J W Holloway

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years
    Nelís Soto-Ramírez
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC, 29208, USA
    Clin Epigenetics 5:1. 2013
  2. pmc Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study
    Ali H Ziyab
    Department of Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA
    BMC Med Genet 14:67. 2013
  3. pmc Leukotriene B4 receptor locus gene characterisation and association studies in asthma
    Asif S Tulah
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    BMC Med Genet 13:110. 2012
  4. doi request reprint Genomics and the respiratory effects of air pollution exposure
    John W Holloway
    Human Development and Health, University of Southampton, Southampton, UK
    Respirology 17:590-600. 2012
  5. ncbi request reprint Beta2-Adrenergic receptor polymorphism and asthma: true or false?
    John W Holloway
    Division of Infection, Inflammation and Repair, University of Southhampton, UK
    J Allergy Clin Immunol 115:960-2. 2005
  6. ncbi request reprint Identifying novel genes contributing to asthma pathogenesis
    John W Holloway
    Divisions of Infection, Inflammation and Repair, University of Southampton, Southampton, UK
    Curr Opin Allergy Clin Immunol 7:69-74. 2007
  7. ncbi request reprint Genetics
    John W Holloway
    Human Genetics, Southampton General Hospital, University of Southampton, Southampton, UK
    Chem Immunol Allergy 84:1-35. 2004
  8. doi request reprint Interpatient variability in rates of asthma progression: can genetics provide an answer?
    John W Holloway
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:573-9. 2008
  9. ncbi request reprint Comparison of three methods for single nucleotide polymorphism typing for DNA bank studies: sequence-specific oligonucleotide probe hybridisation, TaqMan liquid phase hybridisation, and microplate array diagonal gel electrophoresis (MADGE)
    J W Holloway
    Human Genetics Research Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Hum Mutat 14:340-7. 1999
  10. doi request reprint Using genetics to predict the natural history of asthma?
    John W Holloway
    Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, UK
    J Allergy Clin Immunol 126:200-9; quiz 210-1. 2010

Collaborators

Detail Information

Publications59

  1. pmc The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years
    Nelís Soto-Ramírez
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC, 29208, USA
    Clin Epigenetics 5:1. 2013
    ..abstract:..
  2. pmc Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study
    Ali H Ziyab
    Department of Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA
    BMC Med Genet 14:67. 2013
    ..Our aim was to investigate whether SNPs in IL13 and STAT6 genes, which share a biological pathway, have an interactive effect on eczema risk...
  3. pmc Leukotriene B4 receptor locus gene characterisation and association studies in asthma
    Asif S Tulah
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    BMC Med Genet 13:110. 2012
    ..The aim of this study was to characterise the genes for the two pivotal LTB4 receptors, LTB4R1 and LTB4R2 in lung tissue and determine if polymorphisms spanning these genes are associated with asthma and disease severity...
  4. doi request reprint Genomics and the respiratory effects of air pollution exposure
    John W Holloway
    Human Development and Health, University of Southampton, Southampton, UK
    Respirology 17:590-600. 2012
    ..Careful study of genomic responses will improve our understanding of mechanisms of lung injury from air pollution and enable future clinical testing of interventions against the toxic effects of air pollutants...
  5. ncbi request reprint Beta2-Adrenergic receptor polymorphism and asthma: true or false?
    John W Holloway
    Division of Infection, Inflammation and Repair, University of Southhampton, UK
    J Allergy Clin Immunol 115:960-2. 2005
  6. ncbi request reprint Identifying novel genes contributing to asthma pathogenesis
    John W Holloway
    Divisions of Infection, Inflammation and Repair, University of Southampton, Southampton, UK
    Curr Opin Allergy Clin Immunol 7:69-74. 2007
    ..To illustrate recent examples of novel asthma genes such as those encoding G-protein-coupled receptor for asthma susceptibility, filaggrin and tenascin-C, and to describe the process that is needed to translate these findings to the clinic...
  7. ncbi request reprint Genetics
    John W Holloway
    Human Genetics, Southampton General Hospital, University of Southampton, Southampton, UK
    Chem Immunol Allergy 84:1-35. 2004
  8. doi request reprint Interpatient variability in rates of asthma progression: can genetics provide an answer?
    John W Holloway
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:573-9. 2008
    ....
  9. ncbi request reprint Comparison of three methods for single nucleotide polymorphism typing for DNA bank studies: sequence-specific oligonucleotide probe hybridisation, TaqMan liquid phase hybridisation, and microplate array diagonal gel electrophoresis (MADGE)
    J W Holloway
    Human Genetics Research Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Hum Mutat 14:340-7. 1999
    ..Throughputs achievable are similar, but there are major differences in cost and time for set-up, equipment, consumables, and staff time, which may determine the choice for individual laboratories...
