Peter W H Holland

Summary

Affiliation: University of Reading
Country: UK

Publications

  1. pmc An unusual choanoflagellate protein released by Hedgehog autocatalytic processing
    Elizabeth A Snell
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Proc Biol Sci 273:401-7. 2006
  2. ncbi request reprint The future of evolutionary developmental biology
    P W Holland
    School of Animal and Microbial Sciences, University of Reading, UK
    Nature 402:C41-4. 1999
  3. ncbi request reprint More genes in vertebrates?
    Peter W H Holland
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, United Kingdom
    J Struct Funct Genomics 3:75-84. 2003
  4. pmc Beyond the Hox: how widespread is homeobox gene clustering?
    P W Holland
    School of Animal and Microbial Sciences, The University of Reading, UK
    J Anat 199:13-23. 2001
  5. ncbi request reprint Ciona
    Peter W H Holland
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, UK
    Curr Biol 12:R609. 2002
  6. ncbi request reprint Gene duplication: past, present and future
    P W Holland
    School of Animal and Microbial Sciences, University of Reading, UK
    Semin Cell Dev Biol 10:541-7. 1999
  7. ncbi request reprint Vertebrate evolution: something fishy about Hox genes
    P W Holland
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading, RG6 6AJ, UK
    Curr Biol 7:R570-2. 1997
  8. ncbi request reprint Gene and domain duplication in the chordate Otx gene family: insights from amphioxus Otx
    N A Williams
    School of Animal and Microbial Sciences, University of Reading, U K
    Mol Biol Evol 15:600-7. 1998
  9. ncbi request reprint Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes
    H Wada
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Development 125:1113-22. 1998
  10. ncbi request reprint An amphioxus Emx homeobox gene reveals duplication during vertebrate evolution
    N A Williams
    School of Animal and Microbial Sciences, University of Reading, Reading, England
    Mol Biol Evol 17:1520-8. 2000

