S A Hosgood

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA
    Cheng Yang
    Department of Urology, Zhongshan Hospital, Fudan University Shanghai Key Laboratory of Organ Transplantation, 180 Fenglin Road, Shanghai 200032, PR China
    J Transl Med 11:210. 2013
  2. doi request reprint Renal transplantation after ex vivo normothermic perfusion: the first clinical study
    S A Hosgood
    Department of Infection, Immunity and Inflammation, Transplant Group, Leicester General Hospital, University of Leicester, Leicester, UK
    Am J Transplant 13:1246-52. 2013
  3. pmc A nodulo-cystic eumycetoma caused by Pyrenochaeta romeroi in a renal transplant recipient: A case report
    Umasankar Mathuram Thiyagarajan
    Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK
    J Med Case Reports 5:460. 2011
  4. doi request reprint Randomized clinical trial of laparoscopic versus open donor nephrectomy
    M L Nicholson
    Transplant Surgery Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 97:21-8. 2010
  5. doi request reprint Health-related quality of life after living donor nephrectomy: a randomized controlled trial of laparoscopic versus open nephrectomy
    Michael L Nicholson
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester, UK
    Transplantation 91:457-61. 2011
  6. ncbi request reprint A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic loci
    M J Bown
    Department of Surgery, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Int J Immunogenet 32:83-90. 2005
  7. ncbi request reprint The novel antifibrotic agent pirfenidone attenuates the profibrotic environment generated by calcineurin inhibitors in the rat salt-depletion model
    N R Brook
    Transplant Surgery Group, University of Leicester, Leicester, UK
    Transplant Proc 37:130-3. 2005
  8. ncbi request reprint Sub-clinical acute rejection detected using protocol biopsies in patients with delayed graft function
    S Jain
    Department of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Transpl Int 13:S52-5. 2000
  9. ncbi request reprint Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia
    J R Waller
    Division of Transplant Surgery, University of Leicester, Leicester, UK
    Br J Surg 89:1390-5. 2002
  10. ncbi request reprint Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation
    G J Murphy
    University Department of Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 88:261-6. 2001

Collaborators

Detail Information

Publications71

  1. pmc Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA
    Cheng Yang
    Department of Urology, Zhongshan Hospital, Fudan University Shanghai Key Laboratory of Organ Transplantation, 180 Fenglin Road, Shanghai 200032, PR China
    J Transl Med 11:210. 2013
    ..The mechanisms involved, in particular, whether siRNA or complementary systemic feedback eliciting innate immune responses are worthy to be further investigated...
  2. doi request reprint Renal transplantation after ex vivo normothermic perfusion: the first clinical study
    S A Hosgood
    Department of Infection, Immunity and Inflammation, Transplant Group, Leicester General Hospital, University of Leicester, Leicester, UK
    Am J Transplant 13:1246-52. 2013
    ..510, 1.000). This first series of EVNP in renal transplantation demonstrates that this technique is both feasible and safe. Our preliminary data suggests that EVNP offers promise as a new technique of kidney preservation...
  3. pmc A nodulo-cystic eumycetoma caused by Pyrenochaeta romeroi in a renal transplant recipient: A case report
    Umasankar Mathuram Thiyagarajan
    Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK
    J Med Case Reports 5:460. 2011
    ..abstract:..
  4. doi request reprint Randomized clinical trial of laparoscopic versus open donor nephrectomy
    M L Nicholson
    Transplant Surgery Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 97:21-8. 2010
    ..This randomized controlled trial was designed to determine the safety and efficacy of laparoscopic donor nephrectomy (LDN) in comparison with short-incision open donor nephrectomy (ODN)...
  5. doi request reprint Health-related quality of life after living donor nephrectomy: a randomized controlled trial of laparoscopic versus open nephrectomy
    Michael L Nicholson
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester, UK
    Transplantation 91:457-61. 2011
    ..The aim of this study was to compare patient-reported health status and quality of life after randomization to laparoscopic donor nephrectomy (LDN) or short-incision open donor nephrectomy (ODN)...
  6. ncbi request reprint A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic loci
    M J Bown
    Department of Surgery, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Int J Immunogenet 32:83-90. 2005
    ..909; IL-10 -1082, K = 0.876; IL-10 -592, K = 0.920. IHG is a valid method for the determination of genotypes at the loci examined in this study and produces comparable results to those of more traditional methods of genotyping...
