Jemma C Hopewell

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    Eur Heart J 34:982-92. 2013
  2. doi request reprint Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit, University of Oxford, Oxford, England
    Circ Cardiovasc Genet 4:68-73. 2011
  3. doi request reprint No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study
    Jemma C Hopewell
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    J Am Coll Cardiol 57:2000-7. 2011
  4. doi request reprint Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study
    Sarah Parish
    Heart Protection Study, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Bldg, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Circulation 125:2469-78. 2012
  5. pmc Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    PLoS Med 9:e1001177. 2012
  6. doi request reprint Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:2518-28. 2009
  7. doi request reprint A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk
    Theodosios Kyriakou
    From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine T K, A, G, H W, M F, Wellcome Trust Centre for Human Genetics T K, A G, H W, M F, and Clinical Trial Service Unit and Epidemiological Studies Unit J C H, R C, University of Oxford, Oxford, United Kingdom and Leibniz Institut für Arterioskleroseforschung an der Universität Münster, Munster, Germany U S
    Arterioscler Thromb Vasc Biol 34:2095-9. 2014
  8. doi request reprint Pharmacogenomics of statin therapy: any new insights in efficacy or safety?
    Jemma C Hopewell
    CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK Jemma C Hopewell, Christina Reith and Jane Armitage contributed equally to the writing of this article
    Curr Opin Lipidol 25:438-45. 2014
  9. pmc Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014

Detail Information

Publications10

  1. pmc Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    Eur Heart J 34:982-92. 2013
    ..This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response...
  2. doi request reprint Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit, University of Oxford, Oxford, England
    Circ Cardiovasc Genet 4:68-73. 2011
    ....
  3. doi request reprint No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study
    Jemma C Hopewell
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    J Am Coll Cardiol 57:2000-7. 2011
    ..The aim of this study was to test the effects of the KIF6 Trp719Arg polymorphism (rs20455) on vascular risk and response to statin therapy in 18,348 participants from the Heart Protection Study...
  4. doi request reprint Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study
    Sarah Parish
    Heart Protection Study, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Bldg, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Circulation 125:2469-78. 2012
    ..Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk...
  5. pmc Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    PLoS Med 9:e1001177. 2012
    ....
  6. doi request reprint Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:2518-28. 2009
    ..The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood...
  7. doi request reprint A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk
    Theodosios Kyriakou
    From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine T K, A, G, H W, M F, Wellcome Trust Centre for Human Genetics T K, A G, H W, M F, and Clinical Trial Service Unit and Epidemiological Studies Unit J C H, R C, University of Oxford, Oxford, United Kingdom and Leibniz Institut für Arterioskleroseforschung an der Universität Münster, Munster, Germany U S
    Arterioscler Thromb Vasc Biol 34:2095-9. 2014
    ..We have also examined how null allele genotyping complements apolipoprotein(a) isoform typing to refine the relationship between LPA isoform size and circulating lipoprotein(a) levels...
  8. doi request reprint Pharmacogenomics of statin therapy: any new insights in efficacy or safety?
    Jemma C Hopewell
    CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK Jemma C Hopewell, Christina Reith and Jane Armitage contributed equally to the writing of this article
    Curr Opin Lipidol 25:438-45. 2014
    ..To examine the current evidence concerning the effects of genetic variation on statin-related low-density lipoprotein cholesterol reductions, clinical efficacy, and adverse events and the relevance for patient care...
  9. pmc Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014
    ..Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases...