Kieren G Hollingsworth

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Subepicardial dysfunction leads to global left ventricular systolic impairment in patients with limb girdle muscular dystrophy 2I
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Eur J Heart Fail 15:986-94. 2013
  2. pmc Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Appl Physiol (1985) 112:2043-8. 2012
  3. pmc Left ventricular torsion, energetics, and diastolic function in normal human aging
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Heart Circ Physiol 302:H885-92. 2012
  4. pmc Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging
    K G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK
    J Intern Med 271:264-70. 2012
  5. ncbi request reprint Globus pallidus magnetization transfer ratio, T(1) and T(2) in primary biliary cirrhosis: relationship with disease stage and age
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Magn Reson Imaging 29:780-4. 2009
  6. pmc Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers
    Matthew G D Bates
    Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Eur Heart J Cardiovasc Imaging 14:650-8. 2013
  7. ncbi request reprint Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Hepatol 53:155-61. 2010
  8. ncbi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010
  9. pmc Effects of raising muscle glycogen synthesis rate on skeletal muscle ATP turnover rate in type 2 diabetes
    Ee L Lim
    Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Endocrinol Metab 301:E1155-62. 2011
  10. ncbi request reprint Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Subepicardial dysfunction leads to global left ventricular systolic impairment in patients with limb girdle muscular dystrophy 2I
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Eur J Heart Fail 15:986-94. 2013
    ..826C > A FKRP (fukutin-related protein) mutation, using a comprehensive magnetic resonance (MR) examination...
  2. pmc Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Appl Physiol (1985) 112:2043-8. 2012
    ..This is analogous to the changes found in healthy aging for subjects ∼16 yr older than the fatigued PBC patients. Hence the hearts of fatigued PBC patients may be subject to processes of accelerated aging...
  3. pmc Left ventricular torsion, energetics, and diastolic function in normal human aging
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Heart Circ Physiol 302:H885-92. 2012
    ..34, not significant (NS) and TSR vs. PCr/ATP: r = -0.3, P = NS]. In normal aging, changes in EFP and TSR likely share the same pathophysiology, although it is unlikely that energetics have a major role in the functional effects of aging...
  4. pmc Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging
    K G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, NE4 5PL, Newcastle upon Tyne, UK
    J Intern Med 271:264-70. 2012
    ..Magnetic resonance cardiac tagging is a novel technique that assesses myocardial wall function in vivo. We hypothesized that patients with CFS may have impaired development and release of myocardial torsion and strain...
  5. ncbi request reprint Globus pallidus magnetization transfer ratio, T(1) and T(2) in primary biliary cirrhosis: relationship with disease stage and age
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Magn Reson Imaging 29:780-4. 2009
    ....
  6. pmc Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers
    Matthew G D Bates
    Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Eur Heart J Cardiovasc Imaging 14:650-8. 2013
    ..Screening strategies for cardiac disease are unclear. We investigated whether myocardial abnormalities could be identified in mitochondrial DNA mutation carriers without clinical cardiac involvement...
  7. ncbi request reprint Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Hepatol 53:155-61. 2010
    ..We modelled this effect by exploring kinetics of pH recovery during 3 linked exercise episodes using magnetic resonance spectroscopy (MRS)...
  8. ncbi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010
    ..Cognitive impairment is recognised in the early stages of primary biliary cirrhosis (PBC)...
  9. pmc Effects of raising muscle glycogen synthesis rate on skeletal muscle ATP turnover rate in type 2 diabetes
    Ee L Lim
    Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Endocrinol Metab 301:E1155-62. 2011
    ..In type 2 diabetes, skeletal muscle ATP turnover rates reflect the rate of glucose uptake and glycogen synthesis, rather than any primary mitochondrial defect...
  10. ncbi request reprint Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008
    ..Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined...
  11. doi request reprint Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 58:757-62. 2013
    ..This study aimed to address this by defining the effect of NAFLD on cardiac function, structure, and metabolism...
  12. doi request reprint Impaired cardiovascular response to standing in chronic fatigue syndrome
    Kieren G Hollingsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Invest 40:608-15. 2010
    ..This study examined the relationship between skeletal and cardiac muscle function and symptoms on standing in CFS using magnetic resonance spectroscopy (MRS) and impedance cardiography...
  13. pmc Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance
    Peter E Thelwall
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 59:543-9. 2013
    ..Secondly, we used MR spectroscopy to monitor the effects of an enzyme replacement therapy (ERT), sebelipase alfa (a recombinant human lysosomal acid lipase), on hepatic TG and CE content in the preclinical model...
  14. doi request reprint Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control study
    David E J Jones
    Institute of Cellular Medicine Newcastle, Newcastle University, Newcastle, UK
    Eur J Clin Invest 42:186-94. 2012
    ..Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of exercise...
  15. ncbi request reprint Impaired quality of life in growth hormone-deficient adults is independent of the altered skeletal muscle oxidative metabolism found in conditions with peripheral fatigue
    Akash Sinha
    Department of Paediatric Endocrinology, Great North Children s Hospital, Newcastle upon Tyne, UK Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 80:107-14. 2014
    ..We wished to define the role of skeletal muscle metabolism in the impaired QoL observed in patients with GHD...
  16. doi request reprint Magnetic resonance imaging in Duchenne muscular dystrophy: longitudinal assessment of natural history over 18 months
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Muscle Nerve 48:586-8. 2013
    ..In this study we assessed the progression of fat replacement with T(1) -weighted imaging over 2 9-month periods...
  17. pmc Quantitative magnetic resonance imaging in limb-girdle muscular dystrophy 2I: a multinational cross-sectional study
    Tracey A Willis
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    PLoS ONE 9:e90377. 2014
    ..We demonstrated (i) that the quantitative Dixon technique is an objective quantitative marker of disease and (ii) new observations of gender specific patterns of muscle involvement in LGMD2I...
  18. pmc Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates
    Ee L Lim
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Clin Sci (Lond) 121:169-77. 2011
    ..ATP turnover rate in muscle exhibits no relationship to the acute metabolic effect of insulin...
  19. ncbi request reprint MR imaging in Duchenne muscular dystrophy: quantification of T1-weighted signal, contrast uptake, and the effects of exercise
    Penelope Garrood
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom
    J Magn Reson Imaging 30:1130-8. 2009
    ....
  20. ncbi request reprint Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle
    Akash Sinha
    Department of Paediatric Endocrinology, Great North Children s Hospital, Newcastle upon Tyne, United Kingdom
    J Clin Endocrinol Metab 98:E509-13. 2013
    ..The aim of this study was to examine the effects of cholecalciferol therapy on skeletal mitochondrial oxidative function in symptomatic, vitamin D-deficient individuals...
  21. pmc Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, NE4 5PL, UK
    Neuromuscul Disord 22:592-6. 2012
    ..3243A>G. The early detection of cardiac dysfunction with MRI opens up opportunities to prevent heart failure in these patients through early intervention...
  22. pmc Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy
    Ee Lin Lim
    Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    NMR Biomed 23:952-7. 2010
    ..03 vs baseline). The in vivo time course of insulin stimulation of skeletal muscle ATP turnover rate is not consistent with a rate limiting effect upon the initiation of insulin-stimulated glycogen synthesis...
  23. pmc Quantitative muscle MRI as an assessment tool for monitoring disease progression in LGMD2I: a multicentre longitudinal study
    Tracey A Willis
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e70993. 2013
    ..We hypothesised that quantitative fat imaging by MRI (Dixon technique) could provide more discriminating quantitative, patient-independent measurements of the progress of muscle fat replacement within individual muscle groups...
  24. pmc Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK2NIHR Biomedical Research Centre for Ageing and Age related Disease, Newcastle University, Newcastle upon Tyne, UK
    Gut 60:1278-83. 2011
    ..Aerobic exercise is not well sustained and the effectiveness of the better tolerated resistance exercise upon liver lipid and mediators of liver lipid has not been assessed...
  25. ncbi request reprint Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:541-9. 2008
    ..Structural brain lesions were found in PBC, the density of which correlated with degree of cognitive impairment (P = 0.01, r(2) = 0.5) and autonomic function (P = 0.03, r(2) = 0.2)...
  26. pmc Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
    Michael I Trenell
    Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 31:1644-9. 2008
    ..To determine whether increased daily physical activity improves mitochondrial function and/or lipid oxidation in type 2 diabetes...
  27. pmc In vivo mitochondrial function in HIV-infected persons treated with contemporary anti-retroviral therapy: a magnetic resonance spectroscopy study
    Brendan A I Payne
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    PLoS ONE 9:e84678. 2014
    ..Basal energy requirements may nevertheless be increased. ..