Research Topics
| Rig HoltSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Key concepts in screening for depression in people with diabetesRichard I G Holt
Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK Electronic address
J Affect Disord 142:S72-9. 2012..The aim of this review is to assess the justification for screening for depression in people with diabetes...- Medical causes and consequences of hyperprolactinaemia. A context for psychiatristsRichard I G Holt
Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease, School of Medicine, University of Southampton, Southampton, UK
J Psychopharmacol 22:28-37. 2008..The causes, consequences and management of hyperprolactinaemia are discussed in this article... 
Obesity - an epidemic of the twenty-first century: an update for psychiatristsRichard I G Holt
Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
J Psychopharmacol 19:6-15. 2005..While the current trends in obesity are depressing, a better understanding of the pathophysiology and treatment of the condition should allow the clinician to be more optimistic for the future...- Diabetes and schizophrenia 2005: are we any closer to understanding the link?Richard I G Holt
Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
J Psychopharmacol 19:56-65. 2005..Traditional risk factors most probably account for much of the diabetes seen in schizophrenia populations, suggesting that routine screening and aggressive risk factor management are especially important in this patient group... - Association between antipsychotic drugs and diabetesRichard I G Holt
Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
Diabetes Obes Metab 8:125-35. 2006..The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia... - The prevalence of undiagnosed metabolic abnormalities in people with serious mental illnessR I G Holt
Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Disease Division, University of Southampton, Southampton, UK
J Psychopharmacol 24:867-73. 2010..Improved screening of metabolic complications should lead to better identification and treatment of this clinical problem... - Antipsychotic drugs and diabetes--an application of the Austin Bradford Hill criteriaR I G Holt
Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
Diabetologia 49:1467-76. 2006..Consequently, the majority of patients receiving second-generation antipsychotics will not develop diabetes as a result of their medication... - The effectiveness of glibenclamide in women with gestational diabetesR I G Holt
Endocrinology and Metabolism Sub Division, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
Diabetes Obes Metab 10:906-11. 2008..The aim of our study was to assess effectiveness and safety of glibenclamide for GDM in UK clinical practice... - Obesity, serious mental illness and antipsychotic drugsRichard I G Holt
Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, DS Building MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Diabetes Obes Metab 11:665-79. 2009..The complexity of the system regulating body weight allows us to start to understand why some individuals appear much more prone to weight gain and obesity than others... - Antipsychotics and hyperprolactinaemia: mechanisms, consequences and managementRichard I G Holt
Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, University of Southampton School of Medicine, Southampton, UK
Clin Endocrinol (Oxf) 74:141-7. 2011..Tertiary prevention of complications should also be considered... - Bromocriptine: old drug, new formulation and new indicationR I G Holt
Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, University of Southampton School of Medicine, Southampton, UK
Diabetes Obes Metab 12:1048-57. 2010..Thus, a QR formulation of bromocriptine timed for peak delivery in the early morning may provide a novel neurally mediated approach to the control of hyperglycaemia in T2DM... - Intrauterine growth, the vascular system, and the metabolic syndromeRichard I G Holt
Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton, England
Semin Vasc Med 2:33-43. 2002..We will also discuss mechanisms that might explain these associations... - Computer assisted learning is an effective way of teaching endocrinologyR I Holt
Department of Medicine, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, Lambeth Palace Road, London, UK
Clin Endocrinol (Oxf) 55:537-42. 2001..Computers are a part of everyday life and offer an exciting way of learning. The aim of our study was to determine the effectiveness of teaching undergraduate endocrinology using a Computer Assisted Learning (CAL) programme... - Schizophrenia, the metabolic syndrome and diabetesR I G Holt
Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
Diabet Med 21:515-23. 2004..The increased prevalence of diabetes among people with schizophrenia has implications for the delivery of care by psychiatrists, diabetologists and primary care... - A postnatal fasting plasma glucose is useful in determining which women with gestational diabetes should undergo a postnatal oral glucose tolerance testR I G Holt
Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, University of Southampton, Southampton, UK
Diabet Med 20:594-8. 2003..As this test may be unpleasant, time-consuming and has resource implications, we evaluated whether the 6-week postnatal fasting glucose could be used to determine which women should undergo an OGTT... - The role of the growth hormone-insulin-like growth factor axis in glucose homeostasisR I G Holt
Endocrinology Sub Division, Fetal Origins of Adult Disease Division, University of Southampton, Southampton General Hospital, Southampton, UK
Diabet Med 20:3-15. 2003..IGF-I 'replacement' in diabetes is under investigation and new methods of delivering IGF-I as a complex with IGFBP-3 offer exciting new prospects... - Fetal programming of the growth hormone-insulin-like growth factor axisRichard I G Holt
Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, Southampton University, South Academic Block Level D MP811, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK
Trends Endocrinol Metab 13:392-7. 2002..Finally, there are data from both animals and humans suggesting that programming of the GH-IGF axis might exist... - Aging and physical fitness are more important than obesity in determining exercise-induced generation of GHR I Holt
Department of Medicine, Guy s, King s, and St Thomas School of Medicine, St Thomas Hospital, London, United Kingdom SE1 7EH
J Clin Endocrinol Metab 86:5715-20. 2001..Age and physical fitness are more important than body fat in regulating exercise-induced GH secretion. These findings have important clinical implications if we are to prevent the frailty and morbidity associated with aging... - Diagnosis, epidemiology and pathogenesis of diabetes mellitus: an update for psychiatristsRichard I G Holt
Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, University of Southampton, Level F MP113 Centre Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Br J Psychiatry Suppl 47:S55-63. 2004..Diabetes mellitus is a complex metabolic disorder characterised by persistent hyperglycaemia. The prevalence of diabetes is increased in people with schizophrenia... - The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort StudyR I G Holt
The Institute of Developmental Sciences IDS Building, MP887, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Diabet Med 26:641-8. 2009..To assess the relationship between depression scores and diabetes, glucose and insulin in a cross-sectional population-based study... 
Growth hormone, IGF-I and insulin and their abuse in sportR I G Holt
School of Medicine, University of Southampton, Southampton, UK
Br J Pharmacol 154:542-56. 2008..Testing for IGF-I and insulin is in its infancy, but the measurement of markers of GH action may also detect IGF-I usage, while urine mass spectroscopy has begun to identify the use of insulin analogues...- Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohortsR I G Holt
Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
Acta Physiol Scand 180:359-66. 2004..CONCLUSION: In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age... - Electrical muscle stimulation acutely mimics exercise in neurologically intact individuals but has limited clinical benefits in patients with type 2 diabetesR B Poole
Endocrinology and Metabolism Unit, Development Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
Diabetes Obes Metab 7:344-51. 2005..CONCLUSION: Although the muscle stimulator acutely mimics exercise, limitations in the size of the stimulating current mean that the magnitude of these changes is too small to produce clinical benefit... - Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivityH B Holt
Endocrinology and Metabolism, DOHaD Division, School of Medicine, University of Southampton, Southampton, UK
Diabetologia 50:1698-706. 2007..The aim of this study was to determine whether fitness and PAEE are associated with whole-body, liver and fat insulin sensitivity independently of body fat... - Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD)M B R Patel
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
Bone 37:833-41. 2005..CONCLUSIONS: Men with reduced BMD have low IGF-I but normal GH secretion and reserve. Our data suggested, but could not confirm, hepatic resistance to GH as a mechanism for this association... - Association of British Clinical Diabetologists (ABCD) and Diabetes-UK survey of specialist diabetes services in the UK, 2006. 1. The consultant physician perspectiveP H Winocour
Diabetes UK, London, UK
Diabet Med 25:643-50. 2008..To identify the views and working practices of consultant diabetologists in the UK in 2006-2007, the current provision of specialist services, and to examine changes since 2000... - Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjectsH B Holt
Developmental Origins of Health and Disease Division Endocrinology and Metabolism Unit, Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
Diabetologia 49:141-8. 2006..The contribution to this association by factors regulating NEFA concentrations requires further study... - Understanding osteoporosisM Kassim Javaid
