L A Houghton

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome
    M J Lewis
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 48:216-20. 2001
  2. ncbi Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 14:775-82. 2000
  3. ncbi The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 50:471-4. 2002
  4. ncbi Visceral sensation and emotion: a study using hypnosis
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 51:701-4. 2002
  5. ncbi Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome
    L A Houghton
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 52:663-70. 2003
  6. ncbi 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status
    L A Houghton
    Neurogastroenterology Unit, School of Translational Medicine GI Sciences, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Aliment Pharmacol Ther 30:919-29. 2009
  7. ncbi Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 19:724-31. 2007
  8. ncbi Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome
    R Lea
    Academic Department of Medicine, University Hospital of South Manchester, UK
    Aliment Pharmacol Ther 17:635-42. 2003
  9. ncbi Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: effect of 5-hydroxytryptamine 1 receptor agonism
    E L Calvert
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 19:805-15. 2004
  10. ncbi A device for 24 hour ambulatory monitoring of abdominal girth using inductive plethysmography
    B P Reilly
    Northwestern Medical Physics, Christie Hospital, Manchester M20 4BX, UK
    Physiol Meas 23:661-70. 2002

Collaborators

Detail Information

Publications15

  1. ncbi Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome
    M J Lewis
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 48:216-20. 2001
    ..Furthermore, it should aid research into the pathogenesis of this symptom for which no satisfactory explanation has yet emerged...
  2. ncbi Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 14:775-82. 2000
    ..Alosetron is a potent and selective 5-HT3 receptor antagonist, which has been shown to be beneficial in the treatment of female patients with non-constipated irritable bowel syndrome...
  3. ncbi The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 50:471-4. 2002
    ..Patients with irritable bowel syndrome (IBS) often report significant exacerbation of their IBS symptoms with menses, raising the possibility that IBS patients may respond differently to the menstrual cycle...
  4. ncbi Visceral sensation and emotion: a study using hypnosis
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 51:701-4. 2002
    ..The purpose of this study was to investigate the effect of hypnotically induced emotion on the visceral sensitivity of the gut...
  5. ncbi Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome
    L A Houghton
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 52:663-70. 2003
    ..Aim: To expand on previous data by evaluating a larger number of subjects but also to assess plasma 5-hydroxyindole acetic acid (5-HIAA) concentrations, 5-HT turnover, platelet 5-HT stores, and any relationship to symptomatology...
  6. ncbi 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status
    L A Houghton
    Neurogastroenterology Unit, School of Translational Medicine GI Sciences, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Aliment Pharmacol Ther 30:919-29. 2009
    ..Symptomatology and physiology differ between men and women and across the menstrual cycle in irritable bowel syndrome (IBS). Ovarian hormones influence 5-hydroxytryptamine (5-HT), an amine known to play a role in gut motor-sensory function...
  7. ncbi Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 19:724-31. 2007
    ..402; P = 0.003) and fed (r = 0.439; P = 0.001) conditions. These data show a possible relationship between endogenous concentrations of 5-HT and sigmoid-colonic motility recorded in both IBS and healthy subjects...
  8. ncbi Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome
    R Lea
    Academic Department of Medicine, University Hospital of South Manchester, UK
    Aliment Pharmacol Ther 17:635-42. 2003
    ..714, P = 0.07). CONCLUSION: Hypnotherapy improves abnormal sensory perception in irritable bowel syndrome, leaving normal sensation unchanged...
  9. ncbi Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: effect of 5-hydroxytryptamine 1 receptor agonism
    E L Calvert
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 19:805-15. 2004
    ..05). CONCLUSION: 5-HT(1) receptor agonism increases the periodicity of the migrating motor complex and reduces the occurrence of post-prandial co-ordinated motor activity involving the gastric antrum, pylorus and duodenum...
  10. ncbi A device for 24 hour ambulatory monitoring of abdominal girth using inductive plethysmography
    B P Reilly
    Northwestern Medical Physics, Christie Hospital, Manchester M20 4BX, UK
    Physiol Meas 23:661-70. 2002
    ..We conclude that IP promises to be a useful and quantitative tool suitable for ambulatory monitoring of abdominal girth, a hitherto relatively unexplored symptom of IBS...
  11. ncbi Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans
    L A Houghton
    Neurogastroenterology Unit, Wythenshawe Hospital, Academic Division of Medicine and Surgery, University of Manchester, Manchester, UK
    Neurogastroenterol Motil 19:732-43. 2007
    ..At the doses tested, talnetant has no effect on rectal compliance or distension-induced rectal sensation in healthy participants...
  12. ncbi Diagnostic criteria for irritable bowel syndrome: utility and applicability in clinical practice
    R Lea
    Medical Academic Department, South Manchester University Hospitals, Manchester, UK
    Digestion 70:210-3. 2004
    ..The current lack of interest in them, especially amongst GPs, is unlikely to change unless they can be considerably improved...
  13. ncbi Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 17:500-11. 2005
    ..Treatment options are currently rather limited but include dietary changes, pharmacological approaches, probiotics and hypnotherapy...
  14. ncbi Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
    ..Pre-clinical studies suggest that the alpha(2)delta ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity...
  15. ncbi Barostat testing of rectal sensation and compliance in humans: comparison of results across two centres and overall reproducibility
    F Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 17:810-20. 2005
    ....