Andreas Hofmann

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP)
    Adlina Mohd Yusof
    Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Scotland, United Kingdom
    Proteins 58:255-62. 2005
  2. ncbi request reprint Mechanism of oligomerisation of cyclase-associated protein from Dictyostelium discoideum in solution
    Adlina Mohd Yusof
    Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK
    J Mol Biol 362:1072-81. 2006
  3. ncbi request reprint Crystallization of cyclase-associated protein from Dictyostelium discoideum
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI at Frederick, Frederick, MD 21702, USA
    Acta Crystallogr D Biol Crystallogr 58:1858-61. 2002
  4. ncbi request reprint The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster
    Andreas Hofmann
    Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, Scotland
    Eur J Biochem 270:2557-64. 2003
  5. doi request reprint The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexins
    Nien Jen Hu
    Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    J Biol Chem 283:18314-22. 2008
  6. pmc Plant annexins form calcium-independent oligomers in solution
    Andreas Hofmann
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA
    Protein Sci 11:2033-40. 2002
  7. ncbi request reprint Biophysical characterization of cyclic nucleotide phosphodiesterases
    Andreas Hofmann
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Biochem Biophys Res Commun 291:875-83. 2002
  8. ncbi request reprint Structure of cyclized green fluorescent protein
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI at Frederick, Frederick, MD 21702, USA
    Acta Crystallogr D Biol Crystallogr 58:1400-6. 2002
  9. ncbi request reprint Molecular modeling of prohibitin domains
    Anja Winter
    Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Scotland, United Kingdom
    Proteins 68:353-62. 2007
  10. ncbi request reprint Liposomes in assessment of annexin-membrane interactions
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI at Frederick, 539 Boyles Street, Frederick, Maryland 21702, USA
    Methods Enzymol 372:186-216. 2003

Collaborators

  • Hideo Iwai
  • Robert Huber
  • A Wlodawer
  • Rolf Schroder
  • Peter Luger
  • Nien Jen Hu
  • Anja Winter
  • Adlina Mohd Yusof
  • Angelika A Noegel
  • Andre Rosentreter
  • Christoph S Clemen
  • Christian U Hübbers
  • Outi Kämäräinen
  • Maria Stumpf
  • Nicole Dabitz
  • Asiah Osman
  • Julia Buckingham
  • Amy K Reeve
  • Jeremy Bradshaw
  • Egle Solito
  • Hans Lauter
  • Julia Reichelt
  • Kristina Kesper
  • Hanns Lochmuller
  • Jens Reimann
  • Charles Peter Xavier
  • Bernd O Evert
  • Giles Watts
  • Erich E Wanker
  • Udo Roth
  • Dietmar R Thal
  • Virginia Kimonis
  • Karen Tolksdorf
  • Sabine Krause
  • Benedikt G H Schoser
  • Mike P Wattjes
  • Annett Böddrich
  • Katharina Biermann
  • Hong li Yan
  • Shu Han Sun
  • Michael Schleicher
  • Jan Skov Pedersen
  • Erning Gao
  • Elmar Jaenicke
  • Adlina M Yusof
  • Marc Daley
  • Nicola Tranter
  • Olaf Zschornig
  • Alain Brisson

