Philip D Home

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences
    P D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, UK
    Diabetes Obes Metab 14:780-8. 2012
  2. pmc Improved health status with insulin degludec compared with insulin glargine in people with type 1 diabetes
    P D Home
    Institute of Cellular Medicine Diabetes, Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 29:716-20. 2012
  3. pmc Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study)
    Michel Komajda
    Université Pierre et Marie Curie Paris 6 Assistance Publique Hôpitaux de Paris, Hopital Pitie Salpetriere, Paris, France
    Cardiovasc Diabetol 7:10. 2008
  4. ncbi request reprint Pre-meal insulin aspart compared with pre-meal soluble human insulin in type 1 diabetes
    P D Home
    School of Clinical Medical Sciences Diabetes, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Diabetes Res Clin Pract 71:131-9. 2006
  5. ncbi request reprint Insulin detemir: from concept to clinical experience
    Philip Home
    School of Clinical Medical Sciences Diabetes, University of Newcastle upon Tyne, Framlington Place, NE2 4HH, UK
    Expert Opin Pharmacother 7:325-43. 2006
  6. ncbi request reprint Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis
    Philip D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, United Kingdom
    N Engl J Med 357:28-38. 2007
  7. pmc A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes
    P D Home
    School of Medical Sciences Diabetes, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 24:618-25. 2007
  8. ncbi request reprint Hepatic dysfunction and insulin insensitivity in type 2 diabetes mellitus: a critical target for insulin-sensitizing agents
    P D Home
    School of Clinical Medical Sciences Diabetes, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetes Obes Metab 10:699-718. 2008
  9. doi request reprint An observational non-interventional study of people with diabetes beginning or changed to insulin analogue therapy in non-Western countries: the A1chieve study
    Philip Home
    Institute of Cellular Medicine Diabetes, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Res Clin Pract 94:352-63. 2011
  10. doi request reprint Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    Philip D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, UK
    Lancet 373:2125-35. 2009

Collaborators

Detail Information

Publications43

  1. doi request reprint The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences
    P D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, UK
    Diabetes Obes Metab 14:780-8. 2012
    ..No new safety issues have been identified with the marketed rapid-acting analogues, and their insulin-like growth factor 1 receptor affinity and mitogenic activity are comparable to human insulin...
  2. pmc Improved health status with insulin degludec compared with insulin glargine in people with type 1 diabetes
    P D Home
    Institute of Cellular Medicine Diabetes, Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 29:716-20. 2012
    ..Health status, an important aspect of effective diabetes management, was also assessed...
  3. pmc Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study)
    Michel Komajda
    Université Pierre et Marie Curie Paris 6 Assistance Publique Hôpitaux de Paris, Hopital Pitie Salpetriere, Paris, France
    Cardiovasc Diabetol 7:10. 2008
    ..We therefore used ambulatory BP to quantify BP lowering at 6-12 months with rosiglitazone used in combination with metformin or sulfonylureas compared to metformin and sulfonylureas in people with type 2 diabetes...
  4. ncbi request reprint Pre-meal insulin aspart compared with pre-meal soluble human insulin in type 1 diabetes
    P D Home
    School of Clinical Medical Sciences Diabetes, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Diabetes Res Clin Pract 71:131-9. 2006
    ..16 (-0.32, -0.01)% (p=0.035). Insulin aspart was well tolerated and effective during long-term treatment. The HbA(1c) advantage was maintained with insulin aspart without any adverse impact on the rate of major hypoglycaemia...
  5. ncbi request reprint Insulin detemir: from concept to clinical experience
    Philip Home
    School of Clinical Medical Sciences Diabetes, University of Newcastle upon Tyne, Framlington Place, NE2 4HH, UK
    Expert Opin Pharmacother 7:325-43. 2006
    ..Insulin detemir is, therefore, a valuable addition to the range of exogenous insulins, as it should enable treatment regimens to be constructed that offer good outcomes of efficacy and tolerability...
  6. ncbi request reprint Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis
    Philip D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, United Kingdom
    N Engl J Med 357:28-38. 2007
    ..A recent meta-analysis raised concern regarding an increased risk of myocardial infarction and death from cardiovascular causes associated with rosiglitazone treatment of type 2 diabetes...
