M E Horb

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi request reprint Patterning the endoderm: the importance of neighbours
    M E Horb
    Dept Biology and Biochemistry, University of Bath, UK
    Bioessays 22:599-602. 2000
  2. ncbi request reprint Endoderm specification and differentiation in Xenopus embryos
    M E Horb
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, BA2 7AY, United Kingdom
    Dev Biol 236:330-43. 2001
  3. ncbi request reprint Expression of amylase and other pancreatic genes in Xenopus
    Marko E Horb
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Mech Dev 113:153-7. 2002
  4. ncbi request reprint Experimental conversion of liver to pancreas
    Marko E Horb
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, BA2 7AY, Bath, United Kingdom
    Curr Biol 13:105-15. 2003
  5. ncbi request reprint Germ layers to organs: using Xenopus to study "later" development
    Ira L Blitz
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, CA 92697, USA, and Division of Pediatric Cardiology, Ste Justine Hospital, Montreal, QC, Canada
    Semin Cell Dev Biol 17:133-45. 2006
  6. ncbi request reprint In vitro transdifferentiation of hepatoma cells into functional pancreatic cells
    Wan Chun Li
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Mech Dev 122:835-47. 2005
  7. ncbi request reprint Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 274:491-503. 2004
  8. pmc High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells
    Li Zhen Cao
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 53:3168-78. 2004
  9. ncbi request reprint Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 270:474-86. 2004
  10. ncbi request reprint Transdifferentiation of pancreas to liver
    Chia Ning Shen
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, BA2 7AY Bath, UK
    Mech Dev 120:107-16. 2003

Collaborators

  • David Tosh
  • Steven D Leach
  • J Slack
  • Caroline W Beck
  • Li Jun Yang
  • Mona Nemer
  • John W Lin
  • Zeina H Jarikji
  • Genevieve Lavallee
  • Ira L Blitz
  • Gregor Andelfinger
  • Wan Chun Li
  • Nijaguna B Prasad
  • Nelson S Yee
  • Andrew V Biankin
  • Michael A Pack
  • Bidyut Ghosh
  • Li Zhen Cao
  • Chia Ning Shen
  • Chris V E Wright
  • Sandeep Vanamala
  • Chantal Lefebvre
  • Georges Nemer
  • Mathieu Nadeau
  • Shi Wu Li
  • Dong Qi Tang

Detail Information

Publications13

  1. ncbi request reprint Patterning the endoderm: the importance of neighbours
    M E Horb
    Dept Biology and Biochemistry, University of Bath, UK
    Bioessays 22:599-602. 2000
    ..1) They demonstrate that the initial specification and differentiation of the endoderm does not occur cell-autonomously, but requires signals released from the mesectoderm...
  2. ncbi request reprint Endoderm specification and differentiation in Xenopus embryos
    M E Horb
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, BA2 7AY, United Kingdom
    Dev Biol 236:330-43. 2001
    ....
  3. ncbi request reprint Expression of amylase and other pancreatic genes in Xenopus
    Marko E Horb
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Mech Dev 113:153-7. 2002
    ..In the endocrine cell clusters we do not find glucagon-expressing cells surrounding insulin-expressing cells, either in the tadpole or in the mature frog pancreas...
  4. ncbi request reprint Experimental conversion of liver to pancreas
    Marko E Horb
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, BA2 7AY, Bath, United Kingdom
    Curr Biol 13:105-15. 2003
    ..The aim of this study was to determine whether a gene overexpression protocol based on Pdx1 would be able to cause conversion of liver to pancreas...
  5. ncbi request reprint Germ layers to organs: using Xenopus to study "later" development
    Ira L Blitz
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, CA 92697, USA, and Division of Pediatric Cardiology, Ste Justine Hospital, Montreal, QC, Canada
    Semin Cell Dev Biol 17:133-45. 2006
    ..We also highlight how Xenopus researchers have already begun studying a number of major organs, pancreas, liver, kidney and heart, and suggest how Xenopus might contribute more to these areas in the near future...
  6. ncbi request reprint In vitro transdifferentiation of hepatoma cells into functional pancreatic cells
    Wan Chun Li
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Mech Dev 122:835-47. 2005
    ..The transdifferentiation of hepatic to pancreatic cells represents one possible source of beta-cells for human islet transplantation and this study shows that such a transdifferentiation can be achieved in vitro...
  7. ncbi request reprint Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 274:491-503. 2004
    ..Together, these findings suggest the presence of distinct ptf1a-dependent and ptf1a-independent precursor populations in developing zebrafish pancreas...
  8. pmc High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells
    Li Zhen Cao
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 53:3168-78. 2004
    ..Thus, transdifferentiation of hepatocytes into functional IPCs may serve as a viable therapeutic option for patients with type 1 diabetes...
  9. ncbi request reprint Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 270:474-86. 2004
    ..Together, these findings suggest the presence of distinct ptf1a-dependent and ptf1a-independent precursor populations in developing zebrafish pancreas...
  10. ncbi request reprint Transdifferentiation of pancreas to liver
    Chia Ning Shen
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, BA2 7AY Bath, UK
    Mech Dev 120:107-16. 2003
    ..The AR42J cell system has been used to elucidate the cell lineage and the molecular basis of transdifferentiation of pancreas to liver...
  11. ncbi request reprint Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas
    Zeina H Jarikji
    Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, QC, Canada H2W 1R7
    Dev Biol 304:786-99. 2007
    ..Lastly, we demonstrate that, similar to mouse and zebrafish, Xenopus Ptf1a is essential for the initial specification of both endocrine and exocrine cells during normal pancreas development...
  12. pmc The Kruppel-like transcription factor KLF13 is a novel regulator of heart development
    Genevieve Lavallee
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    EMBO J 25:5201-13. 2006
    ....
  13. ncbi request reprint The KLF family of transcriptional regulators in cardiomyocyte proliferation and differentiation
    Mona Nemer
    Institut de Recherches Cliniques de Montreal, Montreal, Canada
    Cell Cycle 6:117-21. 2007
    ..Thus, tissue-specific regulators of the cell cycle may be potential congenital heart disease causing genes in humans...