Detail Information

Publications17

  1. ncbi request reprint Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP)
    Adlina Mohd Yusof
    Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Scotland, United Kingdom
    Proteins 58:255-62. 2005
    ..Comparison with previously published structures of N-CAP reveals variable modes of dimerization of this domain, but the presence of a common interface for the side-to-side dimer...
  2. ncbi request reprint Mechanism of oligomerisation of cyclase-associated protein from Dictyostelium discoideum in solution
    Adlina Mohd Yusof
    Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK
    J Mol Biol 362:1072-81. 2006
    ..Further studies point to the correlation between stability of full-length CAP with its multimerisation behaviour, where oligomer formation leads to a more stable protein...
  3. ncbi request reprint Crystallization of cyclase-associated protein from Dictyostelium discoideum
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI at Frederick, Frederick, MD 21702, USA
    Acta Crystallogr D Biol Crystallogr 58:1858-61. 2002
    ..A complete native data set extending to 2.2 A resolution was collected from a single crystal using an in-house X-ray system. The asymmetric unit contains one molecule of CAP...
  4. ncbi request reprint The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster
    Andreas Hofmann
    Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, Scotland
    Eur J Biochem 270:2557-64. 2003
    ..We therefore hypothesize that the cysteine motif found in the present structure, or possibly even the entire sulfur cluster, forms the molecular basis for annexin function in oxidative stress response...
  5. doi request reprint The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexins
    Nien Jen Hu
    Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    J Biol Chem 283:18314-22. 2008
    ..Furthermore, an additional unfolding step was detected at lower temperatures, which can be explained by the anchoring of the N-terminal domain to the C-terminal core by two conserved hydrogen bonds...
  6. pmc Plant annexins form calcium-independent oligomers in solution
    Andreas Hofmann
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA
    Protein Sci 11:2033-40. 2002
    ..Anx(Gh2) showed a different elution profile than the other plant annexins; while having only a very small trimer content, this annexin seems to exist in a monomer-dimer equilibrium in solution...
  7. ncbi request reprint Biophysical characterization of cyclic nucleotide phosphodiesterases
    Andreas Hofmann
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Biochem Biophys Res Commun 291:875-83. 2002
    ..Within the comparison of the three proteins in this study, the PDase Homolog/RNA ligase (E. coli) shares more similarities with the plant than with the yeast protein...
  8. ncbi request reprint Structure of cyclized green fluorescent protein
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI at Frederick, Frederick, MD 21702, USA
    Acta Crystallogr D Biol Crystallogr 58:1400-6. 2002
    ..This adds further support to the fact that the cylinder surface of GFP is rather versatile and can employ various polar and non-polar patches in protein-protein interactions...
  9. ncbi request reprint Molecular modeling of prohibitin domains
    Anja Winter
    Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Scotland, United Kingdom
    Proteins 68:353-62. 2007
    ..The results are discussed in the context of prohibitin interactions with mitochondrial AAA-proteases and we suggest two possible interaction interfaces between the BAP32:BAP37 building block and the protease...
  10. ncbi request reprint Liposomes in assessment of annexin-membrane interactions
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI at Frederick, 539 Boyles Street, Frederick, Maryland 21702, USA
    Methods Enzymol 372:186-216. 2003
  11. ncbi request reprint Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 277:1419-25. 2002
    ..The ligand is bound within the active site, and the mode of binding is in agreement with the previously proposed enzymatic mechanism. Selected biophysical properties of the oxidized and the semireduced CPDase are also discussed...
  12. ncbi request reprint Structural determinants for plant annexin-membrane interactions
    Nicole Dabitz
    Institut fur Medizinische Physik und Biophysik, Universitat Leipzig, Leipzig, Germany
    Biochemistry 44:16292-300. 2005
    ..Overall, this study demonstrates the importance of subtle changes in an otherwise conserved annexin fold where these two plant annexins possess distinct modalities compared to mammalian and other nonplant annexins...
  13. ncbi request reprint Biochemical characterization of annexin B1 from Cysticercus cellulosae
    Anja Winter
    Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, UK
    FEBS J 273:3238-47. 2006
    ..Results from CD spectroscopy and thermal denaturation indicate that, in solution, the protein binds calcium with a low affinity that leads to a slight increase in folding stability...
  14. ncbi request reprint Pathological consequences of VCP mutations on human striated muscle
    Christian U Hübbers
    Institute of Biochemistry I, University of Cologne, Cologne, Germany
    Brain 130:381-93. 2007
    ..The latter findings provide a novel link to VCP carbohydrate interactions in the complex pathology of IBMPFD...
  15. ncbi request reprint Coronin 3 involvement in F-actin-dependent processes at the cell cortex
    Andre Rosentreter
    Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, 50931 Cologne, Germany
    Exp Cell Res 313:878-95. 2007
    ..Moreover, we show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events...
  16. ncbi request reprint Accurate charge density of the tripeptide Ala-Pro-Ala with the maximum entropy method (MEM): influence of data resolution
    Andreas Hofmann
    Laboratory of Crystallography, University of Bayreuth, Universitatstrasse 30, D 95440 Bayreuth, Germany
    Acta Crystallogr B 63:633-43. 2007
    ..g. from refinements with multipole parameters from a database of transferable multipole parameters...
  17. pmc Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: implications for annexin-induced membrane aggregation
    Nien Jen Hu
    Institute of Structural and Molecular Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Biophys J 94:1773-81. 2008
    ..The results are consistent with the hypothesis that the N-terminal domain of annexin A1 can serve as a secondary membrane binding site in the process of membrane aggregation by providing a peripheral membrane anchor...