Mark A Horsfield

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Mapping eddy current induced fields for the correction of diffusion-weighted echo planar images
    M A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK
    Magn Reson Imaging 17:1335-45. 1999
  2. ncbi request reprint Magnetization transfer imaging in multiple sclerosis
    Mark A Horsfield
    Department of Cardiology, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    J Neuroimaging 15:58S-67S. 2005
  3. ncbi request reprint Algorithms for calculation of kinetic parameters from T1-weighted dynamic contrast-enhanced magnetic resonance imaging
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    J Magn Reson Imaging 20:723-9. 2004
  4. ncbi request reprint Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
    IEEE Trans Med Imaging 26:1670-80. 2007
  5. ncbi request reprint Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences
    M A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
    J Neurol Sci 216:169-77. 2003
  6. doi request reprint MR image postprocessing for multiple sclerosis research
    Mark A Horsfield
    Medical Physics Section, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Neuroimaging Clin N Am 18:637-49, x. 2008
  7. doi request reprint A functional form for injected MRI Gd-chelate contrast agent concentration incorporating recirculation, extravasation and excretion
    Mark A Horsfield
    Department of Cardiovascular Sciences, Leicester Royal Infirmary, University of Leicester, Leicester LE1 5WW, UK
    Phys Med Biol 54:2933-49. 2009
  8. ncbi request reprint Guidelines for using quantitative magnetization transfer magnetic resonance imaging for monitoring treatment of multiple sclerosis
    Mark A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    J Magn Reson Imaging 17:389-97. 2003
  9. ncbi request reprint Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases - a review
    Mark A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK
    NMR Biomed 15:570-7. 2002
  10. pmc Rapid semi-automatic segmentation of the spinal cord from magnetic resonance images: application in multiple sclerosis
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Neuroimage 50:446-55. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Mapping eddy current induced fields for the correction of diffusion-weighted echo planar images
    M A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK
    Magn Reson Imaging 17:1335-45. 1999
    ..It is particularly suitable for use with single-shot echo planar imaging...
  2. ncbi request reprint Magnetization transfer imaging in multiple sclerosis
    Mark A Horsfield
    Department of Cardiology, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    J Neuroimaging 15:58S-67S. 2005
    ....
  3. ncbi request reprint Algorithms for calculation of kinetic parameters from T1-weighted dynamic contrast-enhanced magnetic resonance imaging
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    J Magn Reson Imaging 20:723-9. 2004
    ....
  4. ncbi request reprint Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
    IEEE Trans Med Imaging 26:1670-80. 2007
    ..The operator interaction time required to evaluate one subject was reduced from an average of 111 min with contouring to 16 min with the FC method...
  5. ncbi request reprint Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences
    M A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
    J Neurol Sci 216:169-77. 2003
    ..Automated measurement has high reproducibility especially when 2D sequences are used. Semi-automated measurement may have increased accuracy, but with a decreased efficiency and reliability...
  6. doi request reprint MR image postprocessing for multiple sclerosis research
    Mark A Horsfield
    Medical Physics Section, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Neuroimaging Clin N Am 18:637-49, x. 2008
    ..The aim of these steps is to output reproducible, quantitative assessments of MR imaging scans that can be performed on data generated by the many different scanning sites that may be involved in multicenter studies...
  7. doi request reprint A functional form for injected MRI Gd-chelate contrast agent concentration incorporating recirculation, extravasation and excretion
    Mark A Horsfield
    Department of Cardiovascular Sciences, Leicester Royal Infirmary, University of Leicester, Leicester LE1 5WW, UK
    Phys Med Biol 54:2933-49. 2009
    ....
  8. ncbi request reprint Guidelines for using quantitative magnetization transfer magnetic resonance imaging for monitoring treatment of multiple sclerosis
    Mark A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    J Magn Reson Imaging 17:389-97. 2003
    ..It is anticipated that MT imaging will be incorporated into many new trials in the near future...
