Clive Holmes

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Keep music live: music and the alleviation of apathy in dementia subjects
    Clive Holmes
    School of Medicine, University of Southampton, UK
    Int Psychogeriatr 18:623-30. 2006
  2. ncbi request reprint The Montreal Cognitive Assessment: validity and utility in a memory clinic setting
    Tasha Smith
    University of Southampton, England
    Can J Psychiatry 52:329-32. 2007
  3. doi request reprint Role of infection in the pathogenesis of Alzheimer's disease: implications for treatment
    Clive Holmes
    University of Southampton, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    CNS Drugs 23:993-1002. 2009
  4. doi request reprint Review: systemic inflammation and Alzheimer's disease
    C Holmes
    University of Southampton, Division of Clinical and Experimental Science, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    Neuropathol Appl Neurobiol 39:51-68. 2013
  5. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
  6. pmc Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation
    C Holmes
    University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK
    J Neurol Neurosurg Psychiatry 71:777-9. 2001
  7. pmc Proinflammatory cytokines, sickness behavior, and Alzheimer disease
    C Holmes
    University of Southampton, Memory Assessment and Research Centre, Botley Rd, Southampton, UK, SO30 3JB
    Neurology 77:212-8. 2011
  8. doi request reprint Systemic inflammation and Alzheimer's disease
    Clive Holmes
    Clinical Neurosciences Division, Moorgreen Hospital, University of Southampton, Botley Road, Southampton SO30 3JB, UK
    Biochem Soc Trans 39:898-901. 2011
  9. pmc Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease
    C Holmes
    School of Medicine and Biological Sciences, University of Southampton, Southampton, UK
    J Neurol Neurosurg Psychiatry 74:788-9. 2003
  10. ncbi request reprint Depression in Alzheimer's disease: the effect of serotonin receptor gene variation
    Clive Holmes
    University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 119:40-3. 2003

Detail Information

Publications51

  1. ncbi request reprint Keep music live: music and the alleviation of apathy in dementia subjects
    Clive Holmes
    School of Medicine, University of Southampton, UK
    Int Psychogeriatr 18:623-30. 2006
    ..This randomized placebo-controlled trial with blinded observer rater aimed to explore whether music, live or pre-recorded, is effective in the treatment of apathy in subjects with moderate to severe dementia...
  2. ncbi request reprint The Montreal Cognitive Assessment: validity and utility in a memory clinic setting
    Tasha Smith
    University of Southampton, England
    Can J Psychiatry 52:329-32. 2007
    ..To prospectively validate the Montreal Cognitive Assessment (MoCA) in a UK memory clinic...
  3. doi request reprint Role of infection in the pathogenesis of Alzheimer's disease: implications for treatment
    Clive Holmes
    University of Southampton, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    CNS Drugs 23:993-1002. 2009
    ..However, benefit could also be gained clinically through the meticulous detection, treatment and prevention of infections in individuals either alone or in combination with anti-inflammatory therapy...
  4. doi request reprint Review: systemic inflammation and Alzheimer's disease
    C Holmes
    University of Southampton, Division of Clinical and Experimental Science, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    Neuropathol Appl Neurobiol 39:51-68. 2013
    ....
  5. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
    ..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
  6. pmc Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation
    C Holmes
    University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK
    J Neurol Neurosurg Psychiatry 71:777-9. 2001
    ..Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions...
  7. pmc Proinflammatory cytokines, sickness behavior, and Alzheimer disease
    C Holmes
    University of Southampton, Memory Assessment and Research Centre, Botley Rd, Southampton, UK, SO30 3JB
    Neurology 77:212-8. 2011
    ....
  8. doi request reprint Systemic inflammation and Alzheimer's disease
    Clive Holmes
    Clinical Neurosciences Division, Moorgreen Hospital, University of Southampton, Botley Road, Southampton SO30 3JB, UK
    Biochem Soc Trans 39:898-901. 2011
    ....
  9. pmc Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease
    C Holmes
    School of Medicine and Biological Sciences, University of Southampton, Southampton, UK
    J Neurol Neurosurg Psychiatry 74:788-9. 2003
    ..Further research is needed to determine whether recurrent systemic infections drive cognitive decline in Alzheimer's disease subjects through a cytokine mediated pathway...
  10. ncbi request reprint Depression in Alzheimer's disease: the effect of serotonin receptor gene variation
    Clive Holmes
    University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 119:40-3. 2003
    ..In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele...
  11. ncbi request reprint Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications
    Clive Holmes
    University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton SO30 3JB, UK
    Age Ageing 32:200-4. 2003
    ..However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice...
  12. pmc Systemic inflammation and disease progression in Alzheimer disease
    C Holmes
    Clinical Neurosciences Division, University of Southampton, UK
    Neurology 73:768-74. 2009
    ..Previous preclinical research shows that acute systemic inflammation contributes to an exacerbation of neurodegeneration by activation of primed microglial cells...
