L A Houghton

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome
    M J Lewis
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 48:216-20. 2001
  2. ncbi request reprint Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 14:775-82. 2000
  3. pmc The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 50:471-4. 2002
  4. pmc Visceral sensation and emotion: a study using hypnosis
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 51:701-4. 2002
  5. pmc Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome
    L A Houghton
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 52:663-70. 2003
  6. doi request reprint 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status
    L A Houghton
    Neurogastroenterology Unit, School of Translational Medicine GI Sciences, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Aliment Pharmacol Ther 30:919-29. 2009
  7. ncbi request reprint Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 19:724-31. 2007
  8. ncbi request reprint Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome
    R Lea
    Academic Department of Medicine, University Hospital of South Manchester, UK
    Aliment Pharmacol Ther 17:635-42. 2003
  9. ncbi request reprint Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: effect of 5-hydroxytryptamine 1 receptor agonism
    E L Calvert
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 19:805-15. 2004
  10. ncbi request reprint A device for 24 hour ambulatory monitoring of abdominal girth using inductive plethysmography
    B P Reilly
    Northwestern Medical Physics, Christie Hospital, Manchester M20 4BX, UK
    Physiol Meas 23:661-70. 2002

Collaborators

Detail Information

Publications15

  1. pmc Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome
    M J Lewis
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 48:216-20. 2001
    ..Furthermore, it should aid research into the pathogenesis of this symptom for which no satisfactory explanation has yet emerged...
  2. ncbi request reprint Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 14:775-82. 2000
    ..Alosetron is a potent and selective 5-HT3 receptor antagonist, which has been shown to be beneficial in the treatment of female patients with non-constipated irritable bowel syndrome...
  3. pmc The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 50:471-4. 2002
    ..Patients with irritable bowel syndrome (IBS) often report significant exacerbation of their IBS symptoms with menses, raising the possibility that IBS patients may respond differently to the menstrual cycle...
  4. pmc Visceral sensation and emotion: a study using hypnosis
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 51:701-4. 2002
    ..The purpose of this study was to investigate the effect of hypnotically induced emotion on the visceral sensitivity of the gut...
  5. pmc Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome
    L A Houghton
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 52:663-70. 2003
    ..Aim: To expand on previous data by evaluating a larger number of subjects but also to assess plasma 5-hydroxyindole acetic acid (5-HIAA) concentrations, 5-HT turnover, platelet 5-HT stores, and any relationship to symptomatology...
  6. doi request reprint 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status
    L A Houghton
    Neurogastroenterology Unit, School of Translational Medicine GI Sciences, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Aliment Pharmacol Ther 30:919-29. 2009
    ..Symptomatology and physiology differ between men and women and across the menstrual cycle in irritable bowel syndrome (IBS). Ovarian hormones influence 5-hydroxytryptamine (5-HT), an amine known to play a role in gut motor-sensory function...
  7. ncbi request reprint Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 19:724-31. 2007
    ..402; P = 0.003) and fed (r = 0.439; P = 0.001) conditions. These data show a possible relationship between endogenous concentrations of 5-HT and sigmoid-colonic motility recorded in both IBS and healthy subjects...
  8. ncbi request reprint Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome
    R Lea
    Academic Department of Medicine, University Hospital of South Manchester, UK
    Aliment Pharmacol Ther 17:635-42. 2003
    ..In addition, the study group was symptomatically rather than physiologically defined...
  9. ncbi request reprint Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: effect of 5-hydroxytryptamine 1 receptor agonism
    E L Calvert
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 19:805-15. 2004
    ..Little is known about the effect of 5-hydroxytryptamine 1 (5-HT(1)) receptor agonism on the co-ordinated motor activity of the gastric antrum, pylorus and duodenum under fasting and fed conditions...
  10. ncbi request reprint A device for 24 hour ambulatory monitoring of abdominal girth using inductive plethysmography
    B P Reilly
    Northwestern Medical Physics, Christie Hospital, Manchester M20 4BX, UK
    Physiol Meas 23:661-70. 2002
    ..We conclude that IP promises to be a useful and quantitative tool suitable for ambulatory monitoring of abdominal girth, a hitherto relatively unexplored symptom of IBS...
  11. ncbi request reprint Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans
    L A Houghton
    Neurogastroenterology Unit, Wythenshawe Hospital, Academic Division of Medicine and Surgery, University of Manchester, Manchester, UK
    Neurogastroenterol Motil 19:732-43. 2007
    ..At the doses tested, talnetant has no effect on rectal compliance or distension-induced rectal sensation in healthy participants...
  12. ncbi request reprint Diagnostic criteria for irritable bowel syndrome: utility and applicability in clinical practice
    R Lea
    Medical Academic Department, South Manchester University Hospitals, Manchester, UK
    Digestion 70:210-3. 2004
    ..It was the aim of this study to assess the applicability of the Manning, Rome I and Rome II criteria in the clinical setting and to ascertain how often hospital specialists and general practitioners (GPs) use them...
  13. ncbi request reprint Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 17:500-11. 2005
    ..Treatment options are currently rather limited but include dietary changes, pharmacological approaches, probiotics and hypnotherapy...
  14. pmc Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
    ..Pre-clinical studies suggest that the alpha(2)delta ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity...
  15. ncbi request reprint Barostat testing of rectal sensation and compliance in humans: comparison of results across two centres and overall reproducibility
    F Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 17:810-20. 2005
    ....