  7. ncbi request reprint The novel antifibrotic agent pirfenidone attenuates the profibrotic environment generated by calcineurin inhibitors in the rat salt-depletion model
    N R Brook
    Transplant Surgery Group, University of Leicester, Leicester, UK
    Transplant Proc 37:130-3. 2005
    ..The mechanism of action of pirfenidone is reversal of some CNI-induced changes in fibrotic gene expression. It also attenuates creatinine rise in salt-depleted rats in this model of CNI-induced nephrotoxicity...
  8. ncbi request reprint Sub-clinical acute rejection detected using protocol biopsies in patients with delayed graft function
    S Jain
    Department of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Transpl Int 13:S52-5. 2000
    ..Because of the high detection rate of sub-clinical acute rejection and the low morbidity of renal transplant biopsies, their use is recommended in patients with DGF...
  9. ncbi request reprint Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia
    J R Waller
    Division of Transplant Surgery, University of Leicester, Leicester, UK
    Br J Surg 89:1390-5. 2002
    ..This study assessed the efficacy of combining rapamycin therapy with calcineurin inhibition...
  10. ncbi request reprint Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation
    G J Murphy
    University Department of Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 88:261-6. 2001
    ..Primary thrombosis and chronic allograft nephropathy are important causes of early and late graft loss, respectively, following renal transplantation. This study examined the potential for aspirin therapy to reduce these complications...
  11. ncbi request reprint Experimental renal preservation by normothermic resuscitation perfusion with autologous blood
    A Bagul
    Department of Transplant Surgery, University Hospitals of Leicester, Leicester, UK
    Br J Surg 95:111-8. 2008
    ..This study investigated the effects of NP compared with current methods of organ preservation in a model of controlled non-heart-beating donor (NHBD) kidneys...
  12. ncbi request reprint A case-control comparison of the results of renal transplantation from heart-beating and non-heart-beating donors
    M S Metcalfe
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW UK
    Transplantation 71:1556-9. 2001
    ..CONCLUSION: NHBD kidneys are a valuable additional source of organs for transplantation, with long-term survival, comparable to transplants from HBD...
  13. ncbi request reprint Mycophenolate mofetil inhibits intimal hyperplasia and attenuates the expression of genes favouring smooth muscle cell proliferation and migration
    J R Waller
    Royal College of Surgeons of England Surgical Research Fellow, Division of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Transplant Proc 37:164-6. 2005
    ..This study aimed to assess the efficacy of a combination of mycophenolate mofetil, calcineurin inhibition, and sirolimus on the development of intimal hyperplasia...
  14. ncbi request reprint Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection
    N R Brook
    Division of Transplant Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 90:1009-14. 2003
    ..The aim of this study was to determine mRNA expression of fibrosis-associated genes in glomeruli plucked from protocol renal transplant biopsies, in patients with or without a history of acute rejection...
  15. ncbi request reprint The impact of cyclosporine dose reduction with or without the addition of rapamycin on functional, molecular, and histological markers of chronic allograft nephropathy
    R N Saunders
    Department of Transplant Surgery, University of Leicester, Leicester General Hospital, Leicester, United Kingdom
    Transplantation 75:772-80. 2003
    ..The purpose of this study was to determine the impact of adding the non-nephrotoxic immunosuppressant, rapamycin, after cyclosporine dose reduction in renal-allograft recipients with CAN...
  16. ncbi request reprint Cytokines, their genetic polymorphisms, and outcome after abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 28:274-80. 2004
    ..The aims of this study were to determine if cytokines or their genetic polymorphisms were related to outcome after abdominal aortic aneurysm (AAA) repair...
  17. ncbi request reprint Comparison of techniques of vascular control in laparoscopic donor nephrectomy: The leicester experience
    M Kaushik
    Department of Cardiovascular Sciences, Transplant Group, University Hospitals of Leicester, Leicester General Hospital, Leicester, LE5 4PW, United Kingdom
    Transplant Proc 38:3406-8. 2006
    ..The objective of this study was to compare the safety and efficacy of three different methods to secure the renal vessels during laparoscopic donor nephrectomy (LDN)...
  18. doi request reprint Case-matched comparison of long-term results of non-heart beating and heart-beating donor renal transplants
    A D Barlow
    Department of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Br J Surg 96:685-91. 2009
    ..However, there are few data on outcome after 10 years, particularly from uncontrolled NHBD donors...
