Lynne M Howells

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies
    Lynne M Howells
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
    J Pharmacol Exp Ther 350:483-94. 2014
  2. pmc Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Cancer Prev Res (Phila) 4:1419-25. 2011
  3. ncbi request reprint Prospects for plant-derived chemopreventive agents exhibiting multiple mechanisms of action
    L M Howells
    Cancer Biomarkers and Prevention Group, Departments of Cancer Studies and Molecular Medicine Biochemistry, University of Leicester, Leicester LE1 7RH, UK
    Curr Med Chem Anticancer Agents 5:201-13. 2005
  4. doi request reprint Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
    Int J Cancer 129:476-86. 2011
  5. doi request reprint Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester LE1 7RH, UK
    Biochem Pharmacol 75:1774-82. 2008
  6. ncbi request reprint Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester, United Kingdom
    Int J Cancer 121:175-83. 2007
  7. ncbi request reprint Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, University of Leicester, Leicester LE1 7RH, UK
    Acta Pharmacol Sin 28:1274-304. 2007
  8. pmc Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue
    Lynne M Howells
    Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Cancer Prev Res (Phila) 3:929-39. 2010
  9. pmc Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability
    Glen R B Irving
    Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Cancer Prev Res (Phila) 6:119-28. 2013
  10. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Department of Biochemistry and Cancer Studies, Biocentre, University of Leicester, Leicester, United Kingdom
    Clin Cancer Res 11:8521-7. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies
    Lynne M Howells
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
    J Pharmacol Exp Ther 350:483-94. 2014
    ..This review summarizes and stratifies preclinical evidence for chemopreventive efficacy of curcumin in models of lung cancer, and adjudges the weight of evidence for use of curcumin in lung cancer chemoprevention strategies. ..
  2. pmc Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Cancer Prev Res (Phila) 4:1419-25. 2011
    ..SRT501 warrants further clinical exploration to assess its potential clinical utility...
  3. ncbi request reprint Prospects for plant-derived chemopreventive agents exhibiting multiple mechanisms of action
    L M Howells
    Cancer Biomarkers and Prevention Group, Departments of Cancer Studies and Molecular Medicine Biochemistry, University of Leicester, Leicester LE1 7RH, UK
    Curr Med Chem Anticancer Agents 5:201-13. 2005
    ....
  4. doi request reprint Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
    Int J Cancer 129:476-86. 2011
    ..In vivo, Meriva greatly enhanced oxaliplatin efficacy, without affecting the mode of action of oxaliplatin. Addition of formulated curcumin to oxaliplatin-based chemotherapy regimens has the potential for clinical benefit...
  5. doi request reprint Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester LE1 7RH, UK
    Biochem Pharmacol 75:1774-82. 2008
    ..In SW620 cells, all treatments increased membrane localisation of E-cadherin. Whilst both oxaliplatin and I3C decreased invasive capacity of SW480 cells, this was not further enhanced by the combined treatment...
  6. ncbi request reprint Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester, United Kingdom
    Int J Cancer 121:175-83. 2007
    ....
  7. ncbi request reprint Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, University of Leicester, Leicester LE1 7RH, UK
    Acta Pharmacol Sin 28:1274-304. 2007
    ..However, data are lacking on the full range of activities at low doses in vitro and the benefits or otherwise of combinations in vivo...
  8. pmc Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue
    Lynne M Howells
    Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Cancer Prev Res (Phila) 3:929-39. 2010
    ..TMFol was not mutagenic in the Ames test. The results suggest that chemical modification of the flavonol structure may generate safe and efficacious cancer chemopreventive agents...
  9. pmc Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability
    Glen R B Irving
    Department of Cancer Studies and Molecular Medicine, University of Leicester, United Kingdom
    Cancer Prev Res (Phila) 6:119-28. 2013
    ..In summary, pharmacologically active levels of curcumin were recovered from colonic mucosa. The regimen used here seems safe, and patients support its use in long-term trials...
  10. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Department of Biochemistry and Cancer Studies, Biocentre, University of Leicester, Leicester, United Kingdom
    Clin Cancer Res 11:8521-7. 2005
    ..Comparison is also made with MCF10CA1 breast and PC3 prostate tumor cells...
  11. pmc Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line
    E Ann Hudson
    Cancer Biomarkers and Prevention Group, Departments of Biochemistry and Oncology, University of Leicester, Leicester, LE1 7RH, UK
    BMC Cancer 3:2. 2003
    ..Here, we investigated whether inhibition of ODC by I3C could contribute to a chemopreventive effect in colon cell lines...
  12. ncbi request reprint Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols
    Catherine K Andreadi
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies, Biocenter, University of Leicester, Leicester LE1 7RH, UK
    Mol Pharmacol 69:1033-40. 2006
    ..Induction of HO-1 by curcumin, EGCG, or low concentrations (5-10 microM) of helenalin did not protect MDA-MB468 breast cells or B-lymphoblasts from apoptosis...
  13. ncbi request reprint Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line
    Lynne M Howells
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester LE1 7RH, United Kingdom
    Mol Cancer Ther 1:1161-72. 2002
    ....