MRC Epidemiology Resource Centre, Development Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
J Psychopharmacol 22:38-45. 2008..Therapies should begin with lifestyle measures, such as physical activity and dietary supplementation, with the use of bone-specific agents reserved for those at high absolute risk... - Commentary on Graham et al.: physical effects of short-term rhGH administration in abstinent steroid dependencyPeter H Sonksen
Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK. phsonksen @aol.com
Horm Res 69:355-6. 2008 - The effect of sports injury on insulin-like growth factor-I and type 3 procollagen: implications for detection of growth hormone abuse in athletesIoulietta Erotokritou-Mulligan
The Institute of Developmental Sciences IDS Building, MP887, University of Southampton, Southampton General Hospital, Tremona Road, Southampton United Kingdom
J Clin Endocrinol Metab 93:2760-3. 2008..Skeletal or soft tissue injury may alter these markers. Elevations in either of these proteins after injury might lead to a false accusation of doping with GH... - Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growthEero Kajantie
Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
J Clin Endocrinol Metab 88:1059-65. 2003..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis... - Risk of treatment-emergent diabetes mellitus in patients receiving antipsychoticsLeslie L Citrome
Department of Psychiatry, School of Medicine, New York University, New York, NY, USA
Ann Pharmacother 41:1593-603. 2007..Type 2 diabetes mellitus has been reported during antipsychotic treatment... - Challenges in detecting the abuse of growth hormone in sportCathy M McHugh
Endocrinology and Metabolism Sub Division, Developmental Origins of Adult Health and Disease Division, School of Medicine, University of Southampton, Southampton, United Kingdom
Clin Chem 51:1587-93. 2005..The purpose of this review is to discuss the methodologies being developed to detect GH abuse... - Beyond reasonable doubt: catching the growth hormone cheatsRichard I G Holt
Endocrinology and Metabolism Sub Division, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, UK
Pediatr Endocrinol Rev 4:228-32. 2007..As a result GH abuse can be detected with reasonable sensitivity and specificity... - Antipsychotics and hyperprolactinaemia: clinical recommendationsRobert C Peveler
University of Southampton, Royal South Hants Hospital, Southampton, UK
J Psychopharmacol 22:98-103. 2008..We hope it will add to the debate about this topic... - Exercising in the cold inhibits growth hormone secretion by reducing the rise in core body temperatureAdam Wheldon
Department of Medicine, Guy's, King's and St Thomas' School of Medicine, King's College London, London SE1 7EH, UK
Growth Horm IGF Res 16:125-31. 2006..A change in core body temperature may be one mechanism by which exercise induces GH secretion. The difference in GH between swimmers and rowers during their respective events relates to the conditions under which they compete... - Alternative site self blood glucose testing is preferred by women with gestational diabetesPenny Clarke
Department of Fetal-Maternal Medicine, Princess Anne Hospital, Southampton, United Kingdom
Diabetes Technol Ther 7:604-8. 2005..CONCLUSIONS: Women with GDM preferred the Softsense meter because of its ease of use and painlessness. Women with pre-existing diabetes found this meter less convenient, primarily because of its bulkiness... - International Diabetes Federation re-defines the metabolic syndromeRichard I G Holt
Diabetes Obes Metab 7:618-20. 2005 - The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes: response to Kahn et alLeslie Citrome
Diabetes Care 29:176; author reply 177-8. 2006 - Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in menJunlong Zhang
Diabetes Care 28:755-6. 2005 - The effect of sulphonylureas on the microvascular and macrovascular complications of diabetesPartha Kar
Development Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
Cardiovasc Drugs Ther 22:207-13. 2008.... - Which statin?Richard I G Holt
University of Southampton, UK
Diabetes Obes Metab 6:395-6. 2004 - Consensus development conference on antipsychotic drugs and obesity and diabetes: response to consensus statementRichard I G Holt
Diabetes Care 27:2086-7; author reply 2089-90. 2004 - A case of leg pain and weakness in a man with diabetesRuth B Poole
Royal Hampshire County Hospital, Winchester, UK
J Clin Pathol 60:938-9. 2007 - Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data setsIoulietta Erotokritou Mulligan
Endocrinology and Metabolism Sub Division, School of Medicine, University of Southampton, IDS Building MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
Growth Horm IGF Res 17:416-23. 2007..The measurement of multiple markers in conjunction with discriminant functions can improve the sensitivity and specificity of detection compared with single marker analysis... - The current and future roles of the consultant diabetologistRichard I G Holt
Diabet Med 24:929-30. 2007