J R Hodges

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: Part I
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurocase 7:31-5. 2001
  2. ncbi request reprint The role of conceptual knowledge in object use evidence from semantic dementia
    J R Hodges
    Cognition and Brain Science Unit, Medical Research Council, Cambridge, UK
    Brain 123:1913-25. 2000
  3. pmc Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?
    S Bozeat
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    J Neurol Neurosurg Psychiatry 69:178-86. 2000
  4. ncbi request reprint The neuropsychology of frontal variant frontotemporal dementia and semantic dementia. Introduction to the special topic papers: Part II
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ and Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neurocase 7:113-21. 2001
  5. ncbi request reprint Semantic dementia: a unique clinicopathological syndrome
    John R Hodges
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    Lancet Neurol 6:1004-14. 2007
  6. ncbi request reprint Survival in frontotemporal dementia
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge, UK
    Neurology 61:349-54. 2003
  7. pmc Episodic memory: insights from semantic dementia
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Philos Trans R Soc Lond B Biol Sci 356:1423-34. 2001
  8. pmc "What" and "how": evidence for the dissociation of object knowledge and mechanical problem-solving skills in the human brain
    J R Hodges
    University of Cambridge, Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Proc Natl Acad Sci U S A 96:9444-8. 1999
  9. ncbi request reprint Clinicopathological correlates in frontotemporal dementia
    John R Hodges
    Prince of Wales Medical Research Institute, The University of New South Wales, Randwick, New South Wales, Australia
    Ann Neurol 56:399-406. 2004
  10. ncbi request reprint The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: a comparative neuropsychological study
    J R Hodges
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, United Kingdom
    Neuropsychology 13:31-40. 1999

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. ncbi request reprint The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: Part I
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurocase 7:31-5. 2001
    ..Part II of this review (Hodges and Miller, 2001) sets the special issue papers within the context of advances in the neuropsychology of frontal variant FTD and semantic dementia...
  2. ncbi request reprint The role of conceptual knowledge in object use evidence from semantic dementia
    J R Hodges
    Cognition and Brain Science Unit, Medical Research Council, Cambridge, UK
    Brain 123:1913-25. 2000
    ..The results suggest that object use is heavily dependent upon object-specific conceptual knowledge, supplemented to some degree by a combination of visual affordances and mechanical problem solving...
  3. pmc Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?
    S Bozeat
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    J Neurol Neurosurg Psychiatry 69:178-86. 2000
    ..To establish whether the frontal and temporal variants of FTD are characterised by different behavioural changes...
  4. ncbi request reprint The neuropsychology of frontal variant frontotemporal dementia and semantic dementia. Introduction to the special topic papers: Part II
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ and Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neurocase 7:113-21. 2001
    ..Other topics discussed include the impact of semantic breakdown on phonological processes and episodic memory. We also review recent structural and functional neuroimaging findings in semantic dementia...
  5. ncbi request reprint Semantic dementia: a unique clinicopathological syndrome
    John R Hodges
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    Lancet Neurol 6:1004-14. 2007
    ..Unlike other frontotemporal dementia syndromes, the neuropathological findings in SD are fairly predictable: most patients have ubiquitin-positive, tau-negative neuronal inclusions...
  6. ncbi request reprint Survival in frontotemporal dementia
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge, UK
    Neurology 61:349-54. 2003
    ..To establish survival in patients with pathologically confirmed frontotemporal dementia (FTD) and to determine whether clinical or pathologic subtype affects prognosis...
  7. pmc Episodic memory: insights from semantic dementia
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Philos Trans R Soc Lond B Biol Sci 356:1423-34. 2001
    ....
  8. pmc "What" and "how": evidence for the dissociation of object knowledge and mechanical problem-solving skills in the human brain
    J R Hodges
    University of Cambridge, Department of Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Proc Natl Acad Sci U S A 96:9444-8. 1999
    ..Although the temporal lobe system clearly is necessary to identify "what" an object is, we suggest that sensory inputs to a parietal "how" system can trigger the use of objects without reference to object-specific conceptual knowledge...