  10. doi request reprint Using genetics to predict the natural history of asthma?
    John W Holloway
    Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, UK
    J Allergy Clin Immunol 126:200-9; quiz 210-1. 2010
    ....
  11. ncbi request reprint Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families
    J W Holloway
    Human Genetics, Division School of Medicine, University of Southampton, UK
    Genes Immun 2:20-4. 2001
    ..946 at location 171.3 cM and a standard error of 3.3 for the asthma quantitative score. There was no evidence of linkage with atopy, the atopy quantitative score or total serum IgE...
  12. ncbi request reprint Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population
    B Beghe
    Divisions of Human Genetics Infection, Inflammation and Repair, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:1111-7. 2003
    ..IL-4 by binding to its receptor (IL-4R) is essential for the development of airway inflammation present in asthma, through the induction of IgE synthesis in B cells and differentiation of T cells to a Th2 phenotype...
  13. ncbi request reprint Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population
    I Sayers
    Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Clin Exp Allergy 33:1103-10. 2003
    ..5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma...
  14. ncbi request reprint Toll-like receptor 4 polymorphism and severity of atopy in asthmatics
    I A Yang
    Asthma Genetics Laboratory, Division of Human Genetics and Infection, University of Southampton, Southampton, UK
    Genes Immun 5:41-5. 2004
    ..05). This study confirms the previously observed lack of association of TLR4 polymorphisms with asthma. In contrast, the findings suggest that genetically determined hyporesponsiveness to endotoxin may increase atopy severity...
  15. ncbi request reprint The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma
    L Hao
    Division of Human Genetics, University of Southampton School of Medicine, Southampton, UK
    Clin Exp Allergy 36:735-41. 2006
    ..We screened the CYSLTR1 gene on chromosome Xq13-21 for coding region polymorphisms, and investigated their associations with allergy and asthma...
  16. ncbi request reprint Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis
    T Iwanaga
    Division of Human Genetics, School of Medicine, University of Southampton, Southampton General Hospital, Southhampton, UK
    Clin Exp Allergy 34:1037-42. 2004
    ..We have examined association of a CMA1 variant in relation to asthma in a large UK Caucasian family cohort...
  17. ncbi request reprint Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy
    A K Konstantinidis
    Divisions of Human Genetics, School of Medicine, University of Southampton, Southampton, UK
    Eur Respir J 30:40-7. 2007
    ....
  18. ncbi request reprint Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma
    S T Holgate
    Respiratory Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, Southampton, UK
    Int Arch Allergy Immunol 124:253-8. 2001
    ..This report describes a series of studies that identify aberrant epithelial mesenchymal signalling in the airways as an important event in maintaining inflammation and driving remodelling in response to environmental injury...
  19. doi request reprint The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility
    J W Holloway
    Divisios of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    Allergy 63:1046-53. 2008
    ..Objective: To assess the contribution of LTA4H and ALOX5AP polymorphism to asthma and allergy susceptibility...
  20. ncbi request reprint Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction
    John W Holloway
    Human Genetics Division, School of Medicine, University of Southampton, Southampton, UK
    Pharmacogenet Genomics 15:15-21. 2005
    ....
  21. doi request reprint Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development
    H M Haitchi
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur Respir J 33:1095-104. 2009
    ..Chronological regulation of CBE1/Cbe1 expression during pulmonary differentiation suggests involvement in ciliogenesis, with an additional role during early lung development...
  22. ncbi request reprint IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts
    Allison Lynn Andrews
    Brooke Laboratories, Division of Infection, Inflammation, and Repair, UK
    J Allergy Clin Immunol 118:858-65. 2006
    ..The nonsignaling receptor IL-13 receptor alpha 2 (IL-13Ralpha2) binds IL-13 with high affinity and specificity and is believed to be a decoy receptor for IL-13...
  23. doi request reprint PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline
    Sheila J Barton
    Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 123:1391-400.e17. 2009
    ..Several studies have suggested that chromosome 19q13.1-3 contains asthma susceptibility genes...
  24. doi request reprint Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells
    Youwen Yang
    Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:1393-9, 1399.e1-14. 2008
    ..Although considered to be a mesenchymal cell-specific gene, recent reports have suggested epithelial expression of ADAM33 in patients with severe asthma...
  25. ncbi request reprint Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
    James L Lordan
    School of Medicine, Respiratory Cell and Molecular Biology Division, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 169:407-14. 2002
    ....