  7. pmc A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes
    P D Home
    School of Medical Sciences Diabetes, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 24:618-25. 2007
    ..To compare the efficacy and safety of either continuing or discontinuing rosiglitazone + metformin fixed-dose combination when starting insulin therapy in people with Type 2 diabetes inadequately controlled on oral therapy...
  8. ncbi request reprint Hepatic dysfunction and insulin insensitivity in type 2 diabetes mellitus: a critical target for insulin-sensitizing agents
    P D Home
    School of Clinical Medical Sciences Diabetes, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetes Obes Metab 10:699-718. 2008
    ....
  9. doi request reprint An observational non-interventional study of people with diabetes beginning or changed to insulin analogue therapy in non-Western countries: the A1chieve study
    Philip Home
    Institute of Cellular Medicine Diabetes, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Res Clin Pract 94:352-63. 2011
    ..The aim of A(1)chieve was to remedy the deficit of data on the efficacy and safety of insulin analogues in routine clinical care in less well-resourced/newly developed countries...
  10. doi request reprint Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    Philip D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, UK
    Lancet 373:2125-35. 2009
    ..We assessed cardiovascular outcomes after addition of rosiglitazone to either metformin or sulfonylurea compared with the combination of the two over 5-7 years of follow-up. We also assessed comparative safety...
  11. pmc Combined randomised controlled trial experience of malignancies in studies using insulin glargine
    P D Home
    ICM Diabetes, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 52:2499-506. 2009
    ..The aim of the present study was investigate this possible relationship using data from the manufacturer's (sanofi-aventis) pharmacovigilance database...
  12. pmc Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials
    P D Home
    ICM Diabetes, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Diabetologia 53:1838-45. 2010
    ....
  13. doi request reprint Meta-analysis of individual patient data to assess the risk of hypoglycaemia in people with type 2 diabetes using NPH insulin or insulin glargine
    P D Home
    Institute of Cellular Medicine Diabetes, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Obes Metab 12:772-9. 2010
    ..To estimate absolute and relative incidence rates of hypoglycaemia when using once-daily evening or morning regimens of insulin glargine (glargine) versus once-daily evening NPH insulin (NPH) using individual patient data (IPD)...
  14. ncbi request reprint Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD): study design and protocol
    P D Home
    School of Clinical Medical Sciences Diabetes, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 48:1726-35. 2005
    ....
  15. ncbi request reprint A randomized multicentre trial of insulin glargine compared with NPH insulin in people with type 1 diabetes
    P D Home
    Newcastle Diabetes Centre and University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetes Metab Res Rev 21:545-53. 2005
    ..To compare insulin glargine with NPH human insulin for basal insulin supply in adults with type 1 diabetes...
  16. ncbi request reprint Contributions of basal and post-prandial hyperglycaemia to micro- and macrovascular complications in people with type 2 diabetes
    Philip Home
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Curr Med Res Opin 21:989-98. 2005
    ..Moreover, emerging evidence suggests that reducing meal-time hyperglycaemia may delay the progression from pre-diabetic states toward overt diabetes...
  17. ncbi request reprint Insulin aspart vs. human insulin in the management of long-term blood glucose control in Type 1 diabetes mellitus: a randomized controlled trial
    P D Home
    Human Diabetes and Metabolism Research Centre, University of Newcastle upon Tyne, UK
    Diabet Med 17:762-70. 2000
    ..To compare the efficacy of insulin aspart, a rapid-acting insulin analogue, with that of unmodified human insulin on long-term blood glucose control in Type 1 diabetes mellitus...
  18. ncbi request reprint Considerations on blood glucose management in Type 2 diabetes mellitus
    Philip Home
    University of Newcastle upon Tyne, UK
    Diabetes Metab Res Rev 18:273-85. 2002
    ..Serial measurements should be made and, where possible, the use of blood glucose meters encouraged, in order to obtain a blood glucose profile for the patient...