  9. ncbi request reprint Clinicopathological correlates in frontotemporal dementia
    John R Hodges
    Prince of Wales Medical Research Institute, The University of New South Wales, Randwick, New South Wales, Australia
    Ann Neurol 56:399-406. 2004
    ..Therefore, the pathological substrate can be predicted in a significant proportion of FTD patients, which has important implications for studies targeting mechanistic treatments...
  10. ncbi request reprint The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: a comparative neuropsychological study
    J R Hodges
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, United Kingdom
    Neuropsychology 13:31-40. 1999
    ..The frontal and temporal presentations of FTD are clearly separable from each other and from early AD...
  11. pmc Cognitive assessment for clinicians
    C M Kipps
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    J Neurol Neurosurg Psychiatry 76:i22-30. 2005
  12. ncbi request reprint Pure retrograde amnesia exists but what is the explanation?
    John R Hodges
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Cortex 38:674-7. 2002
  13. ncbi request reprint Frontotemporal dementia (Pick's disease): clinical features and assessment
    J R Hodges
    University Department of Neurology, Addenbrooke s Hospital, and the MRC Brain and Cognitive Sciences Unit, Cambridge, UK
    Neurology 56:S6-10. 2001
    ....
  14. ncbi request reprint Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects
    John R Hodges
    MRC CBU, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Brain 129:2811-22. 2006
    ..The second part attempts to review the current status of our knowledge concerning behavioural, neuropsychological and neuropsychiatric aspects of the disease, emphasizing areas of continuing controversy...
  15. ncbi request reprint Semantic knowledge and episodic memory for faces in semantic dementia
    J S Simons
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Neuropsychology 15:101-14. 2001
    ..These results support the view that new episodic learning typically draws on information from both perceptual and semantic systems...
  16. ncbi request reprint Multidimensional measures of person knowledge and spatial associative learning: can these be applied to the differentiation of Alzheimer's disease from frontotemporal and vascular dementia?
    F Clague
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuropsychologia 43:1338-50. 2005
    ..Person knowledge deficits are, therefore, not specific to AD and the employment of face stimuli may influence the performance of SD patients on tasks of episodic memory...
  17. ncbi request reprint Focal cortical presentations of Alzheimer's disease
    S Alladi
    Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Brain 130:2636-45. 2007
    ..The focal syndrome may remain pure for many years. Patients with atypical AD tend to be older than those with non-AD pathology...
  18. pmc Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
    J M S Pereira
    Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neurology 72:1653-60. 2009
    ..Our aim was to test the hypothesis that clinical, but not pathologic, classification (FTD with ubiquitin inclusions [FTD-U] and FTD with tau inclusions [FTD-T]) is associated with predictable patterns of regional atrophy...
  19. ncbi request reprint Insights from semantic dementia on the relationship between episodic and semantic memory
    K S Graham
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neuropsychologia 38:313-24. 2000
    ..To account for these findings, we propose a revision to current models of long-term memory, in which sensory/perceptual information and semantic memory work in concert to support new learning...
  20. ncbi request reprint Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits
    A D Lawrence
    Department of Experimental Psychology, University of Cambridge, MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Brain 123:1349-64. 2000
    ..The results of our investigations suggest a particular role for the striatum in context-dependent action selection, in line with current computational theories of basal ganglia function...
  21. ncbi request reprint Relearning and subsequent forgetting of semantic category exemplars in a case of semantic dementia
    K S Graham
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Neuropsychology 13:359-80. 1999
    ..The results are discussed with respect to current views of long-term memory, particularly new word learning and forgetting, and to current techniques for facilitating word finding in aphasia...
  22. ncbi request reprint Memory consolidation and the hippocampus: further evidence from studies of autobiographical memory in semantic dementia and frontal variant frontotemporal dementia
    P J Nestor
    Addenbrooke s Hospital, University of Cambridge Neurology Unit, Box 165, Cambridge CB2 2QQ, UK
    Neuropsychologia 40:633-54. 2002
    ..Nonetheless, we discuss how damage to semantic knowledge could result in an autobiographical memory deficit and suggest that data from semantic dementia may be consistent with both views of hippocampal involvement in long-term memory...