  26. ncbi request reprint Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells
    Mark D Steel
    The Brooke Laboratories, School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Biochem Cell Biol 37:1281-95. 2005
    ..Recognising that many chronic inflammatory disorders of the airways involve epithelial damage and repair, altered Wnt signalling might contribute to disease pathogenesis or progression...
  27. ncbi request reprint Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms
    S T Holgate
    Allergy and Inflammation Research, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Respir J 29:793-803. 2007
    ....
  28. pmc The relationship between infant lung function and the risk of wheeze in the preschool years
    K C Pike
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Pediatr Pulmonol 46:75-82. 2011
    ....
  29. ncbi request reprint Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts
    A K Konstantinidis
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    J Investig Allergol Clin Immunol 18:174-80. 2008
    ..Another IL-13 binding chain, IL-13Ralpha2, binds IL-13 with high affinity but has no known signaling capability and is thought to serve as a decoy receptor providing tight regulation of IL-13 responses...
  30. pmc Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma
    I Sayers
    Human Genetics Research Division, University of Southampton, Southampton SO16 6YD, UK
    Thorax 58:417-24. 2003
    ..We have identified a novel promoter polymorphism at position -1072 (G/A) and a -444 (A/C) polymorphism has previously been reported. The role of these polymorphisms in the genetic susceptibility to asthma was examined...
  31. ncbi request reprint ADAM33: a newly identified gene in the pathogenesis of asthma
    Stephen T Holgate
    Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
    Immunol Allergy Clin North Am 25:655-68. 2005
    ..For each of these genes, as is the case for ADAM33, determining their normal function(s) and how these become disordered in asthma is the future challenge...
  32. ncbi request reprint Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation
    Hajime Yoshisue
    Infection, Inflammation, and Repair Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 31:491-500. 2004
    ..Regulated expression during differentiation and the subcellular localization of CBE1 suggest that it may play an important role in the differentiation and/or function of ciliated cells in human airways...
  33. ncbi request reprint The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts
    Robert M Powell
    Brooke Laboratories, Division of Infection, School of Medicine, Southampton General Hospital, Southampton, UK
    Am J Respir Cell Mol Biol 31:13-21. 2004
    ..These findings demonstrate that ADAM33 exists in multiple isoforms, suggesting that it is a complex molecule that plays multiple roles within mesenchymal cells...
  34. ncbi request reprint TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis
    Ian A Yang
    Human Genetics Division Mailpoint 808, University of Southampton School of Medicine, Tremona Road, Southampton SO16 6YD, UK
    Atherosclerosis 170:187-90. 2003
    ..We analyzed this polymorphism in relation to susceptibility to and severity of coronary artery disease...
  35. ncbi request reprint ADAM33: a novel therapeutic target for asthma
    Robert M Powell
    Expert Opin Ther Targets 7:485-94. 2003
    ..The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target...
  36. doi request reprint Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction
    Allison Lynn Andrews
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Biochem Soc Trans 37:873-6. 2009
    ..The receptor has more complicated functions than a simple decoy receptor. In this review, we discuss newly revealed functions of IL-13Ralpha2...
  37. doi request reprint Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism
    John V Pappachan
    Pediatric Intensive Care Unit, Southampton General Hospital, Southampton, UK
    Immunogenetics 61:657-62. 2009
    ..Genotypes that either favour inflammation or its counter-regulatory anti-inflammatory response are likely to influence mortality and morbidity...
  38. doi request reprint The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms
    Jim Stevenson
    School of Psychology, University of Southampton, Highfield, Southampton, SO17 1BJ, England
    Am J Psychiatry 167:1108-15. 2010
    ..The authors hypothesized that genetic polymorphisms affecting histamine degradation would explain the diversity of responses to additives...
  39. ncbi request reprint Kinetic analysis of the interleukin-13 receptor complex
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, 97 Tremona Rd, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 277:46073-8. 2002
    ....
  40. ncbi request reprint ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma
    Stephen T Holgate
    Respiratory Cell and Molecular Biology Research Division, School of Medicine, University of Southampton, UK, University of Cambridge, UK
    Clin Rev Allergy Immunol 27:23-34. 2004
    ..The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity...
  41. ncbi request reprint Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Allergy Clin Immunol 120:91-7. 2007
    ..Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy...
  42. ncbi request reprint The discovery and role of ADAM33, a new candidate gene for asthma
    John W Holloway
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Expert Rev Mol Med 6:1-12. 2004
    ..ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling...
  43. ncbi request reprint IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets
    Allison Lynn Andrews
    The Brooke Laboratories, Division of Infection, Inflammation, and Repair, Southampton General Hospital, UK
    J Immunol 176:7456-61. 2006
    ....
