Nikolos J Hodges

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Induction of DNA-strand breaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: association with 8-oxo-2-deoxyguanosine formation and inter-individual variability
    N J Hodges
    Institute of Occupational Health and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 16:467-74. 2001
  2. ncbi Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells
    N J Hodges
    Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Carcinogenesis 23:55-60. 2002
  3. ncbi Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin
    N J Hodges
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Toxicology 197:101-12. 2004
  4. ncbi Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression
    Nikolas J Hodges
    The School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 22:189-94. 2007
  5. ncbi Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro
    Nikolos J Hodges
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 23:293-8. 2008
  6. ncbi Modified comet assay as a biomarker of sodium dichromate-induced oxidative DNA damage: optimization and reproducibility
    Amanda J Lee
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Biomarkers 9:103-15. 2004
  7. ncbi Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1
    Amanda J Lee
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:497-505. 2005
  8. ncbi Oxidative damage produced by Cr(VI) and repair in mussel (Mytilus edulis L.) gill
    Christina Emmanouil
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mar Environ Res 62:S292-6. 2006
  9. ncbi Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity
    Richard M Green
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 21:383-90. 2006

Collaborators

Detail Information

Publications9

  1. ncbi Induction of DNA-strand breaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: association with 8-oxo-2-deoxyguanosine formation and inter-individual variability
    N J Hodges
    Institute of Occupational Health and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 16:467-74. 2001
    ....
  2. ncbi Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells
    N J Hodges
    Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Carcinogenesis 23:55-60. 2002
    ..We conclude that the elevation of 8-oxo dG levels observed in A549 cells treated with sodium dichromate may be, at least in part, due to a reduced capacity to repair endogenous and hexavalent chromium-induced 8-oxo dG...
  3. ncbi Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin
    N J Hodges
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Toxicology 197:101-12. 2004
    ..We hypothesise that dissociation of apoptosis signal regulating kinase-1 from thioredoxin may be at least partially responsible for Jun N-terminal kinase activation...
  4. ncbi Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression
    Nikolas J Hodges
    The School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 22:189-94. 2007
    ....
  5. ncbi Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro
    Nikolos J Hodges
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 23:293-8. 2008
    ..In conclusion, the current study provides evidence supportive of a role for cytoglobin in cytoprotection of neuronal cells from oxidative-related damage, for example, during ischaemic reperfusion injury following hypoxia...
  6. ncbi Modified comet assay as a biomarker of sodium dichromate-induced oxidative DNA damage: optimization and reproducibility
    Amanda J Lee
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Biomarkers 9:103-15. 2004
    ..This consistency is sufficient to suggest that the modified comet assay might prove to be a useful and sensitive biomonitoring tool for individuals occupationally exposed to hexavalent chromium...
  7. ncbi Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1
    Amanda J Lee
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:497-505. 2005
    ..In conclusion, the homozygous Cys(326) genotype may represent a biomarker of individual susceptibility of lung cancer risk in individuals that are occupationally exposed to CrVI...
  8. ncbi Oxidative damage produced by Cr(VI) and repair in mussel (Mytilus edulis L.) gill
    Christina Emmanouil
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mar Environ Res 62:S292-6. 2006
    ..In support of evidence for repair of oxidative DNA damage, we have also demonstrated for the first time repair activity in mussel gill towards 8-oxo-dG using an oligonucleotide cutting assay...
  9. ncbi Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity
    Richard M Green
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mutagenesis 21:383-90. 2006
    ..The findings highlight the critical roles of the mitochondrial and nuclear GSH pools in protecting cellular components, particularly DNA, from oxidative modification...