  19. ncbi request reprint Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trial
    Philip Home
    Department of Diabetes and Metabolism, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetes Care 27:1081-7. 2004
    ..Accordingly, insulin detemir has been compared with NPH insulin with respect to glycemic control (HbA1c, prebreakfast glucose levels and variability, and hypoglycemia) and timing of administration...
  20. ncbi request reprint Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers
    P D Home
    Human Diabetes and Metabolism Research Centre, The Medical School, Newcastle upon Tyne, UK
    Eur J Clin Pharmacol 55:199-203. 1999
    ..The pharmacokinetics of a new insulin analogue, insulin aspart, were compared with unmodified human insulin in a double-blind crossover study of 25 fasting healthy men following a single subcutaneous dose...
  21. ncbi request reprint Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspart Study Group
    P D Home
    Human Diabetes and Metabolism Research Centre, University of Newcastle upon Tyne, UK
    Diabetes Care 21:1904-9. 1998
    ..To compare glycemic control obtained with the new rapid-acting insulin analog insulin aspart with that obtained with unmodified human insulin using algorithm-driven dosage adjustment...
  22. doi request reprint Treatment satisfaction and quality of life with insulin glargine plus insulin lispro compared with NPH insulin plus unmodified human insulin in individuals with type 1 diabetes
    Simon G Ashwell
    Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 31:1112-7. 2008
    ....
  23. ncbi request reprint Improved glycaemic control with insulin glargine plus insulin lispro: a multicentre, randomized, cross-over trial in people with Type 1 diabetes
    S G Ashwell
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabet Med 23:285-92. 2006
    ..To compare blood glucose control using insulin glargine + insulin lispro with that on NPH insulin + unmodified human insulin in adults with Type 1 diabetes managed with a multiple injection regimen...
  24. ncbi request reprint Optimal timing of injection of once-daily insulin glargine in people with Type 1 diabetes using insulin lispro at meal-times
    S G Ashwell
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabet Med 23:46-52. 2006
    ..To compare blood glucose control when insulin glargine is given at lunch-time, dinner-time, and bed-time in people with Type 1 diabetes using insulin lispro at meal-times...
  25. pmc Rosiglitazone RECORD study: glucose control outcomes at 18 months
    P D Home
    Newcastle Diabetes Centre and Newcastle University, UK
    Diabet Med 24:626-34. 2007
    ..To compare glucose control over 18 months between rosiglitazone oral combination therapy and combination metformin and sulphonylurea in people with Type 2 diabetes...
  26. ncbi request reprint The effect of improved post-prandial blood glucose control on post-prandial metabolism and markers of vascular risk in people with Type 2 diabetes
    A Gallagher
    School of Clinical Medical Sciences, Floor 4, William Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Diabetes Res Clin Pract 67:196-203. 2005
    ..Insulin aspart resulted in improved post-prandial glycaemic control when compared to human insulin in Type 2 diabetic patients, but this was not associated with changes in markers of vascular risk...
  27. ncbi request reprint Insulin glargine in combination with nateglinide in people with Type 2 diabetes: a randomized placebo-controlled trial
    U K Dashora
    School of Clinical Medical Sciences Diabetes, University of Newcastle upon Tyne, UK
    Diabet Med 24:344-9. 2007
    ..To determine the effect of adding nateglinide to therapy with insulin glargine in adults with Type 2 diabetes previously treated with insulin and with poor blood glucose control...
  28. doi request reprint An exploratory study of the effect of using high-mix biphasic insulin aspart in people with type 2 diabetes
    U Dashora
    Institute of Cellular Medicine Diabetes, Newcastle University, UK
    Diabetes Obes Metab 11:680-7. 2009
    ....
  29. doi request reprint Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins
    V Arutchelvam
    School of Clinical Medical Sciences Diabetes, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Diabet Med 26:1027-32. 2009
    ..The aim of this study was to compare the effects of exercise on plasma glucose excursions when using each of three basal insulins in people with Type 1 diabetes...
  30. ncbi request reprint Twice-daily compared with once-daily insulin glargine in people with Type 1 diabetes using meal-time insulin aspart
    S G Ashwell
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabet Med 23:879-86. 2006
    ..To compare blood glucose control when using insulin glargine twice daily at breakfast- and dinner-times with insulin glargine once daily at dinner time, in unselected people with Type 1 diabetes using insulin aspart at meal-times...