  19. ncbi request reprint Cyclosporine and rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage
    N R Brook
    Transplantation Surgery Group, University of Leicester, Leicester, UK
    Transplant Proc 37:837-8. 2005
    ..Addition of RAPA can attenuate this damage, but only with a dose reduction of both agents. The most favorable results were for the dose combination CSA 7.5 mg/kg/d plus RAPA 0.5 mg/kg/d...
  20. ncbi request reprint Molecular mechanisms of renal allograft fibrosis
    J R Waller
    Division of Transplant Surgery, University of Leicester, Leicester, UK
    Br J Surg 88:1429-41. 2001
    ..The pathogenesis is unclear, but is likely to involve both immunological and non-immunological factors. Despite improvements in short-term graft survival rates, new immunosuppressive regimens have made no impact on CGN...
  21. ncbi request reprint Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis
    G J Murphy
    University Department of Surgery, Leicester General Hospital, Leicester, UK
    Br J Surg 90:680-6. 2003
    ..The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial...
  22. ncbi request reprint Prograf produces a molecular environment favoring antifibrosis, an effect reversed by the addition of rapamune
    N R Brook
    University of Leicetser, Transplant Surgery Group, Leicester General Hospital, Leicetser, UK
    Transplant Proc 37:148-9. 2005
    ..Rapamune alone has no deleterious effect on gene expression but addition of Rapamune cancels out the beneficial effects of Prograf...
  23. ncbi request reprint Laparoscopic donor nephrectomy yields kidneys with structure and function equivalent to those retrieved by open surgery
    N R Brook
    University of Leicester, Leicester, UK
    Transplant Proc 37:625-6. 2005
    ..This data may go some way towards allaying concerns over the effect of laparoscopic procurement on live donor kidneys...
  24. ncbi request reprint Alterations in the practice of open and laparoscopic live donor nephrectomy at renal transplant centers in the UK and Ireland
    N R Brook
    University of Leicester, Leicester, UK
    Transplant Proc 37:623-4. 2005
    ..There is widespread practice of live kidney donation in the UK and Ireland, but BTS guidelines are not closely adhered to. Laparoscopic donor nephrectomy is offered at a small number of centers, but many have plans to introduce it...
  25. ncbi request reprint A comparison of traditional open, minimal-incision donor nephrectomy and laparoscopic donor nephrectomy
    G R R Lewis
    University Division of Transplant Surgery, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK
    Transpl Int 17:589-95. 2004
    ..055). Donor and recipient complication rates and recipient allograft function were comparable. We concluded that MILD and LDN reduce postoperative pain and allow a faster recovery without compromising recipient outcome...
  26. ncbi request reprint A consecutive series of 70 laparoscopic donor nephrectomies demonstrates the safety of this new operation
    N R Brook
    Transplant Surgery Group, Leicester General Hospital, University of Leicetser, Leicetser, UK
    Transplant Proc 37:627-8. 2005
    ..4%), and reoperation for division of adhesions (3%). In conclusion, LDN is a safe procedure with low postoperative morbidity. There were some unexpected complications, but recovery time was short...
  27. ncbi request reprint Morbidity rates with reduced mycophenolate mofetil dosage: a single-center experience
    M Kaushik
    Division of Transplant Surgery, University of Leicester, Leicester, UK
    Transplant Proc 38:2864-5. 2006
    ..The aim of this study was to assess the incidence of side effects and rejection rates with reduced doses compared to standard regimens of MMF...
  28. ncbi request reprint Primary immunosuppression with tacrolimus is associated with a reduction in renal allograft fibrosis compared with neoral therapy
    J R Waller
    Division of Transplant Surgery, Leicester General Hospital, Cuenden Road, Leicester LE5 4PW, United Kingdom
    Transplant Proc 34:1587-8. 2002
  29. ncbi request reprint Comparison of renal allograft fibrosis after transplantation from heart-beating and non-heart-beating donors
    J C Bains
    University Division of Transplant Surgery, Leicester General Hospital, Leicester LE5 4PW, UK
    Br J Surg 92:113-8. 2005
    ..The aim of this study was to compare allograft fibrosis in kidneys transplanted from NHBDs and conventional heart-beating donors (HBDs)...
  30. doi request reprint Role of human leukocyte antigen, donor-specific antibodies, and their impact in renal transplantation
    U Mathuram Thiyagarajan
    Department of Infection, Immunity and Inflammation, Transplant Surgery Group, University Hospitals of Leicester, Leicester General Hospital, Leicester, United Kingdom
    Transplant Proc 44:1231-5. 2012
    ..This study was done to assess the impact of HLAb and DSAb on graft function, rejection episodes, and graft survival in renal transplantation...
