Anne Hinks

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 66:683-6. 2007
  2. ncbi Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, The University of Manchester, Manchester M139PT, UK
    Arthritis Res Ther 13:R12. 2011
  3. ncbi Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci
    Annie McClure
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:1369-74. 2009
  4. ncbi Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
    Anne Hinks
    Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1049-53. 2010
  5. ncbi Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes
    Anne Barton
    University of Manchester, Manchester, UK
    Hum Mol Genet 18:2518-22. 2009
  6. ncbi PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
  7. ncbi Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p
    William Brintnell
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:3823-30. 2004
  8. ncbi Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
  9. ncbi Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
  10. ncbi Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009

Detail Information

Publications29

  1. ncbi Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 66:683-6. 2007
    ....
  2. ncbi Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, The University of Manchester, Manchester M139PT, UK
    Arthritis Res Ther 13:R12. 2011
    ..We, therefore, hypothesized that two well-established susceptibility loci for AS and Ps, ERAP1 and IL23R, could also confer susceptibility to these JIA subtypes...
  3. ncbi Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci
    Annie McClure
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:1369-74. 2009
    ..The largest single effect is conferred by SE. We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone...
  4. ncbi Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
    Anne Hinks
    Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1049-53. 2010
    ..Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci...
  5. ncbi Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes
    Anne Barton
    University of Manchester, Manchester, UK
    Hum Mol Genet 18:2518-22. 2009
    ..94, P = 1.1 x 10(-4) and OR 0.86, 95% CI 0.79-0.94, P = 5.4 x 10(-4), respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases...
  6. ncbi PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
    ..However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population...
  7. ncbi Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p
    William Brintnell
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:3823-30. 2004
    ..To investigate whether the large linkage peak on chromosome 6p harbors rheumatoid arthritis (RA) susceptibility loci in addition to the well-characterized HLA-DRB1 gene...
  8. ncbi Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
    ....
  9. ncbi Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
    ..The aim of the current study was to validate these potential RA susceptibility markers in a UK population...
  10. ncbi Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
    ..This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for...
  11. ncbi A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
    ..Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression...
  12. ncbi Association of the CCR5 gene with juvenile idiopathic arthritis
    A Hinks
    Manchester Academy of Health Sciences, The University of Manchester, UK
    Genes Immun 11:584-9. 2010
    ....
  13. ncbi Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2169-72. 2010
    ..There is strong evidence suggesting that juvenile idiopathic arthritis (JIA) shares many susceptibility loci with other autoimmune diseases...
  14. ncbi Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:251-7. 2009
    ..The aim of this study was to determine whether SNPs within the IL2RA/CD25 gene are associated with juvenile idiopathic arthritis (JIA)...
  15. ncbi Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    Anne Barton
    Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK
    Nat Genet 40:1156-9. 2008
    ....
  16. ncbi Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:748-52. 2004
    ..The aim of this study was to investigate the association of the CTLA-4 polymorphism with RA...
  17. ncbi Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
    Stephen Eyre
    Arthritis Research UK, Epidemiology Unit, Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 12:R175. 2010
    ..Here we have attempted to define overlapping genetic variants between rheumatoid arthritis (RA), type 1 diabetes (T1D) and coeliac disease (CeD)...
  18. ncbi A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:1117-21. 2004
    ..In the present study, we investigated the association of single-nucleotide polymorphisms (SNPs) in the PADI4 gene with RA in a UK population...
  19. ncbi Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Manchester M13 9PT, UK
    Ann Rheum Dis 70:463-8. 2011
    ..Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) that are common to both diseases...
  20. ncbi Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
    Anne Barton
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Hum Mol Genet 17:2274-9. 2008
    ..The effect sizes are less than those reported previously but are likely to be a more accurate reflection of the true effect size given the larger size of the cohort investigated in the current study...
  21. ncbi Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Ann Rheum Dis 71:1117-21. 2012
    ..A plethora of newly validated RA loci has been reported in the past year. Therefore, the aim of this study was to investigate these single nucleotide polymorphisms (SNP) to determine if they were also associated with JIA...
  22. ncbi Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:258-63. 2009
    ..The purpose of this study was to perform a systematic search of the genome to identify novel susceptibility loci for JIA...
  23. ncbi Rheumatoid arthritis association at 6q23
    Wendy Thomson
    Arthritis Research Campaign ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Nat Genet 39:1431-3. 2007
    ..1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3)...
  24. ncbi Fine mapping of genes within the IDDM8 region in rheumatoid arthritis
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 8:R145. 2006
    ..Our study has failed to detect evidence of association with any of the known genes mapping to the IDDM8 locus with RA...
  25. ncbi Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites
    Sally John
    University of Manchester, Manchester, United Kingdom
    Am J Hum Genet 75:54-64. 2004
    ..The high SNP density allows loci to be defined more precisely and provides a partial scaffold for association studies, substantially reducing the resource requirement for gene-mapping studies...
  26. ncbi Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
    ..All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed...
  27. ncbi Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1395-400. 2011
    ..Using a candidate gene approach, single nucleotide polymorphisms (SNPs) within genes in the metabolic pathway of MTX, were investigated for association with response to treatment in JIA cases...
  28. ncbi Investigation of susceptibility loci identified in the UK rheumatoid arthritis whole-genome scan in a further series of 217 UK affected sibling pairs
    Stephen Eyre
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 50:729-35. 2004
    ..03). CONCLUSION: These results support the evidence for heterogeneity of RA. This information will inform the future design of association-based investigations as the search for disease genes in the linked regions begins...
  29. ncbi Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure
    Neil Shephard
    ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    BMC Genet 4:S26. 2003
    ....