Stephen Holgate

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study
    Tillie Louise Hackett
    School of Biological Sciences, University of Southampton, Southampton, UK
    Respir Res 9:47. 2008
  2. pmc Human bronchial fibroblasts express the 5-lipoxygenase pathway
    Anna J James
    Division of Infection, Inflammation and Repair IIR, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Respir Res 7:102. 2006
  3. pmc IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics
    Luminita A Stanciu
    Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute for Infection and Immunity, Imperial College London, Norfolk Place, London, UK
    Respir Res 6:67. 2005
  4. pmc Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways
    Anne B Knol
    Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 6:19. 2009
  5. pmc Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 5:8. 2008
  6. pmc The epidemic of asthma and allergy
    Stephen T Holgate
    Respiratory Cell and Molecular Biology Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J R Soc Med 97:103-10. 2004
  7. ncbi request reprint Summary of recommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma
    S T Holgate
    RCMB Division, School of Medicine, University of Southampton, UK
    Respir Med 98:479-87. 2004
  8. ncbi request reprint ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma
    Stephen T Holgate
    Respiratory Cell and Molecular Biology Research Division, School of Medicine, University of Southampton, UK, University of Cambridge, UK
    Clin Rev Allergy Immunol 27:23-34. 2004
  9. ncbi request reprint Epithelial-mesenchymal communication in the pathogenesis of chronic asthma
    Stephen T Holgate
    Respiratory Cell and Molecular Biology, Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, D Level Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Proc Am Thorac Soc 1:93-8. 2004
  10. ncbi request reprint The Brussels Declaration: the need for change in asthma management
    S Holgate
    Infection, Inflammation and Repair AIR Division, Level F, South Block, MP810, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Eur Respir J 32:1433-42. 2008

Collaborators

Detail Information

Publications132 found, 100 shown here

  1. pmc Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study
    Tillie Louise Hackett
    School of Biological Sciences, University of Southampton, Southampton, UK
    Respir Res 9:47. 2008
    ..The aim of this study was to asses the kinetics of cytokine release from COPD parenchymal explants using an ex vivo model of lipopolysaccharide (LPS) induced acute inflammation...
  2. pmc Human bronchial fibroblasts express the 5-lipoxygenase pathway
    Anna J James
    Division of Infection, Inflammation and Repair IIR, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Respir Res 7:102. 2006
    ..Fibroblast activity is influenced by members of the leukotriene family of bronchoconstrictor and inflammatory mediators, but it is not known whether human bronchial fibroblasts can synthesize leukotrienes...
  3. pmc IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics
    Luminita A Stanciu
    Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute for Infection and Immunity, Imperial College London, Norfolk Place, London, UK
    Respir Res 6:67. 2005
    ..In this study, we investigated whether excess IL-4 during repeated TCR/CD3 stimulation of CD8+ T cells from atopic asthmatic subjects alters the balance of type 1/type 2 cytokine production in favour of the latter...
  4. pmc Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways
    Anne B Knol
    Dutch National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 6:19. 2009
    ..abstract:..
  5. pmc Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 5:8. 2008
    ..abstract:..
  6. pmc The epidemic of asthma and allergy
    Stephen T Holgate
    Respiratory Cell and Molecular Biology Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J R Soc Med 97:103-10. 2004
  7. ncbi request reprint Summary of recommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma
    S T Holgate
    RCMB Division, School of Medicine, University of Southampton, UK
    Respir Med 98:479-87. 2004
    ..As with all drugs introduced into practice, careful attention needs to be paid to both short- and long-term safety...
  8. ncbi request reprint ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma
    Stephen T Holgate
    Respiratory Cell and Molecular Biology Research Division, School of Medicine, University of Southampton, UK, University of Cambridge, UK
    Clin Rev Allergy Immunol 27:23-34. 2004
    ..The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity...
  9. ncbi request reprint Epithelial-mesenchymal communication in the pathogenesis of chronic asthma
    Stephen T Holgate
    Respiratory Cell and Molecular Biology, Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, D Level Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Proc Am Thorac Soc 1:93-8. 2004
    ....