  23. pmc Visuospatial functions in atypical parkinsonian syndromes
    T H Bak
    MRC Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    J Neurol Neurosurg Psychiatry 77:454-6. 2006
    ..The aim of the present study was to assess visuoperceptual and visuospatial abilities in three atypical parkinsonian syndromes while minimising the influence of confounding variables...
  24. ncbi request reprint Can episodic memory tasks differentiate semantic dementia from Alzheimer's disease?
    V L Scahill
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neurocase 11:441-51. 2005
    ..Standard verbal episodic memory tests, therefore, failed to discriminate patients with SD from those with probable AD and even visual memory tests may result in misclassification of SDR cases...
  25. ncbi request reprint Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks
    R Swainson
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Dement Geriatr Cogn Disord 12:265-80. 2001
    ..QD patients' performance correlated with the degree of subsequent global cognitive decline. Elements of contextual and cued recall may account for the task's sensitivity and specificity for AD...
  26. ncbi request reprint Heterogeneity of semantic and visuospatial deficits in early Alzheimer's disease
    D Caine
    Department of Neurology, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neuropsychology 15:155-64. 2001
    ....
  27. ncbi request reprint On the relationship between knowledge and memory for pictures: evidence from the study of patients with semantic dementia and Alzheimer's disease
    K S Graham
    University Neurology Unit, Addenbrooke s Hospital, Cambridge, U K
    J Int Neuropsychol Soc 3:534-44. 1997
    ..This result provides support for the view that new learning is primarily dependent upon the hippocampus and related structures...
  28. pmc How preserved is episodic memory in behavioral variant frontotemporal dementia?
    M Hornberger
    Prince of Wales Medical Research Institute, Cnr Barker St and Easy St, Randwick, Sydney, NSW 2031, Australia
    Neurology 74:472-9. 2010
    ..Our study investigated whether this variability is due to the admixture of patients with true bvFTD and phenocopy patients. We also sought to compare performance of patients with bvFTD and patients with Alzheimer disease (AD)...
  29. ncbi request reprint The effects of motor neurone disease on language: further evidence
    Thomas H Bak
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Brain Lang 89:354-61. 2004
    ..N., a pathologically confirmed case of MND/dementia. Finally, we attempt to characterise the nature of the linguistic impairment in MND in the light of current debates about the mechanisms underlying noun/verb dissociation...
  30. doi request reprint Neural correlates of activities of daily living in frontotemporal dementia
    E Mioshi
    Neuroscience Research Australia, Sydney, Australia
    J Geriatr Psychiatry Neurol 26:51-7. 2013
    ..Little research to date has investigated neural correlates of functional disability in frontotemporal dementia (FTD)...
  31. doi request reprint Brain correlates of musical and facial emotion recognition: evidence from the dementias
    S Hsieh
    Neuroscience Research Australia, Sydney, NSW 2031, Australia
    Neuropsychologia 50:1814-22. 2012
    ....
  32. ncbi request reprint Is a picture worth a thousand words? Evidence from concept definitions by patients with semantic dementia
    M A Lambon Ralph
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Brain Lang 70:309-35. 1999
    ..The results lead us to favor a model of the semantic system that is divided by attribute type but not by modality...
  33. ncbi request reprint Naming in semantic dementia--what matters?
    M A Lambon Ralph
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neuropsychologia 36:775-84. 1998
    ..Age-of-acquisition and word frequency (at a phonological-lexical level) predicts naming success, because frequent, early-acquired words are relatively easy to activate even with reduced semantic "input"...
  34. ncbi request reprint Episodic memory: new insights from the study of semantic dementia
    K S Graham
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF, UK
    Curr Opin Neurobiol 9:245-50. 1999
    ..Recent findings indicate that the syndrome of semantic dementia can inform us about the organisation of long-term memory and the relationship between semantic memory and other cognitive systems...
  35. ncbi request reprint Activities of daily living in frontotemporal dementia and Alzheimer disease
    E Mioshi
    University of Cambridge Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Neurology 68:2077-84. 2007
    ..To evaluate activities of daily living (ADLs) in three clinical variants of frontotemporal dementia and the relationship to cognitive dysfunction...
  36. doi request reprint Clinical staging and disease progression in frontotemporal dementia
    E Mioshi
    Prince of Wales Medical Research Institute, Cnr Barker St and Easy St, Randwick, NSW 2031 Sydney, Australia
    Neurology 74:1591-7. 2010
    ....
  37. ncbi request reprint Motor neurone disease, dementia and aphasia: coincidence, co-occurrence or continuum?
    T H Bak
    MRC, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    J Neurol 248:260-70. 2001
    ..Further studies are required to establish whether MND/dementia and MND/aphasia form separate disease entities or can be viewed as extreme forms of a cognitive deficit characteristic of MND in general...
  38. pmc Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia
    O Piguet
    Prince of Wales Medical Research Institute, Randwick NSW, Australia
    Neurology 72:732-7. 2009
    ..Some features are open to clinical interpretation and their prevalence unknown. This study investigated the sensitivity of current diagnostic criteria in a large group of patients with bvFTD...
  39. ncbi request reprint Dissociation of social cognition and executive function in frontal variant frontotemporal dementia
    S Lough
    Psychology Department, Fulbourn Hospital, Addenbrooke s NHS Trust, Cambridge, UK
    Neurocase 7:123-30. 2001
    ..The implications of this finding for diagnostic procedures and possible behavioural management are discussed...
  40. ncbi request reprint Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA)
    T H Bak
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neurocase 11:268-73. 2005
    ..The pattern of cognitive impairment is likely to reflect a different distribution of pathology, in particular a higher degree of cortical involvement in PSP and CBD...
  41. ncbi request reprint Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers
    G E Berrios
    Department of Psychiatry, University of Cambridge, Addenbrookes Hospital (Box 189, Hills Road, CB2-2QQ, Cambridge, UK
    Psychiatry Res 102:217-25. 2001
    ..Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed...
  42. doi request reprint Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?
    M Hornberger
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    J Neurol Neurosurg Psychiatry 80:591-3. 2009
    ..The current study investigates whether the two groups can be discriminated by their clinical features at first presentation...
  43. ncbi request reprint Severe anterograde amnesia with extensive hippocampal degeneration in a case of rapidly progressive frontotemporal dementia
    D Caine
    University Department of Neurology, Addenbrooke s Hospital, Cambridge, UK
    Neurocase 7:57-64. 2001
    ..This case demonstrates that the pattern of FTD may include severe anterograde amnesia as a prominent and early consequence of the disease...
  44. doi request reprint Dissociation of explicit and implicit long-term memory consolidation in semantic dementia: a case study
    S Tu
    Neuroscience Research Australia, Sydney, Australia
    Neurocase 19:401-7. 2013
    ..The results also indicate that learnt information can be still accessed with implicit retrieval strategies when explicit retrieval fails. ..
  45. pmc Similar early clinical presentations in familial and non-familial frontotemporal dementia
    O Piguet
    Prince of Wales Medical Research Institute, Univeristy of New South Wales, Sydney, New South Wales, Australia
    J Neurol Neurosurg Psychiatry 75:1743-5. 2004
    ..It is unclear whether there are early clinical features that can distinguish between patients with familial and non-familial frontotemporal dementia (FTD)...
  46. doi request reprint Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease
    M Hornberger
    Neuroscience Research Australia, Barker and Easy Streets, Randwick, Sydney, NSW 2031, Australia
    Dement Geriatr Cogn Disord 30:547-52. 2010
    ..Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy...
  47. ncbi request reprint Profile of cognitive progression in early Huntington's disease
    A K Ho
    University of Cambridge, UK
    Neurology 61:1702-6. 2003
    ..To examine the pattern of cognitive decline in early Huntington's disease (HD)...
  48. pmc Distinctive cognitive profiles in Alzheimer's disease and subcortical vascular dementia
    N L Graham
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, and MRC Cognition and Brain Sciences Unit, 15 Chaucer Rd, Cambridge, UK
    J Neurol Neurosurg Psychiatry 75:61-71. 2004
    ..There are inconsistencies in published reports regarding the profile of cognitive impairments in vascular dementia, and its differentiation from Alzheimer's disease...
