Research Topics
| Mark A HorsfieldSummaryAffiliation: University of Leicester Country: UK Publications
| Collaborators
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Detail Information
Publications
Mapping eddy current induced fields for the correction of diffusion-weighted echo planar imagesM A Horsfield
Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK
Magn Reson Imaging 17:1335-45. 1999..It is particularly suitable for use with single-shot echo planar imaging...- Magnetization transfer imaging in multiple sclerosisMark A Horsfield
Department of Cardiology, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
J Neuroimaging 15:58S-67S. 2005.... - Algorithms for calculation of kinetic parameters from T1-weighted dynamic contrast-enhanced magnetic resonance imagingMark A Horsfield
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
J Magn Reson Imaging 20:723-9. 2004.... - Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosisMark A Horsfield
Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
IEEE Trans Med Imaging 26:1670-80. 2007..The operator interaction time required to evaluate one subject was reduced from an average of 111 min with contouring to 16 min with the FC method... - Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequencesM A Horsfield
Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
J Neurol Sci 216:169-77. 2003..Automated measurement has high reproducibility especially when 2D sequences are used. Semi-automated measurement may have increased accuracy, but with a decreased efficiency and reliability... 
MR image postprocessing for multiple sclerosis researchMark A Horsfield
Medical Physics Section, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Neuroimaging Clin N Am 18:637-49, x. 2008..The aim of these steps is to output reproducible, quantitative assessments of MR imaging scans that can be performed on data generated by the many different scanning sites that may be involved in multicenter studies...- A functional form for injected MRI Gd-chelate contrast agent concentration incorporating recirculation, extravasation and excretionMark A Horsfield
Department of Cardiovascular Sciences, Leicester Royal Infirmary, University of Leicester, Leicester LE1 5WW, UK
Phys Med Biol 54:2933-49. 2009.... - Guidelines for using quantitative magnetization transfer magnetic resonance imaging for monitoring treatment of multiple sclerosisMark A Horsfield
Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, UK
J Magn Reson Imaging 17:389-97. 2003..It is anticipated that MT imaging will be incorporated into many new trials in the near future... - Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases - a reviewMark A Horsfield
Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK
NMR Biomed 15:570-7. 2002..With the now common availability of scanners equipped to perform echo-planar imaging, the acquisition of diffusion tensor images is sure to become more widespread and routine... 
Rapid semi-automatic segmentation of the spinal cord from magnetic resonance images: application in multiple sclerosisMark A Horsfield
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Neuroimage 50:446-55. 2010....- Using diffusion-weighted MRI in multicenter clinical trials for multiple sclerosisM A Horsfield
Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
J Neurol Sci 186:S51-4. 2001..The quantitative nature of diffusion MRI makes it an attractive proposition for inclusion in clinical trials for MS therapeutic agents, but without further validation work with clinical correlates cannot be recommended at present... - Imaging the cerebral hemispheres: technical issuesM A Horsfield
Division of Medical Physics, University of Leicester, Leicester, UK
J Neurol Sci 172:S54-6. 2000.... - Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancerAnne L Thomas
University of Leicester, United Kingdom
J Clin Oncol 23:4162-71. 2005..In this phase I dose-escalating study, PTK/ZK was administered bid to exploit the theoretical advantage of maintaining constant drug levels above a threshold known from preclinical data to interfere with VEGF receptor signaling... - A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imagingB Morgan
Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Br J Cancer 94:1420-7. 2006..The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE-MRI technique... - Does stroke subtype and measurement technique influence estimation of cerebral autoregulation in acute ischaemic stroke?Nazia P Saeed
Ageing and Stroke Medicine, University of Leicester, Leicester, UK
Cerebrovasc Dis 35:257-61. 2013..Importantly, no differences were observed between UA and AF. This has implications for the assessment of CA after stroke and reinforces the need to define a 'gold standard' test for the investigation of CA... - A method for obtaining tract-specific diffusion tensor MRI measurements in the presence of disease: application to patients with clinically isolated syndromes suggestive of multiple sclerosisE Pagani
Department of Cardiovascular Sciences, University of Leicester, UK
Neuroimage 26:258-65. 2005..Its extension to other white matter fiber bundles is therefore limited to bundles with high orientational coherence... - Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imagingMark A Horsfield
