Research Topics
Genomes and Genes | Andreas HofmannSummaryAffiliation: University of Edinburgh Country: UK Publications
| Collaborators
|
Detail Information
Publications
Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP)Adlina Mohd Yusof
Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Scotland, United Kingdom
Proteins 58:255-62. 2005..Comparison with previously published structures of N-CAP reveals variable modes of dimerization of this domain, but the presence of a common interface for the side-to-side dimer...- Mechanism of oligomerisation of cyclase-associated protein from Dictyostelium discoideum in solutionAdlina Mohd Yusof
Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK
J Mol Biol 362:1072-81. 2006..Further studies point to the correlation between stability of full-length CAP with its multimerisation behaviour, where oligomer formation leads to a more stable protein... - Crystallization of cyclase-associated protein from Dictyostelium discoideumAndreas Hofmann
Macromolecular Crystallography Laboratory, NCI at Frederick, Frederick, MD 21702, USA
Acta Crystallogr D Biol Crystallogr 58:1858-61. 2002..A complete native data set extending to 2.2 A resolution was collected from a single crystal using an in-house X-ray system. The asymmetric unit contains one molecule of CAP... - The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 clusterAndreas Hofmann
Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, Scotland
Eur J Biochem 270:2557-64. 2003..We therefore hypothesize that the cysteine motif found in the present structure, or possibly even the entire sulfur cluster, forms the molecular basis for annexin function in oxidative stress response... 
The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexinsNien Jen Hu
Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
J Biol Chem 283:18314-22. 2008..Furthermore, an additional unfolding step was detected at lower temperatures, which can be explained by the anchoring of the N-terminal domain to the C-terminal core by two conserved hydrogen bonds...
Plant annexins form calcium-independent oligomers in solutionAndreas Hofmann
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA
Protein Sci 11:2033-40. 2002..Anx(Gh2) showed a different elution profile than the other plant annexins; while having only a very small trimer content, this annexin seems to exist in a monomer-dimer equilibrium in solution...- Biophysical characterization of cyclic nucleotide phosphodiesterasesAndreas Hofmann
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
Biochem Biophys Res Commun 291:875-83. 2002..Within the comparison of the three proteins in this study, the PDase Homolog/RNA ligase (E. coli) shares more similarities with the plant than with the yeast protein... - Structure of cyclized green fluorescent proteinAndreas Hofmann
Macromolecular Crystallography Laboratory, NCI at Frederick, Frederick, MD 21702, USA
Acta Crystallogr D Biol Crystallogr 58:1400-6. 2002..This adds further support to the fact that the cylinder surface of GFP is rather versatile and can employ various polar and non-polar patches in protein-protein interactions... - Molecular modeling of prohibitin domainsAnja Winter
Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Scotland, United Kingdom
Proteins 68:353-62. 2007..The results are discussed in the context of prohibitin interactions with mitochondrial AAA-proteases and we suggest two possible interaction interfaces between the BAP32:BAP37 building block and the protease... - Liposomes in assessment of annexin-membrane interactionsAndreas Hofmann
Macromolecular Crystallography Laboratory, NCI at Frederick, 539 Boyles Street, Frederick, Maryland 21702, USA
Methods Enzymol 372:186-216. 2003 - Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thalianaAndreas Hofmann
Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 277:1419-25. 2002..The ligand is bound within the active site, and the mode of binding is in agreement with the previously proposed enzymatic mechanism. Selected biophysical properties of the oxidized and the semireduced CPDase are also discussed... - Structural determinants for plant annexin-membrane interactionsNicole Dabitz
, , Leipzig, Germany
Biochemistry 44:16292-300. 2005..Overall, this study demonstrates the importance of subtle changes in an otherwise conserved annexin fold where these two plant annexins possess distinct modalities compared to mammalian and other nonplant annexins... - Biochemical characterization of annexin B1 from Cysticercus cellulosaeAnja Winter
Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, UK
FEBS J 273:3238-47. 2006..Results from CD spectroscopy and thermal denaturation indicate that, in solution, the protein binds calcium with a low affinity that leads to a slight increase in folding stability... - Pathological consequences of VCP mutations on human striated muscleChristian U Hübbers
Institute of Biochemistry I, University of Cologne, Cologne, Germany
Brain 130:381-93. 2007..The latter findings provide a novel link to VCP carbohydrate interactions in the complex pathology of IBMPFD... - Coronin 3 involvement in F-actin-dependent processes at the cell cortexAndre Rosentreter
Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, 50931 Cologne, Germany
Exp Cell Res 313:878-95. 2007..Moreover, we show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events... - Accurate charge density of the tripeptide Ala-Pro-Ala with the maximum entropy method (MEM): influence of data resolutionAndreas Hofmann
Laboratory of Crystallography, University of Bayreuth, Universitatstrasse 30, D 95440 Bayreuth, Germany
Acta Crystallogr B 63:633-43. 2007..g. from refinements with multipole parameters from a database of transferable multipole parameters... - Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: implications for annexin-induced membrane aggregationNien Jen Hu
Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
Biophys J 94:1773-81. 2008..The results are consistent with the hypothesis that the N-terminal domain of annexin A1 can serve as a secondary membrane binding site in the process of membrane aggregation by providing a peripheral membrane anchor...