  49. doi request reprint Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease
    M Irish
    Neuroscience Research Australia, Barker Street, Randwick, Sydney, Australia
    Neuropsychologia 49:2694-702. 2011
    ..In addition, these results point towards the importance of investigating the constituent elements of emotion processing and strategic retrieval processes as potential variables mediating recent episodic ABM retrieval...
  50. ncbi request reprint Spatial and non-spatial working memory at different stages of Parkinson's disease
    A M Owen
    Department of Psychiatry, University of Cambridge, UK
    Neuropsychologia 35:519-32. 1997
    ....
  51. ncbi request reprint Episodic and semantic memory in mild cognitive impairment
    R B Dudas
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychologia 43:1266-76. 2005
    ..Patients with MCI show deficits of episodic and semantic memory. The extent of impairment suggests dysfunction beyond the medial temporal lobe. The FPT might form the basis of a sensitive early indicator of AD...
  52. ncbi request reprint The rise and fall of frequency and imageability: noun and verb production in semantic dementia
    H Bird
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Brain Lang 73:17-49. 2000
    ..Both verbs and nouns are affected by the degradation of semantic memory; the fact that the impairment to noun production is manifested earlier and more catastrophically may be attributed to the relatively lower frequency of these terms...
  53. ncbi request reprint Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
    C J Galton
    University Neurology Unit, Addenbrooke's Hospital, Cambridge, UK
    Neurology 57:216-25. 2001
    ..These findings have implications for diagnosis and understanding of the cognitive deficits in AD and semantic dementia...
  54. ncbi request reprint Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: a cross-sectional and longitudinal study of 55 cases
    Matthew A Lambon Ralph
    MRC Cognition and Brain Sciences Unit, Addenbrooke s Hospital, Cambridge, UK
    Brain 126:2350-62. 2003
    ..Although such cases may mimic more focal lobar degenerative conditions, patients with atypical Alzheimer's disease have pronounced episodic memory impairments, suggesting amnesia as a critical diagnostic feature...
  55. ncbi request reprint The human perirhinal cortex and semantic memory
    R R Davies
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Eur J Neurosci 20:2441-6. 2004
    ..In conclusion, atrophy of the human perirhinal cortex, and of directly connected areas, was associated with semantic memory impairment but not episodic memory impairment, as predicted from the primate work...
  56. doi request reprint Naming of objects, faces and buildings in mild cognitive impairment
    Samrah Ahmed
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
    Cortex 44:746-52. 2008
    ..A semantic deficit together with the hallmark episodic deficit may be common in MCI, and that the use of graded tasks tapping semantic memory may be useful for the early identification of patients with MCI...
  57. ncbi request reprint Semantic memory in Alzheimer's disease and the frontotemporal dementias: a longitudinal study of 236 patients
    Timothy T Rogers
    MRC Cognition and Brain Sciences Unit, Cambridge, England
    Neuropsychology 20:319-35. 2006
    ....
  58. ncbi request reprint Differing profiles of face and scene discrimination deficits in semantic dementia and Alzheimer's disease
    Andy C H Lee
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neuropsychologia 45:2135-46. 2007
    ..These findings extend existing theoretical accounts of MTL function, and challenge current concepts of cognitive impairment in dementia...
  59. doi request reprint Activities of daily living in progressive non-fluent aphasia, logopenic progressive aphasia and Alzheimer's disease
    J Jang
    Neuroscience Research Australia, Sydney, Australia
    Dement Geriatr Cogn Disord 33:354-60. 2012
    ..This study examined functional changes in progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA) and Alzheimer's disease (AD) and the association between function, cognition and behaviour...
  60. doi request reprint Incidence of early-onset dementias in Cambridgeshire, United Kingdom
    L Mercy
    MFPH, Institute of Public Health, University of Cambridge, University Forvie Site, Robinson Way, Cambridge, UK
    Neurology 71:1496-9. 2008
    ..To estimate the incidence of early-onset dementias in a defined area of Cambridgeshire served by Addenbrooke's Hospital...
