Stephen T Holgate
Affiliation: University of Southampton
Holgate S, Walker S, West B, Boycott K. The Future of Asthma Care: Personalized Asthma Treatment. Clin Chest Med. 2019;40:227-241 pubmed publisher
..Novel technologies, such as wearables and intelligent inhalers, enable real-time remote monitoring of asthma, creating a unique opportunity for personalized health care. ..
Holgate S. Immune circuits in asthma. Curr Opin Pharmacol. 2013;13:345-50 pubmed publisher
..This mandates a new view of the disease in which causal pathways linked to biomarkers are found and treatments targeted to these pathways as described in a more personalised approach to medicine. ..
Holgate S. ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease. Drug News Perspect. 2010;23:381-7 pubmed publisher
..These all point to ADAM33 being a key molecule in the development and progression of asthma by contributing to smooth muscle and vascular modeling and remodeling. ..
Holgate S. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev. 2011;242:205-19 pubmed publisher
Holgate S, Canonica G, Simons F, Taglialatela M, Tharp M, Timmerman H, et al
. Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations. Clin Exp Allergy. 2003;33:1305-24 pubmed
Holgate S, Yang Y, Haitchi H, Powell R, Holloway J, Yoshisue H, et al
. The genetics of asthma: ADAM33 as an example of a susceptibility gene. Proc Am Thorac Soc. 2006;3:440-3 pubmed
Holgate S. Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?. J Allergy Clin Immunol. 2011;128:495-505 pubmed publisher
Holgate S. Has the time come to rethink the pathogenesis of asthma?. Curr Opin Allergy Clin Immunol. 2010;10:48-53 pubmed publisher
..However, ranges of approaches that have targeted this immunological component have so far been disappointing. Most asthma therapy still relies on bronchodilators and corticosteroids rather than treating underlying disease mechanisms...
Holgate S. Innate and adaptive immune responses in asthma. Nat Med. 2012;18:673-83 pubmed publisher