Collaborators

Detail Information

Publications44

  1. pmc An unusual choanoflagellate protein released by Hedgehog autocatalytic processing
    Elizabeth A Snell
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Proc Biol Sci 273:401-7. 2006
    ..Since Hh-C and Hoglet-C are homologous, but Hh-N and Hoglet-N are not, we argue that metazoan hedgehog genes evolved by fusion of two distinct genes...
  2. ncbi request reprint The future of evolutionary developmental biology
    P W Holland
    School of Animal and Microbial Sciences, University of Reading, UK
    Nature 402:C41-4. 1999
    ..In the next century this should give us far greater mechanistic insight into how evolution has produced the vast diversity of living organisms, past and present...
  3. ncbi request reprint More genes in vertebrates?
    Peter W H Holland
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, United Kingdom
    J Struct Funct Genomics 3:75-84. 2003
    ..These data confirm that vertebrates have more genes than their closest invertebrate relatives, acquired through gene duplication...
  4. pmc Beyond the Hox: how widespread is homeobox gene clustering?
    P W Holland
    School of Animal and Microbial Sciences, The University of Reading, UK
    J Anat 199:13-23. 2001
    ..A novel hypothesis for the evolution of ParaHox gene expression in deuterostomes is presented...
  5. ncbi request reprint Ciona
    Peter W H Holland
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, UK
    Curr Biol 12:R609. 2002
  6. ncbi request reprint Gene duplication: past, present and future
    P W Holland
    School of Animal and Microbial Sciences, University of Reading, UK
    Semin Cell Dev Biol 10:541-7. 1999
    ..I also outline the major unresolved questions in the study of gene duplication, and its relevance to evolution and development...
  7. ncbi request reprint Vertebrate evolution: something fishy about Hox genes
    P W Holland
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading, RG6 6AJ, UK
    Curr Biol 7:R570-2. 1997
    ..One of the many surprises is that this strange fish has lost an unusually large number of Hox genes...
  8. ncbi request reprint Gene and domain duplication in the chordate Otx gene family: insights from amphioxus Otx
    N A Williams
    School of Animal and Microbial Sciences, University of Reading, U K
    Mol Biol Evol 15:600-7. 1998
    ..These roles were elaborated following Otx gene duplication in vertebrates, accompanied by regulatory and structural divergence, particularly of Otx1 descendant genes...
  9. ncbi request reprint Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes
    H Wada
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Development 125:1113-22. 1998
    ..Therefore, placodes are not likely to be a newly acquired feature in vertebrates, but may have already been possessed by the earliest chordates...
  10. ncbi request reprint An amphioxus Emx homeobox gene reveals duplication during vertebrate evolution
    N A Williams
    School of Animal and Microbial Sciences, University of Reading, Reading, England
    Mol Biol Evol 17:1520-8. 2000
    ..Finally, our molecular phylogenetic analysis strongly supports the presence of a single Emx gene in the ancestor of chordates and gene duplication along the vertebrate lineage...
  11. ncbi request reprint The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx
    D E Ferrier
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading, RG6 6AJ, UK
    Dev Genes Evol 211:103-7. 2001
    ..We propose a new homeobox class, Mnx, to include AmphiMnx, HB9, MNR2 and their Drosophila and echinoderm orthologues; we suggest that vertebrate HB9 is renamed Mnx1 and MNR2 be renamed Mnx2...
  12. pmc Were vertebrates octoploid?
    Rebecca F Furlong
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Philos Trans R Soc Lond B Biol Sci 357:531-44. 2002
    ..We propose that early vertebrates passed through an autoautooctoploid phase in the evolution of their genomes...
  13. ncbi request reprint Cloning and analysis of an HMG gene from the lamprey Lampetra fluviatilis: gene duplication in vertebrate evolution
    A C Sharman
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, UK
    Gene 184:99-105. 1997
    ..We also show that the HMG1/2 family originated before the protostomes and deuterostomes diverged, over 525 million years ago...
  14. ncbi request reprint Bayesian phylogenetic analysis supports monophyly of ambulacraria and of cyclostomes
    Rebecca F Furlong
    School of Animal and Microbial Sciences, The University of Reading, Whiteknoghts, UK
    Zoolog Sci 19:593-9. 2002
    ..Using robust Bayesian statistical analysis of 18S ribosomal DNA, mitochondrial genes and nuclear protein-coding DNA, we find strong support for a hemichordate-echinoderm clade, and for monophyly of the cyclostomes...
  15. ncbi request reprint Ciona intestinalis ParaHox genes: evolution of Hox/ParaHox cluster integrity, developmental mode, and temporal colinearity
    David E K Ferrier
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ, UK
    Mol Phylogenet Evol 24:412-7. 2002
    ..This disintegration may be mediated by the invasion of transposable elements into the clusters, and subsequent genomic rearrangements...
  16. pmc Dispersal of NK homeobox gene clusters in amphioxus and humans
    Graham N Luke
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
    Proc Natl Acad Sci U S A 100:5292-5. 2003
    ..This evolutionary pattern is in marked contrast to the Hox and ParaHox gene clusters, which are compact in amphioxus and vertebrates, but have been disrupted in Drosophila...
  17. ncbi request reprint Neural tube is partially dorsalized by overexpression of HrPax-37: the ascidian homologue of Pax-3 and Pax-7
    H Wada
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, United Kingdom
    Dev Biol 187:240-52. 1997
    ..These results suggest that dorsal specification in the neural tube by Pax-3/7 subfamily genes was established in the ancestors of extant chordates during emergence of the dorsal tubular nervous system...
  18. ncbi request reprint Sipunculan ParaHox genes
    D E Ferrier
    School of Animal and Microbial Sciences, University of Reading, UK
    Evol Dev 3:263-70. 2001
    ..Furthermore, it implies that the ParaHox genes are of sufficient functional importance in both protostomes and deuterostomes that they have all been conserved in both of these bilaterian clades...
  19. ncbi request reprint An amphioxus Krox gene: insights into vertebrate hindbrain evolution
    R D Knight
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK
    Dev Genes Evol 210:518-21. 2000
    ....
  20. pmc Vertebrate innovations
    S M Shimeld
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
    Proc Natl Acad Sci U S A 97:4449-52. 2000
    ..Comparative molecular and developmental data give new insights into the evolutionary origins of these characteristics and the complexity of the vertebrate body...
  21. ncbi request reprint Ancient origin of the Hox gene cluster
    D E Ferrier
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Nat Rev Genet 2:33-8. 2001
    ..The characterization of Hox-like genes from Hydra, sea anemones and jellyfish has revealed that a Hox gene cluster is extremely ancient, having originated even before the divergence of these basal animals...
  22. ncbi request reprint Hsp70 sequences indicate that choanoflagellates are closely related to animals
    E A Snell
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights PO Box 228, RG6 6AJ, Reading, United Kingdom
    Curr Biol 11:967-70. 2001
    ..We infer that animals and at least some choanoflagellates are part of a clade that excludes the fungi. This is consistent with the origin of animals from a choanoflagellate-like ancestor...
  23. ncbi request reprint Phylogenomics of eukaryotes: impact of missing data on large alignments
    Hervé Philippe
    School of Animal and Microbial Sciences, The University of Reading, Reading, UK
    Mol Biol Evol 21:1740-52. 2004
    ....
  24. ncbi request reprint An orphan PRD class homeobox gene expressed in mouse brain and limb development
    Tokiharu Takahashi
    School of Animal and Microbial Science, The University of Reading, Whiteknights, Reading, RG6 6AJ, UK
    Dev Genes Evol 212:293-7. 2002
    ..Unusually for homeobox genes, there is no orthologue in the Drosophila or Caenorhabditis genomes; we argue this reflects secondary loss...
  25. pmc Classification and nomenclature of all human homeobox genes
    Peter W H Holland
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    BMC Biol 5:47. 2007
    ..Increasingly, homeobox genes are being compared between genomes in an attempt to understand the evolution of animal development. Despite their importance, the full diversity of human homeobox genes has not previously been described...
  26. pmc Breakup of a homeobox cluster after genome duplication in teleosts
    John F Mulley
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 103:10369-72. 2006
    ..We propose that this homeobox gene cluster is held together in chordates by the existence of interdigitated control regions that could be separated after locus duplication in the teleost fish...
  27. ncbi request reprint A Gbx homeobox gene in amphioxus: insights into ancestry of the ANTP class and evolution of the midbrain/hindbrain boundary
    L Filipe C Castro
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Dev Biol 295:40-51. 2006
    ..Comparison with hemichordates suggests that anterior Otx and posterior Gbx domains were probably overlapping in the ancestral deuterostome and came to abut at the MHB early in the chordate lineage before MHB organizer properties evolved...
  28. ncbi request reprint Buddenbrockia is a cnidarian worm
    Eva Jimenez-Guri
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Science 317:116-8. 2007
    ..This active muscular worm increases the known diversity in cnidarian body plans and demonstrates that a muscular, wormlike form can evolve in the absence of overt bilateral symmetry...
  29. pmc No more than 14: the end of the amphioxus Hox cluster
    Carolina Minguillon
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona Av Diagonal, 645 E 08028, Barcelona, Spain