  9. ncbi request reprint Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases - a review
    Mark A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK
    NMR Biomed 15:570-7. 2002
    ..With the now common availability of scanners equipped to perform echo-planar imaging, the acquisition of diffusion tensor images is sure to become more widespread and routine...
  10. pmc Rapid semi-automatic segmentation of the spinal cord from magnetic resonance images: application in multiple sclerosis
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Neuroimage 50:446-55. 2010
    ....
  11. ncbi request reprint Using diffusion-weighted MRI in multicenter clinical trials for multiple sclerosis
    M A Horsfield
    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
    J Neurol Sci 186:S51-4. 2001
    ..The quantitative nature of diffusion MRI makes it an attractive proposition for inclusion in clinical trials for MS therapeutic agents, but without further validation work with clinical correlates cannot be recommended at present...
  12. ncbi request reprint Imaging the cerebral hemispheres: technical issues
    M A Horsfield
    Division of Medical Physics, University of Leicester, Leicester, UK
    J Neurol Sci 172:S54-6. 2000
    ....
  13. doi request reprint Does stroke subtype and measurement technique influence estimation of cerebral autoregulation in acute ischaemic stroke?
    Nazia P Saeed
    Ageing and Stroke Medicine, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Cerebrovasc Dis 35:257-61. 2013
    ....
  14. doi request reprint Gray matter damage predicts the accumulation of disability 13 years later in MS
    Massimo Filippi
    From the Neuroimaging Research Unit M F, P P, G R, M A R, Institute of Experimental Neurology, and Department of Neurology M F, P P, V M, G C, M A R, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan Biostatistics Unit M C, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy and Medical Physics Group M A H, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, UK
    Neurology 81:1759-67. 2013
    ....
  15. ncbi request reprint Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer
    Anne L Thomas
    University of Leicester, United Kingdom
    J Clin Oncol 23:4162-71. 2005
    ..In this phase I dose-escalating study, PTK/ZK was administered bid to exploit the theoretical advantage of maintaining constant drug levels above a threshold known from preclinical data to interfere with VEGF receptor signaling...
  16. pmc A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging
    B Morgan
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Br J Cancer 94:1420-7. 2006
    ..The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE-MRI technique...
  17. doi request reprint Cortical abnormalities in patients with migraine: a surface-based analysis
    Roberta Messina
    Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy
    Radiology 268:170-80. 2013
    ....
  18. ncbi request reprint A method for obtaining tract-specific diffusion tensor MRI measurements in the presence of disease: application to patients with clinically isolated syndromes suggestive of multiple sclerosis
    E Pagani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Neuroimage 26:258-65. 2005
    ..Its extension to other white matter fiber bundles is therefore limited to bundles with high orientational coherence...
  19. pmc Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
    PLoS ONE 8:e62588. 2013
    ..The techniques described may have practical importance in detecting regional changes in autoregulation consequent to disease...
  20. ncbi request reprint Dynamic change of the upper airway during inhalation via aerosol delivery devices
    Touraj Ehtezazi
    Department of Child Health, Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Aerosol Med 17:325-34. 2004
    ..These changes are likely to be produced by a number of factors, including tongue position, device airflow resistance, and patient effort...
  21. ncbi request reprint The role of imaging in the clinical development of antiangiogenic agents
    Bruno Morgan
    Department of Cancer and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Hematol Oncol Clin North Am 18:1183-206, x. 2004
    ..This article discusses the development of such "functional" clinical imaging and attempts to address the questions that are being asked of imaging departments by oncologists and pharmaceutical companies...
  22. pmc Measurement of cerebral blood flow responses to the thigh cuff maneuver: a comparison of TCD with a novel MRI method
    Nazia P Saeed
    Department of Cardiovascular Sciences, Ageing and Stroke Medicine Group, University of Leicester NHS Trust, Gwendolen Road, Leicester, UK
    J Cereb Blood Flow Metab 31:1302-10. 2011
    ..The new MRI method may provide opportunities for assessing regional autoregulatory changes following acute stroke, and in other conditions in which poor autoregulation is implicated...