  61. pmc Emotion recognition in progressive supranuclear palsy
    B C P Ghosh
    Department of Clinical Neurosciences, Cambridge University, Cambridge, UK
    J Neurol Neurosurg Psychiatry 80:1143-5. 2009
    ..The acknowledgement of deficits in emotion recognition is important for management of both patients and their carers...
  62. doi request reprint Clinical phenotypes in autopsy-confirmed Pick disease
    O Piguet
    Neuroscience Research Australia, Sydney, Australia
    Neurology 76:253-9. 2011
    ..This study aimed to improve sensitivity of clinicopathologic relations in cases with neuropathologically confirmed Pick disease and to identify clinical symptoms and signs predictive of disease progression...
  63. ncbi request reprint Perceptual and semantic components of memory for objects and faces: a pet study
    J S Simons
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    J Cogn Neurosci 13:430-43. 2001
    ..These results have implications for our understanding of the neural correlates of perceptual and semantic contributions to recognition memory...
  64. ncbi request reprint Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial
    J B Deakin
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, CB2 2QQ Cambridge, England, UK
    Psychopharmacology (Berl) 172:400-8. 2004
    ..A non-randomized clinical trial found improvement in these symptoms after treatment with a selective serotonin reuptake inhibitor (SSRI)...
  65. pmc A study of stereotypic behaviours in Alzheimer's disease and frontal and temporal variant frontotemporal dementia
    S Nyatsanza
    Psychiatric Services for the Elderly, Fulbourn Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 74:1398-402. 2003
    ..Secondly, to examine the relationship between stereotypic and other neuropsychiatric behaviours...
  66. ncbi request reprint Behavioural variant frontotemporal dementia: not all it seems?
    C M Kipps
    Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Neurocase 13:237-47. 2007
    ..At present there is a paucity of prospective work addressing the specificity of current diagnostic criteria for bvFTD with respect to long-term outcome (i.e., false positives versus true positives)...
  67. pmc The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer's disease) with FDG-PET
    P J Nestor
    University of Cambridge, Neurology Unit, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 74:1521-9. 2003
    ....
  68. ncbi request reprint Social reasoning, emotion and empathy in frontotemporal dementia
    Sinclair Lough
    Department of Clinical Psychology, Fulbourn Hospital, Cambridge, UK
    Neuropsychologia 44:950-8. 2006
    ..Social cognition is crucial for human interaction, and is markedly impaired in the frontal variant of frontotemporal dementia (fvFTD). The relationship of various aspects of social functioning, however, remains controversial in this group...
  69. doi request reprint Anomia: a doubly typical signature of semantic dementia
    Anna M Woollams
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, England, UK
    Neuropsychologia 46:2503-14. 2008
    ....
  70. ncbi request reprint Verbal fluency in Huntington's disease: a longitudinal analysis of phonemic and semantic clustering and switching
    Aileen K Ho
    Cambridge Centre for Brain Repair, University of Cambridge, UK
    Neuropsychologia 40:1277-84. 2002
    ..Hence, phonemic switching alone drove verbal fluency performance and this selective impairment can be explained by the progressive involvement of frontostriatal circuitry in the natural progression of HD...
  71. ncbi request reprint Evolution of cognitive deficits and conversion to dementia in patients with mild cognitive impairment: a very-long-term follow-up study
    John R Hodges
    MRC Cognition and Brain Sciences Unit, Addenbrooke s Hospital, Cambridge, UK
    Dement Geriatr Cogn Disord 21:380-91. 2006
    ..Full-blown dementia may take many years to develop in patients with MCI but was a universal feature in this study...
  72. ncbi request reprint Dissociating person-specific from general semantic knowledge: roles of the left and right temporal lobes
    Sian A Thompson
    University Neurology Unit, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Neuropsychologia 42:359-70. 2004
    ..P.'s deficit for person knowledge and predominantly left temporal atrophy in M.A. who was impaired in general conceptual knowledge...
  73. ncbi request reprint A reversal of the temporal gradient for famous person knowledge in semantic dementia: implications for the neural organisation of long-term memory
    J R Hodges
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, UK
    Neuropsychologia 36:803-25. 1998
    ..The results are discussed with respect to current views of the neural organisation of person-specific and general semantic memory...