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
PLoS ONE 8:e62588. 2013..The techniques described may have practical importance in detecting regional changes in autoregulation consequent to disease... - Measurement of cerebral blood flow responses to the thigh cuff maneuver: a comparison of TCD with a novel MRI methodNazia P Saeed
Department of Cardiovascular Sciences, Ageing and Stroke Medicine Group, University of Leicester NHS Trust, Gwendolen Road, Leicester, UK
J Cereb Blood Flow Metab 31:1302-10. 2011..The new MRI method may provide opportunities for assessing regional autoregulatory changes following acute stroke, and in other conditions in which poor autoregulation is implicated... - Dynamic change of the upper airway during inhalation via aerosol delivery devicesTouraj Ehtezazi
Department of Child Health, Institute of Lung Health, University of Leicester, Leicester, United Kingdom
J Aerosol Med 17:325-34. 2004..These changes are likely to be produced by a number of factors, including tongue position, device airflow resistance, and patient effort... - The role of imaging in the clinical development of antiangiogenic agentsBruno Morgan
Department of Cancer and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Hematol Oncol Clin North Am 18:1183-206, x. 2004..This article discusses the development of such "functional" clinical imaging and attempts to address the questions that are being asked of imaging departments by oncologists and pharmaceutical companies... - Restoration of myocardial blood flow following percutaneous coronary balloon dilatation and stent implantation: assessment with qualitative and quantitative contrast-enhanced magnetic resonance imagingP R Sensky
Department of Cardiology, University of Leicester, Glenfield Hospital, Leicester, UK
Clin Radiol 57:593-9. 2002..To examine the serial use of magnetic resonance imaging (MRI) to evaluate regional myocardial perfusion changes following percutaneous coronary angioplasty and stent implantation (PTCA)... - A comparison of polyacrylamide gels and radiochromic film for source measurements in intravascular brachytherapyM N Amin
Department of Medical Physics, University Hospitals of Leicester, Leicester LE1 5WW, UK
Br J Radiol 76:824-31. 2003.... - Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophreniaDerek K Jones
Section on Tissue Biophysics and Biomimetics, LIMB, NICHD, National Institutes of Health, Bethesda, Maryland, USA
Hum Brain Mapp 27:230-8. 2006.... - Assessing atrophy of the major white matter fiber bundles of the brain from diffusion tensor MRI dataElisabetta Pagani
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Magn Reson Med 58:527-34. 2007..The effectiveness of the method was then tested on data from five patients with multiple sclerosis (MS) and two patients with amyotrophic lateral sclerosis (ALS)... - Spatial normalization and averaging of diffusion tensor MRI data setsDerek K Jones
Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Neuroimage 17:592-617. 2002..Finally, the feasibility of performing tractography on the group-averaged DT-MRI data set is investigated and the possibility and implications of generating a generic map of brain connectivity from a group of subjects is considered... - Sensitivity-encoded diffusion tensor MR imaging of the cervical cordMara Cercignani
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
AJNR Am J Neuroradiol 24:1254-6. 2003..Off-resonance artifacts were notably reduced compared with those of full-FOV EPI sequences. This approach to diffusion tensor MR imaging of the cervical cord is promising for future, more extensive clinical applications... - Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and livBruno Morgan
University of Leicester, United Kingdom
J Clin Oncol 21:3955-64. 2003.... - MRI in multiple sclerosis: current status and future prospectsRohit Bakshi
Center for Neurological Imaging, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lancet Neurol 7:615-25. 2008..Advances in MRI should improve our ability to diagnose, monitor, and understand the pathophysiology of MS... - Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patientsPaola Valsasina
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
Neuroimage 26:822-8. 2005.... - A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosisJitendra Sharma
Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham/Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuroimaging 16:302-10. 2006..It remains to be determined if other MRI techniques are more sensitive than MTI for detecting pathology in these areas... - A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosisDerek K Jones
Section on Tissue Biophysics and Biomimetics, National Institute of Child Health and Human Development/NIH, Bethesda, MD 20892, USA
Am J Geriatr Psychiatry 13:1092-9. 2005.... - Interhemispheric asymmetry of brain diffusivity in normal individuals: a diffusion-weighted MR imaging studyAndrew J Fabiano
Department of Neurosurgery, State University of New York, Buffalo, NY, USA
AJNR Am J Neuroradiol 26:1089-94. 2005..Analysis of deep gray matter lesions requires caution, as statistically significant interhemispheric differences may not always be indicative of disease...