J Hodgkin

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Seven types of pleiotropy
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Int J Dev Biol 42:501-5. 1998
  2. ncbi request reprint Changing styles in C. elegans genetics
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Trends Genet 14:352-7. 1998
  3. pmc Natural variation and copulatory plug formation in Caenorhabditis elegans
    J Hodgkin
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genetics 146:149-64. 1997
  4. ncbi request reprint Sex determination compared in Drosophila and Caenorhabditis
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 344:721-8. 1990
  5. ncbi request reprint Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development
    A Woollard
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Mech Dev 82:95-108. 1999
  6. pmc Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro
    D Zarkower
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nucleic Acids Res 21:3691-8. 1993
  7. ncbi request reprint A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Genes Dev 1:731-45. 1987
  8. ncbi request reprint Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins
    D Zarkower
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 70:237-49. 1992
  9. pmc The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family
    T M Barnes
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 15:4477-84. 1996
  10. ncbi request reprint The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans
    A D Chisholm
    MRC Laboratory of Molecular Biology, Cambridge, England
    Genes Dev 3:1413-23. 1989

Collaborators

  • S Ahmed
  • P E Kuwabara
  • A Woollard
  • J Kimble
  • R Aronoff
  • C A Milne
  • A C Epstein
  • L Friedman
  • M Skipper
  • D Zarkower
  • C S Raymond
  • T M Barnes
  • M Mukherji
  • K S Hewitson
  • J M Gleadle
  • N Masson
  • Y M Tian
  • L A McNeill
  • M I Wilson
  • E Metzen
  • R Barstead
  • C W Pugh
  • P Jaakkola
  • C J Schofield
  • P H Maxwell
  • A Dhanda
  • J O'ROURKE
  • D R Mole
  • D L Hamilton
  • P J Ratcliffe
  • S Santa Anna-Arriola
  • K J Seifert
  • M M Shen
  • C E Shamu
  • B Hirsch
  • A D Chisholm
  • H Haack

