Christian Holscher

Summary

Affiliation: University of Ulster
Country: UK

Publications

  1. pmc Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model
    Vadivel Parthsarathy
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    PLoS ONE 8:e58784. 2013
  2. pmc Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK
    Alzheimers Res Ther 5:20. 2013
  3. doi Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    CNS Drugs 26:871-82. 2012
  4. ncbi Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning
    Christian Holscher
    School of Biomed Sci, Ulster University, Coleraine, UK
    Eur J Pharmacol 561:85-90. 2007
  5. pmc Anaesthesia generates neuronal insulin resistance by inducing hypothermia
    Christian Holscher
    Biomedical Research Institute, University of Dundee, Ninewells Hospital, Dundee, Scotland, DD1 9SY, UK
    BMC Neurosci 9:100. 2008
  6. ncbi Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory
    Christian Holscher
    Department of Cognitive Neuroscience, University of Tubingen, Auf der Morgenstelle 28, Germany
    Learn Mem 12:450-5. 2005
  7. ncbi Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
    Christian Holscher
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Rev Neurosci 16:181-212. 2005
  8. ncbi Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Recent Pat CNS Drug Discov 5:109-17. 2010
  9. ncbi Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background
    Simon Gengler
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland
    Exp Brain Res 179:621-30. 2007
  10. doi Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    Talib Abbas
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Behav Brain Res 205:265-71. 2009