  31. ncbi request reprint Ureteric stenosis after renal transplantation: no effect of acute rejection or immunosuppression
    N R Brook
    Department of Surgery, University of Leicester, Leicester General Hospital, Leicester, United Kingdom
    Transplant Proc 34:3007-8. 2002
  32. ncbi request reprint Rapamycin inhibits vascular remodeling in an experimental model of allograft vasculopathy and attenuates associated changes in fibrosis-associated gene expression
    G J Murphy
    University Department of Surgery, Leicester General Hospital, Leicester, UK
    J Heart Lung Transplant 22:533-41. 2003
    ..The aim of this study was to assess the effect of rapamycin on the expression of fibrosis-associated genes and correlate this with observed changes in ECM remodeling in an experimental of model allograft vasculopathy...
  33. ncbi request reprint A neural network approach to the biopsy diagnosis of early acute renal transplant rejection
    P N Furness
    Department of Pathology, Leicester General Hospital, UK
    Histopathology 35:461-7. 1999
    ..To develop and test a neural network to assist in the histological diagnosis of early acute renal allograft rejection...
  34. ncbi request reprint Pre-incision infiltration of local anesthetic reduces postoperative pain with no effects on bruising and wound cosmesis after thyroid surgery
    A Bagul
    Department of Transplant and Endocrine Surgery, Leicester General Hospital, UK
    Thyroid 15:1245-8. 2005
    ..3339) at discharge. Preincision infiltration with bupivacaine provides easy and better analgesic control postoperatively in patients following thyroid surgery with no effects on bruising or wound cosmesis...
  35. ncbi request reprint Cytokines and inflammatory pathways in the pathogenesis of multiple organ failure following abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 22:485-95. 2001
    ..The combination of these individual changes in organ function is the multiple-organ dysfunction syndrome, which may progress to multiple organ failure...
  36. doi request reprint Hypothermic machine perfusion after static cold storage does not improve the preservation condition in an experimental porcine kidney model
    S A Hosgood
    Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK
    Br J Surg 98:943-50. 2011
    ..Combining hypothermic techniques, as a more practical approach to preservation, may enhance the condition of kidneys donated after cardiac death...
  37. ncbi request reprint Human islet cell transplantation--future prospects
    S A White
    Department of Surgery, University of Leicester, Leicester, UK
    Diabet Med 18:78-103. 2001
    ..The aim of this review is to discuss why insulin-independence after islet allotransplantation has been so difficult to achieve...
  38. doi request reprint Arteriovenous fistula formation using transposed basilic vein: extensive single centre experience
    S J F Harper
    Department of Infection, Immunity and Inflammation, Transplantation Division, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 36:237-41. 2008
    ..The expanding haemodialysis population has lead to increased requirement for more complex vascular access. The aim of this study is to present the results of an extensive series of brachiobasilic arteriovenous fistulae...
  39. doi request reprint Comparison of preservation solutions in an experimental model of organ cooling in kidney transplantation
    M D Kay
    Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK
    Br J Surg 96:1215-21. 2009
    ..This study assessed the temperature changes of kidneys flushed with UW and hyperosmolar citrate (HOC)...
  40. pmc Use of non-heart-beating donors in renal transplantation
    R M Kimber
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Postgrad Med J 77:681-5. 2001
    ..If used safely, they enable significant expansion of the donor pool. Techniques in the future, such as machine perfusion preservation, may further improve the results from non-heart beating programmes...
  41. doi request reprint Hydrogen sulphide ameliorates ischaemia-reperfusion injury in an experimental model of non-heart-beating donor kidney transplantation
    S A Hosgood
    Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK
    Br J Surg 97:202-9. 2010
    ..This study used a porcine model of non-heart-beating (NHB) donor kidneys to investigate the effects of hydrogen sulphide on IR injury...
  42. ncbi request reprint Rapamycin in transplantation: a review of the evidence
    R N Saunders
    Department of Surgery, Leicester General Hospital, Leicester, England, United Kingdom
    Kidney Int 59:3-16. 2001
    ..This review examines the current in vitro animal and human work underlying the use of rapamycin and, in addition, comments on the pharmacokinetics and side-effect profile of this promising new agent...
  43. ncbi request reprint Kidney transplantation from non heart-beating donors
    N R Brook
    The University Division of Transplant Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE1 6GF
    Surgeon 1:311-22. 2003
    ..The ethical and legal implications of running a NHBD programme are discussed, and some areas of current and likely future research are covered...