  74. ncbi request reprint Nuclear imaging can predict pathologic diagnosis in progressive nonfluent aphasia
    P J Nestor
    Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurology 68:238-9. 2007
  75. ncbi request reprint Deficits in irregular past-tense verb morphology associated with degraded semantic knowledge
    K Patterson
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuropsychologia 39:709-24. 2001
    ..These results, plus other features of the data such as the nature of the errors to irregular verbs, are discussed in relation to currently developing theories of the language system...
  76. doi request reprint Measuring progression in frontotemporal dementia: implications for therapeutic interventions
    C M Kipps
    Department of Clinical Neurosciences, University of Cambridge, UK
    Neurology 70:2046-52. 2008
    ..There is a need for instruments which can measure progression of disease in frontotemporal dementia (FTD), particularly with respect to the assessment of potential therapeutic agents...
  77. ncbi request reprint Knowing about people and naming them: can Alzheimer's disease patients do one without the other?
    J R Hodges
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, U K
    Q J Exp Psychol A 51:121-34. 1998
    ..The implication of these findings for models of face identification and naming are discussed...
  78. pmc Determinants of survival in behavioral variant frontotemporal dementia
    B Garcin
    Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia
    Neurology 73:1656-61. 2009
    ..Little is known about its rate of progression but a recently identified subgroup seems to have an excellent prognosis. Other determinants of survival are unclear...
  79. pmc Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia
    Shibley Rahman
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Neuropsychopharmacology 31:651-8. 2006
    ..The results are discussed in terms of the 'somatic marker' hypothesis of impaired decision-making following orbitofrontal dysfunction...
  80. doi request reprint Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia
    Michael Hornberger
    Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia
    Neurology 71:1481-8. 2008
    ..We investigated executive and behavioral profiles of progressive and nonprogressive bv-FTD patients to establish diagnostic markers discriminating the two groups...
  81. ncbi request reprint Neural correlates of semantic and behavioural deficits in frontotemporal dementia
    Guy B Williams
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Neuroimage 24:1042-51. 2005
    ..The frontal paracingulate correlation suggests that damage to this region may significantly contribute to the genesis of the behavioural syndrome seen in FTD...
  82. ncbi request reprint Dissociation between top-down attentional control and the time course of visual attention as measured by attentional dwell time in patients with mild cognitive impairment
    Richard J Perry
    University of Cambridge Neurology Unit, Addenbrooke s Hospital, Cambridge, UK
    Eur J Neurosci 18:221-6. 2003
    ..This dissociation suggests that these two aspects of visual attention are subserved by different neural systems. The possible neural correlates of these two attentional functions are discussed...
  83. ncbi request reprint Recollection-based memory in frontotemporal dementia: implications for theories of long-term memory
    Jon S Simons
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Brain 125:2523-36. 2002
    ..These results provide further compelling evidence in favour of the multiple input model of long-term memory and highlight the role of frontal lobe systems in recollection-based memory...
  84. doi request reprint "I remember it as if it were yesterday": memory for recent events in patients with semantic dementia
    A L R Adlam
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
    Neuropsychologia 47:1344-51. 2009
    ..These findings are discussed with regard to the neural substrate of episodic memory and psychological models of long-term memory...
  85. ncbi request reprint Corticobasal degeneration as a cognitive disorder
    Naida L Graham
    University Neurology Unit, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 18:1224-32. 2003
    ..More systematic investigation of the clinical and neuropathological overlap between progressive nonfluent aphasia (generally considered to be a form of frontotemporal dementia) and CBD is needed...
  86. ncbi request reprint Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing
    Thomas H Bak
    MRC Cognition and Brain Sciences Unit, Addenbrooke s Hospital, UK
    Brain 129:321-32. 2006
    ..By demonstrating a link between pathology, genetics, imaging and abstract cognitive impairments this study advances our understanding of degenerative brain disease with implications for both neuroscience and clinical practice...
  87. ncbi request reprint Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications
    Carol Gregory
    Fulbourn Hospital, Cambridge, UK
    Brain 125:752-64. 2002
    ..This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD...