  13. ncbi request reprint Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study
    Clive Holmes
    University of Southampton, School of Medicine, Community Clinical Sciences Research Division, Memory Assessment and Research Unit, Moorgreen Hospital, Southampton, UK
    Int J Geriatr Psychiatry 17:305-8. 2002
    ..To determine whether aromatherapy with lavender oil is effective in the treatment of agitated behaviour in patients with severe dementia...
  14. ncbi request reprint The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease
    Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    J Alzheimers Dis 28:377-87. 2012
    ..However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study...
  15. doi request reprint Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization
    Elina Zotova
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 806, Southampton General Hospital, Southampton SO16 6YD, UK
    Brain 136:2677-96. 2013
    ..The results suggest that, in the long term, amyloid-β immunotherapy results in downregulation of microglial activation and potentially reduces the inflammation-mediated component of the neurodegeneration of Alzheimer's disease. ..
  16. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
    ..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10))...
  17. ncbi request reprint Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
    Delphine Boche
    Southampton General Hospital, University of Southampton, UK
    Acta Neuropathol 120:13-20. 2010
    ..However, the continuing progression of cognitive decline in AD patients after Abeta immunisation may be explained by its lack of apparent effect on tangles...
  18. ncbi request reprint Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease
    Michelle C McCulley
    University of Southampton, Human Genetics Division, School of Medicine, Duthie Building Mp808, Southampton General Hospital, Tremona Road, Southampton, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 124:50-3. 2004
    ..However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes...
  19. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
    ..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes...
  20. doi request reprint Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
    Clive Holmes
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
    Lancet 372:216-23. 2008
    ..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes...
  21. ncbi request reprint Abeta species removal after abeta42 immunization
    James A R Nicoll
    Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
    J Neuropathol Exp Neurol 65:1040-8. 2006
    ..Abeta immunotherapy can clear all Abeta species from the cortex. However, if it is to be used for treatment of established Alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study...
  22. ncbi request reprint Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis
    Delphine Boche
    Division of Clinical Neurosciences, School of Medicine, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Acta Neuropathol 120:369-84. 2010
    ..The information obtained will be important in helping to understand the pathogenesis not only of AD but also of other neurodegenerative disorders associated with protein aggregation...
  23. ncbi request reprint Does lithium therapy protect against the onset of dementia?
    Nick Dunn
    Primary Medical Care, University of Southampton, Southampton, UK
    Alzheimer Dis Assoc Disord 19:20-2. 2005
    ..8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia...
  24. ncbi request reprint Systemic infections and inflammation affect chronic neurodegeneration
    V Hugh Perry
    Southampton Neuroscience Group, School of Biological Sciences and School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    Nat Rev Immunol 7:161-7. 2007
    ....
  25. ncbi request reprint Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies
    Paul M Kemp
    Department of Nuclear Medicine and Medical Physics, Southampton University Hospitals Trust, Southampton, UK
    Nucl Med Commun 28:451-6. 2007
    ..To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the 123I-FP-CIT findings as the diagnostic 'gold standard'...
  26. doi request reprint Microglia in neurodegenerative disease
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Building 62, Boldrewood Campus, Southampton SO16 7PX, UK
    Nat Rev Neurol 6:193-201. 2010
    ..The fact that diseases with a chronic systemic inflammatory component are risk factors for Alzheimer disease implies that crosstalk occurs between systemic inflammation and microglia in the CNS...
  27. ncbi request reprint Genotype and phenotype in Alzheimer's disease
    Clive Holmes
    Thornhill Research Unit, University of Southampton, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK
    Br J Psychiatry 180:131-4. 2002
    ..Genetic research has been largely concerned with the role of mutations or common variants as risk factors for the disease. Do genetic factors also influence clinical phenotype?..
  28. ncbi request reprint Association between dementia and infectious disease: evidence from a case-control study
    Nicholas Dunn
    University of Southampton, UK
    Alzheimer Dis Assoc Disord 19:91-4. 2005
    ..Smoking and diabetes mellitus are associated with onset of dementia in the elderly. The evidence from this study may represent cause and effect, since there is a credible biologic explanation...
  29. doi request reprint Male sex hormones and systemic inflammation in Alzheimer disease
    Joe Butchart
    Memory Assessment and Research Centre, Clinical Neurosciences, Faculty of Medicine, University of Southampton, Southampton, UK
    Alzheimer Dis Assoc Disord 27:153-6. 2013
    ..05). These data support the hypothesis that sex hormones and the immune system influence each other in AD. Furthermore, modulatory effects between LH and TNF-α may provide a mechanism for an effect of male sex hormones on AD risk...
  30. ncbi request reprint The effect of link nurses on hospital readmission rates
    Paul Anthony Ashton
    Memory Assessment and Research Centre MARC, Moorgreen Hospital, Southampton
    Nurs Times 102:34-5. 2006
    ..This is a summary of the paper the full version can be accessed at nursingtimes.net...
