Andrew D Hope
Affiliation: University College London
- Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expressionAndrew D Hope
Reta Lila Weston Institute of Neurological Studies, University College, London, UK
J Neurochem 86:394-404. 2003..We conclude that although UBB+1-expressing cells have a compromised ubiquitin-proteasome system, they are protected against oxidative stress conditions...
- Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humansAndrew D Hope
Reta Lila Weston Institute of Neurological Studies, University College London, 46 Cleveland Street, London, W1T 4JF, UK
Neurosci Lett 359:94-8. 2004..As HSPs are involved in both normal tau and proteasome function, these findings may be relevant to the aetiology of PSP and other tauopathies...
- The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's diseaseRina Bandopadhyay
Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, 46 Cleveland Street, London W1T 4JF, UK
Brain 127:420-30. 2004..These results are consistent with the hypothesis that neuronal-glial interactions are important in the pathophysiology of Parkinson's disease...