  23. ncbi request reprint Restoration of myocardial blood flow following percutaneous coronary balloon dilatation and stent implantation: assessment with qualitative and quantitative contrast-enhanced magnetic resonance imaging
    P R Sensky
    Department of Cardiology, University of Leicester, Glenfield Hospital, Leicester, UK
    Clin Radiol 57:593-9. 2002
    ..To examine the serial use of magnetic resonance imaging (MRI) to evaluate regional myocardial perfusion changes following percutaneous coronary angioplasty and stent implantation (PTCA)...
  24. ncbi request reprint A comparison of polyacrylamide gels and radiochromic film for source measurements in intravascular brachytherapy
    M N Amin
    Department of Medical Physics, University Hospitals of Leicester, Leicester LE1 5WW, UK
    Br J Radiol 76:824-31. 2003
    ....
  25. ncbi request reprint Assessing atrophy of the major white matter fiber bundles of the brain from diffusion tensor MRI data
    Elisabetta Pagani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Magn Reson Med 58:527-34. 2007
    ..The effectiveness of the method was then tested on data from five patients with multiple sclerosis (MS) and two patients with amyotrophic lateral sclerosis (ALS)...
  26. ncbi request reprint Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liv
    Bruno Morgan
    University of Leicester, United Kingdom
    J Clin Oncol 21:3955-64. 2003
    ....
  27. ncbi request reprint Sensitivity-encoded diffusion tensor MR imaging of the cervical cord
    Mara Cercignani
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    AJNR Am J Neuroradiol 24:1254-6. 2003
    ..Off-resonance artifacts were notably reduced compared with those of full-FOV EPI sequences. This approach to diffusion tensor MR imaging of the cervical cord is promising for future, more extensive clinical applications...
  28. ncbi request reprint Spatial normalization and averaging of diffusion tensor MRI data sets
    Derek K Jones
    Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuroimage 17:592-617. 2002
    ..Finally, the feasibility of performing tractography on the group-averaged DT-MRI data set is investigated and the possibility and implications of generating a generic map of brain connectivity from a group of subjects is considered...
  29. ncbi request reprint Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia
    Derek K Jones
    Section on Tissue Biophysics and Biomimetics, LIMB, NICHD, National Institutes of Health, Bethesda, Maryland, USA
    Hum Brain Mapp 27:230-8. 2006
    ....
  30. ncbi request reprint Interhemispheric asymmetry of brain diffusivity in normal individuals: a diffusion-weighted MR imaging study
    Andrew J Fabiano
    Department of Neurosurgery, State University of New York, Buffalo, NY, USA
    AJNR Am J Neuroradiol 26:1089-94. 2005
    ..The purpose of this study was to assess whether water diffusivity in deep gray matter structures shown by diffusion-weighted (DW) imaging differs between the right and left cerebral hemispheres in normal individuals...
  31. ncbi request reprint A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis
    Derek K Jones
    Section on Tissue Biophysics and Biomimetics, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Am J Geriatr Psychiatry 13:1092-9. 2005
    ..The authors looked within white-matter tracts, which mediate connectivity of the frontal lobes, in psychotic patients for evidence of loss of fiber integrity consistent with degenerative damage...
  32. ncbi request reprint A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosis
    Jitendra Sharma
    Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 16:302-10. 2006
    ..Magnetization transfer imaging (MTI), an advanced MRI technique, is sensitive to disease in normal appearing white matter (NAWM) in patients with MS...
  33. pmc MRI in multiple sclerosis: current status and future prospects
    Rohit Bakshi
    Center for Neurological Imaging, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet Neurol 7:615-25. 2008
    ..Advances in MRI should improve our ability to diagnose, monitor, and understand the pathophysiology of MS...
  34. ncbi request reprint Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients
    Paola Valsasina
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
    Neuroimage 26:822-8. 2005
    ....