Karl F Hoffmann
Affiliation: University of Wales
Whiteland H, Chakroborty A, Forde Thomas J, Crusco A, Cookson A, Hollinshead J, et al
. An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni. Int J Parasitol Drugs Drug Resist. 2018;8:465-474 pubmed publisher
Padalino G, Ferla S, Brancale A, Chalmers I, Hoffmann K. Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni. Int J Parasitol Drugs Drug Resist. 2018;8:559-570 pubmed publisher
Crusco A, Bordoni C, Chakroborty A, Whatley K, Whiteland H, Westwell A, et al
. Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues. Eur J Med Chem. 2018;152:87-100 pubmed publisher
..Further modifications of 7d could lead to greater potency and selectivity metrics resulting in a new class of broad-spectrum anthelmintic. ..
Geyer K, Munshi S, Vickers M, Squance M, Wilkinson T, Berrar D, et al
. The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities. Int J Parasitol Drugs Drug Resist. 2018;8:213-222 pubmed publisher
..This study demonstrates that the anti-fecundity activity of 5-AzaC affects more than just DNA methylation in schistosome parasites. Further characterisation of these processes may reveal novel targets for schistosomiasis control. ..
Nowacki F, Swain M, Klychnikov O, Niazi U, Ivens A, Quintana J, et al
. Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni. J Extracell Vesicles. 2015;4:28665 pubmed publisher
..Further work defining the role of these schistosomula EVs and the function/stability of intra- and extra-vesicular sncRNA components presents tremendous opportunities for developing novel schistosomiasis diagnostics or interventions. ..
Lockyer A, Spinks J, Kane R, Hoffmann K, Fitzpatrick J, Rollinson D, et al
. Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni. BMC Genomics. 2008;9:634 pubmed publisher
..Examining differential gene expression between S. mansoni-exposed schistosome-resistant and susceptible snail lines will identify genes and pathways that may be involved in snail defences...
Chalmers I, McArdle A, Coulson R, Wagner M, Schmid R, Hirai H, et al
. Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family. BMC Genomics. 2008;9:89 pubmed publisher