Robert P Hirt

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution
    Jan O Andersson
    Institute of Cell and Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden
    BMC Genomics 8:51. 2007
  2. pmc Evolution of four gene families with patchy phylogenetic distributions: influx of genes into protist genomes
    Jan O Andersson
    Institute of Cell and Molecular Biology, Uppsala University, Biomedical Center, Box 596, S 751 24 Uppsala, Sweden
    BMC Evol Biol 6:27. 2006
  3. ncbi request reprint Trichomonas vaginalis surface proteins: a view from the genome
    R P Hirt
    Institute for Cellular and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Trends Parasitol 23:540-7. 2007
  4. doi request reprint Trichomonas vaginalis pathobiology new insights from the genome sequence
    Robert P Hirt
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Adv Parasitol 77:87-140. 2011
  5. doi request reprint Microbase2.0: a generic framework for computationally intensive bioinformatics workflows in the cloud
    Keith Flanagan
    School of Computing Science, Newcastle University, Newcastle upon Tyne, UK
    J Integr Bioinform 9:212. 2012
  6. pmc Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics
    Christophe J Noel
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    BMC Genomics 11:99. 2010
  7. pmc The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution
    Eva Heinz
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Pathog 8:e1002979. 2012
  8. doi request reprint Data mining the human gut microbiota for therapeutic targets
    Matthew Collison
    Biopharmaceutical Process Development Centre, School of Chemical Engineering and Advanced Materials, Newcastle University, UK
    Brief Bioinform 13:751-68. 2012
  9. pmc Diversity and reductive evolution of mitochondria among microbial eukaryotes
    Karin Hjort
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Philos Trans R Soc Lond B Biol Sci 365:713-27. 2010
  10. pmc A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes
    Sirintra Nakjang
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e30287. 2012

Collaborators

  • Simon R Harris
  • James R Brown
  • T Martin Embley
  • Tal Dagan
  • Eva Heinz
  • Jörg Bernhardt
  • Thomas Rattei
  • Neil Hall
  • Thomas Schweder
  • Stephanie Markert
  • J Tachezy
  • Jeremy C Mottram
  • Sirintra Nakjang
  • Anil Wipat
  • Jan O Andersson
  • Matthew Collison
  • Keith Flanagan
  • Christophe J Noel
  • Karin Hjort
  • Thomas Sicheritz-Ponten
  • U Cecilia Alsmark
  • Peter G Foster
  • C G Clark
  • Andrew J Roger
  • Didier A Ndeh
  • Matthew R Pocock
  • Jennifer Hallinan
  • Philippe Sanseau
  • Colin Harwood
  • David N Bolam
  • Lucie Safarikova
  • Pier Luigi Fiori
  • Anastasios D Tsaousis
  • Petrus Tang
  • Nicia Diaz
  • Alina V Goldberg
  • C J Noel
  • M Tazreiter
  • M Leippe
  • A Lohia
  • T Nozaki
  • C Weber
  • David S Horner
  • P G Foster
  • E Tannich
  • U C M Alsmark
  • C A Gilchrist
  • Asa M Sjögren
  • V Ali
  • T Sicheritz-Ponten
  • Mark A Ragan
  • Staffan G Svard
  • B J Mann
  • N Guillen
  • A Bhattacharya
  • I Bruchhaus
  • S Bhattacharya
  • Y Saito-Nakano
  • John M Logsdon
  • S Marion
  • Patricia L Dyal
  • J P Ackers
  • Colleen A Murphy
  • U Singh
  • C Mukherjee
  • J Samuelson
  • M Duchene

Detail Information

Publications13

  1. pmc A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution
    Jan O Andersson
    Institute of Cell and Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden
    BMC Genomics 8:51. 2007
    ..barkhanus)...
  2. pmc Evolution of four gene families with patchy phylogenetic distributions: influx of genes into protist genomes
    Jan O Andersson
    Institute of Cell and Molecular Biology, Uppsala University, Biomedical Center, Box 596, S 751 24 Uppsala, Sweden
    BMC Evol Biol 6:27. 2006
    ....
  3. ncbi request reprint Trichomonas vaginalis surface proteins: a view from the genome
    R P Hirt
    Institute for Cellular and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Trends Parasitol 23:540-7. 2007
    ..Here, we review the existing data on T. vaginalis surface proteins and summarize some of the main findings from the recent in silico characterization of its candidate surface proteins...
  4. doi request reprint Trichomonas vaginalis pathobiology new insights from the genome sequence
    Robert P Hirt
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Adv Parasitol 77:87-140. 2011
    ....
  5. doi request reprint Microbase2.0: a generic framework for computationally intensive bioinformatics workflows in the cloud
    Keith Flanagan
    School of Computing Science, Newcastle University, Newcastle upon Tyne, UK
    J Integr Bioinform 9:212. 2012
    ..Microbase2.0 is freely available from http://www.microbase.org.uk/...
  6. pmc Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics
    Christophe J Noel
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    BMC Genomics 11:99. 2010
    ..Initial annotations of T. vaginalis genome identified a plethora of candidate extracellular proteins...
  7. pmc The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution
    Eva Heinz
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Pathog 8:e1002979. 2012
    ....
  8. doi request reprint Data mining the human gut microbiota for therapeutic targets
    Matthew Collison
    Biopharmaceutical Process Development Centre, School of Chemical Engineering and Advanced Materials, Newcastle University, UK
    Brief Bioinform 13:751-68. 2012
    ..In addition, integrative bioinformatics analysis will further our understanding of the microbial biotransformation of exogenous compounds or xenobiotics, which could lead to safer and more efficacious drugs...
  9. pmc Diversity and reductive evolution of mitochondria among microbial eukaryotes
    Karin Hjort
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Philos Trans R Soc Lond B Biol Sci 365:713-27. 2010
    ..These investigations are contributing to understanding the essential functions of mitochondria, defined in the broadest sense, and the limits to which reductive evolution can proceed while maintaining a viable organelle...
  10. pmc A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes
    Sirintra Nakjang
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e30287. 2012
    ....
  11. doi request reprint Horizontal gene transfer in eukaryotic parasites: a case study of Entamoeba histolytica and Trichomonas vaginalis
    U Cecilia Alsmark
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Methods Mol Biol 532:489-500. 2009
    ..We found a broad range of prokaryotic lineages represented among the donors, but organisms that share similar environmental niches with E. histolytica and T. vaginalis, such as the gut and the vaginal mucosa, dominate...
  12. ncbi request reprint Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis
    R P Hirt
    Department of Zoology, The Natural History Museum, Cromwell Rd, London SW7 5BD, UK
    Mol Biochem Parasitol 129:179-89. 2003
    ..Based on the sequence features of the cloned gene and the biochemical properties of the purified proteins, we suggest that these alpha subunits are likely to be part of classic heterotrimeric G-protein complexes...
  13. ncbi request reprint Structure and content of the Entamoeba histolytica genome
    C G Clark
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Adv Parasitol 65:51-190. 2007
    ..In this chapter we summarise the features of the genome as they are currently understood and provide previously unpublished analyses of many of the genes...