    Int J Biol Sci 1:19-23. 2005
    ..We suggest that 14 is the end...
  30. pmc The amphioxus genome illuminates vertebrate origins and cephalochordate biology
    Linda Z Holland
    Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
    Genome Res 18:1100-11. 2008
    ..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates...
  31. ncbi request reprint Amphioxus and ascidian Dmbx homeobox genes give clues to the vertebrate origins of midbrain development
    Tokiharu Takahashi
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Development 131:3285-94. 2004
    ..We discuss the evolution of midbrain development in relation to the ancestry of the tripartite neural ground plan and the origin of the MHB organiser...
  32. ncbi request reprint The amphioxus genome and the evolution of the chordate karyotype
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Nature 453:1064-71. 2008
    ..These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution...
  33. pmc Correlating Bayesian date estimates with climatic events and domestication using a bovine case study
    Simon Y W Ho
    Department of Zoology, University of Oxford, Oxford, UK
    Biol Lett 4:370-4. 2008
    ..The divergence age estimates support domestication-associated expansion times (less than 12 kyr) for the major haplogroups of cattle. We compare the molecular and palaeontological estimates for the Bison-Bos divergence...
  34. ncbi request reprint Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line
    H Anne F Booth
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Gene 387:7-14. 2007
    ..Deducing the evolutionary origins of these genes is not straightforward, but we propose that TPRX1, DPRX and DUXA are highly divergent derivatives of the CRX gene, itself a member of the Otx homeobox gene family...
  35. ncbi request reprint A degenerate ParaHox gene cluster in a degenerate vertebrate
    Rebecca F Furlong
    Department of Zoology, Oxford University, Oxford, United Kingdom
    Mol Biol Evol 24:2681-6. 2007
    ..Furthermore, our phylogenetic analyses suggest that hagfishes may have diverged from the vertebrate lineage before the duplications, which created the multiple ParaHox clusters in jawed vertebrates...
  36. doi request reprint The urbilaterian Super-Hox cluster
    Thomas Butts
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Trends Genet 24:259-62. 2008
    ..Here we show that this cluster was embedded within a larger homeobox gene cluster, the Super-Hox cluster, in the ancestral bilaterian. This Super-Hox cluster contained at least eight genes alongside the core Hox genes ('EuHox' genes)...
  37. ncbi request reprint The origins of multicellularity: a multi-taxon genome initiative
    Inaki Ruiz-Trillo
    Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Trends Genet 23:113-8. 2007
    ..Here, we introduce this initiative and the biological questions that underpin it, summarize the rationale guiding the choice of organisms and discuss the anticipated benefits to the broader scientific community...
  38. pmc Patterns of conservation and change in honey bee developmental genes
    Peter K Dearden
    Laboratory for Evolution and Development, Biochemistry Department, University of Otago, Dunedin, Aotearoa New Zealand
    Genome Res 16:1376-84. 2006
    ....
  39. ncbi request reprint The evolution of multicellularity and early animal genomes
    Nina M Brooke
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Curr Opin Genet Dev 13:599-603. 2003
    ..The homeobox and kinase gene families have been further analysed in basal animals, although more data are required to enable detailed comparison with Bilateria...
  40. ncbi request reprint Orphan worm finds a home: Buddenbrockia is a myxozoan
    Ana Sara Monteiro
    Mol Biol Evol 19:968-71. 2002
  41. ncbi request reprint The evolution of homeobox genes: Implications for the study of brain development
    Peter W H Holland
    Department of Zoology, University of Oxford, UK
    Brain Res Bull 66:484-90. 2005
    ..We argue that understanding evolutionary history is important for establishing consistent gene nomenclature, and for comparing gene expression patterns and gene functions between species and between gene families...
  42. ncbi request reprint Eleven daughters of NANOG
    H Anne F Booth
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Genomics 84:229-38. 2004
    ..The mouse genome has two processed pseudogenes, which are not clear orthologues of the primate pseudogenes...
  43. ncbi request reprint An antecedent of the MHC-linked genomic region in amphioxus
    L Filipe C Castro
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Immunogenetics 55:782-4. 2004
    ..The composition of the MHC-linked genomic region, therefore, pre-dates vertebrate origins...
  44. pmc Protein evolution of ANTP and PRD homeobox genes
    Nuno A Fonseca
    Instituto de Biologia Molecular e Celular IBMC, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    BMC Evol Biol 8:200. 2008
    ..Although homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes...