Research Topics
| Roman HovorkaSummaryAffiliation: University of Cambridge Country: UK Publications
Research Grants
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Detail Information
Publications
Associations of glucose control with insulin sensitivity and pancreatic beta-cell responsiveness in newly presenting type 2 diabetesAhmed I Albarrak
Metabolic Modelling Group, Centre for Measurement and Information in Medicine, City University, London, EC1V OHB, United Kingdom
J Clin Endocrinol Metab 87:198-203. 2002..Indices of insulin sensitivity and pancreatic beta-cell responsiveness explain fasting glucose and HbA(1C) well but fail to explain postprandial glucose...- Blood glucose control by a model predictive control algorithm with variable sampling rate versus a routine glucose management protocol in cardiac surgery patients: a randomized controlled trialRoman Hovorka
Department of Pediatrics, University of Cambridge, UK
J Clin Endocrinol Metab 92:2960-4. 2007..Elevated blood glucose levels occur frequently in the critically ill. Tight glucose control by intensive insulin treatment markedly improves clinical outcome... - The future of continuous glucose monitoring: closed loopRoman Hovorka
Diabetes Modelling Group, Institute of Medical Science, University of Cambridge, Box 289, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Curr Diabetes Rev 4:269-79. 2008..The most important question is what is achievable with existing technologies and when the first generation of closed-loop systems will find its way into clinical practice... 
Assessing performance of closed-loop insulin delivery systems by continuous glucose monitoring: drawbacks and way forwardRoman Hovorka
1 Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom
Diabetes Technol Ther 15:4-12. 2013..Stochastic CGM provided unbiased estimate of time when glucose is in target and below target and may be acceptable for assessment of closed-loop in the outpatient setting...- Validity of triple- and dual-tracer techniques to estimate glucose appearanceA Haidar
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, United Kingdom
Am J Physiol Endocrinol Metab 302:E1493-501. 2012..The TT technique tends to outperform slightly the DT technique, but the latter benefits from reduced experimental and computational complexity... 
A simulation model of glucose regulation in the critically illRoman Hovorka
Institute of Metabolic Science, Metabolic Research Laboratories, Level 4, Box 289, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
Physiol Meas 29:959-78. 2008..In conclusion, a novel glucoregulatory model has been developed to create a virtual population of critically ill facilitating in silico testing of glucose controllers at the intensive care unit...- Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trialRoman Hovorka
Department of Paediatrics, University of Cambridge, Cambridge, UK
Lancet 375:743-51. 2010..Closed-loop systems link continuous glucose measurements to insulin delivery. We aimed to establish whether closed-loop insulin delivery could control overnight blood glucose in young people... - Calculating glucose fluxes during meal tolerance test: a new computational approachRoman Hovorka
Diabetes Modelling Group, Dept of Paediatrics, Univ of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Am J Physiol Endocrinol Metab 293:E610-9. 2007..An example study is shown demonstrating the utility of the approach. A better performance of the new method is demonstrated in a simulation study... - Closed-loop insulin delivery: from bench to clinical practiceRoman Hovorka
Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
Nat Rev Endocrinol 7:385-95. 2011.... - Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studiesRoman Hovorka
Institute of Metabolic Science, University of Cambridge, Cambridge, UK
BMJ 342:d1855. 2011..To compare the safety and efficacy of overnight closed loop delivery of insulin (artificial pancreas) with conventional insulin pump therapy in adults with type 1 diabetes... - Overnight closed-loop insulin delivery with model predictive control: assessment of hypoglycemia and hyperglycemia risk using simulation studiesMalgorzata E Wilinska
Cambridge University Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
J Diabetes Sci Technol 3:1109-20. 2009..Additionally, a comparison was made against incidence observed experimentally during open-loop single-night in-clinic studies in young people with type 1 diabetes mellitus (T1DM) treated by continuous SC insulin infusion... - Closed-loop insulin delivery during pregnancy complicated by type 1 diabetesHelen R Murphy
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Hills Road, Cambridge, UK
Diabetes Care 34:406-11. 2011..This study evaluated closed-loop insulin delivery with a model predictive control (MPC) algorithm during early (12-16 weeks) and late gestation (28-32 weeks) in pregnant women with type 1 diabetes... - Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetesMalgorzata E Wilinska
Cambridge University Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
J Diabetes Sci Technol 4:132-44. 2010..We present a simulation environment designed to support the development and testing of closed-loop insulin delivery systems in type 1 diabetes mellitus (T1DM)... - Evaluating glycemic control algorithms by computer simulationsMalgorzata E Wilinska
Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
Diabetes Technol Ther 13:713-22. 2011..Their strengths and weaknesses are difficult to assess without head-to-head comparison in time-consuming clinical trials. We hypothesized that computer simulations may be useful... - Evaluation of a portable ambulatory prototype for automated overnight closed-loop insulin delivery in young people with type 1 diabetesDaniela Elleri
Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, UK
Pediatr Diabetes 13:449-53. 2012..To evaluate an ambulatory, portable prototype, overnight automated closed-loop (CL) system and to explore optimal time of CL initiation... - Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes: a randomized crossover case seriesHelen R Murphy
Metabolic Research Laboratories and the National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge, Cambridge, UK
Diabetes Care 34:2527-9. 2011..To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII)... - Meta-analysis of overnight closed-loop randomized studies in children and adults with type 1 diabetes: the Cambridge cohortKavita Kumareswaran
Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
J Diabetes Sci Technol 5:1352-62. 2011.... - Parental attitudes towards overnight closed-loop glucose control in children with type 1 diabetesDaniela Elleri
Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
Diabetes Technol Ther 12:35-9. 2010..This study examined parental attitudes towards overnight closed-loop (CL) glucose control in children and young people with type 1 diabetes (T1D)... - Automated overnight closed-loop glucose control in young children with type 1 diabetesDaniela Elleri
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
Diabetes Technol Ther 13:419-24. 2011..We evaluated the effectiveness of automated overnight closed-loop (AOCL) insulin delivery and the influence of timing of initiation on glucose control overnight in young children with type 1 diabetes (T1D)... - Insulin kinetics in type-I diabetes: continuous and bolus delivery of rapid acting insulinMalgorzata E Wilinska
Department of Paediatrics, University of Cambridge, Cambridge, CB2 2QQ, UK
IEEE Trans Biomed Eng 52:3-12. 2005.... - Effect of delay on measurement of blood glucose levels in young subjects with type 1 diabetesDaniela Elleri
Department of Paediatrics, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
Diabetes Res Clin Pract 86:e31-3. 2009..Blood glucose decreased by 0.47 mmol/L despite samples being collected in fluoride tubes and placed on ice. The extent of reduction differs among subjects, prevailing blood glucose and time-of-day of sample withdrawal... - Interstitial glucose kinetics in subjects with type 1 diabetes under physiologic conditionsMalgorzata E Wilinska
Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
Metabolism 53:1484-91. 2004..In conclusion, we developed and quantified a model of IG kinetics in the adipose tissue applicable to physiologic conditions in subjects with T1DM... - Evaluating the accuracy and large inaccuracy of two continuous glucose monitoring systemsLalantha Leelarathna
1 Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom
Diabetes Technol Ther 15:143-9. 2013..Further evaluations are required to confirm that FSN is more suitable for integration into closed-loop delivery systems... - Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetesRoman Hovorka
Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Physiol Meas 25:905-20. 2004..In conclusion, adaptive nonlinear model predictive control is promising for the control of glucose concentration during fasting conditions in subjects with type 1 diabetes... - Closed-Loop Basal Insulin Delivery Over 36 Hours in Adolescents With Type 1 Diabetes: Randomized clinical trialDaniela Elleri
Corresponding author Roman Hovorka
Diabetes Care 36:838-44. 2013..However, unannounced moderate-intensity exercise and excessive prandial boluses pose challenges to hypoglycemia-free closed-loop basal insulin delivery... - Accuracy of continuous glucose monitoring during exercise in type 1 diabetes pregnancyKavita Kumareswaran
University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom
Diabetes Technol Ther 15:223-9. 2013..Our aim was to evaluate accuracy of a current-generation CGM during moderate-intensity exercise in type 1 diabetes (T1D) pregnancy... - Artificial pancreas: an emerging approach to treat Type 1 diabetesKavita Kumareswaran
Institute of Metabolic Science, University of Cambridge, Metabolic Research Laboratories, Box 289, Level 4, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
Expert Rev Med Devices 6:401-10. 2009..In this article, we review closed-loop glucose control, including its components, development, testing and clinical application... - Grading system to assess clinical performance of closed-loop glucose controlLudovic J Chassin
Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Diabetes Technol Ther 7:72-82. 2005..We conclude that the grading system provides suitable means to assess efficacy and safety of glucose controllers complementing existing measures of glucose control... - Evaluation of glucose controllers in virtual environment: methodology and sample applicationLudovic J Chassin
Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK
Artif Intell Med 32:171-81. 2004..The thorough testing in the virtual environment reduces costs and speeds up the development process... - Closing the loop: the adicol experienceRoman Hovorka
Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Diabetes Technol Ther 6:307-18. 2004..The ADICOL project demonstrated feasibility of a semi-closed-loop glucose control during fasting and fed conditions with a wearable, modular extracorporeal artificial pancreas... - Estimating postprandial glucose fluxes using hierarchical Bayes modellingAhmad Haidar
University of Cambridge Metabolic Research Laboratories, Cambridge, UK
Comput Methods Programs Biomed 108:102-12. 2012..2±1.3; new method vs. ML method; P<0.01, paired t-test). We conclude that the new method increases plausibility of the endogenous glucose production and improves accuracy of glucose disposal compared to the maximum likelihood method... - Insulin administration and rate of glucose appearance in people with type 1 diabetesMary E Pennant
Medical Research Council, Human Nutrition Research, Cambridge, UK
Diabetes Care 31:2183-7. 2008..To assess whether prandial insulin, in addition to basal insulin, has an effect on the rate of glucose appearance from a meal in people with type 1 diabetes... - Automated glucose control in the ICU: effect of nutritional protocol and measurement errorMalgorzata E Wilinska
Dept of Paediatrics, University of Cambridge, UK
Conf Proc IEEE Eng Med Biol Soc 1:67-70. 2006..We conclude that nutritional protocol should be kept simple to facilitate efficacious glucose control with an adaptive model predictive controller. The measurement error of the glucose measuring device should be less or equal to 10%.. - Closed-loop insulin delivery in type 1 diabetesHood Thabit
Institute of Metabolic Science, Addenbrookes Hospital, University of Cambridge, Box 289, Level 4, Cambridge CB2 0QQ, UK
Endocrinol Metab Clin North Am 41:105-17. 2012..The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology... - Closed-loop insulin delivery: towards improved diabetes careKavita Kumareswaran
Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom
Discov Med 13:159-70. 2012..Outpatient evaluation is required as the next step, leading to deployment into clinical practice... - Closed-loop insulin delivery for treatment of type 1 diabetesDaniela Elleri
Department of Paediatrics and Institute of Metabolic Science, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
BMC Med 9:120. 2011.... - Treatment with recombinant human insulin-like growth factor (rhIGF)-I/rhIGF binding protein-3 complex improves metabolic control in subjects with severe insulin resistanceFiona M Regan
University of Cambridge, Department of Pediatrics, Cambridge, United Kingdom
J Clin Endocrinol Metab 95:2113-22. 2010..We report clinical and physiological outcomes after adjunctive therapy with rhIGF-I/rhIGFBP-3 in five subjects with SIR... - Evaluation of nonlinear regression approaches to estimation of insulin sensitivity by the minimal model with reference to Bayesian hierarchical analysisIan F Godsland
Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Hospital, Mint Wing 2nd Floor, London W2 1PG, UK
Am J Physiol Endocrinol Metab 291:E167-74. 2006..S(I)(NLR) compared favorably with S(I)(BH) in the proportion of variance explained in known correlates of insulin sensitivity... - Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patientsJohannes Plank
Department of Internal Medicine, Medical University Hospital, Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Diabetes Care 29:271-6. 2006.... - Population and individual minimal modeling of the frequently sampled insulin-modified intravenous glucose tolerance testLars Erichsen
Pharmacometrics, Novo Nordisk A/S, Bagsvaerd, Denmark
Metabolism 53:1349-54. 2004..The standard two-stage technique is the preferred method under such circumstances... - Bayesian hierarchical approach to estimate insulin sensitivity by minimal modelOlorunsola F Agbaje
Metabolic Modelling Group, Centre for Measurement and Information in Medicine, City University, Northampton Square, London EC1V OHB, UK
Clin Sci (Lond) 105:551-60. 2003..99; P <0.001). We conclude that the Bayesian hierarchical analysis is an appealing method to estimate SI and SG, as it avoids parameter estimation failures, and should be considered when investigating insulin-resistant subjects... - Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTTRoman Hovorka
Centre for Measurement and Information in Medicine, City University, London EC1V 0HB
Am J Physiol Endocrinol Metab 282:E992-1007. 2002..Suppression of EGP matches the effect in the periphery... - Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients: Response to Ligtenberg et alJohannes Plank
Diabetes Care 29:1987-8. 2006
Research Grants
- Home testing of 24/7 closed-loop control in children and adolescents with type 1Roman Hovorka; Fiscal Year: 2010..This will be preceded by evaluating 24/7 closed-loop control in compliant and non-compliant subjects in clinical research centre settings to collect data supporting regulatory submission for home testing. ..