Alexander J Howie

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi Problems with 'focal segmental glomerulosclerosis'
    Alexander J Howie
    Department of Pathology, University College London, London, WC1E 6JJ, UK
    Pediatr Nephrol 26:1197-205. 2011
  2. doi Optical properties of amyloid stained by Congo red: history and mechanisms
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Micron 40:285-301. 2009
  3. ncbi Discrepancies between descriptions and illustrations of colours in Congo red-stained amyloid, and explanation of discrepant colours
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Amyloid 17:109-17. 2010
  4. doi Glomerular tip changes in childhood minimal change nephropathy
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Pediatr Nephrol 23:1281-6. 2008
  5. ncbi Physical basis of colors seen in Congo red-stained amyloid in polarized light
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Lab Invest 88:232-42. 2008
  6. ncbi The association among C4d staining in renal transplant biopsies, the production of donor-specific HLA antibodies, and graft outcome
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Transplantation 83:373-4. 2007
  7. ncbi Evolution of nephrotic-associated focal segmental glomerulosclerosis and relation to the glomerular tip lesion
    Alexander J Howie
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Kidney Int 67:987-1001. 2005
  8. doi Vasculitic IgA nephropathy: prognosis and outcome
    Tanya Pankhurst
    Department of Immunity and Infection, Institute of Biomedical Research Medical School, University of Birmingham, Edgbaston Birmingham, UK
    Nephron Clin Pract 112:c16-24. 2009
  9. ncbi Early changes in scores of chronic damage on transplant kidney protocol biopsies reflect donor characteristics, but not future graft function
    Ben Caplin
    Centre for Nephrology, UCL Medical School, London, UK
    Clin Transplant 27:E669-78. 2013
  10. doi Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation
    Steven T Cox
    Anthony Nolan Research Institute, London, United Kingdom
    Hum Immunol 72:827-34. 2011