  10. ncbi request reprint The Brussels Declaration: the need for change in asthma management
    S Holgate
    Infection, Inflammation and Repair AIR Division, Level F, South Block, MP810, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Eur Respir J 32:1433-42. 2008
    ..The present paper reviews the evidence supporting the need for change in asthma management and summarises the ten key points contained in the Brussels Declaration...
  11. ncbi request reprint The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update
    Stephen Holgate
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, D level Centre Block MP810, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Respir Med 103:1098-113. 2009
    ..Omalizumab is generally well tolerated. Anaphylactic-like reactions are rare (0.1% of patients) and less common than encountered with other biologics...
  12. pmc Improving the management of atopic disease
    S T Holgate
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    Arch Dis Child 90:826-31. 2005
    ..The importance of allergy testing and the options available are described, particularly with reference to the role of the non-allergist...
  13. ncbi request reprint Rethinking the pathogenesis of asthma
    Stephen T Holgate
    III Division, School of Medicine, University of Southampton, Southampton S016 61D, UK
    Immunity 31:362-7. 2009
    ..It may be worthwhile to focus on increasing the resilience of the airways to environmental insults in addition to improving strategies that modify adaptive immunity or suppress inflammation...
  14. ncbi request reprint Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease
    Stephen T Holgate
    Respiratory Cell and Molecular Biology Research Division, School of Medicine, University of Southampton, Mid I Level D Centre Block, 810, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Cytokine 28:152-7. 2004
    ..It is likely that asthma is not a single disease but a group of disorders which differ in the relative contribution of specific pathophysiological pathways...
  15. pmc The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma
    Stephen T Holgate
    Allergy and Inflammation Research, School of Medicine, University of Southampton, Southampton
    Br J Pharmacol 145:1009-15. 2005
    ..These data have provided a firm basis for developing adenosine A(2B) receptor antagonists as a new therapeutic approach to this disease...
  16. ncbi request reprint A look at the pathogenesis of asthma: the need for a change in direction
    Stephen T Holgate
    Infection, Inflammation and Immunity Division, Southampton General Hospital, School of Medicine, University of Southampton, Southampton, United Kingdom
    Discov Med 9:439-47. 2010
    ....
  17. ncbi request reprint The epithelium takes centre stage in asthma and atopic dermatitis
    Stephen T Holgate
    School of Medicine, University of Southampton, Southampton, UK, SO16 6YD
    Trends Immunol 28:248-51. 2007
    ..Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease...
  18. ncbi request reprint Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics
    M L Seymour
    Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Crit Care Med 164:2051-6. 2001
    ..Inverse correlations between PEF and 5-LO(+) cell counts link increased expression of 5-LO pathway enzymes in eosinophils and macrophages within the bronchial mucosa to deterioration of lung function during seasonal allergen exposure...
  19. ncbi request reprint The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma
    L Hao
    Division of Human Genetics, University of Southampton School of Medicine, Southampton, UK
    Clin Exp Allergy 36:735-41. 2006
    ..We screened the CYSLTR1 gene on chromosome Xq13-21 for coding region polymorphisms, and investigated their associations with allergy and asthma...
  20. ncbi request reprint Genetic and environmental influences on airway inflammation in asthma
    S T Holgate
    University Medicine, Southampton General Hospital, UK
    Int Arch Allergy Immunol 107:29-33. 1995
    ..These latter findings, being more evident in severe chronic disease, suggest that the 'formed' airway elements are also important in mediating the ongoing inflammation characteristic of asthma...
  21. ncbi request reprint Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population
    B Beghe
    Divisions of Human Genetics Infection, Inflammation and Repair, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:1111-7. 2003
    ..IL-4 by binding to its receptor (IL-4R) is essential for the development of airway inflammation present in asthma, through the induction of IgE synthesis in B cells and differentiation of T cells to a Th2 phenotype...
  22. ncbi request reprint The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma
    L M Hamilton
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:233-40. 2003
    ..Although the EGFR is involved in epithelial growth and differentiation, it is unknown whether it also contributes to the inflammatory response in asthma...
  23. ncbi request reprint Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells
    A Papi
    University Medicine, University of Southampton, Southampton, UK
    J Allergy Clin Immunol 108:221-8. 2001
    ..CONCLUSION: These effects are unlikely to be mediated by H(1)-receptor antagonism and suggest a novel mechanism of action that may be important for the therapeutic control of virus-induced asthma exacerbations...
  24. ncbi request reprint Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma
    G D Phillips
    Immunopharmacology Group, Southampton General Hospital, United Kingdom
    J Appl Physiol 66:304-12. 1989
    ..05) but not for FEV1 (P less than 0.05). We conclude that inhaled LTC4 interacts synergistically with histamine and PGD2 and that this effect, although small, may be a relevant interaction in asthma...
  25. ncbi request reprint The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
    Stephen Holgate
    RCMB Research Division, Southampton General Hospital, United Kingdom
    J Allergy Clin Immunol 115:459-65. 2005
    ....
  26. ncbi request reprint The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma
    L Camporota
    Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
    Eur Respir J 21:287-93. 2003
    ..07). This study shows a trend toward significance for the effects of heat-killed Mycobacterium vaccae (SRL172) on allergen-induced airway responses. Further clinical trials, involving multiple dosing, are needed...
  27. ncbi request reprint Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population
    I Sayers
    Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Clin Exp Allergy 33:1103-10. 2003
    ..5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma...
  28. ncbi request reprint Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects
    S H Cho
    University Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 32:427-33. 2002
    ..However, CD8+ T cells also produce type 1 and type 2 cytokines and the relative roles of CD4+ and CD8+ T cell cytokine production in asthma have not been previously studied...
  29. ncbi request reprint Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium
    L M Hamilton
    The Brooke Laboratories, Mailpoint 888, Southampton General Hospital, Southampton, SO16 6YD, UK
    Eur Respir J 25:978-85. 2005
    ..The epidermal growth factor receptor and/or other tyrosine kinase pathways may contribute to persistent, corticosteroid-unresponsive inflammation in severe asthma...
  30. ncbi request reprint Inhibition of adenosine 5'-monophosphate- and methacholine-induced bronchoconstriction in asthma by inhaled frusemide
    R Polosa
    Dept of Immunopharmacology, Southampton General Hospital, UK
    Eur Respir J 3:665-72. 1990
    ..Its more potent activity against AMP and other bronchoconstrictor stimuli, that are considered to involve mast cell mediators, suggests an additional action on mast cell functions possibly at the level of the Ca++/Mg(++)-ATPase...
  31. ncbi request reprint Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium
    R E Mullings
    Division of Respiratory Cell and Molecular Biology, School of Medicine, Southampton General Hospital, United Kingdom
    J Allergy Clin Immunol 108:832-8. 2001
    ..Asthma is associated with increased production of IL-4 and IL-13...
  32. ncbi request reprint The effect of inhaled 15-(s)-hydroxyeicosatetraenoic acid (15-HETE) on airway calibre and non-specific responsiveness in normal and asthmatic human subjects
    C K Lai
    Immunopharmacology Group, Southampton General Hospital, UK
    Eur Respir J 3:38-45. 1990
    ..41-fold of baseline after diluent (p less than 0.01) compared with a 1.1-fold increase after 15-HETE, p less than 0.01). These data suggest 15-HETE may play an autacoid role in airway function...
  33. pmc Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment
    A E Redington
    University Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Thorax 56:351-7. 2001
    ..We hypothesised that the in vivo expression of iNOS and COX-2 in the airways would be increased in asthma, and that these cytokine inducible enzymes may represent targets for regulation by corticosteroid treatment...
  34. doi request reprint Effect of bronchoconstriction on airway remodeling in asthma
    Christopher L Grainge
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, United Kingdom
    N Engl J Med 364:2006-15. 2011
    ..We evaluated the influence of repeated experimentally induced bronchoconstriction on airway structural changes in patients with asthma...
  35. ncbi request reprint Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations
    S T Holgate
    Respiratory Cell and Molecular Biology, Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:1305-24. 2003
  36. ncbi request reprint Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
    A J Jame
    Division of Infection, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 37:880-92. 2007
    ....
  37. ncbi request reprint Inhaled synthetic surfactant abolishes the early allergen-induced response in asthma
    K S Babu
    Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK
    Eur Respir J 21:1046-9. 2003
    ..Exogenous surfactant administration could serve as a useful adjunct in controlling the early allergen-induced symptoms in patients with allergic asthma...
  38. pmc Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma
    I Sayers
    Human Genetics Research Division, University of Southampton, Southampton SO16 6YD, UK
    Thorax 58:417-24. 2003
    ..We have identified a novel promoter polymorphism at position -1072 (G/A) and a -444 (A/C) polymorphism has previously been reported. The role of these polymorphisms in the genetic susceptibility to asthma was examined...
  39. ncbi request reprint The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial
    J B Morjaria
    Infection, Inflammation and Repair Division, Southampton University Hospitals Trust, Southampton, UK
    Thorax 63:584-91. 2008
    ..Tumour necrosis factor alpha (TNFalpha) is a cytokine recognised as a therapeutic target in chronic inflammatory diseases...
  40. ncbi request reprint Role of carbohydrates in repair of human respiratory epithelium using an in vitro model
    E C Adam
    Respiratory Cell and Molecular Biology Division, University of Southampton, Southampton, UK
    Clin Exp Allergy 33:1398-404. 2003
    ..The epithelial layer in the conducting airway provides a primary protective barrier. Repair of this barrier normally occurs rapidly after damage, but is compromised in diseases such as asthma...
  41. pmc Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways
    S Pathmanathan
    University of Southampton, Southampton, UK
    Occup Environ Med 60:892-6. 2003
    ..Repeated daily exposure of healthy human subjects to NO2 induces an acute airway inflammatory response characterised by neutrophil influx in the bronchial mucosa..
  42. ncbi request reprint Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma
    S T Holgate
    Division of Infection, Inflammation and Repair, Mailpoint 810, Level D, Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Respir J Suppl 44:24s-29s. 2003
  43. ncbi request reprint Toll-like receptor 4 polymorphism and severity of atopy in asthmatics
    I A Yang
    Asthma Genetics Laboratory, Division of Human Genetics and Infection, University of Southampton, Southampton, UK
    Genes Immun 5:41-5. 2004
    ..05). This study confirms the previously observed lack of association of TLR4 polymorphisms with asthma. In contrast, the findings suggest that genetically determined hyporesponsiveness to endotoxin may increase atopy severity...
  44. ncbi request reprint Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms
    S T Holgate
    Allergy and Inflammation Research, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Respir J 29:793-803. 2007
    ....
  45. ncbi request reprint Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma
    S T Holgate
    RCMB Research Division, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 34:632-8. 2004
    ..Patients with severe asthma are often inadequately controlled on existing anti-asthma therapy, constituting an unmet clinical need...
  46. ncbi request reprint The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma
    C Boxall
    The Brooke Laboratories, Division of Infection, Inflammation and Repair, F Level South Lab and Path Block 888, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Respir J 27:208-29. 2006
    ....
  47. ncbi request reprint Lessons learnt from the epidemic of asthma
    S T Holgate
    Allergy and Inflammation Research Division, Southampton General Hospital, Southampton, UK
    QJM 97:247-57. 2004
  48. pmc Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
    P H Howarth
    Allergy and Inflammation Research, Division of Infection, Inflammation and Repair, School of Medicine, F Level South Block 810, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 60:1012-8. 2005
    ....
  49. pmc Expression of ErbB receptors and mucins in the airways of long term current smokers
    R A O'Donnell
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Thorax 59:1032-40. 2004
    ..Although the epidermal growth factor receptor has been implicated in this process, neither ErbB receptor expression nor the mucosecretory phenotype of the epithelium have been characterised in current smokers...
  50. ncbi request reprint Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy
    S T Holgate
    Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 35:408-16. 2005
    ..These impressive clinical data and the studies elucidating the anti-inflammatory profile of omalizumab also serve to emphasize the fundamental importance of IgE in the pathogenesis of allergic diseases...
  51. ncbi request reprint Aetiology of asthma: how public health and molecular medicine work together
    A J Chauhan
    University Medicine, Southampton General Hospital, UK
    Mol Med Today 2:192-7. 1996
    ..It focuses on the recognition that asthma is an inflammatory disorder, and that the public health burden of the disease can be reduced by identifying environmental factors that may trigger asthma in genetically susceptible individuals...
  52. ncbi request reprint Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families
    J W Holloway
    Human Genetics, Division School of Medicine, University of Southampton, UK
    Genes Immun 2:20-4. 2001
    ..946 at location 171.3 cM and a standard error of 3.3 for the asthma quantitative score. There was no evidence of linkage with atopy, the atopy quantitative score or total serum IgE...
  53. pmc Use of ultramolecular potencies of allergen to treat asthmatic people allergic to house dust mite: double blind randomised controlled clinical trial
    G T Lewith
    Medical Specialties, Southampton General Hospital, Southampton, Hampshire SO16 6YD
    BMJ 324:520. 2002
    ..To evaluate the efficacy of homoeopathic immunotherapy on lung function and respiratory symptoms in asthmatic people allergic to house dust mite...
  54. ncbi request reprint Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
    S Salvi
    University Medicine Department, Southampton General Hospital, Southampton, and Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Respir Crit Care Med 159:702-9. 1999
    ....
  55. ncbi request reprint Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma
    S J Wilson
    Respiratory Cell and Molecular Biology Research Division, School of Medicine, University of Southampton, Southhampton, United Kingdom
    Am J Respir Crit Care Med 164:1047-52. 2001
    ....
  56. pmc Role of cysteinyl leukotrienes in adenosine 5'-monophosphate induced bronchoconstriction in asthma
    S Rorke
    Division of Respiratory Cell and Molecular Biology, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 57:323-7. 2002
    ..We hypothesised that adenosine induced bronchoconstriction in asthmatic patients may be blocked by pretreatment with the orally active selective cysteinyl leukotriene-1 (CysLT(1)) receptor antagonist, montelukast...
  57. ncbi request reprint The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma
    A Richter
    Respiratory, Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 25:385-91. 2001
    ..In contrast, direct activation of submucosal fibroblasts by IL-4 and IL-13 has a proinflammatory effect via eotaxin release and recruitment of eosinophils into the airways...
  58. ncbi request reprint Omalizumab, a novel anti-IgE therapy in allergic disorders
    K S Babu
    Department of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
    Expert Opin Biol Ther 1:1049-58. 2001
    ..Omalizumab also demonstrated a high level of safety in adults, adolescents and children with a side effect profile no different from the placebo. Its development is an exciting milestone in the treatment of allergic diseases...
  59. ncbi request reprint Immunohistochemical analysis of the activation of NF-kappaB and expression of associated cytokines and adhesion molecules in human models of allergic inflammation
    S J Wilson
    University Medicine, University of Southampton, U K
    J Pathol 189:265-72. 1999
    ..Thus, immunohistochemistry can be used to determine the cellular provenance of NF-kappaB and its activation status in single cell and complex tissue systems, in parallel with appropriate inflammatory markers...
  60. ncbi request reprint The epidemic of allergy and asthma
    S T Holgate
    Respiratory, Cell and Molecular Biology Research Division of the School of Medicine, University of Southampton, Southampton General Hospital, UK
    Nature 402:B2-4. 1999
    ....
  61. ncbi request reprint Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways
    S S Salvi
    Department of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Respir Crit Care Med 161:550-7. 2000
    ....
  62. pmc Is electrodermal testing as effective as skin prick tests for diagnosing allergies? A double blind, randomised block design study
    G T Lewith
    Department of Medicine, University of Southampton, Southampton SO16 6YD, UK
    BMJ 322:131-4. 2001
    ....
  63. ncbi request reprint The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma
    J L Lordan
    Respiratory, Cell and Molecular Biology Division, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 108:976-81. 2001
    ..The different requirements for CD28-mediated costimulation in PBMC cultures and bronchial tissue cultures emphasizes the importance of the tissue microenvironment in pulmonary inflammatory responses in severe asthma...
  64. ncbi request reprint The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma
    S S Salvi
    Respiratory Cell and Molecular Biology Division, Department of University Medicine, Southampton General Hospital, Southampton, UK
    Chest 119:1533-46. 2001
    ....
  65. ncbi request reprint Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma
    D E Davies
    Respiratory Cell and Molecular Biology Division, Southampton General Hospital, University of Southampton School of Medicine, Southampton SO16 6YD, UK
    Int J Biochem Cell Biol 34:1520-6. 2002
    ..Fundamental to this is the concept of aberrant signalling between the airway epithelium and underlying mesenchyme and persistent activation of the epithelial mesenchymal trophic unit...
  66. pmc Age specific trends in asthma mortality in England and Wales, 1983-95: results of an observational study
    M J Campbell
    Southampton University, Department of Medical Statistics and Computing, Southampton General Hospital
    BMJ 314:1439-41. 1997
    ..To determine trends in asthma mortality by age group in England and Wales during 1983-95...
  67. ncbi request reprint Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study
    L K Josephs
    Department of Primary Medical Care, University of Southampton, United Kingdom
    Am Rev Respir Dis 140:350-7. 1989
    ..We conclude that nonspecific bronchial reactivity is only one mechanism underlying airflow obstruction in asthma, and that its relationship to the clinical state of asthma is not sufficiently close to be of practical clinical use...
  68. ncbi request reprint The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the associated change in nonspecific bronchial responsiveness
    C K Lai
    Immunopharmacology Group, Southampton General Hospital, United Kingdom
    Am Rev Respir Dis 140:917-23. 1989
    ..01 on rimiterol day). However, despite the increase in the magnitude of LAR on the rimiterol day, the reduction in postchallenge PC20 did not differ significantly from that occurring on the control day.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. ncbi request reprint Inhaled PAF fails to induce airway hyperresponsiveness to methacholine in normal human subjects
    C K Lai
    Immunopharmacology Group, Southampton General Hospital, United Kingdom
    J Appl Physiol (1985) 68:919-26. 1990
    ..We conclude that PAF causes dose-dependent bronchoconstriction but does not change airways responsiveness to methacholine and that repeated high-dose methacholine challenge leads to loss of responsiveness to this agonist...
  70. ncbi request reprint Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores
    J Wilkinson
    University Medicine, University of Southampton, Southampton, SO16 5YA, United Kingdom
    Genomics 53:251-9. 1998
    ..We hope that the methods presented will encourage researchers to use phenotypic information in a way that encourages meta-analysis...
  71. ncbi request reprint Toxicological mechanisms underlying oxidant pollutant-induced airway injury
    M T Krishna
    University of Southampton, UK
    Rev Environ Health 13:59-71. 1998
    ..This article will review various studies addressing the toxicological mechanisms underlying oxidant pollutant-induced airways injury...
  72. ncbi request reprint Dose-response relationship of the H1-histamine antagonist, ebastine, against histamine and methacholine-induced bronchoconstriction in patients with asthma
    R Wood-Baker
    Immunopharmacology Group, Southampton General Hospital, Hampshire, UK
    Agents Actions 30:284-6. 1990
    ..We conclude that ebastine is an effective antagonist of histamine-induced bronchoconstriction in the asthmatic airway with evidence of minor blockade of methacholine-induced bronchoconstriction...
  73. ncbi request reprint Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma
    S T Holgate
    Respiratory Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, Southampton, UK
    Int Arch Allergy Immunol 124:253-8. 2001
    ..This report describes a series of studies that identify aberrant epithelial mesenchymal signalling in the airways as an important event in maintaining inflammation and driving remodelling in response to environmental injury...
  74. ncbi request reprint Uneasy breather: the implications of dust mite allergens
    S Sharma
    Acambis PLC, Peterhouse Technology Park, Cambridge and Respiratory, Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 33:163-5. 2003
  75. ncbi request reprint Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis
    T Iwanaga
    Division of Human Genetics, School of Medicine, University of Southampton, Southampton General Hospital, Southhampton, UK
    Clin Exp Allergy 34:1037-42. 2004
    ..We have examined association of a CMA1 variant in relation to asthma in a large UK Caucasian family cohort...
  76. ncbi request reprint Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy
    A K Konstantinidis
    Divisions of Human Genetics, School of Medicine, University of Southampton, Southampton, UK
    Eur Respir J 30:40-7. 2007
    ....
  77. ncbi request reprint Matrix metalloproteinase-2 from bronchial epithelial cells induces the proliferation of subepithelial fibroblasts
    J Xu
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 32:881-8. 2002
    ..In bronchial asthma, subepithelial fibrosis in the conducting airways is associated with increased numbers of subepithelial fibroblasts...
  78. ncbi request reprint Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts
    A K Konstantinidis
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    J Investig Allergol Clin Immunol 18:174-80. 2008
    ..Another IL-13 binding chain, IL-13Ralpha2, binds IL-13 with high affinity but has no known signaling capability and is thought to serve as a decoy receptor providing tight regulation of IL-13 responses...
  79. ncbi request reprint Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells
    N G Papadopoulos
    University Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 31:1060-6. 2001
    ..Induction of eosinophil chemoattractants could represent a central mechanism, as well as a prime target for intervention...
  80. doi request reprint Health impact and toxicological effects of nanomaterials in the lung
    Michaela Kendall
    Truro III Division, Faculty of Medicine, European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, University of Exeter, Southampton General Hospital, Southampton, UK
    Respirology 17:743-58. 2012
    ..Human exposures via medical and dental applications appear important in terms of dose and toxicity, and may need to be assessed for risk on a case-by-case basis...
  81. ncbi request reprint A treatment for allergic rhinitis: a view on the role of levocetirizine
    Stephen Holgate
    Southampton General Hospital, and University of Southampton, Southampton, UK
    Curr Med Res Opin 21:1099-106. 2005
    ..This is largely owing to lack of knowledge about, and poor adherence to, established treatment guidelines...
  82. ncbi request reprint Susceptibility genes in severe asthma
    Stephen T Holgate
    Infection, Inflammation and Repair Division, MP810, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Curr Allergy Asthma Rep 6:345-8. 2006
    ..In this review, we bring together recent literature in the field of genetic influences over disease severity and discuss some of the clinical implications in terms of drug discovery and personalized medicine...
  83. ncbi request reprint IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts
    Allison Lynn Andrews
    Brooke Laboratories, Division of Infection, Inflammation, and Repair, UK
    J Allergy Clin Immunol 118:858-65. 2006
    ..The nonsignaling receptor IL-13 receptor alpha 2 (IL-13Ralpha2) binds IL-13 with high affinity and specificity and is believed to be a decoy receptor for IL-13...
  84. ncbi request reprint The mechanisms, diagnosis, and management of severe asthma in adults
    Stephen T Holgate
    AIR Division, Level D Centre Block, Southampton General Hospital, Southampton, UK
    Lancet 368:780-93. 2006
    ....
  85. ncbi request reprint Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Curr Drug Targets 7:699-706. 2006
    ....
  86. pmc Asthma out of control? A structured review of recent patient surveys
    Stephen T Holgate
    Infection, Inflammation and Repair AIR Division, Level F, South Block, MP810, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    BMC Pulm Med 6:S2. 2006
    ..The primary goal of the present review was to assess patient perspectives on key issues in asthma and its management, as captured in patient surveys...
