Rig Holt

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. doi request reprint Key concepts in screening for depression in people with diabetes
    Richard I G Holt
    Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK
    J Affect Disord 142:S72-9. 2012
  2. doi request reprint Medical causes and consequences of hyperprolactinaemia. A context for psychiatrists
    Richard I G Holt
    Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease, School of Medicine, University of Southampton, Southampton, UK
    J Psychopharmacol 22:28-37. 2008
  3. ncbi request reprint Obesity - an epidemic of the twenty-first century: an update for psychiatrists
    Richard I G Holt
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    J Psychopharmacol 19:6-15. 2005
  4. ncbi request reprint Diabetes and schizophrenia 2005: are we any closer to understanding the link?
    Richard I G Holt
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    J Psychopharmacol 19:56-65. 2005
  5. ncbi request reprint Association between antipsychotic drugs and diabetes
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetes Obes Metab 8:125-35. 2006
  6. ncbi request reprint The prevalence of undiagnosed metabolic abnormalities in people with serious mental illness
    R I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Disease Division, University of Southampton, Southampton, UK
    J Psychopharmacol 24:867-73. 2010
  7. ncbi request reprint Antipsychotic drugs and diabetes--an application of the Austin Bradford Hill criteria
    R I G Holt
    Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetologia 49:1467-76. 2006
  8. ncbi request reprint The effectiveness of glibenclamide in women with gestational diabetes
    R I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Diabetes Obes Metab 10:906-11. 2008
  9. doi request reprint Obesity, serious mental illness and antipsychotic drugs
    Richard I G Holt
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, DS Building MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Diabetes Obes Metab 11:665-79. 2009
  10. doi request reprint Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, University of Southampton School of Medicine, Southampton, UK
    Clin Endocrinol (Oxf) 74:141-7. 2011

Collaborators

Detail Information

Publications46

  1. doi request reprint Key concepts in screening for depression in people with diabetes
    Richard I G Holt
    Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK
    J Affect Disord 142:S72-9. 2012
    ..The aim of this review is to assess the justification for screening for depression in people with diabetes...
  2. doi request reprint Medical causes and consequences of hyperprolactinaemia. A context for psychiatrists
    Richard I G Holt
    Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease, School of Medicine, University of Southampton, Southampton, UK
    J Psychopharmacol 22:28-37. 2008
    ..The causes, consequences and management of hyperprolactinaemia are discussed in this article...
  3. ncbi request reprint Obesity - an epidemic of the twenty-first century: an update for psychiatrists
    Richard I G Holt
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    J Psychopharmacol 19:6-15. 2005
    ..While the current trends in obesity are depressing, a better understanding of the pathophysiology and treatment of the condition should allow the clinician to be more optimistic for the future...
  4. ncbi request reprint Diabetes and schizophrenia 2005: are we any closer to understanding the link?
    Richard I G Holt
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    J Psychopharmacol 19:56-65. 2005
    ..Traditional risk factors most probably account for much of the diabetes seen in schizophrenia populations, suggesting that routine screening and aggressive risk factor management are especially important in this patient group...
  5. ncbi request reprint Association between antipsychotic drugs and diabetes
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetes Obes Metab 8:125-35. 2006
    ..The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia...
  6. ncbi request reprint The prevalence of undiagnosed metabolic abnormalities in people with serious mental illness
    R I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Disease Division, University of Southampton, Southampton, UK
    J Psychopharmacol 24:867-73. 2010
    ..Improved screening of metabolic complications should lead to better identification and treatment of this clinical problem...
  7. ncbi request reprint Antipsychotic drugs and diabetes--an application of the Austin Bradford Hill criteria
    R I G Holt
    Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetologia 49:1467-76. 2006
    ..Consequently, the majority of patients receiving second-generation antipsychotics will not develop diabetes as a result of their medication...
  8. ncbi request reprint The effectiveness of glibenclamide in women with gestational diabetes
    R I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Diabetes Obes Metab 10:906-11. 2008
    ..The aim of our study was to assess effectiveness and safety of glibenclamide for GDM in UK clinical practice...
  9. doi request reprint Obesity, serious mental illness and antipsychotic drugs
    Richard I G Holt
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, DS Building MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Diabetes Obes Metab 11:665-79. 2009
    ..The complexity of the system regulating body weight allows us to start to understand why some individuals appear much more prone to weight gain and obesity than others...
  10. doi request reprint Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, University of Southampton School of Medicine, Southampton, UK
    Clin Endocrinol (Oxf) 74:141-7. 2011
    ..Tertiary prevention of complications should also be considered...
  11. doi request reprint Bromocriptine: old drug, new formulation and new indication
    R I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, University of Southampton School of Medicine, Southampton, UK
    Diabetes Obes Metab 12:1048-57. 2010
    ..Thus, a QR formulation of bromocriptine timed for peak delivery in the early morning may provide a novel neurally mediated approach to the control of hyperglycaemia in T2DM...
  12. ncbi request reprint Intrauterine growth, the vascular system, and the metabolic syndrome
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton, England
    Semin Vasc Med 2:33-43. 2002
    ..We will also discuss mechanisms that might explain these associations...
  13. ncbi request reprint Computer assisted learning is an effective way of teaching endocrinology
    R I Holt
    Department of Medicine, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, Lambeth Palace Road, London, UK
    Clin Endocrinol (Oxf) 55:537-42. 2001
    ..Computers are a part of everyday life and offer an exciting way of learning. The aim of our study was to determine the effectiveness of teaching undergraduate endocrinology using a Computer Assisted Learning (CAL) programme...
  14. ncbi request reprint Schizophrenia, the metabolic syndrome and diabetes
    R I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Diabet Med 21:515-23. 2004
    ..The increased prevalence of diabetes among people with schizophrenia has implications for the delivery of care by psychiatrists, diabetologists and primary care...
  15. ncbi request reprint A postnatal fasting plasma glucose is useful in determining which women with gestational diabetes should undergo a postnatal oral glucose tolerance test
    R I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, University of Southampton, Southampton, UK
    Diabet Med 20:594-8. 2003
    ..As this test may be unpleasant, time-consuming and has resource implications, we evaluated whether the 6-week postnatal fasting glucose could be used to determine which women should undergo an OGTT...
  16. ncbi request reprint The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis
    R I G Holt
    Endocrinology Sub Division, Fetal Origins of Adult Disease Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Diabet Med 20:3-15. 2003
    ..IGF-I 'replacement' in diabetes is under investigation and new methods of delivering IGF-I as a complex with IGFBP-3 offer exciting new prospects...
  17. ncbi request reprint Fetal programming of the growth hormone-insulin-like growth factor axis
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, Southampton University, South Academic Block Level D MP811, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:392-7. 2002
    ..Finally, there are data from both animals and humans suggesting that programming of the GH-IGF axis might exist...
  18. ncbi request reprint Aging and physical fitness are more important than obesity in determining exercise-induced generation of GH
    R I Holt
    Department of Medicine, Guy s, King s, and St Thomas School of Medicine, St Thomas Hospital, London, United Kingdom SE1 7EH
    J Clin Endocrinol Metab 86:5715-20. 2001
    ..Age and physical fitness are more important than body fat in regulating exercise-induced GH secretion. These findings have important clinical implications if we are to prevent the frailty and morbidity associated with aging...
  19. ncbi request reprint Diagnosis, epidemiology and pathogenesis of diabetes mellitus: an update for psychiatrists
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, University of Southampton, Level F MP113 Centre Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Psychiatry Suppl 47:S55-63. 2004
    ..Diabetes mellitus is a complex metabolic disorder characterised by persistent hyperglycaemia. The prevalence of diabetes is increased in people with schizophrenia...
  20. doi request reprint The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study
    R I G Holt
    The Institute of Developmental Sciences IDS Building, MP887, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Diabet Med 26:641-8. 2009
    ..To assess the relationship between depression scores and diabetes, glucose and insulin in a cross-sectional population-based study...
  21. pmc Growth hormone, IGF-I and insulin and their abuse in sport
    R I G Holt
    School of Medicine, University of Southampton, Southampton, UK