Collaborators

Detail Information

Publications38

  1. pmc Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model
    Vadivel Parthsarathy
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    PLoS ONE 8:e58784. 2013
    ..These results demonstrate that liraglutide, which is currently on the market as a treatment for type 2 diabetes (Victoza(TM)), increases neurogenesis, which may have beneficial effects in neurodegenerative disorders like AD...
  2. pmc Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK
    Alzheimers Res Ther 5:20. 2013
    ..CONCLUSION: The results demonstrate that D-Ala2GIP has neuroprotective properties on key hallmarks found in AD. This finding shows that novel GIP analogues have the potential as a novel therapeutic for AD...
  3. doi Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    CNS Drugs 26:871-82. 2012
    ..Therefore, GLP-1 analogues show great promise as a novel treatment for AD or other neurodegenerative conditions...
  4. ncbi Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning
    Christian Holscher
    School of Biomed Sci, Ulster University, Coleraine, UK
    Eur J Pharmacol 561:85-90. 2007
    ..These results suggest that treatment at very early stages of Alzheimer's disease could prevent later irreversible neuronal degeneration...
  5. pmc Anaesthesia generates neuronal insulin resistance by inducing hypothermia
    Christian Holscher
    Biomedical Research Institute, University of Dundee, Ninewells Hospital, Dundee, Scotland, DD1 9SY, UK
    BMC Neurosci 9:100. 2008
    ....
  6. ncbi Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory
    Christian Holscher
    Department of Cognitive Neuroscience, University of Tubingen, Auf der Morgenstelle 28, Germany
    Learn Mem 12:450-5. 2005
    ....
  7. ncbi Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
    Christian Holscher
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Rev Neurosci 16:181-212. 2005
    ..They could help to prolong the time of unimpaired cognitive abilities of people who develop AD, allowing them to lead an independent life...
  8. ncbi Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Recent Pat CNS Drug Discov 5:109-17. 2010
    ..Currently, there are three patents covering native GLP-1 and different GLP-1 analogues and one patent for the use of GIP and different GIP analogues for the treatment of neurodegenerative diseases...
  9. ncbi Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background
    Simon Gengler
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland
    Exp Brain Res 179:621-30. 2007
    ....
  10. doi Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    Talib Abbas
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Behav Brain Res 205:265-71. 2009
    ..The results shed light on the molecular processes that underlie the neuroprotective properties of GLP-1 analogues in animal models of Alzheimer's disease...
  11. doi D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    J Alzheimers Dis 35:267-83. 2013
    ..This suggests that novel GIP analogues may have beneficial effects in non-demented aged people and perhaps even in AD patients even when the disease is further progressed...
  12. doi Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice
    David Porter
    The SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    Peptides 35:1-8. 2012
    ..These data indicate that incretin metabolites do not influence locomotor activity, cognitive function and hippocampal synaptic plasticity when administered at pharmacological doses to mice fed a high-fat diet...
  13. ncbi Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory
    Christian Holscher
    Department of Cognitive Neuroscience, University of Tubingen, Auf der Morgenstelle 28, Germany
    Behav Brain Res 154:473-81. 2004
    ..The effects on WM are task-dependent and become apparent in more complex but not simple learning tasks. We discuss how mGluR7 could influence WM...
  14. doi GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, United Kingdom
    Eur J Pharmacol 587:112-7. 2008
    ..Therefore, longer-acting GLP-1 agonists show great potential as a novel treatment for preventing neurodegenerative processes in neurodegenerative disorders...
  15. ncbi Inactivation of the rat dorsal striatum impairs performance in spatial tasks and alters hippocampal theta in the freely moving rat
    Simon Gengler
    Cognitive Neuroscience, Department of Zoology, University of Tubingen, Germany
    Behav Brain Res 164:73-82. 2005
    ..While the dorsal striatum coordinates the execution of complex motor programs, the hippocampus integrates spatial and other sensory information required for the planning and execution of goal-directed movements...
  16. doi Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    Eur J Pharmacol 674:294-306. 2012
    ....
  17. doi Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    Victor A Gault
    School of Biomedical Schiences, University of Ulster, Coleraine, Northern Ireland
    J Neurophysiol 99:1590-5. 2008
    ..The use of enzyme-resistant analogues of GIP show great promise as a potential novel treatment for preventing neurodegenerative processes in AD and other related disorders...
  18. doi The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    Paula L McClean
    School of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    J Neurosci 31:6587-94. 2011
    ..Our results show that liraglutide prevents key neurodegenerative developments found in Alzheimer's disease, suggesting that GLP-1 analogs represent a novel treatment strategy for Alzheimer's disease...
  19. doi The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease
    Alison Hamilton
    School of Biomedical Science, University of Ulster, Coleraine, Northern Ireland, UK
    Brain Res 1449:83-93. 2012
    ..Therefore, therapies would have the best effects if started early, but promoting neurogenesis may act in a protective and reconstructive way even in later stages of AD...
  20. doi Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    Simon Gengler
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    Neurobiol Aging 33:265-76. 2012
    ..In 18-month-old mice, however, the number of Congo red positive dense-core amyloid plaques was reduced. Treatment with Val(8)GLP-1 might prevent or delay neurodegenerative processes...
  21. ncbi Learned association of allocentric and egocentric information in the hippocampus
    Christian Holscher
    Department of Cognitive Neuroscience, Faculty of Biology, Tubingen University, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Exp Brain Res 158:233-40. 2004
    ..It is proposed that these cells associate egocentric motor information with allocentric spatial information rather than encode episodic memory...
  22. pmc Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice
    Simon Gengler
    School of Biomed Sciences, Ulster University, Coleraine, United Kingdom
    PLoS ONE 5:e9764. 2010
    ..This model shows initial plaque formation at 2 months in the neocortex and 4 months in the hippocampus and displays beta-amyloid-associated pathologies and learning impairments...
  23. doi Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease
    Paula L McClean
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Eur J Pharmacol 630:158-62. 2010
    ..Therefore, the drug effects seen here could potentially ameliorate the impairments in neuronal communication and cognitive processes observed in Alzheimer's disease...
  24. doi Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    J Neurophysiol 105:1574-80. 2011
    ..Together the results suggest that GIP receptors play an important role in cognition, neurotransmission, and cell proliferation...
  25. ncbi Reward modulates neuronal activity in the hippocampus of the rat
    Christian Holscher
    Cognitive Neuroscience, Faculty of Biology, Tubingen University, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Behav Brain Res 142:181-91. 2003
    ..001). Since no alterations to the maze or cues have been made, we interpret the increased firing probability of neurons in baited arms compared to unbaited arms as a correlate for 'attention' or 'expectation'...
  26. ncbi Time, space and hippocampal functions
    Christian Holscher
    Department of Cognitive Neuroscience, University of Tubingen, Germany
    Rev Neurosci 14:253-84. 2003
    ..In addition, the concept of allocating specific functions (such as the development of a cognitive map) exclusively to the hippocampus is rejected...
  27. pmc A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease
    Vadivel Parthsarathy
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Londonderry, United Kingdom
    PLoS ONE 8:e54769. 2013
    ....
  28. doi Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
    David W Porter
    SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Eur J Pharmacol 650:688-93. 2011
    ....
  29. doi Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain
    Stephen F J McGovern
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Brain Res 1473:204-13. 2012
    ..The results demonstrate that (Val8)GLP-1 is safe in a range of doses, crosses the BBB and has potentially beneficial effects in the CNS by enhancing neurogenesis...
  30. doi Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Biochem Soc Trans 39:891-7. 2011
    ....
  31. doi The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain
    Vadivel Parthsarathy
    School of Biomedical Sciences, Ulster University, Cromore Road, BT52 1SA Coleraine, Northern Ireland
    Eur J Pharmacol 700:42-50. 2013
    ..Liraglutide or similar GLP-1 analogues may be a suitable treatment for reducing the chronic inflammatory response in the brain found in several neurodegenerative conditions...
  32. pmc Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    Kerry Hunter
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    BMC Neurosci 13:33. 2012
    ..Therefore, if GLP-1 analogues can cross the blood brain barrier, diffuse through the brain to reach the receptors and most importantly activate them, their neuroprotective effects may be realized...
  33. ncbi Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1
    Christian Holscher
    Department of Zoology, Cognitive Neuroscience, University of Tubingen, Auf der Morgenstelle 28, Tubingen, Germany
    Pharmacol Biochem Behav 73:307-16. 2002
    ..This suggests that burst transmission is not blocked in the network, while high-frequency trains are reduced to prevent overexcitation and the transmission of nonphysiologic stimuli patterns...
  34. doi New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    Neurobiol Aging 31:1495-502. 2010
    ..Therefore, incretins show great promise as a novel treatment for reducing degenerative processes in AD...
  35. doi The role of GLP-1 in neuronal activity and neurodegeneration
    Christian Holscher
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Vitam Horm 84:331-54. 2010
    ..Therefore, GLP-1 analogues show great promise as a novel treatment for AD or other neurodegenerative conditions...
  36. doi Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
    Alison Hamilton
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    Neuroreport 20:1161-6. 2009
    ..The fact that the receptor is located on neurons and dendrites suggests that the neuroprotective action is caused by the modulation of neuronal excitation...
  37. ncbi Different strains of rats show different sensitivity to block of long-term potentiation by nitric oxide synthase inhibitors
    Christian Holscher
    Faculty of Biology, Cognitive Neuroscience, Tubingen University, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Eur J Pharmacol 457:99-106. 2002
    ..Such large strain differences suggest that results from studies that use laboratory rats could have strain-dependent components and should be generalised cautiously...
  38. doi Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    Paula L McClean
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA Northern Ireland, UK
    Neuropharmacology 76:57-67. 2014
    ..Liraglutide is now being tested in clinical trials in AD patients. This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'. ..