  44. pmc Four gland parathyroidectomy without reimplantation in patients with chronic renal failure
    R N Saunders
    Department of Surgery, Leicester General Hospital, Leicester, UK
    Postgrad Med J 81:255-8. 2005
    ..One approach advocated is four gland parathyroidectomy without reimplantation. The aim of this study was to review the medium term results of this procedure...
  45. ncbi request reprint Sirolimus attenuates the expression of metalloproteinase-2 and -9 and inhibits intimal hyperplasia following balloon angioplasty
    J R Waller
    Division of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Transplant Proc 34:2881-3. 2002
  46. ncbi request reprint A randomized trial of mycophenolate mofetil versus azathioprine as calcineurin inhibitor sparing agents in the treatment of chronic allograft nephropathy
    M S Metcalfe
    Transplant Division, University Department of Surgery, Leicester General Hospital, Gwendolen Road, Leicester, United Kingdom
    Transplant Proc 34:1812-4. 2002
  47. doi request reprint Effects of hydrogen sulphide in an experimental model of renal ischaemia-reperfusion injury
    J P Hunter
    Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, UK
    Br J Surg 99:1665-71. 2012
    ..The aim of this study was to investigate the efficacy of the endogenous gaseous signalling molecule hydrogen sulphide in protecting against renal IRI...
  48. ncbi request reprint Cytokine gene polymorphisms and the inflammatory response to abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 90:1085-92. 2003
    ..The aim of this study was to determine whether cytokine gene polymorphisms affect cytokine production in vivo in patients undergoing abdominal aortic aneurysm (AAA) repair...
  49. ncbi request reprint Pirfenidone inhibits early neointimal proliferation following arterial injury
    Julian R Waller
    Division of Transplant Surgery, Royal College of Surgeons of England, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Transplant Proc 34:1486-8. 2002
  50. ncbi request reprint Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs
    M G A Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Br J Surg 91:1153-6. 2004
    ..In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair...
  51. pmc Living kidney donation: a comparison of laparoscopic and conventional open operations
    J R Waller
    University Division of Transplant Surgery, Leicester General Hospital, UK
    Postgrad Med J 78:153-7. 2002
    ..It is not yet clear whether or not the outcome of the recipient kidney transplants are the same after ODN and LDN and much more experience is required before the place of this new technique can be defined...
  52. ncbi request reprint Interaction of eicosanoids and nitric oxide in renal reperfusion injury
    S C Weight
    University Department of Surgery, Leicester General Hospital, UK
    Transplantation 72:614-9. 2001
    ..There was no evidence of coinduction of nitric oxide synthase and cyclooxygenase in this model...
  53. ncbi request reprint A paired study comparing the efficacy of renal preservation by normothermic autologous blood perfusion and hypothermic pulsatile perfusion
    M S Metcalfe
    Transplant Division, Faculty of Medical and Biological Sciences, University of Leicester, Leicester LE5 4PW, UK
    Transplant Proc 34:1473-4. 2002
  54. doi request reprint Application of nitric oxide and carbon monoxide in a model of renal preservation
    S A Hosgood
    Department of Transplant Surgery, University Hospitals of Leicester, Leicester, UK
    Br J Surg 95:1060-7. 2008
    ....
  55. doi request reprint Use of internal iliac artery as a side-to-end anastomosis in renal transplantation
    I H Mohamed
    Department of Transplant Surgery, Leicester General Hospital, UK
    Ann R Coll Surg Engl 94:e36-7. 2012
    ..This technique can provide adequate perfusion to the transplant kidney without the associated risks and complications in the patient whose internal iliac artery is of a good diameter and quality...
  56. ncbi request reprint The post-operative mortality of ruptured abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, Leicester Royal Infirmary, University of Leicester, UK
    Eur J Vasc Endovasc Surg 27:65-74. 2004
    ..Late peri-operative death after ruptured abdominal aortic aneurysm (RAAA) repair is usually due to multiple-organ failure. The aim of this study was to identify any factors that are associated with mortality in this group of patients...
  57. ncbi request reprint An audit over 2 years' practice of open and laparoscopic live-donor nephrectomy at renal transplant centres in the UK and Ireland
    N R Brook
    Division of Transplantation, The University Department of Surgery, Leicester General Hospital, Leicester, UK
    BJU Int 93:1027-31. 2004
    ....