    Br J Pharmacol 154:542-56. 2008
    ..Testing for IGF-I and insulin is in its infancy, but the measurement of markers of GH action may also detect IGF-I usage, while urine mass spectroscopy has begun to identify the use of insulin analogues...
  22. ncbi request reprint Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts
    R I G Holt
    Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Acta Physiol Scand 180:359-66. 2004
    ..Fetal programming of the growth hormone-insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings...
  23. ncbi request reprint Electrical muscle stimulation acutely mimics exercise in neurologically intact individuals but has limited clinical benefits in patients with type 2 diabetes
    R B Poole
    Endocrinology and Metabolism Unit, Development Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetes Obes Metab 7:344-51. 2005
    ..Physical activity improves features of the metabolic syndrome in patients with type 2 diabetes but many patients find it difficult to exercise...
  24. ncbi request reprint Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity
    H B Holt
    Endocrinology and Metabolism, DOHaD Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetologia 50:1698-706. 2007
    ..The aim of this study was to determine whether fitness and PAEE are associated with whole-body, liver and fat insulin sensitivity independently of body fat...
  25. ncbi request reprint Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD)
    M B R Patel
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 37:833-41. 2005
    ..Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to support these hypotheses...
  26. ncbi request reprint Association of British Clinical Diabetologists (ABCD) and Diabetes-UK survey of specialist diabetes services in the UK, 2006. 1. The consultant physician perspective
    P H Winocour
    Diabetes UK, London, UK
    Diabet Med 25:643-50. 2008
    ..To identify the views and working practices of consultant diabetologists in the UK in 2006-2007, the current provision of specialist services, and to examine changes since 2000...
  27. ncbi request reprint Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects
    H B Holt
    Developmental Origins of Health and Disease Division Endocrinology and Metabolism Unit, Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Diabetologia 49:141-8. 2006
    ..We tested the hypothesis that NEFA concentrations are higher in obese subjects with fatty liver than in obese subjects without fatty liver...
  28. doi request reprint Understanding osteoporosis
    M Kassim Javaid
    MRC Epidemiology Resource Centre, Development Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    J Psychopharmacol 22:38-45. 2008
    ..Therapies should begin with lifestyle measures, such as physical activity and dietary supplementation, with the use of bone-specific agents reserved for those at high absolute risk...
  29. doi request reprint Commentary on Graham et al.: physical effects of short-term rhGH administration in abstinent steroid dependency
    Peter H Sonksen
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK phsonksen aol com
    Horm Res 69:355-6. 2008
  30. doi request reprint The effect of sports injury on insulin-like growth factor-I and type 3 procollagen: implications for detection of growth hormone abuse in athletes
    Ioulietta Erotokritou-Mulligan
    The Institute of Developmental Sciences IDS Building, MP887, University of Southampton, Southampton General Hospital, Tremona Road, Southampton United Kingdom
    J Clin Endocrinol Metab 93:2760-3. 2008
    ..Skeletal or soft tissue injury may alter these markers. Elevations in either of these proteins after injury might lead to a false accusation of doping with GH...
  31. ncbi request reprint Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
    ..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis...
  32. ncbi request reprint Risk of treatment-emergent diabetes mellitus in patients receiving antipsychotics
    Leslie L Citrome
    Department of Psychiatry, School of Medicine, New York University, New York, NY, USA
    Ann Pharmacother 41:1593-603. 2007
    ..Type 2 diabetes mellitus has been reported during antipsychotic treatment...
  33. ncbi request reprint Challenges in detecting the abuse of growth hormone in sport
    Cathy M McHugh
    Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, School of Medicine, University of Southampton, Southampton, United Kingdom
    Clin Chem 51:1587-93. 2005
    ..The purpose of this review is to discuss the methodologies being developed to detect GH abuse...
  34. ncbi request reprint Beyond reasonable doubt: catching the growth hormone cheats
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, UK
    Pediatr Endocrinol Rev 4:228-32. 2007
    ..As a result GH abuse can be detected with reasonable sensitivity and specificity...
  35. doi request reprint Antipsychotics and hyperprolactinaemia: clinical recommendations
    Robert C Peveler
    University of Southampton, Royal South Hants Hospital, Southampton, UK
    J Psychopharmacol 22:98-103. 2008
    ..We hope it will add to the debate about this topic...
  36. ncbi request reprint Exercising in the cold inhibits growth hormone secretion by reducing the rise in core body temperature
    Adam Wheldon
    Department of Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 7EH, UK
    Growth Horm IGF Res 16:125-31. 2006
    ..It is unknown whether temperature affects GH secretion at exercise intensities above the anaerobic threshold when other factors may override the relationship seen at lower intensities...
  37. ncbi request reprint Alternative site self blood glucose testing is preferred by women with gestational diabetes
    Penny Clarke
    Department of Fetal Maternal Medicine, Princess Anne Hospital, Southampton, United Kingdom
    Diabetes Technol Ther 7:604-8. 2005
    ..The Softsense meter (MediSense Products, Witney, UK) is used on less sensitive body sites and combines lancing with testing. The study aim was to compare alternative site testing with traditional blood glucose monitoring in pregnancy...
  38. ncbi request reprint International Diabetes Federation re-defines the metabolic syndrome
    Richard I G Holt
    Diabetes Obes Metab 7:618-20. 2005
  39. ncbi request reprint The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes: response to Kahn et al
    Leslie Citrome
    Diabetes Care 29:176; author reply 177-8. 2006
  40. ncbi request reprint Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men
    Junlong Zhang
    Diabetes Care 28:755-6. 2005
  41. doi request reprint The effect of sulphonylureas on the microvascular and macrovascular complications of diabetes
    Partha Kar
    Development Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Cardiovasc Drugs Ther 22:207-13. 2008
    ....
  42. ncbi request reprint Which statin?
    Richard I G Holt
    University of Southampton, UK
    Diabetes Obes Metab 6:395-6. 2004
  43. ncbi request reprint Consensus development conference on antipsychotic drugs and obesity and diabetes: response to consensus statement
    Richard I G Holt
    Diabetes Care 27:2086-7; author reply 2089-90. 2004
  44. pmc A case of leg pain and weakness in a man with diabetes
    Ruth B Poole
    Royal Hampshire County Hospital, Winchester, UK
    J Clin Pathol 60:938-9. 2007
  45. ncbi request reprint Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets
    Ioulietta Erotokritou-Mulligan
    Endocrinology and Metabolism Sub Division, School of Medicine, University of Southampton, IDS Building MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Growth Horm IGF Res 17:416-23. 2007
    ..The measurement of multiple markers in conjunction with discriminant functions can improve the sensitivity and specificity of detection compared with single marker analysis...
  46. ncbi request reprint The current and future roles of the consultant diabetologist
    Richard I G Holt
    Diabet Med 24:929-30. 2007