Collaborators

Detail Information

Publications19

  1. doi Problems with 'focal segmental glomerulosclerosis'
    Alexander J Howie
    Department of Pathology, University College London, London, WC1E 6JJ, UK
    Pediatr Nephrol 26:1197-205. 2011
    ..Collapsing glomerulopathy' is distinctive, and its inclusion in classifications emphasises the lack of specificity of 'FSGS'...
  2. doi Optical properties of amyloid stained by Congo red: history and mechanisms
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Micron 40:285-301. 2009
    ..These are called anomalous colours...
  3. ncbi Discrepancies between descriptions and illustrations of colours in Congo red-stained amyloid, and explanation of discrepant colours
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Amyloid 17:109-17. 2010
    ..These other anomalous colours are just as characteristic of amyloid as the pure green colour. Many papers on Congo red-stained amyloid appear to describe what is expected theoretically rather than what is actually seen...
  4. doi Glomerular tip changes in childhood minimal change nephropathy
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Pediatr Nephrol 23:1281-6. 2008
    ..This should make little difference in clinical practice, because the clinical course should resemble that of minimal change nephropathy...
  5. ncbi Physical basis of colors seen in Congo red-stained amyloid in polarized light
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Lab Invest 88:232-42. 2008
    ..Rather than showing 'apple-green birefringence in polarized light' as often reported, Congo red-stained amyloid, when examined between crossed polarizer and analyzer, should more accurately be said to show anomalous colors...
  6. ncbi The association among C4d staining in renal transplant biopsies, the production of donor-specific HLA antibodies, and graft outcome
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Transplantation 83:373-4. 2007
  7. ncbi Evolution of nephrotic-associated focal segmental glomerulosclerosis and relation to the glomerular tip lesion
    Alexander J Howie
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Kidney Int 67:987-1001. 2005
    ..Several entities or variants within focal segmental glomerulosclerosis (FSGS) have been described, but their changes with time and interrelationships are undetermined...
  8. doi Vasculitic IgA nephropathy: prognosis and outcome
    Tanya Pankhurst
    Department of Immunity and Infection, Institute of Biomedical Research Medical School, University of Birmingham, Edgbaston Birmingham, UK
    Nephron Clin Pract 112:c16-24. 2009
    ..A vasculitic glomerulonephritis is seen in both IgA nephropathy and Henoch-Schonlein purpura. No study has examined prognostic factors in vasculitic IgA nephropathy...
  9. ncbi Early changes in scores of chronic damage on transplant kidney protocol biopsies reflect donor characteristics, but not future graft function
    Ben Caplin
    Centre for Nephrology, UCL Medical School, London, UK
    Clin Transplant 27:E669-78. 2013
    ..These findings suggest that graft damage develops shortly after transplantation and reflects donor factors, but does not predict future biochemical outcomes...
  10. doi Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation
    Steven T Cox
    Anthony Nolan Research Institute, London, United Kingdom
    Hum Immunol 72:827-34. 2011
    ..We conclude that mismatching for MICA epitopes in renal transplantation is a mechanism leading to production of MICA antibodies that associate with AR and graft dysfunction...
  11. ncbi Measurement of chronic damage in the donor kidney and graft survival
    Alexander J Howie
    Department of Pathology, University of Birmingham, Birmingham, United Kingdom
    Transplantation 77:1058-65. 2004
    ..So-called marginal kidneys are used increasingly in renal transplantation, but features of marginal kidneys are disputed...
  12. doi Immune profile and Epstein-Barr virus infection in acute interstitial nephritis: an immunohistochemical study in 78 patients
    Abdurrezagh Mansur
    Renal Immunobiology, University of Birmingham, College of Medical and Dental Sciences, London, UK
    Nephron Clin Pract 119:c293-300. 2011
    ..The purpose of our study was to define the nature of the interstitial immune infiltrate and to investigate the possibility of renal infection with EBV...
  13. ncbi Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria
    Marcus Quinkler
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Circulation 112:1435-43. 2005
    ..There is also experimental evidence that aldosterone contributes to the development of nephrosclerosis and renal fibrosis in rodent models, but little is known of its role in clinical renal disease...
  14. ncbi Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis
    Janette C Cansick
    Department of Paediatric Nephrology, Birmingham Children s Hospital, Birmingham, UK
    Nephrol Dial Transplant 19:2769-77. 2004
    ..Prognostic factors and outcome are incompletely known in childhood mesangiocapillary glomerulonephritis (MCGN). This study aimed to correlate renal outcome with clinical and histopathological variables...
  15. doi CD248+ stromal cells are associated with progressive chronic kidney disease
    Stuart W Smith
    Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Kidney Int 80:199-207. 2011
    ..Thus, CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD...
  16. pmc The incidence of major hemorrhagic complications after renal biopsies in patients with monoclonal gammopathies
    Richard Fish
    Department of Renal Medicine, King s College Hospital, London, UK
    Clin J Am Soc Nephrol 5:1977-80. 2010
    ..The purpose of this study was to determine the incidence of significant hemorrhagic complications after renal biopsies in patients with monoclonal gammopathies...
  17. ncbi Induction treatment of ANCA-associated vasculitis with a single dose of rituximab
    Tabitha Turner-Stokes
    UCL Centre for Nephrology, Royal Free Hospital, Department of Pathology, University College London, London, UK and Trinity Health Kidney Centre, Tallaght Hospital, Dublin, Ireland
    Rheumatology (Oxford) 53:1395-403. 2014
    ..As B cell depletion (BCD) appears to occur very rapidly after the first dose, we questioned the need for repeat dosing and adopted a standard single-dose protocol of 375 mg/m(2) to treat active AAV...
  18. ncbi Pathology of minimal change nephropathy and segmental sclerosing glomerular disorders
    Alexander J Howie
    Department of Pathology, University of Birmingham, Birmingham, UK
    Nephrol Dial Transplant 18:vi33-8. 2003
    ..Hilar abnormalities are a characteristic finding in reduced glomerular numbers. Focal segmental glomerulosclerosis is an ambiguous term, applied to many different types of segmental sclerosing glomerular disorders...
  19. ncbi Mycophenolate mofetil in the treatment of resistant idiopathic nephrotic syndrome
    Clara J Day
    New Cross Hospital, Wolverhampton, UK
    Nephrol Dial Transplant 17:2011-3. 2002
    ..A small proportion of patients with initially steroid-sensitive nephrotic syndrome relapse frequently, despite treatment with cyclophosphamide and/or cyclosporin. We investigated the efficacy of mycophenolate mofetil (MMF) in this group...