R F Howard
Affiliation: University College London
- Current status of pain management in childrenRichard F Howard
Anaesthesia and Pain Management, Children Nationwide Pain Research Centre, and Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London, England
JAMA 290:2464-9. 2003..The assessment and treatment of this pain and its functional consequences present a considerable unmet challenge. There is a pressing need for further research and clinical development in the management of pain in children...
- Inflammatory pain and hypersensitivity are selectively reversed by epidural bupivacaine and are developmentally regulatedR F Howard
Department of Anesthesia, Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health, London, United Kingdom
Anesthesiology 95:421-7. 2001..The aim of this work was to investigate whether such low doses applied epidurally selectively reduce nociceptive responses in vivo and to investigate the influence of postnatal development on such local anesthetic actions...
- Nurse-controlled analgesia (NCA) following major surgery in 10,000 patients in a children's hospitalRichard F Howard
Department of Anaesthesia and Pain Management, Great Ormond Street Hospital for Children, London, UK
Paediatr Anaesth 20:126-34. 2010....
- The ontogeny of neuropathic pain: postnatal onset of mechanical allodynia in rat spared nerve injury (SNI) and chronic constriction injury (CCI) modelsRichard F Howard
Department of Anaesthesia, Level 4, Old Building, Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health, London WC1N 2JH, UK
Pain 115:382-9. 2005..The results are consistent with human neonatal responses to nerve injury; further study of underlying mechanisms are likely to yield important information about the pathogenesis and treatment of neuropathic pain...
- The efficacy of morphine and Entonox analgesia during chest drain removal in childrenElizabeth Bruce
Pain Control Service, Great Ormond Street Hospital for Children NHS Trust, London, UK
Paediatr Anaesth 16:302-8. 2006..Morphine is commonly used for chest drain removal pain, although a few studies in adults suggest that inhalation agents may be effective for this procedure. Little is known about chest drain removal pain and its management in children...
- Chest drain removal pain and its management: a literature reviewElizabeth A Bruce
Great Ormond Street Hospital for Children NHS Trust, London, UK
J Clin Nurs 15:145-54. 2006..The findings of descriptive and non-pharmacological intervention studies were summarized and studies of analgesic efficacy were critiqued in depth...
- Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pupsSuellen M Walker
University of Sydney Pain Management and Research Centre, Royal North Shore Hospital, St Leonard s, New South Wales, Australia
Anesthesiology 102:1226-34. 2005..The aim of this study was to determine the effect of epidural dexmedetomidine on sensory processing, reversal of inflammatory hyperalgesia, and sedation during early development in rats...
- The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis painPaul J James
Evelina Children s Hospital, London, UK
Paediatr Anaesth 20:805-11. 2010..To assess the efficacy of adding ketamine to morphine nurse- or patient-controlled analgesia (NCA/PCA) infusions in treating mucositis pain in children...
- Developmental regulation of codeine analgesia in the ratD Glyn Williams
Portex Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health, University College London, United Kingdom
Anesthesiology 100:92-7. 2004..Effects in the adult rat were not predictive of efficacy in development in either strain, which has important implications for further study and, possibly, for clinical use...
- Clinical signs of infection during continuous postoperative epidural analgesia in children: the value of catheter tip cultureN Seth
Department of Anaesthesia, Guys and St Thomas's Hospitals NHS Trust, London, UK
Paediatr Anaesth 14:996-1000. 2004..Routine culture of catheter tips is unnecessary as it is not a good predictor of epidural space infection...
- Epidural analgesia in children. A survey of current opinions and practices amongst UK paediatric anaesthetistsD G Williams
Great Ormond Street Hospital for Children, NHS Trust and Children Nationwide Pain Research Centre, London Portex Department of Anaesthesia, Institute of Child Health, London, UK
Paediatr Anaesth 13:769-76. 2003..In order to investigate the current practice of paediatric epidural analgesia in the UK paediatric anaesthetists and paediatric pain management teams were surveyed...
- Population pharmacokinetics of oral diclofenac for acute pain in childrenJoseph F Standing
Great Ormond Street Hospital for Children, London, UK
Br J Clin Pharmacol 66:846-53. 2008..To develop a population pharmacokinetic model for a new diclofenac suspension (50 mg 5 ml(-1)) in adult volunteers and paediatric patients, and recommend a dose for acute pain in children...
- Prospective observational study of adverse drug reactions to diclofenac in childrenJoseph F Standing
Great Ormond Street Hospital for Children, School of Pharmacy, University of London, London, UK
Br J Clin Pharmacol 68:243-51. 2009..The aim of this study was to investigate the type of common (occurring in >1% of patients) adverse reactions caused by diclofenac when given to children for acute pain...
- The functional expression of mu opioid receptors on sensory neurons is developmentally regulated; morphine analgesia is less selective in the neonateReema Nandi
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E6BT, UK
Pain 111:38-50. 2004..These results have important clinical implications for the use of morphine in neonates and provide a possible explanation for the differences in morphine requirements observed in the youngest patients...