  31. ncbi request reprint The effect of the optimal use of rapid-acting insulin analogues on insulin secretion in Type 2 diabetes
    A Gallagher
    School of Clinical Medical Sciences, The Medical School, Framlington Place, Newcastle upon Tyne, UK
    Diabetes Res Clin Pract 76:327-34. 2007
    ....
  32. ncbi request reprint Rapid-acting insulin secretagogues: a clinical need?
    P D Home
    Newcastle Diabetes Centre, University of Newcastle upon Tyne, UK
    Exp Clin Endocrinol Diabetes 107:S115-9. 1999
    ..Evidently, this can be usefully combined with other pharmacological approaches (insulin sensitizers or basal insulin). The need for combination therapy is increasingly likely as the defect in insulin secretion progresses...
  33. pmc The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease
    Latika Sibal
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Curr Cardiol Rev 6:82-90. 2010
    ..Interventions such as treatment with L-arginine have been shown to improve endothelium-mediated vasodilatation in people with high ADMA levels. However the clinical utility of modifying circulating ADMA levels remains uncertain...
  34. pmc A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria
    Latika Sibal
    Newcastle University, Newcastle upon Tyne, UK
    Cardiovasc Diabetol 8:27. 2009
    ..The aim of the present study was to measure circulating ADMA, and define its association with endothelial dysfunction and endothelial markers in people with Type 1 diabetes with low likelihood of macrovascular disease...
  35. ncbi request reprint Therapeutic targets in the management of Type 1 diabetes
    P D Home
    Human Metabolism and Diabetes Research Centre, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetes Metab Res Rev 18:S7-13. 2002
    ..In many people with type 1 diabetes targets for blood pressure, LDL cholesterol, and serum triglycerides will also be appropriate, and need to be part of any protocol of management...
  36. doi request reprint Impact of the UKPDS--an overview
    P D Home
    Newcastle University and Newcastle Diabetes Centre, SCMS Diabetes, The Medical School, Newcastle upon Tyne, UK
    Diabet Med 25:2-8. 2008
    ..By inference it must be responsible for a significant part of the improvement in health outcomes in people with Type 2 diabetes over the last decade...
  37. ncbi request reprint An overview of insulin glargine
    Philip D Home
    Department of Diabetes and Metabolism, University of Newcastle upon Tyne, UK
    Diabetes Metab Res Rev 18:S57-63. 2002
    ..Thus, insulin glargine represents the first major advance in the provision of basal insulin injection therapy for people with type 1 and type 2 diabetes for over 50 years...
  38. ncbi request reprint Insulin glargine: the first clinically useful extended-action insulin analogue
    S G Ashwell
    Department of Diabetes and Metabolism, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Expert Opin Pharmacother 2:1891-902. 2001
    ..The use of insulin glargine with a rapid-acting insulin analogue brings us the closest we have ever been to providing the physiological insulin replacement that has long been awaited...
  39. doi request reprint Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria
    L Sibal
    ICM Diabetes, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Diabetologia 52:1464-73. 2009
    ..The hypothesis tested was that circulating EPCs are reduced in young people with type 1 diabetes without vascular injury and that this is associated with impaired endothelial function and increased carotid intima-media thickness (CIMT)...
  40. ncbi request reprint Immune responses to insulin aspart and biphasic insulin aspart in people with type 1 and type 2 diabetes
    Anders Lindholm
    Novo Nordisk, Bagsvaerd, Denmark
    Diabetes Care 25:876-82. 2002
    ....
  41. ncbi request reprint Standardization of glycated haemoglobin
    Sally M Marshall
    Ann Clin Biochem 39:78-9. 2002
  42. ncbi request reprint A model of long-term metabolic progression of type 2 diabetes mellitus for evaluating treatment strategies
    Adrian Bagust
    University of Liverpool Management School, UK
    Pharmacoeconomics 24:5-19. 2006
    ....
  43. ncbi request reprint Guidelines for the treatment and management of new-onset diabetes after transplantation
    Alan Wilkinson
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Clin Transplant 19:291-8. 2005
    ....