  87. ncbi request reprint Inflammatory cytokines can enhance CD44-mediated airway epithelial cell adhesion independently of CD44 expression
    Shih Hsing Leir
    Respiratory Cell and Molecular Biology, Infection Immunity and Repair Division, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Physiol Lung Cell Mol Physiol 285:L1305-11. 2003
    ..These data indicate that CD44 is important for bronchial epithelial cell binding to HA and that cytokines known to be expressed in inflammation can increase HA binding independently of the level of CD44 expression...
  88. ncbi request reprint Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells
    Youwen Yang
    Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:1393-9, 1399.e1-14. 2008
    ..Although considered to be a mesenchymal cell-specific gene, recent reports have suggested epithelial expression of ADAM33 in patients with severe asthma...
  89. ncbi request reprint The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma
    Ilaria Puxeddu
    Division of Infection, Inflammation, and Repair, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:1400-6, 1406.e1-4. 2008
    ..A disintegrin and metalloprotease (ADAM)-33 is a susceptibility gene for asthma and chronic obstructive pulmonary disease whose function remains unknown...
  90. ncbi request reprint Interpatient variability in rates of asthma progression: can genetics provide an answer?
    John W Holloway
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:573-9. 2008
    ....
  91. ncbi request reprint Epithelium dysfunction in asthma
    Stephen T Holgate
    Allergy and Inflammation Research, Division of Infection, School of Medicine, Southampton General Hospital and the University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 120:1233-44; quiz 1245-6. 2007
    ....
  92. ncbi request reprint IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
    Peter A B Wark
    Brooke Laboratories, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 120:586-93. 2007
    ..Rhinovirus-induced acute asthma is the most frequent trigger for asthma exacerbations...
  93. ncbi request reprint The airway epithelium is central to the pathogenesis of asthma
    Stephen T Holgate
    School of Medicine, Southampton General Hospital, Southampton, UK
    Allergol Int 57:1-10. 2008
    ....
  94. ncbi request reprint Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Allergy Clin Immunol 120:91-7. 2007
    ..Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy...
  95. ncbi request reprint Treatment strategies for allergy and asthma
    Stephen T Holgate
    IIR Division, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Nat Rev Immunol 8:218-30. 2008
    ....
  96. ncbi request reprint Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts
    Hajime Yoshisue
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, UK
    J Allergy Clin Immunol 119:132-40. 2007
    ..Cysteinyl leukotrienes (cys-LTs) are potent asthma-related mediators that function through their G protein-coupled receptors, cys-LT receptor type 1 (CysLT1R) and cys-LT receptor type 2 (CysLT2R)...
  97. ncbi request reprint Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease
    Stefan Pierrou
    AstraZeneca R and D, Department of Biological Sciences, Lund, Sweden
    Am J Respir Crit Care Med 175:577-86. 2007
    ..The molecular mechanisms involved in airway oxidative stress responses reported in healthy smokers and in those with chronic obstructive pulmonary disease (COPD) are poorly understood...
  98. doi request reprint Pathogenesis of asthma
    Stephen T Holgate
    Clin Exp Allergy 38:872-97. 2008
    ....
  99. ncbi request reprint IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets
    Allison Lynn Andrews
    The Brooke Laboratories, Division of Infection, Inflammation, and Repair, Southampton General Hospital, UK
    J Immunol 176:7456-61. 2006
    ....
  100. ncbi request reprint The role of Toll-like receptors and related receptors of the innate immune system in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Curr Opin Allergy Clin Immunol 6:23-8. 2006
    ..This review summarizes recent studies of the role of innate immunity receptors, including Toll-like receptors and CD14, in the pathogenesis of asthma...
  101. ncbi request reprint Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease
    Steuart Rorke
    Division of Respiratory Cell and Molecular Biology, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Am J Respir Med 1:99-105. 2002
    ....