Detail Information

Publications22

  1. ncbi request reprint Seven types of pleiotropy
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Int J Dev Biol 42:501-5. 1998
    ..Pleiotropy, a situation in which a single gene influences multiple phenotypic traits, can arise in a variety of ways. This paper discusses possible underlying mechanisms and proposes a classification of the various phenomena involved...
  2. ncbi request reprint Changing styles in C. elegans genetics
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Trends Genet 14:352-7. 1998
    ..In this review we consider the ways in which genetical investigations of this species have begun to change and what some of the consequences of the completion of the sequence are likely to be...
  3. pmc Natural variation and copulatory plug formation in Caenorhabditis elegans
    J Hodgkin
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genetics 146:149-64. 1997
    ..Crosses between N2 and CB4855 indicate that the higher virility is due to multiple factors. Size differences between N2 and CB4855 are associated with factors mapping to LGV and LGX...
  4. ncbi request reprint Sex determination compared in Drosophila and Caenorhabditis
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 344:721-8. 1990
    ..In contrast, the underlying molecular mechanisms appear to be very different in these two species. Developmental processes such as sex determination need not be strongly conserved in evolution...
  5. ncbi request reprint Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development
    A Woollard
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Mech Dev 82:95-108. 1999
    ..Multicopy expression of stu-7 also causes mitotic defects, suggesting that the level of this protein must be tightly controlled in order to maintain genetic stability during development...
  6. pmc Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro
    D Zarkower
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nucleic Acids Res 21:3691-8. 1993
    ..We find that a protein sequence amino-terminal to the finger domain also appears to play a role in DNA binding...
  7. ncbi request reprint A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Genes Dev 1:731-45. 1987
    ..A low level of both spermatogenesis and oogenesis can occur in the absence of tra-1 activity. Both the function and the regulation of this gene must be complex...
  8. ncbi request reprint Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins
    D Zarkower
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 70:237-49. 1992
    ..The tra-1 fingers are strikingly similar to those of three other proteins, the products of the human GLI and GLI3 and Drosophila cubitus interruptus Dominant (ciD) genes...
  9. pmc The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family
    T M Barnes
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 15:4477-84. 1996
    ..Based on these observations and new genetic data, we suggest a refinement of the position of tra-3 within the sex determination cascade and discuss possible mechanisms of action for the TRA-3 protein...
  10. ncbi request reprint The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans
    A D Chisholm
    MRC Laboratory of Molecular Biology, Cambridge, England
    Genes Dev 3:1413-23. 1989
    ..We propose that the fates of the four rectal cells are initially specified as two pairs (B and Y, F and U) and that the function of mab-9 in both sexes is to differentiate the posterior member of each pair from its anterior neighbor...
  11. ncbi request reprint MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
    S Ahmed
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 403:159-64. 2000
    ..These results indicate that telomeres may be identified as a type of DNA damage and then repaired by the telomere-replication enzyme telomerase...
  12. pmc A new kind of informational suppression in the nematode Caenorhabditis elegans
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, England
    Genetics 123:301-13. 1989
    ..This suggests that the smg suppressors affect a process other than translation, for example mRNA processing, transport, or stability...
  13. ncbi request reprint ETR-1, a homologue of a protein linked to myotonic dystrophy, is essential for muscle development in Caenorhabditis elegans
    C A Milne
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Biol 9:1243-6. 1999
    ..elegans, perhaps by playing a role in post-transcriptional processing of some muscle component, and thus suggesting a possible conservation of gene function with human CUG-bp...
  14. ncbi request reprint A novel bacterial pathogen, Microbacterium nematophilum, induces morphological change in the nematode C. elegans
    J Hodgkin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 10:1615-8. 2000
    ..Certain mutants of C. elegans with altered surface antigenicity are resistant to infection. The induced deformation appears to be part of a survival strategy for the bacteria, as C. elegans are potentially their predators...
  15. pmc Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination
    M Skipper
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, England
    Genetics 151:617-31. 1999
    ..Additionally, fox-1(Delta) impairs male mating efficiency, which, we propose, represents another function of fox-1, independent of xol-1 and its role in sex determination...
  16. ncbi request reprint Genetic sex determination mechanisms and evolution
    J Hodgkin
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Bioessays 14:253-61. 1992
    ..The similarities must have arisen by convergent evolution. Studies of sex determination demonstrate that evolution can produce a variety of solutions to the same basic problems in development...
  17. ncbi request reprint Tests for parental imprinting in the nematode Caenorhabditis elegans
    H Haack
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mol Gen Genet 228:482-5. 1991
    ..These results (together with previous data for the X chromosome) indicate that major chromosomal imprinting effects do not occur during gametogenesis in this organism...
  18. ncbi request reprint Evidence for evolutionary conservation of sex-determining genes
    C S Raymond
    Institute of Human Genetics, Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455, USA
    Nature 391:691-5. 1998
    ..DMT1 maps to the distal short arm of chromosome 9, a location implicated in human XY sex reversal. Proteins with DM domains may therefore also regulate sexual development in mammals...
  19. pmc The caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut
    A Woollard
    Medical Research Council MRC Laboratory of Molecular Biology LMB, Cambridge CB2 2QH, UK
    Genes Dev 14:596-603. 2000
    ..T-box genes related to brachyury have also been implicated in hindgut patterning, and our results support models for an evolutionarily ancient role for these genes in hindgut formation...
  20. ncbi request reprint gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans
    L Friedman
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Biol 228:350-62. 2000
    ..We conclude that gon-4 is a regulator of the early lineage of Z1 and Z4 and suggest that it is a part of a genetic program common to the regulation of both hermaphrodite and male gonadogenesis...
  21. ncbi request reprint Molecular identification of smg-4, required for mRNA surveillance in C. elegans
    R Aronoff
    Max Planck Institute for Medical Research, Molecular Neurobiology, Jahnstrasse 29, D 69120, Heidelberg, Germany
    Gene 268:153-64. 2001
    ..This SMG-4:GFP fusion exhibits nuclear accumulation and diffuse cytoplasmic staining, and further localizes to what appear to be perinuclear and cytoplasmic punctate structures...
  22. ncbi request reprint C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
    ....