  44. ncbi request reprint The genetics of asthma: ADAM33 as an example of a susceptibility gene
    Stephen T Holgate
    Infection, Inflammation, and Repair Division, MP810, F Level, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Proc Am Thorac Soc 3:440-3. 2006
    ....
  45. ncbi request reprint Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
    N J A Child
    Human Genetics Division and Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton, UK
    Biochem Soc Trans 31:652-3. 2003
    ..A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P =0.076), suggesting a role for TLR4 signalling in the severity of SIRS...
  46. ncbi request reprint Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function
    Ian A Yang
    Asthma Genetics Laboratory, Human Genetics Division, University of Southampton, United Kingdom
    Am J Respir Crit Care Med 171:171-6. 2005
    ..The results of this study support TNF as a genetic factor for susceptibility to ozone-induced changes in lung function in humans, and has potential implications for stratifying health risks of air pollution...
  47. ncbi request reprint Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both
    Catherine A Jones
    Divisions of Infection, Inflammation and Repair and Human Genetics, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 109:858-66. 2002
    ..Exposure to various microbial products in early life reduces the risk of atopy. Such exposure induces downregulation of T(H)2 allergy-biased responses by means of pattern recognition molecules, such as CD14, an LPS receptor...
  48. ncbi request reprint The role of ADAM33 in the pathogenesis of asthma
    Julie A Cakebread
    RCMB, Division of Infection, Inflammation and Repair, Southampton General Hospital, University of Southampton, UK
    Springer Semin Immunopathol 25:361-75. 2004
    ..Its association with progressive asthma and in predicting reduced lung function in young children suggest that ADAM33 has an important role in the natural history and possibly the origins of asthma, a disease unique to humans...
  49. ncbi request reprint ADAM33: a newly identified protease involved in airway remodelling
    Stephen T Holgate
    School of Medicine, University of Southampton, SO17 1BJ Southampton, UK
    Pulm Pharmacol Ther 19:3-11. 2006
    ....
  50. ncbi request reprint In that case. A multi-national pharmaceutical company wishes to recruit some of your patients to a pharmaco-genetic study. Response
    John W Holloway
    Asthma Genetics Research Group, Human Genetics Division, University of Southampton, UK
    N Z Bioeth J 3:29-30. 2002
  51. doi request reprint Genetics of allergic disease
    John W Holloway
    Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 125:S81-94. 2010
    ....
  52. doi request reprint Copy-number variation genotyping of GSTT1 and GSTM1 gene deletions by real-time PCR
    Matthew J Rose-Zerilli
    Respiratory Genetics Group, Human Genetics, Infection, Inflammation and Immunity, Public Health Sciences and Medical Statistics, Community Clinical Sciences Divisions, School of Medicine, University of Southampton, Southampton, UK
    Clin Chem 55:1680-5. 2009
    ..Analysis of large qPCR data sets can be complicated and time-consuming, however...
  53. doi request reprint ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis
    John W Holloway
    Human Genetics, School of Medicine, University of Southampton, and Cardiothoracic Unit, Southampton General Hospital, Southampton, UK
    Atherosclerosis 211:224-30. 2010
    ..These findings suggest that ADAM33 is implicated in the pathogenesis of atherosclerosis...
  54. ncbi request reprint Association between a TGFbeta1 promoter polymorphism and rhinosinusitis in aspirin-intolerant asthmatic patients
    Seung Hyun Kim
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Republic of Korea
    Respir Med 101:490-5. 2007
    ..The goal of this study was to evaluate the association of TGFbeta1 gene polymorphism with an AIA phenotype in the Korean population...
  55. ncbi request reprint Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function
    Angela Simpson
    North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Am J Respir Crit Care Med 172:55-60. 2005
    ..Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood...
  56. ncbi request reprint Association of asthma with a functional promoter polymorphism in the IL16 gene
    Kristin M Burkart
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 117:86-91. 2006
    ..A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described...
  57. ncbi request reprint The role of Toll-like receptors and related receptors of the innate immune system in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Curr Opin Allergy Clin Immunol 6:23-8. 2006
    ..This review summarizes recent studies of the role of innate immunity receptors, including Toll-like receptors and CD14, in the pathogenesis of asthma...
  58. ncbi request reprint Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    Paul Van Eerdewegh
    Genome Therapeutics Corporation, 100 Beaver St, Waltham, Massachusetts 02453, USA
    Nature 418:426-30. 2002
    ..The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease...
  59. ncbi request reprint Gene-environmental interaction in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Curr Opin Allergy Clin Immunol 7:75-82. 2007
    ..Asthma is likely to result from the effects of environmental stimuli in genetically susceptible individuals. This review summarizes recent studies of gene-environmental interaction in the pathogenesis of asthma, focusing on study designs...