E J Hollox

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. doi request reprint The challenges of studying complex and dynamic regions of the human genome
    Edward J Hollox
    Department of Genetics, University of Leicester, Adrian Building, University Road, Leicester, UK
    Methods Mol Biol 838:187-207. 2012
  2. doi request reprint Copy number variation of beta-defensins and relevance to disease
    E J Hollox
    Department of Genetics, University of Leicester, Leicester, UK
    Cytogenet Genome Res 123:148-55. 2008
  3. doi request reprint Defensins and the dynamic genome: what we can learn from structural variation at human chromosome band 8p23.1
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genome Res 18:1686-97. 2008
  4. pmc Directional and balancing selection in human beta-defensins
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester, UK
    BMC Evol Biol 8:113. 2008
  5. pmc Psoriasis is associated with increased beta-defensin genomic copy number
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Nat Genet 40:23-5. 2008
  6. pmc An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 30:477-84. 2009
  7. pmc Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats
    John A L Armour
    Institute of Genetics, University of Nottingham, Nottingham, NG7 2UH, UK
    Nucleic Acids Res 35:e19. 2007
  8. pmc Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
    Edward J Hollox
    Institute of Genetics, University of Nottingham, Nottingham, UK
    J Negat Results Biomed 4:9. 2005
  9. ncbi request reprint Duplications and copy number variants of 8p23.1 are cytogenetically indistinguishable but distinct at the molecular level
    John C K Barber
    Wessex Regional Genetics Laboratory, Salisbury Hospital NHS Trust, Salisbury, Wiltshire, UK
    Eur J Hum Genet 13:1131-6. 2005
  10. ncbi request reprint DNA copy number analysis by MAPH: molecular diagnostic applications
    Edward J Hollox
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    Expert Rev Mol Diagn 2:370-8. 2002

Collaborators

Detail Information

Publications10

  1. doi request reprint The challenges of studying complex and dynamic regions of the human genome
    Edward J Hollox
    Department of Genetics, University of Leicester, Adrian Building, University Road, Leicester, UK
    Methods Mol Biol 838:187-207. 2012
    ....
  2. doi request reprint Copy number variation of beta-defensins and relevance to disease
    E J Hollox
    Department of Genetics, University of Leicester, Leicester, UK
    Cytogenet Genome Res 123:148-55. 2008
    ..I also suggest future directions for research, with an emphasis on improvement of methods for accurately typing CNV...
  3. doi request reprint Defensins and the dynamic genome: what we can learn from structural variation at human chromosome band 8p23.1
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genome Res 18:1686-97. 2008
    ..Finally, we discuss the bioinformatics challenges raised, discuss the evolution of the region, and suggest some future priorities for structural variation research...
  4. pmc Directional and balancing selection in human beta-defensins
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester, UK
    BMC Evol Biol 8:113. 2008
    ..Here we examine evolution of beta-defensins in catarrhine primates and variation within different human populations...
  5. pmc Psoriasis is associated with increased beta-defensin genomic copy number
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Nat Genet 40:23-5. 2008
    ..Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis...
  6. pmc An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 30:477-84. 2009
    ....
  7. pmc Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats
    John A L Armour
    Institute of Genetics, University of Nottingham, Nottingham, NG7 2UH, UK
    Nucleic Acids Res 35:e19. 2007
    ....
  8. pmc Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
    Edward J Hollox
    Institute of Genetics, University of Nottingham, Nottingham, UK
    J Negat Results Biomed 4:9. 2005
    ..No significant association was found...
  9. ncbi request reprint Duplications and copy number variants of 8p23.1 are cytogenetically indistinguishable but distinct at the molecular level
    John C K Barber
    Wessex Regional Genetics Laboratory, Salisbury Hospital NHS Trust, Salisbury, Wiltshire, UK
    Eur J Hum Genet 13:1131-6. 2005
    ..These results distinguish duplications of 8p23.1 with clinically significant consequences from benign copy number variants, which have not yet been associated with qualitative or quantitative traits...
  10. ncbi request reprint DNA copy number analysis by MAPH: molecular diagnostic applications
    Edward J Hollox
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    Expert Rev Mol Diagn 2:370-8. 2002
    ..The analysis of the data produced by MAPH is also considered, along with its potential for automation and development of microarray-based MAPH...