K Horsburgh

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Marked alterations in the cellular localisation and levels of apolipoprotein E following acute subdural haematoma in rat
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, UK
    Brain Res 763:103-10. 1997
  2. ncbi request reprint beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Glasgow, UK
    Neuropathol Appl Neurobiol 26:124-32. 2000
  3. ncbi request reprint The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Labs, University of Glasgow, Garscube Estate, Bearsden Road, G61 1QH, Glasgow, UK
    Neurobiol Aging 21:245-55. 2000
  4. ncbi request reprint Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia
    K Horsburgh
    Department of Neuropathology, University of Glasgow, Glasgow, UK
    Eur J Neurosci 12:4309-17. 2000
  5. ncbi request reprint 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia
    E McKracken
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, United Kingdom
    Brain Pathol 11:414-21. 2001
  6. ncbi request reprint Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion
    F White
    Wellcome Surgical Institute and Department of Neuropathology, University of Glasgow, Bearsden Road, Garscube Estate, G61 1QH, United Kingdom
    Neurobiol Dis 8:611-25. 2001
  7. ncbi request reprint Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion
    F White
    Wellcome Surgical Institute, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, G61 1QH, United Kingdom
    Exp Neurol 169:307-18. 2001
  8. ncbi request reprint Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia
    K Horsburgh
    Department of Neuropathology and Wellcome Surgical Institute, University of Glasgow, UK
    Neuroreport 10:837-41. 1999
  9. ncbi request reprint Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion
    S Kelly
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Garscube Estate, Bearsden Road, G61 1QH, Glasgow, UK
    Brain Res 914:185-95. 2001
  10. ncbi request reprint Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, UK
    Neuropathol Appl Neurobiol 22:342-9. 1996

Detail Information

Publications12

  1. ncbi request reprint Marked alterations in the cellular localisation and levels of apolipoprotein E following acute subdural haematoma in rat
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, UK
    Brain Res 763:103-10. 1997
    ..These alterations in apoE may occur, at least initially, as part of the brain's protective response to injury...
  2. ncbi request reprint beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Glasgow, UK
    Neuropathol Appl Neurobiol 26:124-32. 2000
    ..Further, the findings may be of relevance to the role of apoE genotype in influencing outcome after acute brain injury...
  3. ncbi request reprint The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Labs, University of Glasgow, Garscube Estate, Bearsden Road, G61 1QH, Glasgow, UK
    Neurobiol Aging 21:245-55. 2000
    ..This review focuses on apoE research, from clinical studies to animal models, in AD, acute brain injury and cerebrovascular disease and explores the common mechanisms that may explain some of the complex underlying neurobiology...
  4. ncbi request reprint Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia
    K Horsburgh
    Department of Neuropathology, University of Glasgow, Glasgow, UK
    Eur J Neurosci 12:4309-17. 2000
    ..The data extend previous work and are consistent with an association of the APOE-epsilon4 allele with a poor outcome after acute brain injury in humans...
  5. ncbi request reprint 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia
    E McKracken
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, United Kingdom
    Brain Pathol 11:414-21. 2001
    ..This substantiates a role for lipid peroxidation in the pathogenesis of cerebral ischemia. There was no indication that APOE genotype influenced the extent of 4-HNE immunoreactivity...
  6. ncbi request reprint Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion
    F White
    Wellcome Surgical Institute and Department of Neuropathology, University of Glasgow, Bearsden Road, Garscube Estate, G61 1QH, United Kingdom
    Neurobiol Dis 8:611-25. 2001
    ..These isoform-specific differences in plasticity may relate to the severity of AD and poor, long-term recovery after head injury in APOE epsilon 4 individuals...
  7. ncbi request reprint Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion
    F White
    Wellcome Surgical Institute, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, G61 1QH, United Kingdom
    Exp Neurol 169:307-18. 2001
    ..This coordinated alteration in apolipoproteins may redistribute lipid material to sprouting fibers to promote neurite extension and may play an important role in long-term plasticity changes following injury...
  8. ncbi request reprint Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia
    K Horsburgh
    Department of Neuropathology and Wellcome Surgical Institute, University of Glasgow, UK
    Neuroreport 10:837-41. 1999
    ..05). The data substantiate a role for apoE in modifying the response of the CNS to acute injury...
  9. ncbi request reprint Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion
    S Kelly
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Garscube Estate, Bearsden Road, G61 1QH, Glasgow, UK
    Brain Res 914:185-95. 2001
    ..These data indicate that MF1 mice are less susceptible to BCCAo than C57Bl/6J mice and that this could be due to maintained increases in MABP during BCCAo and the lower prevalence of abnormalities of the circle of Willis in MF1 mice...
  10. ncbi request reprint Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, UK
    Neuropathol Appl Neurobiol 22:342-9. 1996
    ..This may indicate an inherent protective response of cells to injury. Alternatively, the results are consistent with the hypothesis that apoE is synthesized and released by astrocytes and taken up by neurons following injury...
  11. ncbi request reprint Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro
    S Kelly
    URCN and MRC Center for Synaptic Plasticity, Division of Medicine, University of Bristol, UK
    J Cereb Blood Flow Metab 21:972-81. 2001
    ....
  12. ncbi request reprint Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and -2 in ischemic brain injury
    S Magnoni
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    Gene Ther 14:621-5. 2007
    ..001) and AdTIMP-2 (P< 0.01) as compared to controls. This study provides the first in vivo evidence of the protective effects of TIMP-1 and TIMP-2 via gene transfer in global ischemia...