  31. ncbi request reprint The clinical phenotype of familial and sporadic late onset Alzheimer's disease
    Clive Holmes
    University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    Int J Geriatr Psychiatry 17:146-9. 2002
    ..To date, most studies have focussed on familial influences upon age of onset or duration of illness and few studies have compared the frequency of non-cognitive symptoms between familial and sporadic LOAD...
  32. doi request reprint Depression in elderly life sentence prisoners
    Nicholas Murdoch
    Memory Assessment and Research Centre, University of Southampton, Southampton, UK
    Int J Geriatr Psychiatry 23:957-62. 2008
    ..The life sentence population is growing older and increasing in number. Despite the potential negative physical and social environment in prisons little is known about the prevalence or aetiology of depression in elderly 'lifers'...
  33. doi request reprint Systemic and central immunity in Alzheimer's disease: therapeutic implications
    Joseph Butchart
    Clinical Neurosciences Division, University of Southampton, Moorgreen Hospital, UK
    CNS Neurosci Ther 18:64-76. 2012
    ....
  34. ncbi request reprint Prophylactic therapy with lithium in elderly patients with unipolar major depression
    David Wilkinson
    MARC, Elderly Mental Health Directorate, Moorgreen Hospital, Southampton
    Int J Geriatr Psychiatry 17:619-22. 2002
    ..To compare the relapse rate of elderly depressed patients taking low dose lithium as an additional therapy with antidepressant medication to those receiving antidepressant medication alone...
  35. ncbi request reprint Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    James A R Nicoll
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    Nat Med 9:448-52. 2003
    ..The T-lymphocyte meningoencephalitis is likely to correspond to the side effect seen in some other patients who received AN-1792 (refs. 7-9)...
  36. ncbi request reprint The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementia
    Paul M Kemp
    Department of Nuclear Medicine, Southampton University Hospitals Trust, Southampton, UK
    Nucl Med Commun 26:1099-106. 2005
    ....
  37. ncbi request reprint Imaging in dementia with Lewy bodies: a review
    Paul M Kemp
    Department of Nuclear Medicine, Southampton University Hospitals Trust, Southampton, UK
    Nucl Med Commun 28:511-9. 2007
    ..It is envisaged that this information may be useful to nuclear medicine physicians, radiologists, psychiatrists, neurologists, geriatricians and physicians...
  38. ncbi request reprint Microglial priming in neurodegenerative disease
    V Hugh Perry
    Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Nat Rev Neurol 10:217-24. 2014
    ..Both lifestyle changes and pharmacological therapies could, therefore, provide efficient means to slow down or halt neurodegeneration...
  39. pmc Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy
    Elina Zotova
    Division of Clinical Neurosciences, School of Medicine, University of Southampton, Mailpoint 806, Level D, South Pathology Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Alzheimers Res Ther 2:1. 2010
    ....
  40. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)...
  41. ncbi request reprint Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 24:457-63. 2007
    ..The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD)...
  42. ncbi request reprint 5-HT2A receptor polymorphism may modulate antipsychotic treatment response in Alzheimer's disease
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, and Laboratory of Neurochemistry and Behaviour, Born Bunge Foundation, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 19:1108-9. 2004
  43. ncbi request reprint Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:1-8. 2008
    ..g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia...
  44. ncbi request reprint A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies
    Clive Ballard
    Institute for the Health of the Elderly, University of Newcastle, Newcastle, UK
    J Affect Disord 69:219-23. 2002
    ..The neurochemical basis for depression in DLB has not been investigated...
  45. doi request reprint Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels
    Sawsan Abuhamdah
    Centre for Integrative Neuroscience, School of Biological and Biomedical Sciences, Science Park, South Road, Durham University, Durham, UK
    J Pharm Pharmacol 60:377-84. 2008
    ..The anti-agitation effects in patients and the depressant effects of MO in in-vitro we report in neural membranes are unlikely to reflect a sedative interaction with any of the ionotropic receptors examined here...
  46. ncbi request reprint Risperidone and rivastigmine and agitated behaviour in severe Alzheimer's disease: a randomised double blind placebo controlled study
    Clive Holmes
    Int J Geriatr Psychiatry 22:380-1. 2007
  47. ncbi request reprint Donepezil for the treatment of agitation in Alzheimer's disease
    Robert J Howard
    Medical Research Council Neurogeneration Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    N Engl J Med 357:1382-92. 2007
    ..Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear...
  48. ncbi request reprint Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
    Margaret A Piggott
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Synapse 61:903-11. 2007
    ..That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB...
  49. ncbi request reprint Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies
    Clive G Ballard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Am J Psychiatry 161:843-9. 2004
    ..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies...
  50. ncbi request reprint AD2000: design and conclusions
    Clive Holmes
    Lancet 364:1213-4; author reply 1216-7. 2004
  51. pmc Sensory stimulation in dementia
    Alistair Burns
    BMJ 325:1312-3. 2002