation Laboratory, Cambridge Institute for Medical Research, Departmentof Medical Genetics, University of Cambridge, Cambridge, U K
    Diabetes 60:2635-44. 2011
  8. pmc Genetic analysis of adult-onset autoimmune diabetes
    Joanna M M Howson
    Department of Medical Genetics, Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U K
    Diabetes 60:2645-53. 2011
  9. pmc Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S74-84. 2009
  10. pmc Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Obes Metab 11:31-45. 2009

Collaborators

Detail Information

Publications41

  1. ncbi Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, UK
    Genet Epidemiol 29:51-67. 2005
    ....
  2. pmc Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Cambridge, UK
    Diabetes 61:3012-7. 2012
    ..01). Statistical interaction effects can be detected in type 1 diabetes although they provide a relatively small contribution to our understanding of the familial clustering of the disease...
  3. pmc Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 55:1978-84. 2012
    ..Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are associated with ZnT8A...
  4. pmc Evidence of association with type 1 diabetes in the SLC11A1 gene region
    Jennie H M Yang
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    BMC Med Genet 12:59. 2011
    ..Here, we have conducted association analysis of this candidate gene region, and then investigated potential correlations between the most T1D-associated variant and RNA expression of the SLC11A1 gene and its splice isoform...
  5. pmc Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2XY, UK
    BMC Med Genet 7:20. 2006
    ..Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D...
  6. pmc Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods
    Heather J Cordell
    University of Cambridge, Department of Medical Genetics, JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, United Kingdom
    BMC Genet 4:S6. 2003
    ..All methods performed well, however, when applied to new simulated data in which the true genetic effects were allowed to explain a greater proportion of the overall variance...
  7. pmc Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetesand Inflammation Laboratory, Cambridge Institute for Medical Research, Departmentof Medical Genetics, University of Cambridge, Cambridge, U K
    Diabetes 60:2635-44. 2011
    ..We investigated the association of glutamic acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen-2 autoantibodies (IA-2A) with the HLA region...
  8. pmc Genetic analysis of adult-onset autoimmune diabetes
    Joanna M M Howson
    Department of Medical Genetics, Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U K
    Diabetes 60:2645-53. 2011
    ..In contrast with childhood-onset type 1 diabetes, the genetics of autoimmune diabetes in adults are not well understood. We have therefore investigated the genetics of diabetes diagnosed in adults positive for autoantibodies...
  9. pmc Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S74-84. 2009
    ..0005), with RR=1.14 (1.06-1.23). In contrast, no convincing evidence of association was obtained for SUMO4, VDR, PAX4, OAS1, IRS1, IL4, IL4R, IL13, IL12B, CEACAM21 or CAPSL gene regions (http://www.T1DBase.org)...
  10. pmc Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Obes Metab 11:31-45. 2009
    ..Here we test for HLA class II-independent associations in the MHC using fine mapping data generated by the Type 1 Diabetes Genetics Consortium (T1DGC)...
  11. pmc CD226 Gly307Ser association with multiple autoimmune diseases
    J P Hafler
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Genes Immun 10:5-10. 2009
    ..20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017). The Ser(307) allele of rs763361 in exon 7 of CD226 predisposes to T1D, MS, and possibly AITD and RA, and based on the tag SNP analysis, could be the causal variant...
  12. doi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  13. pmc A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK
    Diabetologia 50:741-6. 2007
    ..Using thyroid peroxidase autoantibodies (TPOAbs) as an indicator of thyroid autoimmunity, we assessed whether the association of these loci is different in type 1 diabetes patients with TPOAbs than in those without...
  14. pmc No association of multiple type 2 diabetes loci with type 1 diabetes
    S M Raj
    Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetologia 52:2109-16. 2009
    ..11 at a false-positive rate of 0.003...
  15. pmc HLA class II gene associations in African American type 1 diabetes reveal a protective HLA-DRB1*03 haplotype
    J M M Howson
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Biomedical Research Centre, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabet Med 30:710-6. 2013
    ..We aimed to study the human leukocyte antigen (HLA) region in African American Type 1 diabetes...
  16. ncbi Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene
    L M Maier
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 4:469-75. 2003
    ..001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one...
  17. pmc Confirmation of novel type 1 diabetes risk loci in families
    J D Cooper
    Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 55:996-1000. 2012
    ....
  18. ncbi Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians
    S E Jamieson
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Cambridge, UK
    Genes Immun 5:46-57. 2004
    ..Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2...
  19. doi Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes
    Sarah F Field
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1753-6. 2008
    ....
  20. pmc Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK
    Nature 450:887-92. 2007