  58. ncbi request reprint Laparoscopic live donor nephrectomy
    N R Brook
    University Division of Transplant Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 90:1313-4. 2003
  59. pmc An alternative vascular access technique for haemodialysis; the loop mid-thigh graft
    A Bagul
    Department of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Ann R Coll Surg Engl 88:500-1. 2006
  60. ncbi request reprint The aetiology and pathogenesis of chronic allograft nephropathy
    P J Yates
    Division of Transplant Surgery, Department of Cardiovascular Sciences, University of Leicester, Leicester, LE5 4PW UK
    Transpl Immunol 16:148-57. 2006
    ..This paper aims to present a concise yet accurate and up-to-date review of the literature concerning the aetiological factors and pathological processes which are present in the generation of CAN...
  61. ncbi request reprint Microemulsion cyclosporin inhibits vascular remodelling and attenuates associated changes in profibrotic gene expression in an experimental model of allograft vasculopathy
    G J Murphy
    University Department of Surgery, Leicester General Hospital, Leicester, UK
    Br J Surg 89:1055-61. 2002
    ..The aim of this study was to characterize the changes in fibrosis-associated gene expression in an experimental model of CAD and to measure the effect of the immunosuppressant cyclosporin on these changes...
  62. doi request reprint Complete resolution of oral Kaposi's sarcoma achieved by changing immunosuppression: a case report
    Y Johari
    Division of Transplantation, University Hospitals of Leicester NHS Trust, Leicester, UK
    Ann R Coll Surg Engl 92:W45-6. 2010
    ..This study documents her imunosuppression therapy including resolution of an oral Kaposi's sarcoma and explores the many underlying problems with converting to an mTOR inhibitor...
  63. pmc Elbow fistulas using autogeneous vein: patency rates and results of revision
    G J Murphy
    University Department of Surgery, Leicester General Hospital, Leicester, UK
    Postgrad Med J 78:483-6. 2002
    ..The provision and maintenance of vascular access remains a major cost to end stage renal failure programmes. There are few reports regarding the surgical revision of the failing native elbow arteriovenous fistula (AVF)...
  64. ncbi request reprint Tunnelled catheters for the haemodialysis patient
    A Bagul
    Transplant Department, Leicester General Hospital, Leicester, UK
    Eur J Vasc Endovasc Surg 33:105-12. 2007
    ..The aim of this review is to highlight recent evidence based developments in tunnelled catheters, including methods of placement, complications and possible management strategies...
  65. ncbi request reprint Effect of rapamycin in combination with calcineurin inhibitors, FK506 and cyclosporin, following arterial injury
    Julian R Waller
    Division of Transplant Surgery, Royal College of Surgeons of England, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Transplant Proc 34:1481-3. 2002
  66. ncbi request reprint Effects of arterial pressure in an experimental isolated haemoperfused porcine kidney preservation system
    S Hosgood
    Department of Cardiovascular Sciences, Transplant Group, University of Leicester, Leicester General Hospital, Leicester, UK
    Br J Surg 93:879-84. 2006
    ..Optimal conditions for ex vivo preservation have not yet been established. This study examined the effects of arterial pressure on renal preservation using isolated haemoperfused kidneys...
  67. ncbi request reprint Renal transplant fibrosis correlates with intragraft expression of tissue inhibitor of metalloproteinase messenger RNA
    M L Nicholson
    University Department of Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 89:933-7. 2002
    ....
  68. pmc Obtaining explicit consent for the use of archival tissue samples: practical issues
    P N Furness
    Department of Pathology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Med Ethics 30:561-4. 2004
    ..Current UK guidance in this area requires an assessment of whether it is "practical" to obtain explicit consent. Ethics committees have little experience or evidence to help them to judge what is "practical" in this context...
  69. doi request reprint Case-control comparison of laparoscopic and open washout for peritoneal dialysis-associated peritonitis
    A D Barlow
    Department of Transplant Surgery, Leicester General Hospital, Leicester, UK
    Br J Surg 95:1416-9. 2008
    ..Some 25-40 per cent of patients require surgical intervention, traditionally laparotomy, washout and removal of the PD catheter. The aim was to compare this open procedure with laparoscopic washout and catheter removal...
  70. ncbi request reprint The systemic inflammatory response syndrome, organ failure, and mortality after abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Vasc Surg 37:600-6. 2003
    ....
  71. ncbi request reprint Autogeneous elbow fistulas: the effect of diabetes mellitus on maturation, patency, and complication rates
    G J Murphy
    Department of Surgery, Leicester General Hospital, Leicester, U K
    Eur J Vasc Endovasc Surg 23:452-7. 2002
    ....