  88. doi request reprint Predicting rapid clinical progression in amnestic mild cognitive impairment
    Samrah Ahmed
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
    Dement Geriatr Cogn Disord 25:170-7. 2008
    ..We investigated whether an initial neuropsychological assessment could predict rapid progression over 12 months, from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD)...
  89. ncbi request reprint The Cambridge Semantic Memory Test Battery: detection of semantic deficits in semantic dementia and Alzheimer's disease
    Anna Lynne R Adlam
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neurocase 16:193-207. 2010
    ..An assessment including measures of episodic memory and visuospatial abilities as well as the semantic battery is recommended for good characterisation of the cognitive profiles associated with SD and AD...
  90. ncbi request reprint Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment
    Peter J Nestor
    University of Cambridge, Neurology Unit, Cambridge, United Kingdom
    Ann Neurol 54:343-51. 2003
    ..The amnesia of very early AD reflects severe but localized limbic dysfunction...
  91. doi request reprint Is the pathology of corticobasal syndrome predictable in life?
    Bhaskara P Shelley
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, UK
    Mov Disord 24:1593-9. 2009
    ..CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life...
  92. doi request reprint Outcome in subgroups of mild cognitive impairment (MCI) is highly predictable using a simple algorithm
    Joanna Mitchell
    Department of Clinical Neuroscience, Addenbrooke s Hospital, Cambridge, UK
    J Neurol 256:1500-9. 2009
    ..While the latter is an aggressive disorder, the former is more benign and unstable even in a clinic setting. Patients with scores >88 on the ACE and/or <14 errors on the PAL can be confidently reassured of a good prognosis...
  93. ncbi request reprint Psychiatric symptoms in neurologically asymptomatic Huntington's disease gene carriers: a comparison with gene negative at risk subjects
    G E Berrios
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Psychiatr Scand 105:224-30. 2002
    ..Psychiatric profiles of two at-risk groups [Huntington's disease (HD) gene carriers and non-carriers] were compared by means of a computerized battery and a structured interview...
  94. ncbi request reprint Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease)
    P J Nestor
    University of Cambridge, Neurology Unit, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Eur J Neurosci 18:2663-7. 2003
    ....
  95. pmc Neuropsychological and quantitative oculometric study of a case of sporadic Creutzfeldt-Jakob disease at predementia stage
    M Zarei
    Department of Clinical Neurology, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Neurol Neurosurg Psychiatry 73:56-8. 2002
    ....
  96. ncbi request reprint Tau gene mutation K257T causes a tauopathy similar to Pick's disease
    C Rizzini
    Brain Repair Centre and Department of Neurology, University of Cambridge, United Kingdom
    J Neuropathol Exp Neurol 59:990-1001. 2000
    ..Taken together, the present findings indicate that the K257T mutation in Tau can cause a dementing condition similar to Pick's disease...
  97. ncbi request reprint Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?
    A L R Adlam
    Medical Research Council Cognition and Brain Sciences Unit Cambridge, UK
    Brain 129:3066-80. 2006
    ....
  98. ncbi request reprint Differentiation of semantic dementia and Alzheimer's disease using the Addenbrooke's Cognitive Examination (ACE)
    R Rhys Davies
    University of Cambridge, Dept of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Int J Geriatr Psychiatry 23:370-5. 2008
    ....
  99. ncbi request reprint The neural basis of semantic memory: evidence from semantic dementia
    R Rhys Davies
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital Hills Road, Cambridge CB2 2QQ, UK
    Neurobiol Aging 30:2043-52. 2009
    ..In summary, whole-brain regional evaluation in SD, in comparison with normal controls and FTD-MND, found anterior temporal atrophy encompassing the perirhinal cortex with relative sparing of adjacent posterior temporal regions...
  100. doi request reprint Theory of mind in frontotemporal dementia
    Christopher M Kipps
    University of Cambridge, Cambridge, UK
    Soc Neurosci 1:235-44. 2006
    ..The role of executive ability and co-existing emotional deficits are also considered...
  101. ncbi request reprint Measuring and modifying abnormal social cognition in frontal variant frontotemporal dementia
    Sinclair Lough
    Department of Psychiatric Services for the Elderly and Neurology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Psychosom Res 53:639-46. 2002
    ....