    ..Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes...
  21. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
  22. ncbi Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis
    Agnes A Awomoyi
    Medical Research Council Laboratories, Banjul, The Gambia
    J Infect Dis 186:1808-14. 2002
    ..These data therefore confirm the importance of SLC11A1 in tuberculosis susceptibility in humans and suggest that SLC11A1 influences tuberculosis susceptibility by regulation of interleukin-10...
  23. doi PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1730-7. 2008
    ....
  24. ncbi Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    J Allergy Clin Immunol 117:1306-13. 2006
    ..One possible explanation is that susceptibility alleles for one disease provide protection for the other...
  25. pmc Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene
    Rebecca C J Twells
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Genome Res 13:845-55. 2003
    ..The identification of hot spots in between these LD blocks provides additional evidence that LD blocks are separated by areas of higher recombination...
  26. ncbi Association of intercellular adhesion molecule-1 gene with type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, CB2 2XY, Cambridge, UK
    Lancet 362:1723-4. 2003
    ..91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments...
  27. ncbi Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes
    Adrian Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 53:1158-61. 2004
    ..K. affected individuals and identified and genotyped all common SNPs (minor allele frequency >10%; n = 5) in 786 families. We report no evidence of association of these common variants in NEUROD1 and type 1 diabetes in these samples...
  28. pmc Complete MHC haplotype sequencing for common disease gene mapping
    C Andrew Stewart
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 14:1176-87. 2004
    ....
  29. ncbi Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis
    Jemima C Stockton
    Department of Medicine, University of Cambridge School of Clinical Medicine, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    FEMS Immunol Med Microbiol 41:157-60. 2004
    ..CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample...
  30. ncbi Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes
    John S Hulme
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Diabetes 53:2479-82. 2004
    ..We conclude that a major role for the common LCK polymorphisms in type 1 diabetes is unlikely. However, we cannot rule out the possibility of there being a causal variant outside the exonic, intronic, and untranslated regions studied...
  31. ncbi Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Diabetes 53:2709-12. 2004
    ..K. and found no evidence of association. Overall, our results indicate that common sequence variation in the VDR gene has no major effect in type 1 diabetes in the populations tested...
  32. ncbi Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..24 x 10(-4); OR 1.43 [95% CI 1.17-1.76]). Taken together, these results indicate a more general association of the PTPN22 locus with autoimmune disease...
  33. pmc Regression mapping of association between the human leukocyte antigen region and Graves disease
    Matthew J Simmonds
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, and Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom
    Am J Hum Genet 76:157-63. 2005
    ..However, we cannot yet exclude a primary role for DQA1 or for other polymorphisms that affect DRB1 function or expression...
  34. ncbi Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease
    Sarra E Jamieson
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 2XY, UK
    Neurosci Lett 374:124-8. 2005
    ..No other associations with AD were observed at SLC11A1 or SLC11A2, indicating no major effect of either gene for the occurrence of AD...
  35. pmc No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 76:517-21. 2005
    ..Additional support from independent samples will be even more important in the study of gene-gene interactions and other subgroup analyses...
  36. ncbi Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
    Deborah J Smyth
    Nat Genet 37:110-1; author reply 112-3. 2005
  37. ncbi Population structure, differential bias and genomic control in a large-scale, case-control association study
    David G Clayton
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nat Genet 37:1243-6. 2005
    ..To avoid excluding SNPs and losing valuable information, we extended the genomic control method by applying a variable downweighting to each SNP...
  38. ncbi Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing
    Jeffrey S Szeszko
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetes 55:559-62. 2006
    ....
  39. ncbi Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    Hironori Ueda
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nature 423:506-11. 2003
    ..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction...
  40. ncbi Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes
    Christina Eftychi
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U K
    Diabetes 53:870-3. 2004
    ..05). However, the PPARG2 Pro12Ala variant showed evidence of association (RR 1.15, 95% CI 1.04-1.28, P = 0.008). Additional studies need to be conducted to confirm this result...
  41. ncbi A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect
    Matthew J Simmonds
    Division of Medical Sciences, University of Birmingham, UK
    Hum Mol Genet 16:2149-53. 2007
    ..Our results point to a primary role for class I-mediated responses in GD, a condition classically assumed to be a straightforward HLA-class II-restricted autoantibody response to the thyroid stimulating hormone receptor...