Research Topics
Genomes and Genes
Species | Clive HolmesSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Keep music live: music and the alleviation of apathy in dementia subjectsClive Holmes
School of Medicine, University of Southampton, UK
Int Psychogeriatr 18:623-30. 2006..This randomized placebo-controlled trial with blinded observer rater aimed to explore whether music, live or pre-recorded, is effective in the treatment of apathy in subjects with moderate to severe dementia...- The Montreal Cognitive Assessment: validity and utility in a memory clinic settingTasha Smith
University of Southampton, England
Can J Psychiatry 52:329-32. 2007..To prospectively validate the Montreal Cognitive Assessment (MoCA) in a UK memory clinic... 
Role of infection in the pathogenesis of Alzheimer's disease: implications for treatmentClive Holmes
University of Southampton, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
CNS Drugs 23:993-1002. 2009..However, benefit could also be gained clinically through the meticulous detection, treatment and prevention of infections in individuals either alone or in combination with anti-inflammatory therapy...- Review: systemic inflammation and Alzheimer's diseaseC Holmes
University of Southampton, Division of Clinical and Experimental Science, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
Neuropathol Appl Neurobiol 39:51-68. 2013.... 
DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCTRob Jones
Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
Trials 10:57. 2009..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...- Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variationC Holmes
University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK
J Neurol Neurosurg Psychiatry 71:777-9. 2001..Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions... - Systemic inflammation and Alzheimer's diseaseClive Holmes
Clinical Neurosciences Division, Moorgreen Hospital, University of Southampton, Botley Road, Southampton SO30 3JB, UK
Biochem Soc Trans 39:898-901. 2011.... - Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's diseaseC Holmes
School of Medicine and Biological Sciences, University of Southampton, Southampton, UK
J Neurol Neurosurg Psychiatry 74:788-9. 2003..Further research is needed to determine whether recurrent systemic infections drive cognitive decline in Alzheimer's disease subjects through a cytokine mediated pathway... - Depression in Alzheimer's disease: the effect of serotonin receptor gene variationClive Holmes
University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 119:40-3. 2003..In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele... - Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implicationsClive Holmes
University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton SO30 3JB, UK
Age Ageing 32:200-4. 2003..However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice... - Systemic inflammation and disease progression in Alzheimer diseaseC Holmes
Clinical Neurosciences Division, University of Southampton, UK
Neurology 73:768-74. 2009..Previous preclinical research shows that acute systemic inflammation contributes to an exacerbation of neurodegeneration by activation of primed microglial cells... - Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled studyClive Holmes
University of Southampton, School of Medicine, Community Clinical Sciences Research Division, Memory Assessment and Research Unit, Moorgreen Hospital, Southampton, UK
Int J Geriatr Psychiatry 17:305-8. 2002..To determine whether aromatherapy with lavender oil is effective in the treatment of agitated behaviour in patients with severe dementia... - Proinflammatory cytokines, sickness behavior, and Alzheimer diseaseC Holmes
University of Southampton, Memory Assessment and Research Centre, Botley Rd, Southampton, UK, SO30 3JB
Neurology 77:212-8. 2011.... - The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's diseaseAmy Gerrish
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
J Alzheimers Dis 28:377-87. 2012..However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study... - Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's diseasePaul Hollingworth
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Nat Genet 43:429-35. 2011..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10))... - Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's diseaseDelphine Boche
Southampton General Hospital, University of Southampton, UK
Acta Neuropathol 120:13-20. 2010..However, the continuing progression of cognitive decline in AD patients after Abeta immunisation may be explained by its lack of apparent effect on tangles... - Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's diseaseLesley Jones
Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
PLoS ONE 5:e13950. 2010..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes... - Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's diseaseMichelle C McCulley
University of Southampton, Human Genetics Division, School of Medicine, Duthie Building Mp808, Southampton General Hospital, Tremona Road, Southampton, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 124:50-3. 2004..However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes... - Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesisDelphine Boche
Division of Clinical Neurosciences, School of Medicine, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
Acta Neuropathol 120:369-84. 2010..The information obtained will be important in helping to understand the pathogenesis not only of AD but also of other neurodegenerative disorders associated with protein aggregation... - Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trialClive Holmes
Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
Lancet 372:216-23. 2008..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes... - Abeta species removal after abeta42 immunizationJames A R Nicoll
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
J Neuropathol Exp Neurol 65:1040-8. 2006..Abeta immunotherapy can clear all Abeta species from the cortex. However, if it is to be used for treatment of established Alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study... - Microglia in neurodegenerative diseaseV Hugh Perry
School of Biological Sciences, University of Southampton, Building 62, Boldrewood Campus, Southampton SO16 7PX, UK
Nat Rev Neurol 6:193-201. 2010..The fact that diseases with a chronic systemic inflammatory component are risk factors for Alzheimer disease implies that crosstalk occurs between systemic inflammation and microglia in the CNS... - Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodiesPaul M Kemp
Department of Nuclear Medicine and Medical Physics, Southampton University Hospitals Trust, Southampton, UK
Nucl Med Commun 28:451-6. 2007..To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the 123I-FP-CIT findings as the diagnostic 'gold standard'... - Systemic infections and inflammation affect chronic neurodegenerationV Hugh Perry
Southampton Neuroscience Group, School of Biological Sciences and School of Medicine, University of Southampton, Southampton SO16 7PX, UK
Nat Rev Immunol 7:161-7. 2007.... - Association between dementia and infectious disease: evidence from a case-control studyNicholas Dunn
University of Southampton, UK
Alzheimer Dis Assoc Disord 19:91-4. 2005..Smoking and diabetes mellitus are associated with onset of dementia in the elderly. The evidence from this study may represent cause and effect, since there is a credible biologic explanation... - Does lithium therapy protect against the onset of dementia?Nick Dunn
Primary Medical Care, University of Southampton, Southampton, UK
Alzheimer Dis Assoc Disord 19:20-2. 2005..8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia... - Genotype and phenotype in Alzheimer's diseaseClive Holmes
Thornhill Research Unit, University of Southampton, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK
Br J Psychiatry 180:131-4. 2002..Genetic research has been largely concerned with the role of mutations or common variants as risk factors for the disease. Do genetic factors also influence clinical phenotype?.. - The effect of link nurses on hospital readmission ratesPaul Anthony Ashton
Memory Assessment and Research Centre (MARC, Moorgreen Hospital, Southampton
Nurs Times 102:34-5. 2006..This is a summary of the paper the full version can be accessed at nursingtimes.net... - The clinical phenotype of familial and sporadic late onset Alzheimer's diseaseClive Holmes
University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
Int J Geriatr Psychiatry 17:146-9. 2002..CONCLUSIONS: Apart from an earlier age of onset, patients with familial LOAD, as a group, do not have major differences in their clinical phenotype compared to patients with sporadic LOAD... - Depression in elderly life sentence prisonersNicholas Murdoch
Memory Assessment and Research Centre, University of Southampton, Southampton, UK
Int J Geriatr Psychiatry 23:957-62. 2008..The life sentence population is growing older and increasing in number. Despite the potential negative physical and social environment in prisons little is known about the prevalence or aetiology of depression in elderly 'lifers'... - Systemic and central immunity in Alzheimer's disease: therapeutic implicationsJoseph Butchart
Clinical Neurosciences Division, University of Southampton, Moorgreen Hospital, UK
CNS Neurosci Ther 18:64-76. 2012.... - Prophylactic therapy with lithium in elderly patients with unipolar major depressionDavid Wilkinson
MARC, Elderly Mental Health Directorate, Moorgreen Hospital, Southampton
Int J Geriatr Psychiatry 17:619-22. 2002..To compare the relapse rate of elderly depressed patients taking low dose lithium as an additional therapy with antidepressant medication to those receiving antidepressant medication alone... - Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case reportJames A R Nicoll
Division of Clinical Neurosciences, University of Southampton, Southampton, UK
Nat Med 9:448-52. 2003..The T-lymphocyte meningoencephalitis is likely to correspond to the side effect seen in some other patients who received AN-1792 (refs. 7-9)... - The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementiaPaul M Kemp
Department of Nuclear Medicine, Southampton University Hospitals Trust, Southampton, UK
Nucl Med Commun 26:1099-106. 2005.... - Imaging in dementia with Lewy bodies: a reviewPaul M Kemp
Department of Nuclear Medicine, Southampton University Hospitals Trust, Southampton, UK
Nucl Med Commun 28:511-9. 2007..It is envisaged that this information may be useful to nuclear medicine physicians, radiologists, psychiatrists, neurologists, geriatricians and physicians... - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseDenise Harold
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Nat Genet 41:1088-93. 2009..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)... - Inflammation in Alzheimer's disease: relevance to pathogenesis and therapyElina Zotova
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Mailpoint 806, Level D, South Pathology Block, Southampton General Hospital, Southampton, SO16 6YD, UK
Alzheimers Res Ther 2:1. 2010.... - Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part IPauline Aalten
Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
Dement Geriatr Cogn Disord 24:457-63. 2007..The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD)... - AD2000: design and conclusionsClive Holmes
Lancet 364:1213-4; author reply 1216-7. 2004 - Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channelsSawsan Abuhamdah
Centre for Integrative Neuroscience, School of Biological and Biomedical Sciences, Science Park, South Road, Durham University, Durham, UK
J Pharm Pharmacol 60:377-84. 2008..The anti-agitation effects in patients and the depressant effects of MO in in-vitro we report in neural membranes are unlikely to reflect a sedative interaction with any of the ionotropic receptors examined here... - Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodiesClive G Ballard
Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Am J Psychiatry 161:843-9. 2004..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies... - 5-HT2A receptor polymorphism may modulate antipsychotic treatment response in Alzheimer's diseaseSebastiaan Engelborghs
Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, and Laboratory of Neurochemistry and Behaviour, Born-Bunge Foundation, University of Antwerp, Antwerp, Belgium
Int J Geriatr Psychiatry 19:1108-9. 2004 - Sensory stimulation in dementiaAlistair Burns
BMJ 325:1312-3. 2002 - Risperidone and rivastigmine and agitated behaviour in severe Alzheimer's disease: a randomised double blind placebo controlled studyClive Holmes
Int J Geriatr Psychiatry 22:380-1. 2007 - Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive declineMargaret A Piggott
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
Synapse 61:903-11. 2007..That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB... - Donepezil for the treatment of agitation in Alzheimer's diseaseRobert J Howard
Medical Research Council Neurogeneration Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
N Engl J Med 357:1382-92. 2007..Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear... - Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part IIPauline Aalten
Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
Dement Geriatr Cogn Disord 25:1-8. 2008..g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia... - A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodiesClive Ballard
Institute for the Health of the Elderly, University of Newcastle, Newcastle, UK
J Affect Disord 69:219-23. 2002..The neurochemical basis for depression in DLB has not been investigated...